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    Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability
    4.
    发明授权
    Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability 有权
    抛光可植入医疗器械降低血栓形成并增加机械稳定性的方法

    公开(公告)号：US07329366B1

    公开(公告)日：2008-02-12

    申请号：US10871404

    申请日：2004-06-18

    申请人： David C. Gale ,  Syed F. A. Hossainy

    发明人： David C. Gale ,  Syed F. A. Hossainy

    IPC分类号： B44C1/22

    CPC分类号： A61L31/10 ,  A61F2/91 ,  A61F2210/0004 ,  Y10S623/901

    摘要： The present invention relates to a method of polishing an implantable medical device. The method may include positioning an implantable medical device on a support. At least a portion of a surface of the implantable medical device may include a polymer. A fluid may be contacted with at least a portion of the surface of the positioned implantable medical device. In an embodiment, the fluid may be capable of dissolving at least a portion of the polymer at or near the surface of the implantable medical device. The method may further include allowing the fluid to modify at least a portion of the surface of the positioned medical device. A majority of the contacted fluid may be removed from the surface of the implantable medical device. In certain embodiments, the modified portion of the surface may be substantially less thrombogenetic and substantially more mechanically stable than an unmodified surface.

    摘要翻译： 本发明涉及一种抛光可植入医疗器械的方法。 该方法可以包括将可植入医疗装置定位在支撑件上。 可植入医疗装置的表面的至少一部分可以包括聚合物。 流体可以与定位的可植入医疗装置的表面的至少一部分接触。 在一个实施方案中，流体可能能够将聚合物的至少一部分溶解在可植入医疗装置的表面处或附近。 该方法还可以包括允许流体修改定位的医疗装置的表面的至少一部分。 接触流体的大部分可以从可植入医疗装置的表面移除。 在某些实施方案中，表面的改性部分可以比未修饰的表面基本上更少的血栓形成和基本上更机械稳定的。

    Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability
    6.
    发明授权
    Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability 有权
    抛光可植入医疗器械降低血栓形成并增加机械稳定性的方法

    公开(公告)号：US07967998B2

    公开(公告)日：2011-06-28

    申请号：US11969181

    申请日：2008-01-03

    申请人： David C. Gale ,  Syed F. A. Hossainy

    发明人： David C. Gale ,  Syed F. A. Hossainy

    IPC分类号： C03C15/00

    CPC分类号： A61L31/10 ,  A61F2/91 ,  A61F2210/0004 ,  Y10S623/901

    摘要： The present invention relates to a method of polishing an implantable medical device. The method may include positioning an implantable medical device on a support. At least a portion of a surface of the implantable medical device may include a polymer. A fluid may be contacted with at least a portion of the surface of the positioned implantable medical device. In an embodiment, the fluid may be capable of dissolving at least a portion of the polymer at or near the surface of the implantable medical device. The method may further include allowing the fluid to modify at least a portion of the surface of the positioned medical device. A majority of the contacted fluid may be removed from the surface of the implantable medical device. In certain embodiments, the modified portion of the surface may be substantially less thrombogenetic and substantially more mechanically stable than an unmodified surface.

    摘要翻译： 本发明涉及一种抛光可植入医疗器械的方法。 该方法可以包括将可植入医疗装置定位在支撑件上。 可植入医疗装置的表面的至少一部分可以包括聚合物。 流体可以与定位的可植入医疗装置的表面的至少一部分接触。 在一个实施方案中，流体可能能够将聚合物的至少一部分溶解在可植入医疗装置的表面处或附近。 该方法还可以包括允许流体修改定位的医疗装置的表面的至少一部分。 接触流体的大部分可以从可植入医疗装置的表面移除。 在某些实施方案中，表面的改性部分可以比未修饰的表面基本上更少的血栓形成和基本上更机械稳定的。

    Polymer-bioceramic composite implantable medical device with different types of bioceramic particles
    7.
    发明授权
    Polymer-bioceramic composite implantable medical device with different types of bioceramic particles 有权
    具有不同类型生物陶瓷颗粒的聚合物 - 生物陶瓷复合植入式医疗装置

    公开(公告)号：US07955381B1

    公开(公告)日：2011-06-07

    申请号：US11823931

    申请日：2007-06-29

    申请人： Yunbing Wang ,  David C. Gale ,  Syed F. A. Hossainy

    发明人： Yunbing Wang ,  David C. Gale ,  Syed F. A. Hossainy

    IPC分类号： A61F2/06

    CPC分类号： A61L31/148 ,  A61L31/128 ,  A61L31/14 ,  C08L67/04

    摘要： Implantable medical devices fabricated from polymer/bioceramic composites with different types of bioceramic particles are disclosed. The plurality of bioceramic particles can include acidic particles and basic particles, the acidic particles and basic particles having different particle size distributions. The degradation of a selected type of particle can be reduced or prevented during a selected time frame by encapsulating some or all of the selected type of particles with a bioabsorbable polymer.

    摘要翻译： 公开了由具有不同类型的生物陶瓷颗粒的聚合物/生物陶瓷复合材料制成的植入式医疗装置。 多个生物陶瓷颗粒可以包括酸性颗粒和碱性颗粒，酸性颗粒和碱性颗粒具有不同的粒度分布。 通过用生物可吸收的聚合物包封一些或所有选定类型的颗粒，可以在选定的时间范围内减少或预防选定类型的颗粒的降解。

    Drug delivery spiral coil construct
    9.
    发明授权
    Drug delivery spiral coil construct 有权
    药物输送螺旋线圈构造

    公开(公告)号：US09561351B2

    公开(公告)日：2017-02-07

    申请号：US11445079

    申请日：2006-05-31

    申请人： Klaus Kleine ,  David C. Gale ,  Fozan El-Nounou ,  Syed F. A. Hossainy ,  Florian Ludwig

    发明人： Klaus Kleine ,  David C. Gale ,  Fozan El-Nounou ,  Syed F. A. Hossainy ,  Florian Ludwig

    IPC分类号： A61M31/00 ,  A61F2/88

    CPC分类号： A61M31/002 ,  A61F2/88 ,  A61F2/885 ,  A61F2250/0039 ,  A61F2250/0067

    摘要： An implantable medical device is disclosed having a helical construct including a set of spiral coils for local in vivo application of a therapeutic substance in a biological lumen. The helical construct is configured to apply less than 0.75 Bar of pressure to the biological lumen wall. The helical construct can have at least two sets of spiral coils having opposing helical directions. The device can be used for the treatment of vascular disorders such as restenosis and vulnerable plaque.

    摘要翻译： 公开了一种植入式医疗装置，其具有螺旋构造，其包括用于在生物腔内局部体内施用治疗物质的一组螺旋线圈。 螺旋结构被配置为向生物腔壁施加小于0.75巴的压力。 螺旋结构可以具有至少两组具有相反螺旋方向的螺旋线圈。 该装置可用于治疗血管疾病如再狭窄和易损斑块。