公开(公告)号：US08796017B2

公开(公告)日：2014-08-05

申请号：US10557561

申请日：2004-05-21

申请人： Koji Suzuki ,  Junya Fujii ,  Mari Matsuura ,  Seishin Tanaka ,  Ken Kondo

发明人： Koji Suzuki ,  Junya Fujii ,  Mari Matsuura ,  Seishin Tanaka ,  Ken Kondo

IPC分类号： C12N5/00 ,  C12N5/02 ,  A61M31/00 ,  A61K38/54

CPC分类号： A61M1/0209 ,  A61M1/0218 ,  A61M1/0231 ,  A61M1/029 ,  A61M2202/0014 ,  A61M2202/0415

摘要： A blood storage container suitable for quick and efficient production of a large amount of serum while ensuring high safety, and a method of separating blood and a regenerative medical process using the same are provided. In a blood component separator 1 for separating collected blood into a plurality of blood components and preserving them, the separator 1 including a blood reservoir 10 for reserving the blood and a component storage part 20 aseptically connected in an air-tight manner to this blood reservoir 10, to the aforementioned blood reservoir 10 being imparted a serum producing function to remove coagulation factors from the blood to an extent enabling use in practical applications as a serum, and the aforementioned component storage part 20 storing each blood component generated by separation of the blood in the blood reservoir 10.

摘要翻译： 本发明提供一种能够快速高效地生产大量血清，同时确保高安全性的血液储存容器，以及使用该血液储存容器分离血液的方法和使用其的再生医疗方法。 在用于将收集的血液分离成多个血液成分并将其保存的血液成分分离器1中，包括用于储存血液的血液储存器10和气密无菌地与血液储存器无菌连接的部件收纳部20的分离器1 如图10所示，向上述血液储存器10赋予从血液中除去凝血因子的血清产生功能，使其能够作为血清用于实际应用，上述成分存储部20储存通过分离血液而产生的各血液成分 在血液储存器10中。

公开(公告)号：US20060251622A1

公开(公告)日：2006-11-09

申请号：US10557561

申请日：2004-05-21

申请人： Koji Suzuki ,  Junya Fujji ,  Mari Matsuura ,  Seishin Tanaka ,  Ken Kondo

发明人： Koji Suzuki ,  Junya Fujji ,  Mari Matsuura ,  Seishin Tanaka ,  Ken Kondo

IPC分类号： A61K35/14 ,  C12N5/08 ,  A61K48/00 ,  C12N5/00

CPC分类号： A61M1/0209 ,  A61M1/0218 ,  A61M1/0231 ,  A61M1/029 ,  A61M2202/0014 ,  A61M2202/0415

摘要： A blood storage container suitable for quick and efficient production of a large amount of serum while ensuring high safety, and a method of separating blood and a regenerative medical process using the same are provided. In a blood component separator 1 for separating collected blood into a plurality of blood components and preserving them, the separator 1 including a blood reservoir 10 for reserving the blood and a component storage part 20 aseptically connected in an air-tight manner to this blood reservoir 10, to the aforementioned blood reservoir 10 being imparted a serum producing function to remove coagulation factors from the blood to an extent enabling use in practical applications as a serum, and the aforementioned component storage part 20 storing each blood component generated by separation of the blood in the blood reservoir 10.

摘要翻译： 本发明提供一种能够快速高效地生产大量血清，同时确保高安全性的血液储存容器，以及使用该血液储存容器分离血液的方法和使用其的再生医疗方法。 在用于将收集的血液分离成多个血液成分并将其保存的血液成分分离器1中，包括用于储存血液的血液储存器10和气密无菌地与血液储存器无菌连接的部件收纳部20的分离器1 如图10所示，向上述血液储存器10赋予从血液中除去凝血因子的血清产生功能，使其能够作为血清用于实际应用，上述成分存储部20储存通过分离血液而产生的各血液成分 在血液储存器10中。

公开(公告)号：US07428771B2

公开(公告)日：2008-09-30

申请号：US10531999

申请日：2002-10-23

申请人： Junya Fujii ,  Hideyasu Miyahara ,  Seishin Tanaka

发明人： Junya Fujii ,  Hideyasu Miyahara ,  Seishin Tanaka

IPC分类号： B65D33/16 ,  B65D77/10

CPC分类号： A61J1/2093 ,  A61J1/2034 ,  A61M39/284 ,  B65D81/3266 ,  Y10T24/15 ,  Y10T24/44752

摘要： A clip which solves a technical problem that the latching of the clip is not easily released by the external force caused by falling, etc., and is easily released when the clip is used. The clip has opposed clipping arms capable of forming an independent and separate space by pressing and holding a clipped object constituted of a flexible hollow member between them. The clip has a latching means on one end of the opposed clipping arm, which has a latching part capable of latching the clipping arms. The clip further has a latching releasing means capable of releasing the latching by an external force headed to an external direction from the clipping arm. The latching means has a supporting point part acting the latching releasing force, added to the latching means by the latching releasing means, to the direction to release the latching of the latching part.

摘要翻译： 解决了由于坠落等引起的外力不容易释放夹子的夹持的技术问题的夹子，并且当使用夹子时容易释放。 夹子具有相对的夹持臂，能够通过在其间夹持由柔性中空构件构成的夹持物体而形成独立且分离的空间。 夹具在相对的夹持臂的一端具有锁定装置，其具有能够锁定夹持臂的闩锁部分。 夹具还具有能够通过从夹持臂朝向外部方向的外力而释放闩锁的闩锁释放装置。 闩锁装置具有支撑点部分，其作用于通过闩锁释放装置附加到闩锁装置的闩锁释放力到释放闩锁部分的锁定的方向。

公开(公告)号：US20060107502A1

公开(公告)日：2006-05-25

申请号：US10531999

申请日：2002-10-23

申请人： Junya Fujii ,  Hideyasu Miyahara ,  Seishin Tanaka

发明人： Junya Fujii ,  Hideyasu Miyahara ,  Seishin Tanaka

IPC分类号： A44B21/00

CPC分类号： A61J1/2093 ,  A61J1/2034 ,  A61M39/284 ,  B65D81/3266 ,  Y10T24/15 ,  Y10T24/44752

摘要： The present invention relates to a type B clip which solves a technical problem that the latching of the clip is not easily released by the external force caused by falling, etc., and is easily released when the clip is used by users. The clip comprises opposed clipping arms capable of forming an independent and separate space by pressing and holding a clipped object constituted of a flexible hollow member therebetween, and a latching means, disposed on one end of the opposed clipping arm, which has a latching part capable of latching the clipping arms which are pressing and holding the clipped object therebetween, wherein the clip has a latching releasing means capable of releasing the latching by an external force headed to an external direction from the clipping arm, and a structure of the latching means has a supporting point part acting the latching releasing force, added to the latching means by the latching releasing means, to the direction to release the latching of the latching part.

摘要翻译： 本发明涉及一种解决技术问题的B型夹子，该技术问题是夹子的锁定不容易由于由下落等引起的外力而释放，并且当夹子被使用者使用时容易释放。 夹子包括相对的夹持臂，其能够通过按压并保持由它们之间的柔性中空构件构成的夹持物体而形成独立和分离的空间;以及闩锁装置，设置在相对的夹持臂的一端上，该锁定装置具有能够 锁定夹持在其间的夹持臂的夹持臂，其中夹具具有闩锁释放装置，该闩锁释放装置能够通过从夹持臂向外部方向的外力释放闩锁，并且闩锁装置的结构具有 通过闩锁释放装置将闩锁释放力作用于闩锁释放力的支撑点部分朝向释放闩锁部分的锁定的方向。

公开(公告)号：US06293921B1

公开(公告)日：2001-09-25

申请号：US09254319

申请日：1999-08-25

申请人： Kazuhiro Shinmoto ,  Seishin Tanaka ,  Junya Fujii

发明人： Kazuhiro Shinmoto ,  Seishin Tanaka ,  Junya Fujii

IPC分类号： A61M100

CPC分类号： A61M1/28 ,  A61M1/288 ,  A61M39/10

摘要： An automatic exchanger apparatus for peritoneal dialysis fluids is provided having a dialysis fluid bag and a drained fluid bag and arranged for connecting and disconnecting between the end of a peritoneal dialysis circuit equipped with a branching point and the end of a tube extending from a patient to drain the waste dialysis fluid from the cavity of the patient and fill the peritoneal cavity of the patient with a fresh peritoneal dialysis fluid for exchange, and in particular comprises: means A, B, and C for carrying out respectively a step (A) of connecting the end of the patient side tube to the end of the peritoneal dialysis circuit, a step (B) of delivering and draining the waste fluid, and a step (C) of, disconnecting the two ends and connecting the end of the patient side tube to its shut-off member, arranged for carrying out their respective steps (A) and (C) automatically; and a controlling means for controlling the respectively means to execute their respectively steps in a sequence. The apparatus is simple in the construction while carrying out, with much ease, the connection and disconnection of the tubes and the exchange of the fluids including a waste and a fresh supply one, hence avoiding operational errors of the operator and minimizing the possibility of infection and contamination.

摘要翻译： 提供了一种腹膜透析液自动交换装置，其具有透析液袋和排液流体袋，并布置成用于连接和断开配备有分支点的腹膜透析回路的末端和从患者延伸到管的末端 从患者的空腔排出废液透析液，并用新鲜的腹膜透析液填充患者的腹膜以进行交换，特别地包括：用于分别执行步骤（A）的方法A，B和C， 将患者侧管的端部连接到腹膜透析回路的末端，输送和排出废液的步骤（B）;以及步骤（C），断开两端并连接患者侧的端部 管连接到其关闭构件，被布置成自动执行它们各自的步骤（A）和（C）; 以及控制装置，用于按顺序控制分别执行其各自步骤的装置。 该设备结构简单，同时轻松执行管的连接和断开以及包括废物和新鲜供应的流体的交换，从而避免操作者的操作错误并最小化感染的可能性 和污染。

公开(公告)号：US20100120150A1

公开(公告)日：2010-05-13

申请号：US12529664

申请日：2008-03-05

申请人： Koji Suzuki ,  Seishin Tanaka ,  Satoshi Hirai ,  Mari Takabatake

发明人： Koji Suzuki ,  Seishin Tanaka ,  Satoshi Hirai ,  Mari Takabatake

IPC分类号： C12N5/00

CPC分类号： A61K35/16 ,  A61M1/0218 ,  A61M1/0281 ,  A61M1/029 ,  A61M2202/0423

摘要： A method for preparing serum and a serum preparation apparatus is provided that can give a large amount of serum with high culture efficiency regardless of freshness of blood used. In a method for preparing serum from blood containing at least platelets, a platelet processing step is provided in which platelet membrane in the blood is destroyed. After the platelet processing step, a deposition step for depositing thermolabile protein in blood and a removal step for removing the thermolabile protein, which has been deposited in the deposition step, are preferably provided.

摘要翻译： 提供一种制备血清和血清制备装置的方法，其可以产生大量的具有高培养效率的血清，而不管所用血液的新鲜度。 在至少含有血小板的血液制备血清的方法中，提供血小板的血小板膜被破坏的血小板加工步骤。 在血小板处理步骤之后，优选提供用于在血液中沉积热不稳定蛋白质的沉积步骤和用于去除在沉积步骤中沉积的不耐热蛋白质的去除步骤。

公开(公告)号：US08679838B2

公开(公告)日：2014-03-25

申请号：US12705298

申请日：2010-02-12

申请人： Koji Suzuki ,  Seishin Tanaka

发明人： Koji Suzuki ,  Seishin Tanaka

IPC分类号： C12N5/07 ,  C12N5/10 ,  A01N1/02 ,  C12N5/00 ,  C12N5/02 ,  C12N5/071 ,  C12M1/00 ,  C12M1/38 ,  C12M3/00 ,  C12M1/34

CPC分类号： C12N5/0018 ,  A61K35/16 ,  C12N2501/135 ,  C12N2501/15

摘要： It is intended to provide a serum which contains a large amount of growth factors capable of efficiently promoting the growth of stem cells. A human serum for cell culture which shows a residual ratio of platelets remaining within 20 minutes after blood collection in relation to the whole amount of the platelets is 0% to 20%, and a release ratio of cell growth factors is 20% to 100%.

摘要翻译： 旨在提供含有能够有效促进干细胞生长的大量生长因子的血清。 相对于血小板的全部量，血液收集后20分钟内剩余的血小板残留率的细胞培养用人血清为0〜20％，细胞生长因子的释放率为20〜100％ 。

公开(公告)号：US08603821B2

公开(公告)日：2013-12-10

申请号：US12529664

申请日：2008-03-05

申请人： Koji Suzuki ,  Seishin Tanaka ,  Satoshi Hirai ,  Mari Takabatake

发明人： Koji Suzuki ,  Seishin Tanaka ,  Satoshi Hirai ,  Mari Takabatake

IPC分类号： C12N5/00 ,  A61K35/14

CPC分类号： A61K35/16 ,  A61M1/0218 ,  A61M1/0281 ,  A61M1/029 ,  A61M2202/0423

摘要： A method for preparing serum and a serum preparation apparatus is provided that can give a large amount of serum with high culture efficiency regardless of freshness of blood used. In a method for preparing serum from blood containing at least platelets, a platelet processing step is provided in which platelet membrane in the blood is destroyed. After the platelet processing step, a deposition step for depositing thermolabile protein in blood and a removal step for removing the thermolabile protein, which has been deposited in the deposition step, are preferably provided.

摘要翻译： 提供一种制备血清和血清制备装置的方法，其可以产生大量的具有高培养效率的血清，而不管所用血液的新鲜度。 在至少含有血小板的血液制备血清的方法中，提供血小板的血小板膜被破坏的血小板加工步骤。 在血小板处理步骤之后，优选提供用于在血液中沉积热不稳定蛋白质的沉积步骤和用于去除在沉积步骤中沉积的不耐热蛋白质的去除步骤。

公开(公告)号：US20090075355A1

公开(公告)日：2009-03-19

申请号：US11719392

申请日：2005-11-02

申请人： Koji Suzuki ,  Seishin Tanaka

发明人： Koji Suzuki ,  Seishin Tanaka

IPC分类号： C12N9/00

CPC分类号： C12N5/0018 ,  A61K35/16 ,  C12N2501/135 ,  C12N2501/15

摘要： It is intended to provide a serum which contains a large amount of growth factors capable of efficiently promoting the growth of stem cells. A human serum for cell culture which shows a residual ratio of platelets remaining within 20 minutes after blood collection in relation to the whole amount of the platelets is 0% to 20%, and a release ratio of cell growth factors is 20% to 100%.

摘要翻译： 旨在提供含有能够有效促进干细胞生长的大量生长因子的血清。 相对于血小板的全部量，血液收集后20分钟内剩余的血小板残留率的细胞培养用人血清为0〜20％，细胞生长因子的释放率为20〜100％ 。

公开(公告)号：US20100167402A1

公开(公告)日：2010-07-01

申请号：US12705298

申请日：2010-02-12

申请人： Koji SUZUKI ,  Seishin Tanaka

发明人： Koji SUZUKI ,  Seishin Tanaka

IPC分类号： C12N5/02

CPC分类号： C12N5/0018 ,  A61K35/16 ,  C12N2501/135 ,  C12N2501/15

摘要： It is intended to provide a serum which contains a large amount of growth factors capable of efficiently promoting the growth of stem cells. A human serum for cell culture which shows a residual ratio of platelets remaining within 20 minutes after blood collection in relation to the whole amount of the platelets is 0% to 20%, and a release ratio of cell growth factors is 20% to 100%.

摘要翻译： 旨在提供含有能够有效促进干细胞生长的大量生长因子的血清。 相对于血小板的全部量，血液收集后20分钟内剩余的血小板残留率的细胞培养用人血清为0〜20％，细胞生长因子的释放率为20〜100％ 。