公开(公告)号：US20090240197A1

公开(公告)日：2009-09-24

申请号：US12297637

申请日：2007-04-19

申请人： Kevin P. Cowan ,  Eugene A. Gelblum ,  Alan D. Hirschman ,  David M. Reilly ,  Edward J. Rhinehart ,  Frederick W. Trombley, III

发明人： Kevin P. Cowan ,  Eugene A. Gelblum ,  Alan D. Hirschman ,  David M. Reilly ,  Edward J. Rhinehart ,  Frederick W. Trombley, III

IPC分类号： A61M25/092 ,  A61M25/09 ,  A61M25/10

CPC分类号： A61M25/0125 ,  A61M25/0053 ,  A61M25/007 ,  A61M25/0082 ,  A61M25/0113 ,  A61M25/0116 ,  A61M25/0119 ,  A61M25/0122 ,  A61M2025/0058

摘要： Systems, devices, and methods towards improved diagnosis and therapy in connection with central venous catheters (including PICC lines). Included among the many improvements broadly contemplated herein are: arrangements via which a venous catheter can move passively into position in central venous circulation; arrangements via which a catheter can be actively guided without the use of a needle or guide wire; arrangements via which a catheter can be packaged to facilitate easy, rapid, and positionally accurate deployment by medical personnel while maintaining device sterility; and arrangements via which a catheter tip can be imaged during and after insertion.

摘要翻译： 与中心静脉导管（包括PICC系）相关的改进诊断和治疗的系统，装置和方法。 包括在这里广泛考虑的许多改进之中：静脉导管可以被动地移动到中心静脉循环中的位置的布置; 可以不使用针或引导线而可以主动地引导导管的布置; 导管可以被包装的布置，以便医疗人员容易，快速和定位准确的部署，同时保持装置不育; 以及在插入期间和之后可以使导管尖端成像的布置。

公开(公告)号：US20100174183A1

公开(公告)日：2010-07-08

申请号：US12515981

申请日：2007-11-28

申请人： Robert S. Schwartz ,  Robert A. Van Tassel ,  Eugene A. Gelblum ,  Alan D. Hirschman ,  John F. Kalafut ,  David M. Reilly ,  Edward J. Rhinehart ,  Frederick W. Trombley, III ,  Arthur E. Uber, III

发明人： Robert S. Schwartz ,  Robert A. Van Tassel ,  Eugene A. Gelblum ,  Alan D. Hirschman ,  John F. Kalafut ,  David M. Reilly ,  Edward J. Rhinehart ,  Frederick W. Trombley, III ,  Arthur E. Uber, III

IPC分类号： A61B6/00 ,  A61M25/00

CPC分类号： A61M25/007 ,  A61M25/003

摘要： A method and device for the simultaneous or sequential introduction of multiple fluids into the bloodstream including a multiple lumen catheter with corresponding multiple hole sets. By introducing a second fluid such as saline, the concentration and bolus of a first fluid, such as a contrast agent, can be controlled and optimized.

摘要翻译： 一种用于同时或顺序地将多种流体引入血流中的方法和装置，包括具有相应多孔组的多腔导管。 通过引入诸如盐水的第二流体，可以控制和优化第一流体如造影剂的浓度和推注。

公开(公告)号：US20110178359A1

公开(公告)日：2011-07-21

申请号：US12595165

申请日：2007-12-28

申请人： Alan D. Hirschman ,  Arthur E. Uber, III ,  Kevin P. Cowan ,  David M. Reilly ,  Edward J. Rhinehart ,  John Kalafut ,  Bronwyn Uber ,  Frederick W. Trombley, III ,  Steven J. Remis ,  Paul D. Levin ,  Scott Griffith ,  Douglas Descalzi ,  Richard Dewit ,  David M. Griffiths

发明人： Alan D. Hirschman ,  Arthur E. Uber, III ,  Kevin P. Cowan ,  David M. Reilly ,  Edward J. Rhinehart ,  John Kalafut ,  Bronwyn Uber ,  Frederick W. Trombley, III ,  Steven J. Remis ,  Paul D. Levin ,  Scott Griffith ,  Douglas Descalzi ,  Richard Dewit ,  David M. Griffiths

IPC分类号： A61M36/06

CPC分类号： A61N5/1001 ,  A61B5/0205 ,  A61B5/055 ,  A61B5/7289 ,  A61B6/032 ,  A61B6/037 ,  A61B6/0478 ,  A61B6/107 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/4423 ,  A61B6/507 ,  A61B6/508 ,  A61B6/5288 ,  A61B6/548 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1456 ,  A61M5/16827 ,  A61M5/16881 ,  A61M5/1723 ,  A61M5/1785 ,  A61M2205/3576 ,  A61N5/1071 ,  A61N2005/1021 ,  A61N2005/1094 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G21F5/015 ,  G21G4/08

摘要： An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.

摘要翻译： 公开了一种集成的放射性药物患者治疗系统，其包括具有相关联的患者刺激装置的患者支撑平台，靠近患者支撑平台的成像器，用于将放射性药物流体输入患者的放射性药物流体输送系统，与 患者以及与患者刺激装置，成像器，放射性药物流体输送系统和患者监护器可操作地相关联以控制和协调其操作的集成系统控制器。 在患者治疗系统内，可以包括放射性药物流体递送系统，包括放射性核素供应模块，放射性药物处理模块，质量控制模块，患者注射模块和控制器。 进一步公开了一种危险的流体处理系统，其包括对接站和适于与对接站可拆卸地对接的危险流体输送装置。

公开(公告)号：US20080294096A1

公开(公告)日：2008-11-27

申请号：US12092448

申请日：2006-11-06

申请人： Arthur E. Uber, III ,  Alan D. Hirschman ,  Evan Facher ,  Eugene A. Gelblum ,  David M. Griffiths ,  Edward J. Rhinehart ,  David M. Reilly ,  Kevin P. Cowan ,  Page Cedarholm ,  Barry L. Tucker ,  Mark Trocki ,  David Mishler ,  Henry E. Bartony, JR. ,  Robert Parks

发明人： Arthur E. Uber, III ,  Alan D. Hirschman ,  Evan Facher ,  Eugene A. Gelblum ,  David M. Griffiths ,  Edward J. Rhinehart ,  David M. Reilly ,  Kevin P. Cowan ,  Page Cedarholm ,  Barry L. Tucker ,  Mark Trocki ,  David Mishler ,  Henry E. Bartony, JR. ,  Robert Parks

IPC分类号： A61M5/168

CPC分类号： A61M5/142 ,  A61M5/1452 ,  A61M5/1723 ,  A61M5/3291 ,  A61M25/007 ,  A61M25/04 ,  A61M31/005 ,  A61M2025/0089 ,  A61M2025/009 ,  A61M2025/0092

摘要： A system for delivering a fluid comprising cells to tissue of a patient, includes: a least a first container for holding an injection fluid in which the agent is carried; a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container; a control system in operative connection with the first powered drive and operative to control the first powered drive; a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient; a sensor system; and a communication system in connection with at least the control system and the sensor system. The communication system is adapted to provide information to the control system. The control system in adapted to transmit a control signal to at least the first powered drive based at least in part on information provided to the control system. The cells can for example be pregenitor cells or stem cells.

摘要翻译： 一种用于将包含细胞的流体输送到患者的组织的系统，包括：用于保持其中携带有药剂的注射液体的至少第一容器; 与容器操作性连接的第一动力驱动器，第一动力驱动器可操作以对容器的内容物进行加压; 控制系统，其与第一动力驱动器操作连接并且可操作以控制第一动力驱动; 与容器流体连接的流体路径，流体路径包括适于将细胞沉积在患者组织内的患者界面; 传感器系统; 以及至少与控制系统和传感器系统相关的通信系统。 通信系统适于向控制系统提供信息。 控制系统适于至少部分地基于提供给控制系统的信息将控制信号发送到至少第一动力驱动器。 细胞可以例如是前体细胞或干细胞。

公开(公告)号：US08702649B2

公开(公告)日：2014-04-22

申请号：US12515981

申请日：2007-11-28

申请人： Robert S. Schwartz ,  Robert A. Van Tassel ,  Eugene A. Gelblum ,  Alan D. Hirschman ,  John F. Kalafut ,  David M. Reilly ,  Frederick W. Trombley, III ,  Arthur E. Uber, III

发明人： Robert S. Schwartz ,  Robert A. Van Tassel ,  Eugene A. Gelblum ,  Alan D. Hirschman ,  John F. Kalafut ,  David M. Reilly ,  Frederick W. Trombley, III ,  Arthur E. Uber, III

IPC分类号： A61M29/00

CPC分类号： A61M25/007 ,  A61M25/003

摘要： A method and device for the simultaneous or sequential introduction of multiple fluids into the bloodstream including a multiple lumen catheter with corresponding multiple hole sets. By introducing a second fluid such as saline, the concentration and bolus of a first fluid, such as a contrast agent, can be controlled and optimized.

摘要翻译： 一种用于同时或顺序地将多种流体引入血流中的方法和装置，包括具有相应多孔组的多腔导管。 通过引入诸如盐水的第二流体，可以控制和优化第一流体如造影剂的浓度和推注。

公开(公告)号：US5808203A

公开(公告)日：1998-09-15

申请号：US854411

申请日：1997-05-12

申请人： William J. Nolan, Jr. ,  Kevin P. Cowan ,  Alan D. Hirschman ,  David M. Reilly ,  Frederick W. Trombley, III ,  David M. Griffiths

发明人： William J. Nolan, Jr. ,  Kevin P. Cowan ,  Alan D. Hirschman ,  David M. Reilly ,  Frederick W. Trombley, III ,  David M. Griffiths

IPC分类号： A61M5/145 ,  A61M5/168 ,  A61M5/48 ,  G01L7/00 ,  A61M3/00

CPC分类号： A61M5/48 ,  A61M5/14546 ,  A61M5/315 ,  A61M5/31511 ,  A61M5/14566 ,  A61M5/16854

摘要： The present invention provides pressure measuring devices comprising a sensor to detect the force upon at least a portion of a contact surface of a syringe plunger during pressurization of a fluid medium within the syringe. A determination of the pressure of the fluid medium within the syringe is thereby enabled.

摘要翻译： 本发明提供了压力测量装置，其包括传感器，用于在注射器内的流体介质加压期间检测针筒柱塞的接触表面的至少一部分上的力。 从而能够确定注射器内的流体介质的压力。

公开(公告)号：US07351221B2

公开(公告)日：2008-04-01

申请号：US11394946

申请日：2006-03-31

申请人： Frederick W. Trombley, III ,  Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  Alan D. Hirschman

发明人： Frederick W. Trombley, III ,  Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  Alan D. Hirschman

IPC分类号： A61M37/00 ,  B01F5/00

CPC分类号： A61M5/142 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/14566 ,  A61M5/445 ,  A61M2205/3673 ,  B01F9/103 ,  B01F13/005

摘要： A system for dispensing a medium includes at least a first container to hold the medium, a pressurizing device, such as a pump, in fluid connection with the container for pressurizing the medium, and an agitation mechanism or device to maintain the components of the medium in a mixed state. The container and the pressurizing device can be separate units, as in the case of an bag or bottle in fluid connection with a peristaltic or other type of pump. The container and the pump can also be combined in a single unit, as in the case of a syringe, wherein the syringe barrel of the syringe acts to contain the medium and the syringe plunger pressurizes the medium within the syringe barrel. A method of injecting a multi-component medium includes the step of agitating the medium (for example, as described above) before or during an injection procedure to maintain the components of the medium in a mixed state.

摘要翻译： 用于分配介质的系统至少包括用于保持介质的第一容器，与容器流体连接的用于对介质加压的加压装置，例如泵，以及用于维持介质的组分的搅拌机构或装置 处于混合状态。 容器和加压装置可以是分离的单元，如在与蠕动或其它类型的泵流体连接的袋或瓶的情况下。 容器和泵也可以在单个单元中组合，如在注射器的情况下，其中注射器的注射器筒用于容纳介质，并且注射器柱塞对注射器筒内的介质加压。 注射多组分培养基的方法包括在注射过程之前或过程中搅拌培养基（例如，如上所述）以将培养基的组分维持在混合状态的步骤。

公开(公告)号：US06575930B1

公开(公告)日：2003-06-10

申请号：US09267237

申请日：1999-03-12

申请人： Frederick W. Trombley, III ,  Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  Alan D. Hirschman

发明人： Frederick W. Trombley, III ,  Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  Alan D. Hirschman

IPC分类号： A61M3700

CPC分类号： A61M5/142 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/14566 ,  A61M5/445 ,  A61M2205/3673 ,  B01F9/103 ,  B01F13/005

摘要： A system for dispensing a medium includes at least a first container to hold the medium, a pressurizing device, such as a pump, in fluid connection with the container for pressurizing the medium, and an agitation mechanism or device to maintain the components of the medium in a mixed state. The container and the pressurizing device can be separate units, as in the case of an bag or bottle in fluid connection with a peristaltic or other type of pump. The container and the pump can also be combined in a single unit, as in the case of a syringe, wherein the syringe barrel of the syringe acts to contain the medium and the syringe plunger pressurizes the medium within the syringe barrel. A method of injecting a multi-component medium includes the step of agitating the medium (for example, as described above) before or during an injection procedure to maintain the components of the medium in a mixed state.

公开(公告)号：US07060049B2

公开(公告)日：2006-06-13

申请号：US10435802

申请日：2003-05-12

申请人： Frederick W. Trombley, III ,  Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  Alan D. Hirschman

发明人： Frederick W. Trombley, III ,  Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  Alan D. Hirschman

IPC分类号： A61M37/00

CPC分类号： A61M5/142 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/14566 ,  A61M5/445 ,  A61M2205/3673 ,  B01F9/103 ,  B01F13/005

摘要： A system for dispensing a medium includes at least a first container to hold the medium, a pressurizing device, such as a pump, in fluid connection with the container for pressurizing the medium, and an agitation mechanism or device to maintain the components of the medium in a mixed state. The container and the pressurizing device can be separate units, as in the case of an bag or bottle in fluid connection with a peristaltic or other type of pump. The container and the pump can also be combined in a single unit, as in the case of a syringe, wherein the syringe barrel of the syringe acts to contain the medium and the syringe plunger pressurizes the medium within the syringe barrel. A method of injecting a multi-component medium includes the step of agitating the medium (for example, as described above) before or during an injection procedure to maintain the components of the medium in a mixed state.

摘要翻译： 用于分配介质的系统至少包括用于保持介质的第一容器，与容器流体连接的用于对介质加压的加压装置，例如泵，以及用于维持介质的组分的搅拌机构或装置 处于混合状态。 容器和加压装置可以是分离的单元，如在与蠕动或其它类型的泵流体连接的袋或瓶的情况下。 容器和泵也可以在单个单元中组合，如在注射器的情况下，其中注射器的注射器筒用于容纳介质，并且注射器柱塞对注射器筒内的介质加压。 注射多组分培养基的方法包括在注射过程之前或过程中搅拌培养基（例如，如上所述）以将培养基的组分维持在混合状态的步骤。

公开(公告)号：US08747358B2

公开(公告)日：2014-06-10

申请号：US11238666

申请日：2005-09-29

申请人： Frederick W. Trombley, III ,  Robert M. Schmidt ,  David M. Reilly ,  Alan D. Hirschman ,  David M. Griffiths ,  Gerald W. Callan ,  Luis A. Pedraza ,  Jennie Kwo ,  Christopher T. Zirps ,  Roderick H. Beaulieu

发明人： Frederick W. Trombley, III ,  Robert M. Schmidt ,  David M. Reilly ,  Alan D. Hirschman ,  David M. Griffiths ,  Gerald W. Callan ,  Luis A. Pedraza ,  Jennie Kwo ,  Christopher T. Zirps ,  Roderick H. Beaulieu

IPC分类号： A61M1/00

CPC分类号： A61M5/007 ,  A61M5/14546 ,  A61M5/16827 ,  A61M31/005 ,  A61M39/22 ,  A61M2005/1403 ,  A61M2205/582 ,  A61M2209/01 ,  Y10T137/7727

摘要： An injector system includes a powered injector, a pressurizing chamber in operative connection with the powered injection, a fluid path in fluid communication with the pressurizing chamber, and a manual control in fluid connection with the fluid path. The manual control includes at least one actuator for controlling the injector through application of force by an operator. The actuator provides tactile feedback of pressure in the fluid path to the operator via a fluid connection therewith. An injection system for use in angiography includes a source of saline, a pump in fluid connection with the source of saline to pressurized the saline, a source of contrast, a contrast valve in fluid connection with the source of contrast, a powered injector in fluid connection with the contrast valve, and a pressure isolation mechanism.

摘要翻译： 注射器系统包括动力注射器，与动力注射操作连接的加压室，与加压室流体连通的流体路径，以及与流体路径流体连接的手动控制。 手动控制包括至少一个执行器，用于通过操作者施加力来控制喷射器。 致动器通过与其的流体连接提供到操作者的流体路径中的压力的​​触觉反馈。 用于血管造影术的注射系统包括盐水源，与盐水源流体连接的泵以加压盐水，对比源，与对比源流体连接的对比阀，流体中的动力注射器 与对比度阀的连接，以及压力隔离机构。