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    Expression vector
    7.
    发明授权
    Expression vector 有权
    表达载体

    公开(公告)号：US08383398B2

    公开(公告)日：2013-02-26

    申请号：US12425001

    申请日：2009-04-16

    申请人： Yuko Shimatani-Shibata ,  Hiromi Yonekura ,  Hitomi Shimizu

    发明人： Yuko Shimatani-Shibata ,  Hiromi Yonekura ,  Hitomi Shimizu

    IPC分类号： C12N15/00 ,  C12N15/74 ,  A61K48/00 ,  C12N1/21

    CPC分类号： C12N15/74 ,  C12N15/746

    摘要： A conventional shuttle vector constructed by fusing an E. coli-derived plasmid and a transformant-derived plasmid functions in both E. coli and the transformant bacterium, and there exists no expression vector that functions only in a non-E. coli transformant. The present invention provides an plasmid expression vector comprising (1) a plasmid replication unit that functions in an anaerobic microorganism other than E. coli and (2) a protein expression unit formed from DNA coding for a protein having target activity and a DNA fragment containing a promoter and a terminator that function in the anaerobic microorganism. The expression vector of the present invention is capable of being replicated only in a transformant, eliminating the risk of the replication of the transformant gene in other pathogenic or aerobic bacterium, providing an extremely safe and reliable vector and gene transporter for therapeutic application.

    摘要翻译： 通过将来自大肠杆菌的质粒和来自转化体的质粒在大肠杆菌和转化体细菌中的功能融合构建的常规穿梭载体，并且不存在仅在非E中起作用的表达载体。 大肠杆菌转化体。 本发明提供一种质粒表达载体，其包含（1）在除大肠杆菌以外的厌氧微生物中起作用的质粒复制单位和（2）由编码具有靶活性的蛋白质的DNA形成的蛋白质表达单位和含有 在厌氧微生物中起作用的启动子和终止子。 本发明的表达载体只能在转化体中复制，消除转化体基因在其他致病或需氧细菌中复制的风险，为治疗应用提供极其安全可靠的载体和基因转运蛋白。

    EXPRESSION VECTOR
    8.
    发明申请
    EXPRESSION VECTOR 有权
    表达向量

    公开(公告)号：US20090264513A1

    公开(公告)日：2009-10-22

    申请号：US12425001

    申请日：2009-04-16

    申请人： Yuko Shimatani-Shibata ,  Hiromi Yonekura ,  Hitomi Shimizu

    发明人： Yuko Shimatani-Shibata ,  Hiromi Yonekura ,  Hitomi Shimizu

    IPC分类号： A61K31/7088 ,  C12N15/74 ,  A61P35/00

    CPC分类号： C12N15/74 ,  C12N15/746

    摘要： A conventional shuttle vector constructed by fusing an E. coli-derived plasmid and a transformant-derived plasmid functions in both E. coli and the transformant bacterium, and there exists no expression vector that functions only in a non-E. coli transformant. The present invention provides an plasmid expression vector comprising (1) a plasmid replication unit that functions in an anaerobic microorganism other than E. coli and (2) a protein expression unit formed from DNA coding for a protein having target activity and a DNA fragment containing a promoter and a terminator that function in the anaerobic microorganism. The expression vector of the present invention is capable of being replicated only in a transformant, eliminating the risk of the replication of the transformant gene in other pathogenic or aerobic bacterium, providing an extremely safe and reliable vector and gene transporter for therapeutic application.

    摘要翻译： 通过将来自大肠杆菌的质粒和来自转化体的质粒在大肠杆菌和转化体细菌中的功能融合构建的常规穿梭载体，并且不存在仅在非E中起作用的表达载体。 大肠杆菌转化体。 本发明提供一种质粒表达载体，其包含（1）在除大肠杆菌以外的厌氧微生物中起作用的质粒复制单位和（2）由编码具有靶活性的蛋白质的DNA形成的蛋白质表达单位和含有 在厌氧微生物中起作用的启动子和终止子。 本发明的表达载体只能在转化体中复制，消除转化体基因在其他致病或需氧细菌中复制的风险，为治疗应用提供极其安全可靠的载体和基因转运蛋白。

    Therapeutic agent for anaerobic diseases
    9.
    发明授权
    Therapeutic agent for anaerobic diseases 有权
    厌氧性疾病治疗剂

    公开(公告)号：US08470311B2

    公开(公告)日：2013-06-25

    申请号：US12988181

    申请日：2009-04-17

    申请人： Takayuki Sasaki ,  Hitomi Shimizu ,  Yuko Shimatani-Shibata ,  Hiromi Yonekura

    发明人： Takayuki Sasaki ,  Hitomi Shimizu ,  Yuko Shimatani-Shibata ,  Hiromi Yonekura

    IPC分类号： A61K35/74 ,  C07H3/04 ,  C07H3/06 ,  C12N1/38 ,  A61P35/00 ,  A61P9/10

    CPC分类号： C12N15/74 ,  C12N15/746

    摘要： The present invention provides a therapeutic agent for anaerobic diseases such as solid tumor, comprising in combination a pharmaceutical composition for the treatment of an anaerobic disease containing the transformed anaerobic microorganism as an active component and a pharmaceutical composition containing as an active component an anaerobic microorganism colonization and growth enhancer for enhancing the specific colonization and proliferation of the anaerobic microorganism at an anaerobic disease site. Furthermore, the present invention provides to an anaerobic microorganism colonization and growth enhancer for enhancing colonization and growth of the transformed anaerobic microorganism at a disease site that is in an anaerobic environment.

    摘要翻译： 本发明提供了一种用于厌氧性疾病如固体肿瘤的治疗剂，其组合包含用于治疗含有作为活性成分的转化的厌氧微生物的厌氧性疾病的药物组合物和含有作为活性成分的厌氧微生物定植的药物组合物 以及用于在厌氧性疾病部位增强厌氧微生物的特异性定殖和增殖的生长增强剂。 此外，本发明提供了一种用于在处于厌氧环境的疾病部位增强转化的厌氧微生物的定植和生长的厌氧微生物定植和生长增强剂。

    Optical beam scanner, image forming device, and optical beam scanning method
    10.
    发明授权
    Optical beam scanner, image forming device, and optical beam scanning method 失效
    光束扫描器，成像装置和光束扫描方法

    公开(公告)号：US07339713B2

    公开(公告)日：2008-03-04

    申请号：US11509444

    申请日：2006-08-24

    申请人： Hitomi Shimizu

    发明人： Hitomi Shimizu

    IPC分类号： G02B26/08

    CPC分类号： G02B26/122 ,  G06K15/129 ,  H04N1/047 ,  H04N1/1135 ,  H04N2201/02439 ,  H04N2201/0471 ,  H04N2201/04734 ,  H04N2201/04739 ,  H04N2201/04744 ,  H04N2201/04781 ,  H04N2201/04794 ,  Y10S359/90

    摘要： An optical beam scanner includes a driving unit rotating a rotary polygon mirror that deflects and scans an optical beam; a rotation position detection unit; a rotation control unit controlling the driving unit in accordance with a rotation reference signal and an output signal of the rotation position detection unit; an optical beam detection unit detecting the optical beam at a predetermined position on a scanning path so as to generate a horizontal synchronizing signal; a first timing generation unit generating a first reference timing so as to print a first surface; a second timing generation unit generating a second reference timing so as to print a second surface; a timing measurement unit measuring a counter value according to the horizontal synchronizing signal; and a phase control unit controlling a phase of the rotation reference signal in accordance with the counter value obtained by the timing measurement unit.

    摘要翻译： 光束扫描器包括旋转偏转和扫描光束的旋转多面镜的驱动单元; 旋转位置检测单元; 旋转控制单元，其根据旋转参考信号和所述旋转位置检测单元的输出信号来控制所述驱动单元; 光束检测单元，在扫描路径上的预定位置处检测光束，以产生水平同步信号; 产生第一基准定时以便打印第一表面的第一定时产生单元; 产生第二基准定时以便打印第二表面的第二定时产生单元; 定时测量单元，根据水平同步信号测量计数器值; 以及相位控制单元，其根据由定时测量单元获得的计数器值来控制旋转参考信号的相位。