公开(公告)号：US5552157A

公开(公告)日：1996-09-03

申请号：US412107

申请日：1995-03-28

申请人： Kunio Yagi ,  Hitoshi Noda ,  Nobuko Ohishi ,  Masayasu Kurono

发明人： Kunio Yagi ,  Hitoshi Noda ,  Nobuko Ohishi ,  Masayasu Kurono

IPC分类号： C12N15/09 ,  A61K9/127 ,  A61K31/00 ,  A61K48/00 ,  A61P43/00 ,  B01J13/02 ,  C12N15/64 ,  A61K9/27 ,  C12N11/00 ,  C12N11/02

CPC分类号： A61K9/1272 ,  C12N15/64

摘要： For increasing gene entrapping efficiency, it is preferable that liposome membrane to be formed is positively charged. For this purpose, a lipid with quaternary amine has been employed as one of constitutional lipids, but the such lipid may show toxicity to cells to be transformed with the gene for expression. The invention selects, as constitutional lipids for liposomes, N-(.alpha.-trimethylammonioacetyl)-didodecyl-D-glutamate chloride (TMAG), dilauroylphosphatidylcholine (DLPC), and dioleoylphosphatidylethanolamine (DOPE) with molar ratio of 1:2:2, and vortex treatment for preparing the liposomes with multi-layers to entrap the gene therein.

摘要翻译： 为了增加基因捕获效率，优选形成的脂质体膜带正电。 为此，已经使用具有季胺的脂质作为构成脂质之一，但是这样的脂质可能对用于表达的基因转化的细胞显示毒性。 作为脂质体的构成脂质，选择摩尔比为1:2:2的N-（α-三甲基铵乙酰基） - 十二烷基-D-谷氨酸氯化物（TMAG），二月桂酰磷脂酰胆碱（DLPC）和二油酰磷脂酰乙醇胺（DOPE） 用于制备多层脂质体以捕获其中的基因的处理。

公开(公告)号：US4906477A

公开(公告)日：1990-03-06

申请号：US153302

申请日：1988-02-08

申请人： Masayasu Kurono ,  Hitoshi Noda ,  Tomio Ogasawara ,  Hidefumi Yamakawa ,  Takafumi Iida ,  Kunio Yagi

发明人： Masayasu Kurono ,  Hitoshi Noda ,  Tomio Ogasawara ,  Hidefumi Yamakawa ,  Takafumi Iida ,  Kunio Yagi

IPC分类号： A61K9/10 ,  A61K9/127 ,  A61K31/70 ,  A61P35/00

CPC分类号： A61K9/1272 ,  Y10T428/2984

摘要： Some of antineoplastic agents, for instance, adriamycin and daunorubicin, have a positive charge at physiological pH. Such drugs possess high affinity for binding to steroidal sulfate by means of electrostatic force. The invention utilizes this property to prepare steroidal sulfate liposomes having a net negative charge and encapsulating the antineoplastic agent.

公开(公告)号：US5914385A

公开(公告)日：1999-06-22

申请号：US760583

申请日：1996-12-04

申请人： Noriya Hayashi ,  Naomoto Ishikawa ,  Yukihiro Sakaguchi ,  Shunichi Hayashi ,  Hitoshi Noda

发明人： Noriya Hayashi ,  Naomoto Ishikawa ,  Yukihiro Sakaguchi ,  Shunichi Hayashi ,  Hitoshi Noda

IPC分类号： C08G73/10 ,  C09D179/08

CPC分类号： C08G73/1014 ,  C09D179/08 ,  Y10T428/31721

摘要： An addition type polyimide resin raw material composition having high heat resistance and high corrosion resistance comprising a tetracarboxylic anhydride and/or tetracarboxylic diester compound, diamine compound and exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride and/or exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic monoester compound; a composition containing a prepreg; a fiber-reinforced polyimide composite prepreg, coating material and paint using them; and a curing method thereof.

摘要翻译： 包含四羧酸酐和/或四羧酸二酯化合物，二胺化合物和外部-3,6-环氧-1,2,3,6-四氢邻苯二甲酸酐和/ 或外-3,6-环氧-1,2,3,6-四氢邻苯二甲酸酯化合物; 含有预浸料的组合物; 纤维增强聚酰亚胺复合预浸料，涂料和使用它们的油漆; 及其固化方法。

公开(公告)号：US06628248B2

公开(公告)日：2003-09-30

申请号：US09903247

申请日：2001-07-11

申请人： Junji Masumoto ,  Shigekazu Yamagishi ,  Hitoshi Noda ,  Atsushi Hatakeyama ,  Hiroshi Miyai

发明人： Junji Masumoto ,  Shigekazu Yamagishi ,  Hitoshi Noda ,  Atsushi Hatakeyama ,  Hiroshi Miyai

IPC分类号： G09G300

CPC分类号： H05B33/0869 ,  G09G3/02 ,  G09G2320/0233 ,  G09G2320/043 ,  G09G2320/0626

摘要： An image display apparatus is provided for enlarging and projecting a light emitted from a plurality of self-emitting elements on a screen by beam scanning means, which is an image display apparatus having little or no luminance unevenness by solving the conventional problem of causing luminance unevenness in images projected on the screen due to a variance in luminance characteristics of each self-emitting element. It is configured such that a part of the light scanned on the screen from the beam scanning means is provided to a photodetector element that converts the intensity of the light into an electric signal so as to correct a driving signal to be supplied to the self-emitting element by the intensity of the light detected by this photodetector element.

摘要翻译： 一种图像显示装置，用于通过光束扫描装置放大和投影从多个自发光元件发出的光，该扫描装置是通过解决常规的亮度不均匀问题而具有很少或没有亮度不均匀的图像显示装置 由于每个自发光元件的亮度特性的差异，投影在屏幕上的图像。 其被配置为使得从光束扫描装置在屏幕上扫描的光的一部分被提供给光电检测器元件，该光电检测器元件将光的强度转换为电信号，以便校正要供应到自身的驱动信号， 由该光电检测元件检测到的光的强度。

公开(公告)号：US06511184B2

公开(公告)日：2003-01-28

申请号：US09979874

申请日：2001-11-27

申请人： Shigekazu Yamagishi ,  Hiroshi Miyai ,  Hitoshi Noda ,  Atsushi Hatakeyama

发明人： Shigekazu Yamagishi ,  Hiroshi Miyai ,  Hitoshi Noda ,  Atsushi Hatakeyama

IPC分类号： G03B2100

CPC分类号： H04N9/3117 ,  G02B26/123

摘要： Three colors of light beams from a light source travel via a first optical system to strike a reflecting surface of a rotating polygon mirror, or mirrors, at different angles without overlapping. The rotating polygon mirror or mirrors reflect the light beams for scanning. The reflected light beams enter a second optical system at different angles to illuminate an image display panel at different portions. On the image display panel, belt-like regions illuminated by the light beams of individual colors are formed in parallel with each other, and these illuminated regions are moved continuously by scanning. A formed color image is magnified and projected by a projection optical system. With such a projection type image display apparatus, a display having high resolution and light efficiency that is also small, thin and inexpensive is achieved.

摘要翻译： 来自光源的三种光束经由第一光学系统行进，以不同角度撞击旋转多面镜或反射镜的反射表面而不重叠。 旋转的多面镜或反射镜反射用于扫描的光束。 反射光束以不同的角度进入第二光学系统，以在不同部分照射图像显示面板。 在图像显示面板上，由各种颜色的光束照射的带状区域彼此平行地形成，并且这些照射区域通过扫描连续移动。 形成的彩色图像被投影光学系统放大和投影。 利用这种投影型图像显示装置，实现了分辨率和光效率也小，薄且廉价的显示器。

公开(公告)号：US4906071A

公开(公告)日：1990-03-06

申请号：US175409

申请日：1988-03-28

申请人： Hiroshi Takahara ,  Hitoshi Noda ,  Mamoru Takeda ,  Yoshito Miyatake ,  Yasuhiro Horio

发明人： Hiroshi Takahara ,  Hitoshi Noda ,  Mamoru Takeda ,  Yoshito Miyatake ,  Yasuhiro Horio

IPC分类号： H04N9/31

CPC分类号： H04N9/3105

摘要： The invention relates to a liquid crystal display device and a projection TV using same. The liquid crystal display device has microfine conductive bumps formed on terminals of a liquid crystal display panel, and a conductive joint layer formed on each conductive bump. The display panel is connected to wiring leads formed on a substrate provided thereon an IC drive circuit. The projection TV employs a liquid crystal display device in which three liquid crystal display panels corresponding to three colors, red, green, and blue, are mounted on a single substrate. Light beams are made incident on the respective panels, and light beams transmitted through or reflected from specified pixels are projected on a screen to form an image.

摘要翻译： 本发明涉及一种使用其的液晶显示装置和投影电视机。 液晶显示装置具有在液晶显示面板的端子上形成的微细导电凸块和形成在每个导电凸块上的导电接合层。 显示面板连接到形成在其上设置有IC驱动电路的基板上的布线引线。 投影电视采用液晶显示装置，其中三个对应于红色，绿色和蓝色的液晶显示面板安装在单个基板上。 将光束入射到相应的面板上，并且透射或者从特定像素反射的光束投射在屏幕上以形成图像。

公开(公告)号：US06568811B2

公开(公告)日：2003-05-27

申请号：US09870909

申请日：2001-05-31

申请人： Hitoshi Noda ,  Hiroaki Sato ,  Shigekazu Yamagishi

发明人： Hitoshi Noda ,  Hiroaki Sato ,  Shigekazu Yamagishi

IPC分类号： G03B2100

CPC分类号： G09G3/3413 ,  G09G3/342 ,  G09G2310/0235 ,  G09G2310/024 ,  G09G2360/16 ,  H04N9/3117

摘要： Belt-like regions illuminated by red, green and blue light beams are formed on an image display panel, and the illuminated regions are moved continuously. Each pixel of the image display panel is driven by a signal corresponding to the color of light entering the pixel. This makes it possible to display a color image with only one image display panel having neither a color filter nor a pixel exclusively for the respective light beams. The adjacent regions illuminated by two colors of light are overlapped partially, and the pixels in the overlapping portions are driven by a brightness signal component. By overlapping the adjacent illuminated regions, a focused area of the light beams can be enlarged, achieving a smaller focusing optical system, making it possible to reduce the size of the entire device.

摘要翻译： 由红色，绿色和蓝色光束照射的带状区域形成在图像显示面板上，并且照射区域被连续移动。 图像显示面板的每个像素由对应于进入像素的光的颜色的信号驱动。 这使得可以仅对一个既不具有滤色器的图像显示面板也不显示专用于各个光束的像素来显示彩色图像。 由两种颜色的光照亮的相邻区域部分地重叠，并且重叠部分中的像素由亮度信号分量驱动。 通过重叠相邻的照明区域，可以扩大光束的聚焦区域，实现较小的聚焦光学系统，使得可以减小整个装置的尺寸。

公开(公告)号：US5536812A

公开(公告)日：1996-07-16

申请号：US490669

申请日：1995-06-15

申请人： Hitoshi Noda ,  Shigeaki Yoshina ,  Tsutomu Ishida ,  Noboru Tomiya

发明人： Hitoshi Noda ,  Shigeaki Yoshina ,  Tsutomu Ishida ,  Noboru Tomiya

IPC分类号： A61K38/23 ,  A61K38/00 ,  A61P5/00 ,  A61P19/10 ,  A61P43/00 ,  C07K14/575 ,  C07K14/585

CPC分类号： C07K14/585 ,  A61K38/00

摘要： The invention provides a polypeptide of calcitonin analogue and use thereof. The polypeptide has such an amino acid sequence that proline-amide residue (Pro-NH.sub.2) at C-terminal of native eel calcitonin is substituted to a homoserine amide residue (Hse.multidot.NH.sub.2).

摘要翻译： 本发明提供降钙素类似物的多肽及其用途。 多肽具有将天然鳗降钙素C末端的脯氨酰胺残基（Pro-NH 2）置换为高丝氨酸酰胺残基（HsexNH 2）的氨基酸序列。

公开(公告)号：US5521157A

公开(公告)日：1996-05-28

申请号：US361443

申请日：1994-12-20

申请人： Hitoshi Noda ,  Hidehumi Yamakawa ,  Shigeaki Yoshina ,  Tsutomu Ishida ,  Noboru Tomiya

发明人： Hitoshi Noda ,  Hidehumi Yamakawa ,  Shigeaki Yoshina ,  Tsutomu Ishida ,  Noboru Tomiya

IPC分类号： A61K38/00 ,  A61P9/12 ,  A61P11/08 ,  C07K1/113 ,  C07K14/575 ,  A61K38/02 ,  C07K5/00 ,  C07K7/00

CPC分类号： C07K14/57563 ,  A61K38/00

摘要： The modified polypeptide compound of the present invention is represented by the following general formula ((SEQ ID NO: 2)-X):His-Ser-Asp-Ala-Val-Phe-Thr-Gly-Asn-Tyr-Thr-Lys-Leu-Arg-Lys-Gln-Leu-Ala-Ala-Lys-Lys-Tyr-Leu-R.sup.1 -Lys-Ala-Leu-R.sup.2 -Hse-Xwherein R.sup.1 represents an Asn, Lys or Gln residue, R.sup.2 represents a Lys or Arg residue, Hse represents a homoserine residue, and X represents NHR.sup.3 or NR.sup.4 R.sup.5, wherein R.sup.3 represents a hydrocarbon residue having 18 or less carbon atoms or a polyalkylamine having 2 or more amino groups in its molecule, or R.sup.4 and R.sup.5 represent hydrocarbon residues, provided that the total carbon number of R.sup.4 and R.sup.5 is 18 or less. This modified polypeptide compound has a strong activity as a smooth muscle relaxant, and has excellent stability and prolonged duration of action. These characteristics make it suitable as an active ingredient in a drug for preventing and treating bronchial asthma and impotence.

摘要翻译： 本发明的修饰多肽化合物由以下通式（（SEQ ID NO：2）-X）表示：His-Ser-Asp-Ala-Val-Phe-Thr-Gly-Asn-Tyr-Thr-Lys -Leu-Arg-Lys-Gln-Leu-Ala-Ala-Lys-Lys-Tyr-Leu-R1-Lys-Ala-Leu-R2-Hse-X其中R1表示Asn，Lys或Gln残基，R2表示 Lys或Arg残基，Hse表示高丝氨酸残基，X表示NHR3或NR4R5，其中R3表示碳原子数为18以下的烃残基或其分子中具有2个以上氨基的多烷基胺，或者R4和R5表示烃残基 条件是R4和R5的总碳数为18以下。 这种修饰的多肽化合物作为平滑肌松弛剂具有强烈的活性，并且具有优异的稳定性和延长的作用持续时间。 这些特征使其适合作为预防和治疗支气管哮喘和阳a药物的有效成分。

公开(公告)号：US07093941B2

公开(公告)日：2006-08-22

申请号：US10311925

申请日：2002-04-19

申请人： Masahiro Kawashima ,  Hitoshi Noda ,  Takaaki Gyoten

发明人： Masahiro Kawashima ,  Hitoshi Noda ,  Takaaki Gyoten

IPC分类号： G03B21/20 ,  G02F1/13357

CPC分类号： H04N5/74 ,  G09G3/3406 ,  G09G3/36 ,  G09G5/10 ,  G09G2320/0633 ,  G09G2320/0653 ,  G09G2320/066 ,  G09G2360/16 ,  H04N5/57 ,  H04N21/4318 ,  H04N21/44008

摘要： An APL detection unit detects the APL for each unit field time period of an input video signal, and a light source control data production unit produces, depending on the results of the APL detection, a light source control signal at a minimum level which can stably drive a light source when the APL is 0% up to a predetermined value A1, a light source control signal at a maximum level which can stably drive the light source when the APL is a predetermined value A2 up to 100%, and a light source control signal which dynamically varies depending on the APL when the APL is between the predetermined value A1 and the predetermined value A2, to drive the light source on the basis of the light source control signal. As a result, it is possible to mitigate the lack of a contrast feeling and the occurrence of a floating blackness, as well as to improve the reliability of the light source.

摘要翻译： APL检测单元检测输入视频信号的每个单位场时间段的APL，并且光源控制数据生成单元根据APL检测的结果产生可以稳定地进行最小水平的光源控制信号 当APL为0％直到预定值A1时驱动光源，当APL为预定值A2至100％时能够稳定地驱动光源的最大电平的光源控制信号，以及光源 当APL在预定值A1和预定值A2之间时，根据APL动态地变化的控制信号，以基于光源控制信号驱动光源。 结果，可以减轻对比度感觉的缺乏和漂浮黑色的发生，以及提高光源的可靠性。