-
1.发明申请Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase 有权金刚烷基 - 吡唑甲酰胺作为11B-羟基类固醇脱氢酶的抑制剂公开(公告)号：US20070225280A1
公开(公告)日：2007-09-27
申请号：US11717996
申请日：2007-03-14
申请人： Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
发明人： Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
IPC分类号： A61K31/541 , A61K31/496 , A61K31/454 , A61K31/4196 , A61K31/416 , C07D403/02 , C07D417/02
CPC分类号： C07D403/04 , C07D231/12 , C07D231/16 , C07D231/38 , C07D401/04 , C07D403/02 , C07D407/14 , C07D413/04 , C07D417/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
-
2.发明授权Adamantyl-pyrazole carboxamides as inhibitors of 11β-hdroxysteroid dehydrogenase 有权金刚烷基 - 吡唑甲酰胺作为11＆amp; - 类固醇脱氢酶的抑制剂公开(公告)号：US07728029B2
公开(公告)日：2010-06-01
申请号：US11717996
申请日：2007-03-14
申请人： Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
发明人： Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
IPC分类号： A61K31/4155 , A61K31/415 , A61K31/454 , A61K31/5377 , C07D231/14 , C07D401/04 , C07D413/04 , C07D403/04
CPC分类号： C07D403/04 , C07D231/12 , C07D231/16 , C07D231/38 , C07D401/04 , C07D403/02 , C07D407/14 , C07D413/04 , C07D417/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
-
公开(公告)号：US07622492B2
公开(公告)日：2009-11-24
申请号：US11507080
申请日：2006-08-18
申请人： Bruce Lester Banner , Joseph Anthony Bilotta , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Matthew Michael Hamilton , Nancy-Ellen Haynes , Agnieszka Kowalczyk , Alexander Mayweg , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Kevin Richard Guertin
发明人： Bruce Lester Banner , Joseph Anthony Bilotta , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Matthew Michael Hamilton , Nancy-Ellen Haynes , Agnieszka Kowalczyk , Alexander Mayweg , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Kevin Richard Guertin
IPC分类号： A61K31/416 , C07D231/54
CPC分类号： C07D231/54
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
-
公开(公告)号：US07807674B2
公开(公告)日：2010-10-05
申请号：US12194643
申请日：2008-08-20
申请人： Nancy Ellen Haynes , Denis J. Kertesz , Sherrie Lynn Pietranico-Cole , Yimin Qian , Nathan Robert Scott , Sung-Sau So , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley
发明人： Nancy Ellen Haynes , Denis J. Kertesz , Sherrie Lynn Pietranico-Cole , Yimin Qian , Nathan Robert Scott , Sung-Sau So , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley
IPC分类号： C07D237/14 , C07D253/07 , A61K31/50 , A61K31/53 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P9/00 , A61P35/00
CPC分类号： C07D237/14 , C07D237/16 , C07D237/18 , C07D403/10 , C07D403/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如肥胖症，高脂血症，高胆固醇血症和糖尿病等疾病和疾病的疾病，并且可用于其它疾病如NASH，动脉粥样硬化，心血管疾病，甲状腺机能减退 ，甲状腺癌及其相关疾病和疾病。
-
公开(公告)号：US20090005383A1
公开(公告)日：2009-01-01
申请号：US12194643
申请日：2008-08-20
申请人： Nancy-Ellen Haynes , Denis J. Kertesz , Sherrie Lynn Pietranico-Cole , Yimin Qian , Nathan Robert Scott , Sung-Sau So , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley
发明人： Nancy-Ellen Haynes , Denis J. Kertesz , Sherrie Lynn Pietranico-Cole , Yimin Qian , Nathan Robert Scott , Sung-Sau So , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley
IPC分类号： A61K31/50 , A61K31/53 , C07D403/10 , C07D237/14 , A61P3/00
CPC分类号： C07D237/14 , C07D237/16 , C07D237/18 , C07D403/10 , C07D403/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如肥胖症，高脂血症，高胆固醇血症和糖尿病等疾病和疾病的疾病，并且可用于其它疾病如NASH，动脉粥样硬化，心血管疾病，甲状腺机能减退 ，甲状腺癌及其相关疾病和疾病。
-
公开(公告)号：US07452882B2
公开(公告)日：2008-11-18
申请号：US11488870
申请日：2006-07-18
申请人： Nancy-Ellen Haynes , Denis J. Kertesz , Sherrie Lynn Pietranico-Cole , Yimin Qian , Nathan Robert Scott , Sung-Sau So , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley
发明人： Nancy-Ellen Haynes , Denis J. Kertesz , Sherrie Lynn Pietranico-Cole , Yimin Qian , Nathan Robert Scott , Sung-Sau So , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley
IPC分类号： A61K31/53 , C07D403/10 , C07D237/14 , C07D409/10 , A61P3/06
CPC分类号： C07D237/14 , C07D237/16 , C07D237/18 , C07D403/10 , C07D403/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如肥胖症，高脂血症，高胆固醇血症和糖尿病等疾病和其它疾病和疾病的疾病，并且可用于其他疾病如NASH，动脉粥样硬化，心血管疾病，甲状腺机能减退 ，甲状腺癌及其相关疾病和疾病。
-
公开(公告)号：US07132425B2
公开(公告)日：2006-11-07
申请号：US10732838
申请日：2003-12-10
申请人： Shaoqing Chen , Wendy Lea Corbett , Kevin Richard Guertin , Nancy-Ellen Haynes , Robert Francis Kester , Francis A. Mennona , Steven Gregory Mischke , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar
发明人： Shaoqing Chen , Wendy Lea Corbett , Kevin Richard Guertin , Nancy-Ellen Haynes , Robert Francis Kester , Francis A. Mennona , Steven Gregory Mischke , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar
IPC分类号： A61K31/4965 , A61K31/44 , A01N43/40 , C07D401/00 , C07D241/02
CPC分类号： C07D213/75 , C07D213/76 , C07D213/78 , C07D241/20 , C07D241/26 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D413/04 , C07D417/06
摘要： The present invention provides a compound according to formula I where the substituent designations are provided in the specification. Pharmaceutical compositions comprising a compound according to formula I are also provided.
摘要翻译： 本发明提供了在说明书中提供了取代基名称的根据式I的化合物。 还提供了包含式I化合物的药物组合物。
-
公开(公告)号：US07803816B2
公开(公告)日：2010-09-28
申请号：US11526523
申请日：2006-09-25
申请人： Steven Joseph Berthel , Shawn David Erickson , Nader Fotouhi , Robert Francis Kester , Kyungjin Kim , Steven Gregory Mischke , Yimin Qian , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Hong Wang
发明人： Steven Joseph Berthel , Shawn David Erickson , Nader Fotouhi , Robert Francis Kester , Kyungjin Kim , Steven Gregory Mischke , Yimin Qian , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Hong Wang
IPC分类号： A61K31/454 , C07D403/02
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of obesity, hyperphagia, anxiety, depression and related disorders and diseases.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗肥胖，食欲过盛，焦虑，抑郁和相关疾病和疾病。
-
公开(公告)号：US20120270875A1
公开(公告)日：2012-10-25
申请号：US13399117
申请日：2012-02-17
申请人： Paul Gillespie , Christophe Michoud , Kenneth Carey Rupert , Kshitij Chhabilbhai Thakkar , Lin Yi
发明人： Paul Gillespie , Christophe Michoud , Kenneth Carey Rupert , Kshitij Chhabilbhai Thakkar , Lin Yi
IPC分类号： A61K31/5377 , A61K31/506 , C07D413/14 , C07D409/14 , C07D239/42 , C07D409/12 , C07D401/12 , C07D417/14 , A61P11/06 , A61P11/00 , A61K31/505 , A61K31/497 , C07D403/12
CPC分类号： C07D239/42 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗炎性疾病和病症，例如哮喘和COPD。
-
公开(公告)号：US20100137250A1
公开(公告)日：2010-06-03
申请号：US12614478
申请日：2009-11-09
申请人： Fariborz Firooznia , Paul Gillespie , Tai-An Lin , Eric Mertz , Achyutharao Sidduri , Sung-Sau So , Jenny Tan , Kshitij Chhabilbhai Thakkar
发明人： Fariborz Firooznia , Paul Gillespie , Tai-An Lin , Eric Mertz , Achyutharao Sidduri , Sung-Sau So , Jenny Tan , Kshitij Chhabilbhai Thakkar
IPC分类号： A61K31/69 , C07C63/33 , A61K31/18 , C07D295/00 , A61K31/535 , C07C69/76 , C07D239/00 , C07D239/42
CPC分类号： C07D295/26 , C07C57/58 , C07C59/68 , C07C69/76 , C07C255/57 , C07C311/16 , C07C311/29 , C07C317/44 , C07C317/46 , C07C323/62 , C07D231/12 , C07D239/26 , C07D257/04 , C07D317/70
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中X，Q和R 1 -R 6在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂或部分激动剂，可用于治疗与该受体相关的疾病和病症，例如哮喘。
-
-
-
-
-
-
-
-
-
搜索结果
22 条记录 (耗时 0.062 秒)
