MULTIFUNCTIONAL BIOMATERIALS AS SCAFFOLDS FOR ELECTRONIC, OPTICAL, MAGNETIC, SEMICONDUCTING, AND BIOTECHNOLOGICAL APPLICATIONS
    3.
    发明申请
    MULTIFUNCTIONAL BIOMATERIALS AS SCAFFOLDS FOR ELECTRONIC, OPTICAL, MAGNETIC, SEMICONDUCTING, AND BIOTECHNOLOGICAL APPLICATIONS 有权
    多功能生物材料作为电子,光学,磁性,半导体和生物技术应用的SCAFF

    公开(公告)号:US20120264166A1

    公开(公告)日:2012-10-18

    申请号:US13341010

    申请日:2011-12-30

    IPC分类号: C12P1/00

    摘要: One-dimensional ring structures from M13 viruses were constructed by two genetic modifications encoding binding peptides and synthesis of a heterobifunctional linker molecule. The bifunctional viruses displayed an anti-streptavidin peptide and hexahistidine (SEQ ID NO:4) peptide at opposite ends of the virus as pIII and pIX fusions. Stoichiometric addition of the streptavidin-NiNTA linker molecule led to the reversible formation of virus-based nanorings with circumferences corresponding to lengths of the packagable DNAs. These virus-based ring structures can be further engineered to nucleate inorganic materials and form metallic, magnetic, or semiconductor nanorings using trifunctionalized viruses.

    摘要翻译: 通过编码结合肽的两种遗传修饰和异双功能连接子分子的合成构建来自M13病毒的一维环结构。 双功能病毒在病毒的相对端显示抗链亲和素肽和六组氨酸(SEQ ID NO:4)肽作为pIII和pIX融合物。 链霉抗生物素蛋白-NNNTA连接分子的化学计量加成导致可逆形成基于病毒的纳米片,其周长对应于可包装的DNA的长度。 这些基于病毒的环结构可以进一步工程化以使无机材料成核,并使用三官能化病毒形成金属,磁性或半导体纳米片。

    Biomimetic peptoid polymers
    6.
    发明授权
    Biomimetic peptoid polymers 有权
    生物拟肽类聚合物

    公开(公告)号:US09073977B2

    公开(公告)日:2015-07-07

    申请号:US13022548

    申请日:2011-02-07

    摘要: The present invention provides for novel peptoid oligomers that are capable of self-assembling into two-dimensional sheet structures. The peptoid oligomers can have alternately hydrophilic or polar side-chains and hydrophobic or apolar side-chains. The peptoid oligomers, and the two-dimensional sheet structures, can be applied to biological applications where the peptoid plays a role as a biological scaffold or building block. Also, the two-dimensional sheet structures of the present invention can be used as two-dimensional nanostructures in device applications.

    摘要翻译: 本发明提供了能够自组装成二维片状结构的新型拟肽低聚物。 拟肽低聚物可以具有交替的亲水或极性侧链和疏水或非极性侧链。 拟肽低聚物和二维片状结构可以应用于生物应用,其中拟肽作为生物支架或构建块起作用。 此外,本发明的二维片状结构可以用作器件应用中的二维纳米结构。

    Novel biomimetic peptoid polymers
    8.
    发明申请
    Novel biomimetic peptoid polymers 有权
    新型仿生拟肽聚合物

    公开(公告)号:US20120046443A1

    公开(公告)日:2012-02-23

    申请号:US13022548

    申请日:2011-02-07

    IPC分类号: C07K14/00 C07K7/08 C07K7/06

    摘要: The present invention provides for novel peptoid oligomers that are capable of self-assembling into two-dimensional sheet structures. The peptoid oligomers can have alternately hydrophilic or polar side-chains and hydrophobic or apolar side-chains. The peptoid oligomers, and the two-dimensional sheet structures, can be applied to biological applications where the peptoid plays a role as a biological scaffold or building block. Also, the two-dimensional sheet structures of the present invention can be used as two-dimensional nanostructures in device applications.

    摘要翻译: 本发明提供了能够自组装成二维片状结构的新型拟肽低聚物。 拟肽低聚物可以具有交替的亲水或极性侧链和疏水或非极性侧链。 拟肽低聚物和二维片状结构可以应用于生物应用,其中拟肽作为生物支架或构建块起作用。 此外,本发明的二维片状结构可以用作器件应用中的二维纳米结构。

    Self-assembly of macromolecules on multilayered polymer surfaces
    10.
    发明授权
    Self-assembly of macromolecules on multilayered polymer surfaces 有权
    大分子在多层聚合物表面上的自组装

    公开(公告)号:US09274108B2

    公开(公告)日:2016-03-01

    申请号:US12278390

    申请日:2007-02-06

    IPC分类号: C12N7/00 G01N33/545

    摘要: The invention is directed toward systems and methods for the formation of two dimensional monolayer structures of ordered biomacromolecules, such as viruses, atop cohesive polyelectrolyte multilayers to create functional thin films. Methods for the formation of such thin films are disclosed that involve an interdiffusion-induced assembly process of the biomacromolecules. The inventive systems provide a general platform for the systematic incorporation and assembly of organic, biological and inorganic materials and will enable many potential technological applications such as, for example, chemical and biological sensors, power devices and catalytic membranes.

    摘要翻译: 本发明涉及用于形成有序生物大分子的二维单层结构的系统和方法,所述生物大分子例如病毒,在粘性聚电解质多层上形成功能性薄膜。 公开了形成这种薄膜的方法,其涉及生物大分子的相互扩散诱导的组装过程。 本发明的系统为有机,生物和无机材料的系统并入和组装提供了一个通用平台,并且将能够实现许多潜在的技术应用,例如化学和生物传感器,功率器件和催化膜。