公开(公告)号：US20070203095A1

公开(公告)日：2007-08-30

申请号：US11638307

申请日：2006-12-13

申请人： Khalid Sadozai ,  Charles Sherwood ,  Kyle Bui ,  Tamera Gooding ,  Michael Bassett ,  Stephen Kennedy

发明人： Khalid Sadozai ,  Charles Sherwood ,  Kyle Bui ,  Tamera Gooding ,  Michael Bassett ,  Stephen Kennedy

IPC分类号： A61K48/00 ,  A61K31/729 ,  A61K31/573 ,  A61K38/17 ,  A61K39/395

CPC分类号： A61L27/3843 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/573 ,  A61K31/728 ,  A61K31/729 ,  A61K35/28 ,  A61K35/32 ,  A61K38/1841 ,  A61K47/36 ,  A61L27/20 ,  A61L27/227 ,  A61L27/3817 ,  A61L27/3834 ,  A61L27/48 ,  A61L27/52 ,  A61L27/56 ,  A61L2430/06 ,  C08L5/08 ,  A61K2300/00

摘要： A method of treating a subject having a musculoskeletal disorder includes administering to a subject's articular site in need thereof an effective amount of a hyaluronic acid (HA) composition. In one embodiment, the HA composition includes an HA derivative, wherein carboxyl functionalities of the hyaluronic acid derivative are each independently derivatized to include an N-acylurea or 0-acyl isourea, or both N-acylurea and 0-acyl isourea. In another embodiment, the HA composition includes a crosslinked HA gel that is prepared by reacting an uncrosslinked HA with a biscarbodiimide in the presence of pH buffer in a range of between about 4 and about 8. The composite can optionally include at least one second bioactive agent other than the HA derivative, such as a steroid.

摘要翻译： 治疗具有肌肉骨骼疾病的受试者的方法包括向有需要的受试者的关节部位施用有效量的透明质酸（HA）组合物。 在一个实施方案中，HA组合物包括HA衍生物，其中透明质酸衍生物的羧基官能度各自独立地衍生为包括N-酰基脲或O-酰基异脲，或N-酰基脲和O-酰基异脲二者。 在另一个实施方案中，HA组合物包括通过在约4至约8范围内的pH缓冲剂存在下使未交联的HA与双碳二亚胺反应制备的交联HA凝胶。所述复合材料可任选地包括至少一种第二生物活性 除了HA衍生物之外的其它试剂，例如类固醇。

公开(公告)号：US20050136122A1

公开(公告)日：2005-06-23

申请号：US10743557

申请日：2003-12-22

申请人： Khalid Sadozai ,  Tamera Gooding ,  Kyle Bui ,  Charles Sherwood

发明人： Khalid Sadozai ,  Tamera Gooding ,  Kyle Bui ,  Charles Sherwood

IPC分类号： A61K9/00 ,  A61K31/24 ,  A61K39/395 ,  A61K47/36 ,  A61K48/00 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58

CPC分类号： A61K31/24 ,  A61K9/0019 ,  A61K9/0021 ,  A61K9/0024 ,  A61K9/1652 ,  A61K47/36

摘要： A hyaluronic acid (HA) composition includes crosslinked, water-insoluble, hydrated HA gel particles. The HA includes crosslinks represented by the following structural formula: HA—U—R2—U—HA The variables are defined herein. A method of augmenting tissue in a subject includes inserting a needle into a subject at a location in the subject that is in need of tissue augmentation, wherein the needle is coupled to a syringe loaded with the HA composition, and applying force to the syringe, to deliver the HA composition into the subject. A method of preparing the HA composition, includes forming water-insoluble, dehydrated crosslinked HA particles, separating the water-insoluble, dehydrated particles by average diameter, selecting a subset of particles by average diameter, and hydrating the subset of dehydrated particles with a physiologically compatible aqueous solution. Another method of preparing the crosslinked HA composition includes crosslinking a precursor of the crosslinked HA with a biscarbodiimide in the presence of a pH buffer and dehydrating the crosslinked HA. Also included is a method of augmenting tissue in a subject that is in need of tissue augmentation. A method of stabilizing crosslinked HA includes hydrating water-insoluble, dehydrated crosslinked HA with a physiologically compatible aqueous solution that includes a local anesthetic, wherein the value of storage modulus G′ for the stabilized composition is at least about 110% of the value of G′ for a non-stabilized composition,. Also included is the stabilized HA composition.

摘要翻译： 透明质酸（HA）组合物包括交联的水不溶性水合HA凝胶颗粒。 HA包括由以下结构式表示的交联：<？in-line-formula description =“In-line Formulas”end =“lead”？> HA-UR -U-HA < in-line-formula description =“In-line Formulas”end =“tail”？>这里定义变量。 增加受试者中的组织的方法包括在需要组织增大的受试者的位置处将针插入受试者，其中针联接到装有HA组合物的注射器，并向注射器施加力， 将HA组合物输送到受试者。 制备HA组合物的方法包括形成不溶于水的，脱水的交联HA颗粒，将水不溶性脱水颗粒分离成平均直径，通过平均直径选择颗粒子集，并将生理学上的脱水颗粒子集合 相容的水溶液。 制备交联HA组合物的另一种方法包括在pH缓冲剂存在下使双碳酰亚胺交联HA的前体，并使交联的HA脱水。 还包括增加需要组织增大的受试者中的组织的方法。 稳定交联HA的方法包括用包含局部麻醉剂的生理相容性水溶液水合非水溶性脱水交联HA，其中稳定化组合物的储能模量G'的值至少为G值的约110％ “为一个非稳定的组成。 还包括稳定的HA组合物。

公开(公告)号：US20070202084A1

公开(公告)日：2007-08-30

申请号：US11638103

申请日：2006-12-13

申请人： Khalid Sadozai ,  Carol Joth ,  Charles Sherwood

发明人： Khalid Sadozai ,  Carol Joth ,  Charles Sherwood

IPC分类号： A61K48/00 ,  A61K35/12 ,  A61K31/728

CPC分类号： A61K31/728 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/573 ,  A61K31/729 ,  A61K35/28 ,  A61K35/32 ,  A61K38/1841 ,  A61K45/06 ,  A61K47/36 ,  A61L27/20 ,  A61L27/227 ,  A61L27/3817 ,  A61L27/3834 ,  A61L27/3843 ,  A61L27/48 ,  A61L27/52 ,  A61L27/56 ,  A61L2430/06 ,  A61M5/178 ,  C08L5/08 ,  A61K2300/00

摘要： A method for treating an osteochondral defect or a chondral defect in a subject includes implanting a composite in a site of the osteochondral or chondral defect. The composite includes a hyaluronic acid derivative; and at least one member of the group consisting of a cell, a cellular growth factor and a cellular differentiation factor, which is impregnated in, or coupled to, the hyaluronic acid derivative. In one embodiment, carboxyl functionalities of the hyaluronic acid derivative are each independently derivatized to include an N-acylurea or O-acyl isourea, or both N-acylurea and O-acyl isourea. In another embodiment, the hyaluronic acid derivative is prepared by reacting an uncrosslinked hyaluronic acid with a biscarbodimide in the presence of a pH buffer in a range of between about 4 and about 8. The composite can be used for regenerating or stimulating regeneration of meniscal tissues in a subject in need thereof.

摘要翻译： 用于治疗受试者的骨软骨缺损或软骨缺损的方法包括在骨软骨或软骨缺损的部位植入复合物。 该复合物包括透明质酸衍生物; 和由透明质酸衍生物浸渍或偶联的细胞，细胞生长因子和细胞分化因子组成的组中的至少一个成员。 在一个实施方案中，透明质酸衍生物的羧基官能度各自独立地衍生化为包括N-酰基脲或O-酰基异脲，或N-酰基脲和O-酰基异脲二者。 在另一个实施方案中，透明质酸衍生物通过在约4至约8范围内的pH缓冲剂存在下使未交联的透明质酸与双碳酰亚胺反应来制备。该复合物可用于再生或刺激半月板组织的再生 在有需要的受试者中。

公开(公告)号：US20050222083A1

公开(公告)日：2005-10-06

申请号：US11058741

申请日：2005-02-15

申请人： Paul Bulpitt ,  Charles Sherwood ,  Khalid Sadozai

发明人： Paul Bulpitt ,  Charles Sherwood ,  Khalid Sadozai

IPC分类号： A61K31/728 ,  A61P27/02 ,  A61P41/00 ,  C07C323/25 ,  C07C323/32 ,  C07C323/37 ,  C07C323/44 ,  C07C323/45 ,  C07C335/08 ,  C07C335/16 ,  C08B37/08

CPC分类号： C07C323/25 ,  C07C323/32 ,  C07C323/37 ,  C07C323/44 ,  C07C335/08 ,  C07C335/16 ,  C08B37/0072

摘要： The present invention relates to biscarbodiimides, thiourea derivatives, urea derivatives, and cross-linked hyaluronan derivatives having at least one intramolecular disulfide bond, and methods of preparation thereof. The invention also includes thiolated hyaluronan derivatives and salts thereof having at least one pendant thiol group or a modified pendant thiol group, and methods of preparation thereof. An example of a modified pendant thiol group is a sulfhydryl group linked to a small molecule such as a bioactive agent, for example a drug or pharmaceutically active moiety. A hyaluronan derivative having a sulfhydryl group linked to a pharmaceutically active moiety is useful as a sustained or controlled release drug delivery vehicle. Compositions containing the hyaluronan derivatives of the invention can reversibly viscosify in vivo or in vitro, in response to mild changes in condition, and are thus useful in ophthalmic surgery and in tissue engineering.

摘要翻译： 本发明涉及双碳二亚胺，硫脲衍生物，脲衍生物和具有至少一个分子内二硫键的交联透明质酸衍生物及其制备方法。 本发明还包括硫醇化透明质酸衍生物及其盐，其具有至少一个硫醇基侧基或修饰侧链巯基，及其制备方法。 修饰的侧链硫醇基团的实例是与小分子连接的巯基，例如生物活性剂，例如药物或药学活性部分。 具有与药学活性部分连接的巯基的透明质酸衍生物可用作持续或控释药物递送载体。 含有本发明的透明质酸衍生物的组合物可以在体内或体外可逆地粘稠，以响应于条件的轻微变化，因此可用于眼科手术和组织工程。

公开(公告)号：US5944725A

公开(公告)日：1999-08-31

申请号：US721349

申请日：1996-09-26

申请人： Chris Cicenas ,  George Clark ,  Thomas M. Heyman ,  Charles Sherwood

发明人： Chris Cicenas ,  George Clark ,  Thomas M. Heyman ,  Charles Sherwood

IPC分类号： A61F9/007 ,  A61F2/16 ,  A61F9/00

CPC分类号： A61F2/1678 ,  A61F2/1675

摘要： An instrument for inserting a flexible intraocular lens or other flexible membrane into an eye which includes a compressor for laterally compressing the lens into a small cross-sectional configuration to pass the lens through a narrow incision. The compressor includes retainers along the interior of the inserter to maintain the side edges of the lens in a substantially planar orientation during compression. The retainers preferably extend through the inserter to hold the lens during advancement toward the eye to prevent an uncontrolled rotation of the lens.

摘要翻译： 一种用于将柔性眼内透镜或其他柔性膜插入到眼睛中的仪器，其包括用于将透镜横向压缩成小的横截面构造的压缩机，以使透镜通过狭窄的切口。 压缩机包括沿着插入器内部的保持器，以在压缩期间将透镜的侧边缘保持在基本平面的取向。 保持器优选地延伸穿过插入器以在朝向眼睛的前进过程中保持透镜以防止透镜的不受控制的旋转。

公开(公告)号：US5259252A

公开(公告)日：1993-11-09

申请号：US839122

申请日：1992-02-19

申请人： James W. Kruse ,  Gary Krutz ,  Charles Sherwood

发明人： James W. Kruse ,  Gary Krutz ,  Charles Sherwood

IPC分类号： A01K87/00 ,  A01K97/00 ,  G01L1/22 ,  G01L5/10 ,  A01K97/12

CPC分类号： G01L5/106 ,  A01K87/00 ,  A01K97/00 ,  G01L1/2256 ,  G01L5/10 ,  G01L5/108

摘要： Apparatus for detecting and measuring forces on a fishing rod due to pull on a fishing line associated with the rod or to a weight hanging on the rod, includes a transducer responsive to the deflection of the fishing rod to provide an output indicative of the amount of deflection of the fishing rod, and a timing circuit including a signal counter which counts signals during a time interval and provides a numerical display corresponding to the number of signals counted and thus the force being applied to the rod, the timing circuit being controlled by the transducer to vary the duration of the time interval during which signals are counted whereby the number of signals counted by the signal counter varies in correspondence with the amount of force being applied to the rod. In one embodiment, the transducer includes a wire having its ends attached to the under surface of the rod inside chamber and a potentiometer connected in the timing circuit and having its wiper mechanism connected to the wire and movable thereby when the rod deflects, whereby the resistance of the potentiometer varies with rod deflection, varying the duration of the time interval during which the signal counter is enabled to count signals.

摘要翻译： 用于检测和测量由于拉动与杆相关联的钓鱼线或与悬挂在杆上的重物的钓鱼杆上的力的装置包括响应于钓鱼竿的偏转的传感器，以提供指示量 钓鱼竿的偏转，以及定时电路，其包括在时间间隔内对信号进行计数的信号计数器，并提供与计数的信号数量对应的数值显示，并因此施加在杆上的力，定时电路由 换能器来改变信号计数的时间间隔的持续时间，由此信号计数器计数的信号数量与施加到杆的力的量相对应地变化。 在一个实施例中，换能器包括其端部附接到杆内腔室的下表面的电线和连接在定时电路中的电位器，并且其电缆器连接到电线上，并且当该杆偏转时可移动，因此电阻 电位器随杆偏转而变化，改变信号计数器使能计数信号的时间间隔的持续时间。