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16 条记录 (耗时 0.025 秒)

    Optically active esters of 7-substituted 3,5-difunctionalized 6-heptenoic acids
    5.
    发明授权
    Optically active esters of 7-substituted 3,5-difunctionalized 6-heptenoic acids 失效
    7-取代的3,5-二官能化的6-庚烯酸的光学活性酯

    公开(公告)号：US5276154A

    公开(公告)日：1994-01-04

    申请号：US748076

    申请日：1991-08-21

    申请人： Tamejiro Hiyama ,  Tatsuya Minami ,  Takeshi Hanamoto ,  Guntoori B. Reddy

    发明人： Tamejiro Hiyama ,  Tatsuya Minami ,  Takeshi Hanamoto ,  Guntoori B. Reddy

    IPC分类号： C07C67/343 ,  C07C69/732 ,  C07C69/738 ,  C07D209/10 ,  C07D309/30 ,  C07D215/14 ,  C07D215/233

    CPC分类号： C07C69/738 ,  C07C67/343 ,  C07C69/732

    摘要： The present invention provides optically active esters of 7-substituted 3,5-difunctionalized 6-heptenoic acids represented by the following formula: ##STR1## wherein R is a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group or a substituted vinyl group;Ar is a condensed aromatic group;X.sup.1 and Y.sup.1 are not the same and each is a hydrogen atom or a hydroxyl group, or may be combined to represent an oxygen atom which forms a carbonyl group together with the carbon atom to which X.sup.1 and Y.sup.1 are attached; andX.sup.2 and Y.sup.2 are not the same and each is a hydrogen atom or a hydroxyl group, or may be combined to represent an oxygen atom which forms a carbonyl group together with the carbon atom to which X.sup.2 and Y.sup.2 are attached,or enantiomers thereof.The present invention further provides processes for preparing the above optically active esters and 7-substituted (3R, 5S, 6E)-3,5-dihydroxy-6-hepten-1,5-olides.These esters are useful as synthetic intermediates for preparing the above lactones having an inhibitory activity of HMG-CoA reductase as well as a sex attractant pheromone of beetles, endo-1,3-dimethyl-2,9-dioxabicyclo[3.3.1]nonane.

    摘要翻译： 本发明提供由下式表示的7-取代的3,5-二官能的6-庚烯酸的光学活性酯：（*化学结构*）其中R是取代或未取代的芳族基团，取代或未取代的杂芳族基团或 取代乙烯基; Ar是稠合芳族基团; X1和Y1不相同，各自为氢原子或羟基，或者可以组合形成与X1和Y1所连接的碳原子一起形成羰基的氧原子; X2和Y2不相同，各自为氢原子或羟基，或者可以与X2和Y2所连接的碳原子一起形成羰基的氧原子或其对映异构体。 本发明还提供了制备上述光学活性酯和7-取代的（3R，5S，6E）-3,5-二羟基-6-庚烯-1,5-二醇的方法。 这些酯可用作制备具有HMG-CoA还原酶抑制活性的上述内酯的合成中间体以及甲虫的性引诱信息素，内切1,3-二甲基-2,9-二氧杂双环（3.3.1）壬烷 。

    Process for preparing indan derivatives
    8.
    发明授权
    Process for preparing indan derivatives 失效
    制备茚满衍生物的方法

    公开(公告)号：US6057479A

    公开(公告)日：2000-05-02

    申请号：US91229

    申请日：1998-07-09

    申请人： Shuichi Mitamura ,  Yasuhisa Asano ,  Tamejiro Hiyama ,  Hiroshi Kajiro

    发明人： Shuichi Mitamura ,  Yasuhisa Asano ,  Tamejiro Hiyama ,  Hiroshi Kajiro

    IPC分类号： C07C213/02 ,  C07C215/44 ,  C12P7/18 ,  C12P7/26 ,  C12P13/00 ,  C12P41/00 ,  C07C211/42

    CPC分类号： C12P13/001 ,  C07C213/02 ,  C07C215/44 ,  C12P41/002 ,  C12P7/18 ,  C12P7/26 ,  C07B2200/07 ,  C07C2102/08

    摘要： This invention relates to a process for preparing indan derivatives and comprises a process for preparing cis-1-amino-2-indanol by treating (.+-.)indan-1,2-diol and/or its 2-formate derivative with specific microbes to give optically active 2-hydroxy-1-indanone, converting the optically active 2-hydroxy-1-indanone to its oxime, and treating the oxime with hydrogen or a hydrogen donor in the presence of a heterogeneous hydrogenation catalyst, a process for preparing optically active 2-hydroxy-1-indanone and/or optically active indan-1,2-diol by treating (.+-.)indan-1,2-diol and/or its 2-formate derivative with specific microbes, and a process for preparing cis-1-amino-2-indanol by treating the oxime of 2-hydroxy-1-indanone with hydrogen or a hydrogen donor in the presence of a heterogeneous hydrogenation catalyst.

    摘要翻译： PCT No.PCT / JP97 / 00040 Sec。 371日期：1998年7月9日 102（e）日期1998年7月9日PCT 1997年1月10日PCT PCT。 公开号WO97 / 25436 日期1997年7月17日本发明涉及一种制备茚满衍生物的方法，包括通过处理（+/-）茚满-1,2-二醇和/或其2- 甲酸酯衍生物与特定的微生物反应得到光学活性的2-羟基-1-茚满酮，将光学活性的2-羟基-1-二氢茚酮转化成其肟，并在异相氢化催化剂存在下用氢或氢供体处理肟 ，通过用（+/-）茚满-1,2-二醇和/或其2-甲酸酯衍生物处理具有特异性的方法制备光学活性2-羟基-1-茚满酮和/或光学活性茚满-1,2-二醇的方法 微生物和通过在异相氢化催化剂存在下用氢或氢供体处理2-羟基-1-二氢茚酮的肟而制备顺式-1-氨基-2-茚醇的方法。

    Process for the preparation of a trifluorovinylsilane, and fluorine-containing polymer and process for its preparation
    10.
    发明授权
    Process for the preparation of a trifluorovinylsilane, and fluorine-containing polymer and process for its preparation 失效
    制备三氟乙烯基硅烷和含氟聚合物的方法及其制备方法

    公开(公告)号：US4481366A

    公开(公告)日：1984-11-06

    申请号：US572247

    申请日：1984-01-20

    申请人： Tamejiro Hiyama ,  Kiyoharu Nishide

    发明人： Tamejiro Hiyama ,  Kiyoharu Nishide

    IPC分类号： C07F7/08 ,  C08F30/08 ,  C07C7/08

    CPC分类号： C07F7/0827 ,  C08F30/08

    摘要： A process for preparing a trifluorovinylsilane represented by the general formula:(CF.sub.2 .dbd.CF).sub.n SiR.sub.4-n (I)where each R independently represents an alkyl group, an aryl group or an aralkyl group, and n is an integer of 1 to 4, which comprises the reaction of chlorotrifluoroethylene with a chlorosilane represented by the general formula:Cl.sub.n SiR.sub.4-n (II)where R and n are as defined above, in the presence of an alkyllithium. Also disclosed is a fluorine-containing polymer represented by the general formula: ##STR1## where each of x and m is an integer other than O, y is an integer including O, and each of R.sup.1, R.sup.2 and R.sup.3 is a lower alkyl group, an aryl group or an aralkyl group, which is prepared by polymerization of a trifluorovinyl silane (I) with active fluoride-ion generating catalyst.

    摘要翻译： 一种制备由以下通式表示的三氟乙烯基硅烷的方法：（CF 2 = CF）n SiR 4-n（I）其中每个R独立地表示烷基，芳基或芳烷基，n是1至4的整数， 其包括在三烷基锂存在下氯三氟乙烯与由以下通式表示的氯代硅烷的反应：其中R和n如上所定义。 还公开了由以下通式表示的含氟聚合物：其中x和m各自为O以外的整数，y为包括O的整数，R 1，R 2和R 3各自为 低级烷基，芳基或芳烷基，其通过三氟乙烯基硅烷（I）与活性氟离子产生催化剂的聚合制备。