公开(公告)号：US5807730A

公开(公告)日：1998-09-15

申请号：US800751

申请日：1997-02-14

申请人： Kiyoshi Ito ,  Toshifumi Yamaki ,  Teruo Arii ,  Miyuki Tsuruoka ,  Takeshi Nakamura

发明人： Kiyoshi Ito ,  Toshifumi Yamaki ,  Teruo Arii ,  Miyuki Tsuruoka ,  Takeshi Nakamura

IPC分类号： C12N9/78 ,  C12N15/55 ,  C12N9/88

CPC分类号： C12N9/78 ,  Y10S435/822

摘要： The present invention provides the amino acid sequence and base sequence of a Pseudonocardia thermophila-derived nitrile hydratase, provides further a method for changing its amino acid sequence and base sequence without substantially changing the functions of said nitrile hydratase, and nitrile hydratases having a base sequence and an amino acid sequence as changed on the basis of said method, and provides furthermore a recombinant plasmid having the gene of said nitrile hydratase, a transformant containing said recombinant plasmid, a method of using said transformant for producing said enzyme, and a method of using said transformant for producing the corresponding amide compound from a nitrile compound.

公开(公告)号：US5910432A

公开(公告)日：1999-06-08

申请号：US990818

申请日：1997-12-15

申请人： Kiyoshi Ito ,  Toshifumi Yamaki ,  Teruo Arii ,  Miyuki Tsuruoka ,  Takeshi Nakamura

发明人： Kiyoshi Ito ,  Toshifumi Yamaki ,  Teruo Arii ,  Miyuki Tsuruoka ,  Takeshi Nakamura

IPC分类号： C12N9/78 ,  C12N15/55 ,  C12P13/02 ,  C12N1/00 ,  C12N5/10 ,  C12N9/88 ,  C12N15/60 ,  C12N15/63

CPC分类号： C12N9/78 ,  Y10S435/822

摘要： The present invention provides the amino acid sequence and base sequence of a Pseudonocardia thermophila-derived nitrile hydratase, provides further a method for changing its amino acid sequence and base sequence without substantially changing the functions of said nitrile hydratase, and nitrile hydratases having a base sequence and an amino acid sequence as changed on the basis of said method, and provides furthermore a recombinant plasmid having the gene of said nitrile hydratase, a transformant containing said recombinant plasmid, a method of using said transformant for producing said enzyme, and a method of using said transformant for producing the corresponding amide compound from a nitrile compound.

摘要翻译： 本发明提供了嗜热假诺卡氏菌腈水合酶的氨基酸序列和碱基序列，进一步提供了改变其氨基酸序列和碱基序列而基本上不改变所述腈水合酶的功能的方法，以及具有碱基序列的腈水合酶 和基于所述方法改变的氨基酸序列，并且还提供具有所述腈水合酶基因的重组质粒，含有所述重组质粒的转化体，使用所述转化体产生所述酶的方法，和 使用所述转化体从腈化合物制备相应的酰胺化合物。

公开(公告)号：US06730508B1

公开(公告)日：2004-05-04

申请号：US09265383

申请日：1999-03-10

申请人： Kiyoshi Ito ,  Miyuki Tsuruoka ,  Tadashi Suzuki ,  Seiya Nikumaru ,  Takeshi Nakamura

发明人： Kiyoshi Ito ,  Miyuki Tsuruoka ,  Tadashi Suzuki ,  Seiya Nikumaru ,  Takeshi Nakamura

IPC分类号： C12N121

CPC分类号： C12N9/88 ,  C12P13/02

摘要： The invention provides a nitrile hydratase activation protein participating in activation of nitrile hydratase derived from Pseudonocardia thermophila JCM3095, and a gene sequence encoding the same. Further, the invention provides a recombinant plasmid containing the gene, a recombinant plasmid containing the gene and a nitrile hydratase gene, a transformant strain obtained through transformation with the recombinant plasmid, and a process for producing a corresponding amide compound from a nitrile compound using a culture solution and cells obtained by incubating the transformant strain and treated products of the cells.

摘要翻译： 本发明提供了参与来自嗜热假诺卡氏菌JCM3095的腈水合酶的活化的腈水合酶活化蛋白和编码其的基因序列。 此外，本发明提供含有该基因的重组质粒，含有该基因的重组质粒和腈水合酶基因，通过用重组质粒转化而获得的转化体菌株，以及使用腈化合物从腈化合物制备相应的酰胺化合物的方法 培养溶液和通过温育转化体菌株和细胞的处理产物获得的细胞。

公开(公告)号：US07125704B2

公开(公告)日：2006-10-24

申请号：US10885874

申请日：2004-07-08

申请人： Hitoki Miyake ,  Toshifumi Yamaki ,  Toshihiro Oikawa ,  Takeshi Nakamura ,  Hiroki Ishibashi ,  Yasushi Fukuiri ,  Atsushi Sakuma ,  Hironori Komatsu ,  Tomoyuki Ando ,  Kazuhiko Togashi ,  Hideki Umetani

发明人： Hitoki Miyake ,  Toshifumi Yamaki ,  Toshihiro Oikawa ,  Takeshi Nakamura ,  Hiroki Ishibashi ,  Yasushi Fukuiri ,  Atsushi Sakuma ,  Hironori Komatsu ,  Tomoyuki Ando ,  Kazuhiko Togashi ,  Hideki Umetani

IPC分类号： C12N9/88 ,  C12P7/40 ,  C12P7/58 ,  C12P21/06

CPC分类号： C12N9/88 ,  C12P7/58 ,  C12Y402/01039

摘要： A novel gluconate dehydratase derived from Achromobacter xylosoxidans and a gene encoding the gluconate dehydratase are provided. By reacting the gluconate dehydratase or a transformed cell containing the gene with an aldonic acid, the corresponding 2-keto-3-deoxyaldonic acid can be efficiently produced.

公开(公告)号：US07510861B2

公开(公告)日：2009-03-31

申请号：US11523691

申请日：2006-09-20

申请人： Hitoki Miyake ,  Toshifumi Yamaki ,  Toshihiro Oikawa ,  Takeshi Nakamura ,  Hiroki Ishibashi ,  Yasushi Fukuiri ,  Atsushi Sakuma ,  Hironori Komatsu ,  Tomoyuki Ando ,  Kazuhiko Togashi ,  Hideki Umetani

发明人： Hitoki Miyake ,  Toshifumi Yamaki ,  Toshihiro Oikawa ,  Takeshi Nakamura ,  Hiroki Ishibashi ,  Yasushi Fukuiri ,  Atsushi Sakuma ,  Hironori Komatsu ,  Tomoyuki Ando ,  Kazuhiko Togashi ,  Hideki Umetani

IPC分类号： C12N9/88 ,  C12P7/40 ,  C12P7/58 ,  C12P21/06

CPC分类号： C12N9/88 ,  C12P7/58 ,  C12Y402/01039

摘要： A novel gluconate dehydratase derived from Achromobacter xylosoxidans and a gene encoding the gluconate dehydratase are provided. By reacting the gluconate dehydratase or a transformed cell containing the gene with an aldonic acid, the corresponding 2-keto-3-deoxyaldonic acid can be efficiently produced.

摘要翻译： 本发明提供了一种衍生自木糖无色杆菌的新型葡萄糖酸脱水酶和编码葡萄糖酸脱水酶的基因。 通过使葡糖酸脱水酶或含有该基因的转化细胞与醛糖酸反应，可以有效地制备相应的2-酮-3-脱氧醛酸。

公开(公告)号：US20050054042A1

公开(公告)日：2005-03-10

申请号：US10885874

申请日：2004-07-08

申请人： Hitoki Miyake ,  Toshifumi Yamaki ,  Toshihiro Oikawa ,  Takeshi Nakamura ,  Hiroki Ishibashi ,  Yasushi Fukuiri ,  Atsushi Sakuma ,  Hironori Komatsu ,  Tomoyuki Ando ,  Kazuhiko Togashi ,  Hideki Umetani

发明人： Hitoki Miyake ,  Toshifumi Yamaki ,  Toshihiro Oikawa ,  Takeshi Nakamura ,  Hiroki Ishibashi ,  Yasushi Fukuiri ,  Atsushi Sakuma ,  Hironori Komatsu ,  Tomoyuki Ando ,  Kazuhiko Togashi ,  Hideki Umetani

IPC分类号： C12N9/04 ,  C12N9/88 ,  C12N15/55 ,  C12P7/58 ,  C12N9/78 ,  C07H21/04 ,  C12N15/74 ,  C12P7/06

CPC分类号： C12N9/88 ,  C12P7/58 ,  C12Y402/01039

摘要： A novel gluconate dehydratase derived from Achromobacter xylosoxidans and a gene encoding the gluconate dehydratase are provided. By reacting the gluconate dehydratase or a transformed cell containing the gene with an aldonic acid, the corresponding 2-keto-3-deoxyaldonic acid can be efficiently produced.

摘要翻译： 本发明提供了一种衍生自木糖无色杆菌的新型葡萄糖酸脱水酶和编码葡萄糖酸脱水酶的基因。 通过使葡糖酸脱水酶或含有该基因的转化细胞与醛糖酸反应，可以有效地制备相应的2-酮-3-脱氧醛酸。

公开(公告)号：US20070015265A1

公开(公告)日：2007-01-18

申请号：US11523691

申请日：2006-09-20

申请人： Hitoki Miyake ,  Toshifumi Yamaki ,  Toshihiro Oikawa ,  Takeshi Nakamura ,  Hiroki Ishibashi ,  Yasushi Fukuiri ,  Atsushi Sakuma ,  Hironori Komatsu ,  Tomoyuki Ando ,  Kazuhiko Togashi ,  Hideki Umetani

发明人： Hitoki Miyake ,  Toshifumi Yamaki ,  Toshihiro Oikawa ,  Takeshi Nakamura ,  Hiroki Ishibashi ,  Yasushi Fukuiri ,  Atsushi Sakuma ,  Hironori Komatsu ,  Tomoyuki Ando ,  Kazuhiko Togashi ,  Hideki Umetani

IPC分类号： C12P7/58 ,  C07H21/04 ,  C12P21/06 ,  C12N9/04 ,  C12N15/74 ,  C12N1/21

CPC分类号： C12N9/88 ,  C12P7/58 ,  C12Y402/01039

摘要： A novel gluconate dehydratase derived from Achromobacter xylosoxidans and a gene encoding the gluconate dehydratase are provided. By reacting the gluconate dehydratase or a transformed cell containing the gene with an aldonic acid, the corresponding 2-keto-3-deoxyaldonic acid can be efficiently produced.

摘要翻译： 本发明提供了一种衍生自木糖无色杆菌的新型葡萄糖酸脱水酶和编码葡萄糖酸脱水酶的基因。 通过使葡糖酸脱水酶或含有该基因的转化细胞与醛糖酸反应，可以有效地制备相应的2-酮-3-脱氧醛酸。

公开(公告)号：US07038039B2

公开(公告)日：2006-05-02

申请号：US09958305

申请日：2001-02-13

申请人： Hironori Komatsu ,  Hirokazu Awano ,  Nobuyuki Fukazawa ,  Kiyoshi Ito ,  Ichirou Ikeda ,  Tadashi Araki ,  Takeshi Nakamura ,  Tamotsu Asano ,  Junya Fujiwara ,  Tomoyuki Ando ,  Katsutoshi Tsuchiya ,  Kyoko Maruyama ,  Hideki Umetani ,  Takahiro Yamauchi ,  Hitoki Miyake

发明人： Hironori Komatsu ,  Hirokazu Awano ,  Nobuyuki Fukazawa ,  Kiyoshi Ito ,  Ichirou Ikeda ,  Tadashi Araki ,  Takeshi Nakamura ,  Tamotsu Asano ,  Junya Fujiwara ,  Tomoyuki Ando ,  Katsutoshi Tsuchiya ,  Kyoko Maruyama ,  Hideki Umetani ,  Takahiro Yamauchi ,  Hitoki Miyake

IPC分类号： A61K31/665 ,  A61K31/7024 ,  C07F9/6544

CPC分类号： C07H19/10 ,  C07H19/00 ,  C07H19/20

摘要： A desired isomer is selectively prepared by phosphorolyzing and isomerizing an anomer mixture of a 1-phosphorylated saccharide derivative while crystallizing one of the isomers to displace the equilibrium. Furthermore, using the action of a nucleoside phosphorylase, a nucleoside is prepared from the 1-phosphorylated saccharide derivative obtained and a base with improved stereoselectivity and a higher yield. This process is an anomer-selective process for preparing a 1-phosphorylated saccharide derivative and a nucleoside.

公开(公告)号：US20060094869A1

公开(公告)日：2006-05-04

申请号：US11287212

申请日：2005-11-28

申请人： Hironori Komatsu ,  Hirokazu Awano ,  Nobuyuki Fukazawa ,  Kiyoshi Ito ,  Ichirou Ikeda ,  Tadashi Araki ,  Takeshi Nakamura ,  Tamotsu Asano ,  Junya Fujiwara ,  Tomoyuki Ando ,  Katsutoshi Tsuchiya ,  Kyoko Maruyama ,  Hideki Umetani ,  Takahiro Yamauchi ,  Hitoki Miyake

发明人： Hironori Komatsu ,  Hirokazu Awano ,  Nobuyuki Fukazawa ,  Kiyoshi Ito ,  Ichirou Ikeda ,  Tadashi Araki ,  Takeshi Nakamura ,  Tamotsu Asano ,  Junya Fujiwara ,  Tomoyuki Ando ,  Katsutoshi Tsuchiya ,  Kyoko Maruyama ,  Hideki Umetani ,  Takahiro Yamauchi ,  Hitoki Miyake

IPC分类号： C07H19/04

CPC分类号： C07H19/10 ,  C07H19/00 ,  C07H19/20

摘要： A desired isomer is selectively prepared by phosphorolyzing and isomerizing an anomer mixture of a 1-phosphorylated saccharide derivative while crystallizing one of the isomers to displace the equilibrium. Furthermore, using the action of a nucleoside phosphorylase, a nucleoside is prepared from the 1-phosphorylated saccharide derivative obtained and a base with improved stereoselectivity and a higher yield. This process is an anomer-selective process for preparing a 1-phosphorylated saccharide derivative and a nucleoside.

摘要翻译： 通过使1-磷酸化糖衍生物的异头混合物进行磷酸化和异构化同时结晶异构体之一以置换平衡来选择性地制备所需的异构体。 此外，使用核苷磷酰化酶的作用，由所得的1-磷酸化糖衍生物和具有改善的立体选择性和较高产率的碱制备核苷。 该方法是用于制备1-磷酸化糖衍生物和核苷的前体选择性方法。

公开(公告)号：US09838551B2

公开(公告)日：2017-12-05

申请号：US12533566

申请日：2009-07-31

申请人： Haruo Nishiyama ,  Takeshi Nakamura

发明人： Haruo Nishiyama ,  Takeshi Nakamura

IPC分类号： H04N1/00

CPC分类号： H04N1/00222 ,  H04N1/00413 ,  H04N2201/3207 ,  H04N2201/3222 ,  H04N2201/3232 ,  H04N2201/3242 ,  H04N2201/3243

摘要： An image transmitting apparatus is provided that automatically displays an address before transmission if a user gives an instruction for adding a mark such as “CONFIDENTIAL” or “IMPORTANT”. The image transmitting apparatus of the present invention is the image transmitting apparatus transmits image data to a specified address includes an image adding portion that adds a predetermined specific image to the image data in accordance with a user's operation, wherein displays a specified address of image data before transmitting the image data to which it is indicated to add the specific image and transmits the image data with the specific image added in accordance with a user's confirming operation.