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公开(公告)号：US09561351B2
公开(公告)日：2017-02-07
申请号：US11445079
申请日：2006-05-31
CPC分类号： A61M31/002 , A61F2/88 , A61F2/885 , A61F2250/0039 , A61F2250/0067
摘要： An implantable medical device is disclosed having a helical construct including a set of spiral coils for local in vivo application of a therapeutic substance in a biological lumen. The helical construct is configured to apply less than 0.75 Bar of pressure to the biological lumen wall. The helical construct can have at least two sets of spiral coils having opposing helical directions. The device can be used for the treatment of vascular disorders such as restenosis and vulnerable plaque.
摘要翻译： 公开了一种植入式医疗装置，其具有螺旋构造，其包括用于在生物腔内局部体内施用治疗物质的一组螺旋线圈。 螺旋结构被配置为向生物腔壁施加小于0.75巴的压力。 螺旋结构可以具有至少两组具有相反螺旋方向的螺旋线圈。 该装置可用于治疗血管疾病如再狭窄和易损斑块。
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公开(公告)号：US20070282425A1
公开(公告)日：2007-12-06
申请号：US11445079
申请日：2006-05-31
IPC分类号： A61F2/06
CPC分类号： A61M31/002 , A61F2/88 , A61F2/885 , A61F2250/0039 , A61F2250/0067
摘要： An implantable medical device is disclosed having a helical construct including a set of spiral coils for local in vivo application of a therapeutic substance in a biological lumen. The helical construct is configured to apply less than 0.75 Bar of pressure to the biological lumen wall. The helical construct can have at least two sets of spiral coils having opposing helical directions. The device can be used for the treatment of vascular disorders such as restenosis and vulnerable plaque.
摘要翻译： 公开了一种植入式医疗装置，其具有螺旋构造，其包括用于在生物腔内局部体内施用治疗物质的一组螺旋线圈。 螺旋结构被配置为向生物腔壁施加小于0.75巴的压力。 螺旋结构可以具有至少两组具有相反螺旋方向的螺旋线圈。 该装置可用于治疗血管疾病如再狭窄和易损斑块。
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公开(公告)号：US20110009948A1
公开(公告)日：2011-01-13
申请号：US12878937
申请日：2010-09-09
申请人： Bin Huang , David C. Gale , Srinivasan Sridharan , Joseph R. Callol , Klaus Kleine , Syed F. A. Hossainy , Timothy A. Limon , Anthony J. Abbate
发明人： Bin Huang , David C. Gale , Srinivasan Sridharan , Joseph R. Callol , Klaus Kleine , Syed F. A. Hossainy , Timothy A. Limon , Anthony J. Abbate
CPC分类号： A61F2/915 , A61F2/04 , A61F2/06 , A61F2/90 , A61F2/91 , A61F2002/072 , A61F2002/91508 , A61F2002/91575 , A61F2210/0004 , A61F2210/0009 , A61F2210/0076 , A61F2220/005 , A61F2230/0013 , A61F2250/0098 , A61L31/129 , B23K26/402 , B23K26/50 , B23K2103/42 , B23K2103/50 , B29C43/02 , B29C45/0001 , B29C45/0005 , B29C45/0055 , B29C47/0004 , B29C47/0023 , B29C47/0026 , B29C47/0066 , B29C47/06 , B29C47/1045 , B29C53/566 , B29C53/583 , B29C59/02 , B29C59/021 , B29C2043/028 , B29K2101/00 , B29K2105/12 , B29K2267/043 , B29K2995/0056 , B29K2995/006 , B29L2023/003 , B29L2031/7546 , D03D3/02
摘要： Polymeric composite stents reinforced with fibers for implantation into a bodily lumen are disclosed.
摘要翻译： 公开了用纤维增强的用于植入体腔的聚合复合支架。
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4.发明授权公开(公告)号：US09089627B2
公开(公告)日：2015-07-28
申请号：US11827180
申请日：2007-07-10
CPC分类号： A61F2/86 , A61F2210/0076 , A61F2230/0069 , A61L31/10 , A61L31/129
摘要： Stents fabricated from polymer composites toughened by a dispersed phase are disclosed.
摘要翻译： 公开了由分散相增韧的聚合物复合材料制成的支架。
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5.发明授权Method of making a medical device with regioselective structure-property distribution 有权制造具有区域选择性结构 - 属性分布的医疗器械的方法公开(公告)号：US08366762B2
公开(公告)日：2013-02-05
申请号：US12796543
申请日：2010-06-08
申请人： Syed F. A. Hossainy , David C. Gale
发明人： Syed F. A. Hossainy , David C. Gale
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2210/0004 , A61F2250/0018 , A61F2250/0042 , B29C35/0266 , B29C71/0063 , B29C71/02 , B29L2031/753
摘要： A medical device and methods of making the medical device such as a stent having selected regions with different material properties than other regions are disclosed. Selection and modification of the regions may be based on facilitating a desired mechanical behavior and/or therapeutic prophylactic property of the device.
摘要翻译： 公开了一种医疗装置和制造医疗装置的方法，例如具有与其他区域不同的材料性质的选定区域的支架。 区域的选择和修饰可以基于促进装置的期望的机械行为和/或治疗性预防性质。
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6.发明授权Degradable polymeric implantable medical devices with a continuous phase and discrete phase 有权具有连续相和离散相的可降解聚合物可植入医疗器械公开(公告)号：US07964210B2
公开(公告)日：2011-06-21
申请号：US11395048
申请日：2006-03-31
IPC分类号： A61F2/02
CPC分类号： A61F2/91 , A61F2210/0004 , A61F2230/0013 , A61F2240/001 , A61F2250/0031 , A61L31/041 , A61L31/148 , C08G63/08 , C08L67/04 , C08L2666/18
摘要： The invention provides an implantable medical device comprising: a structural element, wherein the structural element includes: a continuous phase comprising a first polymer; a discrete phase within the continuous phase, wherein the discrete phase has a second polymer including discrete phase segments; and anchor segments that have substantially the same chemical make up as the first polymer of the continuous phase; wherein at least some of the anchor segments have partially or completely phase-separated from the discrete phase into the continuous phase.
摘要翻译： 本发明提供了一种可植入医疗装置，其包括：结构元件，其中所述结构元件包括：包含第一聚合物的连续相; 在连续相中的离散相，其中离散相具有包括离散相段的第二聚合物; 以及具有与连续相的第一聚合物基本上相同的化学成分的锚段; 其中至少一些所述锚固段具有从所述离散相部分或完全相分离成连续相。
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7.发明授权Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability 有权抛光可植入医疗器械降低血栓形成并增加机械稳定性的方法公开(公告)号：US07329366B1
公开(公告)日：2008-02-12
申请号：US10871404
申请日：2004-06-18
申请人： David C. Gale , Syed F. A. Hossainy
发明人： David C. Gale , Syed F. A. Hossainy
IPC分类号： B44C1/22
CPC分类号： A61L31/10 , A61F2/91 , A61F2210/0004 , Y10S623/901
摘要： The present invention relates to a method of polishing an implantable medical device. The method may include positioning an implantable medical device on a support. At least a portion of a surface of the implantable medical device may include a polymer. A fluid may be contacted with at least a portion of the surface of the positioned implantable medical device. In an embodiment, the fluid may be capable of dissolving at least a portion of the polymer at or near the surface of the implantable medical device. The method may further include allowing the fluid to modify at least a portion of the surface of the positioned medical device. A majority of the contacted fluid may be removed from the surface of the implantable medical device. In certain embodiments, the modified portion of the surface may be substantially less thrombogenetic and substantially more mechanically stable than an unmodified surface.
摘要翻译： 本发明涉及一种抛光可植入医疗器械的方法。 该方法可以包括将可植入医疗装置定位在支撑件上。 可植入医疗装置的表面的至少一部分可以包括聚合物。 流体可以与定位的可植入医疗装置的表面的至少一部分接触。 在一个实施方案中，流体可能能够将聚合物的至少一部分溶解在可植入医疗装置的表面处或附近。 该方法还可以包括允许流体修改定位的医疗装置的表面的至少一部分。 接触流体的大部分可以从可植入医疗装置的表面移除。 在某些实施方案中，表面的改性部分可以比未修饰的表面基本上更少的血栓形成和基本上更机械稳定的。
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公开(公告)号：US09248034B2
公开(公告)日：2016-02-02
申请号：US11210344
申请日：2005-08-23
CPC分类号： A61F2/82 , A61F2/91 , A61F2210/0004 , A61F2250/0067 , A61L31/148 , A61L31/16 , A61L2300/604 , A61L2300/622
摘要： Implantable medical devices for treating bodily disorders local and distally to a region of implantation are disclosed. The devices include a body structure including an active agent, erodable particles acting as a carrier of the active agent, and an erodable binder. The binder releasably binds the particles together such that after implantation the binder erodes to release the particles.
摘要翻译： 公开了用于治疗局部和远端到植入区域的身体障碍的可植入医疗装置。 这些装置包括主体结构，其包括活性剂，作为活性剂的载体的可侵蚀颗粒和可侵蚀的粘合剂。 粘合剂将颗粒可释放地结合在一起，使得在植入之后，粘合剂侵蚀以释放颗粒。
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9.发明授权Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability 有权抛光可植入医疗器械降低血栓形成并增加机械稳定性的方法公开(公告)号：US07967998B2
公开(公告)日：2011-06-28
申请号：US11969181
申请日：2008-01-03
申请人： David C. Gale , Syed F. A. Hossainy
发明人： David C. Gale , Syed F. A. Hossainy
IPC分类号： C03C15/00
CPC分类号： A61L31/10 , A61F2/91 , A61F2210/0004 , Y10S623/901
摘要： The present invention relates to a method of polishing an implantable medical device. The method may include positioning an implantable medical device on a support. At least a portion of a surface of the implantable medical device may include a polymer. A fluid may be contacted with at least a portion of the surface of the positioned implantable medical device. In an embodiment, the fluid may be capable of dissolving at least a portion of the polymer at or near the surface of the implantable medical device. The method may further include allowing the fluid to modify at least a portion of the surface of the positioned medical device. A majority of the contacted fluid may be removed from the surface of the implantable medical device. In certain embodiments, the modified portion of the surface may be substantially less thrombogenetic and substantially more mechanically stable than an unmodified surface.
摘要翻译： 本发明涉及一种抛光可植入医疗器械的方法。 该方法可以包括将可植入医疗装置定位在支撑件上。 可植入医疗装置的表面的至少一部分可以包括聚合物。 流体可以与定位的可植入医疗装置的表面的至少一部分接触。 在一个实施方案中，流体可能能够将聚合物的至少一部分溶解在可植入医疗装置的表面处或附近。 该方法还可以包括允许流体修改定位的医疗装置的表面的至少一部分。 接触流体的大部分可以从可植入医疗装置的表面移除。 在某些实施方案中，表面的改性部分可以比未修饰的表面基本上更少的血栓形成和基本上更机械稳定的。
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10.发明授权Polymer-bioceramic composite implantable medical device with different types of bioceramic particles 有权具有不同类型生物陶瓷颗粒的聚合物 - 生物陶瓷复合植入式医疗装置公开(公告)号：US07955381B1
公开(公告)日：2011-06-07
申请号：US11823931
申请日：2007-06-29
申请人： Yunbing Wang , David C. Gale , Syed F. A. Hossainy
发明人： Yunbing Wang , David C. Gale , Syed F. A. Hossainy
IPC分类号： A61F2/06
CPC分类号： A61L31/148 , A61L31/128 , A61L31/14 , C08L67/04
摘要： Implantable medical devices fabricated from polymer/bioceramic composites with different types of bioceramic particles are disclosed. The plurality of bioceramic particles can include acidic particles and basic particles, the acidic particles and basic particles having different particle size distributions. The degradation of a selected type of particle can be reduced or prevented during a selected time frame by encapsulating some or all of the selected type of particles with a bioabsorbable polymer.
摘要翻译： 公开了由具有不同类型的生物陶瓷颗粒的聚合物/生物陶瓷复合材料制成的植入式医疗装置。 多个生物陶瓷颗粒可以包括酸性颗粒和碱性颗粒，酸性颗粒和碱性颗粒具有不同的粒度分布。 通过用生物可吸收的聚合物包封一些或所有选定类型的颗粒，可以在选定的时间范围内减少或预防选定类型的颗粒的降解。
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