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公开(公告)号：US09073977B2
公开(公告)日：2015-07-07
申请号：US13022548
申请日：2011-02-07
申请人： Ronald N. Zuckermann , Tammy K. Chu , Ki Tae Nam
发明人： Ronald N. Zuckermann , Tammy K. Chu , Ki Tae Nam
CPC分类号： C07K14/001 , C07K1/13 , C07K7/06 , C07K7/08
摘要： The present invention provides for novel peptoid oligomers that are capable of self-assembling into two-dimensional sheet structures. The peptoid oligomers can have alternately hydrophilic or polar side-chains and hydrophobic or apolar side-chains. The peptoid oligomers, and the two-dimensional sheet structures, can be applied to biological applications where the peptoid plays a role as a biological scaffold or building block. Also, the two-dimensional sheet structures of the present invention can be used as two-dimensional nanostructures in device applications.
摘要翻译： 本发明提供了能够自组装成二维片状结构的新型拟肽低聚物。 拟肽低聚物可以具有交替的亲水或极性侧链和疏水或非极性侧链。 拟肽低聚物和二维片状结构可以应用于生物应用，其中拟肽作为生物支架或构建块起作用。 此外，本发明的二维片状结构可以用作器件应用中的二维纳米结构。
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公开(公告)号：US20120046443A1
公开(公告)日：2012-02-23
申请号：US13022548
申请日：2011-02-07
申请人： Ronald N. Zuckermann , Tammy K. Chu , Ki Tae Nam
发明人： Ronald N. Zuckermann , Tammy K. Chu , Ki Tae Nam
CPC分类号： C07K14/001 , C07K1/13 , C07K7/06 , C07K7/08
摘要： The present invention provides for novel peptoid oligomers that are capable of self-assembling into two-dimensional sheet structures. The peptoid oligomers can have alternately hydrophilic or polar side-chains and hydrophobic or apolar side-chains. The peptoid oligomers, and the two-dimensional sheet structures, can be applied to biological applications where the peptoid plays a role as a biological scaffold or building block. Also, the two-dimensional sheet structures of the present invention can be used as two-dimensional nanostructures in device applications.
摘要翻译： 本发明提供了能够自组装成二维片状结构的新型拟肽低聚物。 拟肽低聚物可以具有交替的亲水或极性侧链和疏水或非极性侧链。 拟肽低聚物和二维片状结构可以应用于生物应用，其中拟肽作为生物支架或构建块起作用。 此外，本发明的二维片状结构可以用作器件应用中的二维纳米结构。
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公开(公告)号：US08952127B2
公开(公告)日：2015-02-10
申请号：US13153141
申请日：2011-06-03
CPC分类号： C01F11/183 , C01P2004/03 , C01P2004/30 , C01P2004/32 , C01P2004/39 , C01P2004/61 , C08G69/10 , Y10S930/03
摘要： The present invention provides for a bio-mimetic polymer capable of catalyzing CO2 into a carbonate.
摘要翻译： 本发明提供了能够将CO 2催化成碳酸盐的生物模拟聚合物。
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公开(公告)号：US20120258918A1
公开(公告)日：2012-10-11
申请号：US13385310
申请日：2012-02-13
CPC分类号： C07K14/785 , A61K38/1709 , Y10S930/32 , A61K31/74 , A61K31/685 , A61K31/66 , A61K31/20 , A61K31/195 , A61K2300/00
摘要： The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.
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公开(公告)号：US07422861B2
公开(公告)日：2008-09-09
申请号：US10025423
申请日：2001-12-18
CPC分类号： A61K51/0491 , C07K14/001 , C12N15/87 , C12N15/88 , Y02P20/582
摘要： Different-sequence peptoids, including lipid- and sterol-conjugated peptoids, are found to be effective in transfection of cells with oligonucleotides. Combinatorial libraries of such peptoids can be screened efficiently in a high-throughput format, and selected peptoids are identified post-screening.
摘要翻译： 发现不同序列的拟肽，包括脂质和固醇共轭的拟肽，在用寡核苷酸转染细胞中是有效的。 可以以高通量格式有效筛选此类拟肽的组合库，筛选后鉴定选择的拟肽。
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6.发明授权公开(公告)号：US06846921B2
公开(公告)日：2005-01-25
申请号：US09826519
申请日：2001-04-03
IPC分类号： A61K38/00 , A61K47/48 , C12N15/113 , C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , A61K47/54 , A61K47/554 , A61K47/6949 , B82Y5/00 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/346 , C12N2310/3515 , C12N2310/3521
摘要： Chimeric oligonucleotide of the formula 5′-W—X1—Y—X2—Z-3′, where W represents a 5′-O-alkyl nucleotide, each of X1 and X2 represents a block of seven to twelve phosphodiester-linked 2′-O-alkyl ribonucleotides, Y represents a block of five to twelve phosphorothioate-linked deoxyribonucleotides, and Z represents a blocking group effective to block nuclease activity at the 3′ end of the oligonucleotide, are described. These compounds exhibit high resistance to endo- and exonucleases, high sequence specificity, and the ability to activate RNAse H, as evidenced by efficient and long-lasting suppression of target mRNA. The oligonucleotides are preferably transfected into cells in formulations containing a lipid-peptoid conjugate carrier molecule of the formula L-linker-[N(CH2CH2NH2)CH2(C═O)—N(CH2CH2R)CH2(C═O)—N(CH2CH2R)CH2(C═O)]3—NH2, where L is a lipid moiety, including a steroid, and each group R is independently selected from alkyl, aminoalkyl, and aralkyl.
摘要翻译： 式5-WX 1 -YX 2 -Z-3'的嵌合寡核苷酸，其中W代表5'-O-烷基核苷酸，X 1和X 2各自表示 7至12个磷酸二酯连接的2'-O-烷基核糖核苷酸，Y表示5至12个硫代磷酸酯连接的脱氧核糖核苷酸的嵌段，Z表示有效阻断寡核苷酸3'末端核酸酶活性的封闭基团。 这些化合物表现出对内切核酸酶和外切核酸酶的高抗性，高序列特异性和激活RNA酶H的能力，如靶mRNA的有效和持久的抑制所证明的。 优选将寡核苷酸转染到含有脂质 - 拟肽结合物载体分子的制剂中，其中L是包含类固醇的脂质部分，每个基团R独立地选自烷基，氨基烷基和芳烷基。
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公开(公告)号：US5840841A
公开(公告)日：1998-11-24
申请号：US853066
申请日：1997-05-08
IPC分类号： B01J19/00 , C07H21/00 , C07K1/04 , C07K7/08 , C07K14/575 , C07K16/00 , C40B40/06 , C40B40/10 , C40B60/14 , C07K1/02 , C07H21/04 , C07K1/06
CPC分类号： C07H21/00 , B01J19/0046 , C07K1/045 , C07K1/047 , B01J2219/00283 , B01J2219/00286 , B01J2219/00308 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01J2219/00466 , B01J2219/00493 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00691 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14
摘要： Method and apparatus for synthesizing biopolymers, such as polypeptides and polynucleotides. The apparatus includes plural reaction vessels in which subunit coupling to biopolymers in a particle suspension is carried out. The vessels are connected to common valving structure for use in mixing the suspension and removing suspension liquid. In one embodiment, a robotic arm in the apparatus is operable to transfer reaction solution to the reaction vessels, and to transfer particle suspensions from the reaction vessels to a mixing vessel and back to the reaction vessels. The method can be used to produce preferably equi-molar amounts of different-sequence biopolymers, such as polypeptides and polynucleotides.
摘要翻译： 用于合成生物聚合物的方法和装置，例如多肽和多核苷酸。 该装置包括多个反应容器，其中进行与颗粒悬浮液中的生物聚合物偶合的亚基。 容器连接到公共阀结构，用于混合悬浮液并除去悬浮液。 在一个实施例中，设备中的机器人手臂可操作以将反应溶液转移到反应容器中，并将颗粒悬浮液从反应容器转移到混合容器并返回到反应容器中。 该方法可用于产生优选等摩尔量的不同序列生物聚合物，例如多肽和多核苷酸。
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公开(公告)号：US07704756B2
公开(公告)日：2010-04-27
申请号：US11343886
申请日：2006-01-30
IPC分类号： G01N33/533 , C07D311/82 , C07D311/88
CPC分类号： C07D493/10 , C09B11/24 , C09B49/126 , Y10T436/173845 , Y10T436/182
摘要： Fluorogenic or chromogenic dyes are useful as reporter molecules for detecting cell entry by a specific molecule.
摘要翻译： 荧光或显色染料可用作用于检测特定分子进入细胞的报道分子。
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公开(公告)号：US06982092B2
公开(公告)日：2006-01-03
申请号：US10448902
申请日：2003-05-30
CPC分类号： C12N15/87 , A61K47/645
摘要： In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.
摘要翻译： 根据本发明，提供了脂质共轭聚酰胺化合物及其相关组合物和方法。 本发明的脂质偶联的聚酰胺化合物特别可用作将生物活性剂递送到靶位点的载体。 特别地，本发明化合物有利于促进将多核苷酸递送至细胞。 本发明还提供了用于制备与递送载体复合的多核苷酸的稳定制剂的方法。
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公开(公告)号：US06887845B2
公开(公告)日：2005-05-03
申请号：US09788308
申请日：2001-02-16
IPC分类号： A61K38/00 , A61K31/685 , A61K38/17 , A61P11/00 , C07K14/785 , C07K5/00
CPC分类号： C07K14/785 , A61K38/1709 , Y10S930/32 , A61K31/74 , A61K31/685 , A61K31/66 , A61K31/20 , A61K31/195 , A61K2300/00
摘要： The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.
摘要翻译： 本发明提供了基于包含拟肽，肽 - 拟肽嵌合体，retropeptoid或复古（peptoid-peptide）嵌合体的序列特异性寡聚体的铺展剂及其使用方法，包括用于治疗呼吸窘迫 肺。 扩散剂是序列特异性寡聚体，包括基于肽骨架的逆序列特异性寡聚体，其被设计为表面活性蛋白B或表面活性蛋白C的类似物。
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