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1.Adamantyl-pyrazole carboxamides as inhibitors of 11β-hdroxysteroid dehydrogenase 有权
标题翻译: 金刚烷基 - 吡唑甲酰胺作为11& - 类固醇脱氢酶的抑制剂公开(公告)号:US07728029B2
公开(公告)日:2010-06-01
申请号:US11717996
申请日:2007-03-14
申请人: Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
发明人: Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
IPC分类号: A61K31/4155 , A61K31/415 , A61K31/454 , A61K31/5377 , C07D231/14 , C07D401/04 , C07D413/04 , C07D403/04
CPC分类号: C07D403/04 , C07D231/12 , C07D231/16 , C07D231/38 , C07D401/04 , C07D403/02 , C07D407/14 , C07D413/04 , C07D417/04
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病,例如II型糖尿病和代谢综合征。
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2.Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase 有权
标题翻译: 金刚烷基 - 吡唑甲酰胺作为11B-羟基类固醇脱氢酶的抑制剂公开(公告)号:US20070225280A1
公开(公告)日:2007-09-27
申请号:US11717996
申请日:2007-03-14
申请人: Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
发明人: Kevin William Anderson , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Kevin Richard Guertin , Nancy-Ellen Haynes , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Lida Qi , Pamela Loreen Rossman , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Qiang Zhang
IPC分类号: A61K31/541 , A61K31/496 , A61K31/454 , A61K31/4196 , A61K31/416 , C07D403/02 , C07D417/02
CPC分类号: C07D403/04 , C07D231/12 , C07D231/16 , C07D231/38 , C07D401/04 , C07D403/02 , C07D407/14 , C07D413/04 , C07D417/04
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病,例如II型糖尿病和代谢综合征。
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3.
公开(公告)号:US07622492B2
公开(公告)日:2009-11-24
申请号:US11507080
申请日:2006-08-18
申请人: Bruce Lester Banner , Joseph Anthony Bilotta , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Matthew Michael Hamilton , Nancy-Ellen Haynes , Agnieszka Kowalczyk , Alexander Mayweg , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Kevin Richard Guertin
发明人: Bruce Lester Banner , Joseph Anthony Bilotta , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Matthew Michael Hamilton , Nancy-Ellen Haynes , Agnieszka Kowalczyk , Alexander Mayweg , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Kevin Richard Guertin
IPC分类号: A61K31/416 , C07D231/54
CPC分类号: C07D231/54
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病,例如II型糖尿病和代谢综合征。
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公开(公告)号:US08188098B2
公开(公告)日:2012-05-29
申请号:US12433921
申请日:2009-05-01
申请人: Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
发明人: Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00
CPC分类号: C07D487/04
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症,例如II型糖尿病。
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公开(公告)号:US20090286812A1
公开(公告)日:2009-11-19
申请号:US12433921
申请日:2009-05-01
申请人: Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
发明人: Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
IPC分类号: A61K31/519 , C07D487/04 , A61P3/10
CPC分类号: C07D487/04
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症,例如II型糖尿病。
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公开(公告)号:US06515124B2
公开(公告)日:2003-02-04
申请号:US09754888
申请日:2001-01-05
申请人: Nader Fotouhi , Paul Gillespie , Robert William Guthrie , Sherrie Lynn Pietranico-Cole , Weiya Yun
发明人: Nader Fotouhi , Paul Gillespie , Robert William Guthrie , Sherrie Lynn Pietranico-Cole , Weiya Yun
IPC分类号: C07C23584
CPC分类号: C07D249/08 , C07B2200/07 , C07C233/85 , C07C233/87 , C07C311/46 , C07D209/08 , C07D211/34 , C07D213/55 , C07D215/14 , C07D233/26 , C07D235/16 , C07D237/28 , C07D239/52 , C07D249/18 , C07D261/08 , C07D271/12 , C07D277/30 , C07D277/38 , C07D277/62 , C07D277/64 , C07D285/14 , C07D307/16 , C07D317/60 , C07D333/24 , C07D333/60 , C07D401/12 , C07D403/12 , C07D409/04 , C07D417/04 , C07F9/4006 , C07F9/5728 , C07F9/6524 , C07F9/65583
摘要: Aromatic dehydroamino acids are disclosed that are active as LFA-1 arnagonists This activity enables these compounds to prevent inflammation which is a consequence of T cell activation and accordingly reduce or eliminate inflammatory skin disease psoriasis.
摘要翻译: 公开了作为LFA-1拮抗剂活性的芳族脱氢氨基酸。该活性使得这些化合物能够预防因T细胞活化而引起的炎症,因此减少或消除炎症性皮肤病牛皮癣。
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公开(公告)号:US07217728B2
公开(公告)日:2007-05-15
申请号:US10945650
申请日:2004-09-21
申请人: Nader Fotouhi , Paul Gillespie , Robert William Guthrie , Sherrie Lynn Pietranico-Cole , Weiya Yun
发明人: Nader Fotouhi , Paul Gillespie , Robert William Guthrie , Sherrie Lynn Pietranico-Cole , Weiya Yun
IPC分类号: A61K31/415 , C07D231/56
CPC分类号: C07D295/15 , C07C65/105 , C07C65/40 , C07C233/65 , C07C233/66 , C07C233/73 , C07C233/83 , C07C235/34 , C07C235/52 , C07C235/60 , C07C237/12 , C07C237/20 , C07C237/24 , C07C237/36 , C07C255/57 , C07C271/22 , C07C271/24 , C07C271/28 , C07C311/06 , C07C311/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2603/18 , C07C2603/74 , C07D207/16 , C07D209/08 , C07D209/16 , C07D209/20 , C07D209/34 , C07D209/42 , C07D211/62 , C07D211/88 , C07D213/78 , C07D215/48 , C07D215/54 , C07D217/26 , C07D219/04 , C07D223/12 , C07D223/16 , C07D223/20 , C07D237/28 , C07D241/44 , C07D249/20 , C07D261/18 , C07D277/06 , C07D277/46 , C07D277/54 , C07D277/56 , C07D285/06 , C07D307/68 , C07D311/08 , C07D311/24 , C07D333/28 , C07D333/38 , C07D335/16 , C07D409/12 , C07D471/04
摘要: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
摘要翻译: 可用于治疗再灌注损伤的式1a化合物,以及盐,前药和相关化合物。
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公开(公告)号:US07491741B2
公开(公告)日:2009-02-17
申请号:US11703925
申请日:2007-02-08
申请人: Nader Fotouhi , Paul Gillespie , Robert William Guthrie , Sherrie Lynn Pietranico-Cole , Weiya Yun
发明人: Nader Fotouhi , Paul Gillespie , Robert William Guthrie , Sherrie Lynn Pietranico-Cole , Weiya Yun
IPC分类号: A61K31/415 , C07D231/56
CPC分类号: C07D295/15 , C07C65/105 , C07C65/40 , C07C233/65 , C07C233/66 , C07C233/73 , C07C233/83 , C07C235/34 , C07C235/52 , C07C235/60 , C07C237/12 , C07C237/20 , C07C237/24 , C07C237/36 , C07C255/57 , C07C271/22 , C07C271/24 , C07C271/28 , C07C311/06 , C07C311/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2603/18 , C07C2603/74 , C07D207/16 , C07D209/08 , C07D209/16 , C07D209/20 , C07D209/34 , C07D209/42 , C07D211/62 , C07D211/88 , C07D213/78 , C07D215/48 , C07D215/54 , C07D217/26 , C07D219/04 , C07D223/12 , C07D223/16 , C07D223/20 , C07D237/28 , C07D241/44 , C07D249/20 , C07D261/18 , C07D277/06 , C07D277/46 , C07D277/54 , C07D277/56 , C07D285/06 , C07D307/68 , C07D311/08 , C07D311/24 , C07D333/28 , C07D333/38 , C07D335/16 , C07D409/12 , C07D471/04
摘要: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
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公开(公告)号:US06803384B2
公开(公告)日:2004-10-12
申请号:US10349289
申请日:2003-01-22
申请人: Nader Fotouhi , Paul Gillespie , Robert William Guthrie , Sherrie Lynn Pietranico-Cole , Weiya Yun
发明人: Nader Fotouhi , Paul Gillespie , Robert William Guthrie , Sherrie Lynn Pietranico-Cole , Weiya Yun
IPC分类号: A61K31166
CPC分类号: C07D295/15 , C07C65/105 , C07C65/40 , C07C233/65 , C07C233/66 , C07C233/73 , C07C233/83 , C07C235/34 , C07C235/52 , C07C235/60 , C07C237/12 , C07C237/20 , C07C237/24 , C07C237/36 , C07C255/57 , C07C271/22 , C07C271/24 , C07C271/28 , C07C311/06 , C07C311/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2603/18 , C07C2603/74 , C07D207/16 , C07D209/08 , C07D209/16 , C07D209/20 , C07D209/34 , C07D209/42 , C07D211/62 , C07D211/88 , C07D213/78 , C07D215/48 , C07D215/54 , C07D217/26 , C07D219/04 , C07D223/12 , C07D223/16 , C07D223/20 , C07D237/28 , C07D241/44 , C07D249/20 , C07D261/18 , C07D277/06 , C07D277/46 , C07D277/54 , C07D277/56 , C07D285/06 , C07D307/68 , C07D311/08 , C07D311/24 , C07D333/28 , C07D333/38 , C07D335/16 , C07D409/12 , C07D471/04
摘要: A compound of formula Id and pharmaceutically acceptable salts and esters thereof, wherein the substituent designations are as provided in the specification. Compounds of the invention are useful for treating reperfusion injury.
摘要翻译: 式Id的化合物及其药学上可接受的盐和酯,其中取代基名称如说明书中所提供。 本发明的化合物可用于治疗再灌注损伤。
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公开(公告)号:US06331640B1
公开(公告)日:2001-12-18
申请号:US09407534
申请日:1999-09-29
申请人: Nader Fotouhi , Paul Gillespie , Robert William Guthrie , Sherrie Lynn Pietranico-Cole , Weiya Yun
发明人: Nader Fotouhi , Paul Gillespie , Robert William Guthrie , Sherrie Lynn Pietranico-Cole , Weiya Yun
IPC分类号: A61K31166
CPC分类号: C07D295/15 , C07C65/105 , C07C65/40 , C07C233/65 , C07C233/66 , C07C233/73 , C07C233/83 , C07C235/34 , C07C235/52 , C07C235/60 , C07C237/12 , C07C237/20 , C07C237/24 , C07C237/36 , C07C255/57 , C07C271/22 , C07C271/24 , C07C271/28 , C07C311/06 , C07C311/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2603/18 , C07C2603/74 , C07D207/16 , C07D209/08 , C07D209/16 , C07D209/20 , C07D209/34 , C07D209/42 , C07D211/62 , C07D211/88 , C07D213/78 , C07D215/48 , C07D215/54 , C07D217/26 , C07D219/04 , C07D223/12 , C07D223/16 , C07D223/20 , C07D237/28 , C07D241/44 , C07D249/20 , C07D261/18 , C07D277/06 , C07D277/46 , C07D277/54 , C07D277/56 , C07D285/06 , C07D307/68 , C07D311/08 , C07D311/24 , C07D333/28 , C07D333/38 , C07D335/16 , C07D409/12 , C07D471/04
摘要: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
摘要翻译: 式1化合物可用于治疗再灌注损伤,以及盐,前药和相关化合物。
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