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公开(公告)号：US07363070B2
公开(公告)日：2008-04-22
申请号：US10875281
申请日：2004-06-25
IPC分类号： A61B5/05
CPC分类号： A61B5/04007 , A61B5/0044
摘要： Disclosed herein is a biomagnetic measurement apparatus capable of visualizing cardiac electrical current distributions with information on the cardiac morphology of a subject. A magnetic field component in the z direction, vertical to the chest surface of a subject, is measured from two directions, front and back of the chest, and then to calculate the current distributions in the two directions and the distributions of the amplitudes of those current distributions. A three-dimensional standard heart model is created from average data on the cardiac morphology obtained from plural healthy subjects. An optimal position of the model is determined using the coordinates of the sinus node and the coordinates of the left ventricle. Then, a weight coefficient is obtained by front and back current distributions and front and back the distributions of the amplitudes of those current distributions on a set boundary of the model.
摘要翻译： 本文公开了一种能够通过关于受试者的心脏形态的信息来可视化心脏电流分布的生物磁测量装置。 从胸部前后两个方向测量z方向的磁场分量，垂直于受试者的胸部表面，然后计算两个方向的电流分布，以及两个方向的振幅分布 当前分布。 从从多个健康受试者获得的心脏形态的平均数据创建三维标准心脏模型。 使用窦房结的坐标和左心室的坐标确定模型的最佳位置。 然后，通过正面和反向电流分布获得权重系数，并且在模型的集合边界上正面和背面的那些电流分布的幅度分布。
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公开(公告)号：US20050148844A1
公开(公告)日：2005-07-07
申请号：US10875281
申请日：2004-06-25
CPC分类号： A61B5/04007 , A61B5/0044
摘要： Disclosed herein is a biomagnetic measurement apparatus capable of visualizing cardiac electrical current distributions with information on the cardiac morphology of a subject. A magnetic field component in the z direction, vertical to the chest surface of a subject, is measured from two directions, front and back of the chest, and then to calculate the current distributions in the two directions and the distributions of the amplitudes of those current distributions. A three-dimensional standard heart model is created from average data on the cardiac morphology obtained from plural healthy subjects. An optimal position of the model is determined using the coordinates of the sinus node and the coordinates of the left ventricle. Then, a weight coefficient is obtained by front and back current distributions and front and back the distributions of the amplitudes of those current distributions on a set boundary of the model.
摘要翻译： 本文公开了一种能够通过关于受试者的心脏形态的信息来可视化心脏电流分布的生物磁测量装置。 从胸部前后两个方向测量z方向的磁场分量，垂直于受试者的胸部表面，然后计算两个方向的电流分布，以及两个方向的振幅分布 当前分布。 从从多个健康受试者获得的心脏形态的平均数据创建三维标准心脏模型。 使用窦房结的坐标和左心室的坐标确定模型的最佳位置。 然后，通过正面和反向电流分布获得权重系数，并且在模型的集合边界上正面和背面的那些电流分布的幅度分布。
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公开(公告)号：US07400984B2
公开(公告)日：2008-07-15
申请号：US10822715
申请日：2004-04-13
CPC分类号： A61B5/04007
摘要： A biomagnetic measurement technique which can obtain a potential waveform corresponding to a ventricular muscle cell action potential in a non-invasive manner. The biomagnetic measurement apparatus including an operating circuit for magnetometer. The output data of the operating circuit for the magnetometer is collected and a current vector at time t is calculated. Further, an absolute value Ixy of the current vector, a potential waveform V (t) in time corresponding to depolarization of a heart from the absolute value of the current vector, and a potential waveform V (t) in a refractory period of the heart to a period corresponding to repolarization from the absolute value of the current vector are calculated.
摘要翻译： 一种能以非侵入性方式获得对应于心室肌细胞动作电位的电位波形的生物磁测量技术。 该生物磁测量装置包括用于磁力计的操作电路。 收集用于磁力计的操作电路的输出数据，计算时刻t的电流矢量。 此外，电流矢量的绝对值Ixy，对应于来自电流矢量的绝对值的心脏去极化的时间的电位波形V（t）和心脏的不应期的电位波形V（t） 计算与当前矢量的绝对值相对应的复极度。
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公开(公告)号：US07340289B2
公开(公告)日：2008-03-04
申请号：US10634772
申请日：2003-08-06
IPC分类号： A61B5/05
CPC分类号： A61B5/04007 , A61B5/7239
摘要： A biomagnetic field measuring apparatus for performing (1) processes for removing a magnetic field waveform generated by a maternal heart from a waveform of a biomagnetic field measured, (2) processes for obtaining a template waveform of a magnetic field waveform generated by the fetal heart from a waveform, from which the magnetic field waveform generated by the maternal heart has been removed, (3) processes for obtaining a waveform of a cross correlation coefficient between the waveform, from which the magnetic field waveform generated by the mother's hears was removed, and the template waveform, and (4) a process for detecting peaks from a waveform of the cross correlation coefficient, and displaying times of appearance of the detected peaks on a display unit.
摘要翻译： 一种生物磁场测量装置，用于执行（1）从测量的生物磁场的波形中去除由母体心脏产生的磁场波形的处理，（2）用于获得由胎心产生的磁场波形的模板波形的处理 从母体心脏产生的磁场波形的波形从波形中除去，（3）获得从母体听到的磁场波形除去的波形之间的互相关系数的波形的处理， 和模板波形，以及（4）用于从互相关系数的波形检测峰值的处理以及在显示单元上显示检测到的峰值的出现次数。
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公开(公告)号：US06681131B2
公开(公告)日：2004-01-20
申请号：US09977213
申请日：2001-10-16
IPC分类号： A61B505
CPC分类号： A61B5/04007 , A61B5/7239 , A61B5/7285
摘要： An apparatus for measuring bio-magnetic fields includes a plurality of magnetometers for detecting magnetic fields generated from a live body; a driving circuit for driving the magnetometers; a computer for collecting output signals of the driving circuit in the form of data representing at least one waveform of the magnetic fields generated from the live body and for performing an arithmetic processing on the data representing the waveform of magnetic fields, a display unit, and at least one signal processing circuit for processing output signals of the driving circuit. The computer further performs an arithmetic processing of first-order differentiation on the waveform of the magnetic fields in a z direction with respect to time in order to create an arrow map and a contour map. The apparatus can also detect mechanical movement which occurs as blood flows in organs and organs move.
摘要翻译： 一种用于测量生物磁场的装置包括：用于检测从活体产生的磁场的多个磁力计; 用于驱动磁力计的驱动电路; 用于以表示从活体产生的磁场的至少一个波形的数据形式收集驱动电路的输出信号并且对表示磁场波形的数据执行算术处理的计算机，显示单元和 至少一个信号处理电路，用于处理驱动电路的输出信号。 计算机进一步对z方向上的磁场波形进行一阶微分的运算处理，以便产生箭头图和轮廓图。 该装置还可以检测器官和器官中的血液流动时发生的机械运动。
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6.发明授权Biomagnetic field measuring apparatus using squid magnetometers for evaluating a rotational property of a current in a subject 有权使用鱿鱼磁力计的用于评价被检体内的电流的旋转特性的生物磁场测定装置公开(公告)号：US06665553B2
公开(公告)日：2003-12-16
申请号：US10120406
申请日：2002-04-12
IPC分类号： A61B505
CPC分类号： A61B5/04009 , A61B5/04007 , A61B2562/02 , A61B2562/046 , G01R33/0354 , G06F19/00
摘要： A biomagnetic field measuring apparatus including: a plurality of magnetometers each employing a superconducting quantum interference device for measuring the magnetic field generated from an organism; a unit for calculating a pseudo-current from a normal component of the magnetic field; a unit for calculating the pseudo-current from the magnetic field obtained from the plurality of magnetometers to integrate the pseudo-current in a fixed direction on the circumference at a fixed distance from each of the associated ones of the sensors; a unit for calculating a maximum value or a minimum value of the integral value obtained by the unit for performing the integral; and a unit for calculating a difference value between the absolute value of the maximum value and the absolute value of the minimum value.
摘要翻译： 一种生物磁场测量装置，包括：多个磁力计，每个磁力计采用超导量子干涉装置来测量从生物体产生的磁场; 用于从磁场的正常分量计算伪电流的单元; 用于从所述多个磁力计获得的磁场计算所述伪电流以将固定方向上的所述伪电流与所述相关传感器中的每一个固定距离的圆周上积分的单元; 用于计算由用于执行积分的单元获得的积分值的最大值或最小值的单元; 以及用于计算最大值的绝对值和最小值的绝对值之间的差值的单元。
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公开(公告)号：US06528994B2
公开(公告)日：2003-03-04
申请号：US09941752
申请日：2001-08-30
申请人： Daisuke Suzuki , Atsushi Ninomiya , Tsuyoshi Miyashita , Akihiko Kandori , Keiji Tsukada , Koichi Yokosawa
发明人： Daisuke Suzuki , Atsushi Ninomiya , Tsuyoshi Miyashita , Akihiko Kandori , Keiji Tsukada , Koichi Yokosawa
IPC分类号： G01R3302
CPC分类号： G01R33/24
摘要： A magnetic field measuring apparatus has a magnetic field shielding apparatus including non-magnetic cylindrical members on which high-permeability sheets are located in a state of being partially overlapped with each other. The cylindrical members are located to surround an axis of a first direction concentrically and having a hollow portion, the cylindrical member located on an innermost-side having a first opening at one end of the first direction, a second opening at the other end of the first direction, and a third opening penetrating the cylindrical members in a direction perpendicular to the axis of the first direction. In addition, the magnetic field measuring apparatus has a living-body holder located in an inner-side space of the cylindrical member and a cryostat inserted into the third opening and maintaining SQUID magnetic-flux meters.
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8.发明授权Magnetic field measuring apparatus which enables external magnetic noise cancellation 有权能够进行外部磁噪声消除的磁场测量装置公开(公告)号：US06462540B1
公开(公告)日：2002-10-08
申请号：US09635450
申请日：2000-08-10
IPC分类号： G01R33035
CPC分类号： G01R33/025 , A61B5/0046 , A61B5/04005 , G01R33/0354 , Y10S505/846
摘要： A magnetic field measuring apparatus for precise cancellation of environmental noise includes a plurality of first SQUID gradiometers to detect noise and biomagnetic fields, a plurality of second SQUID gradiometers to detect noise, a driving circuit to drive these gradiometers, and a computer to execute signal processing after collecting the signals detected by these gradiometers. First and second SQUID gradiometers are provided which include first-order gradient pickup coils with the baselines formed by the coils of second gradiometers being shorter than those of first gradiometers. The apparatus cancels noise, from detected biomagnetic signal waveforms, caused by variant noise cancellation rates of the coils of first gradiometers, different baselines of the coils of second gradiometers, and the frequency property of a magnetically shielded room in which the apparatus is installed.
摘要翻译： 用于精确地消除环境噪声的磁场测量装置包括多个用于检测噪声和生物磁场的第一SQUID梯度计，用于检测噪声的多个第二SQUID梯度计，用于驱动这些梯度计的驱动电路以及计算机执行信号处理 收集这些梯度仪检测到的信号后。 提供了第一和第二SQUID梯度计，其包括一级梯度拾取线圈，其中由第二梯度仪的线圈形成的基线比第一梯度计的线圈短。 该装置从由第一梯度仪的线圈的不同噪声消除率，第二梯度仪的线圈的不同基线以及安装该装置的磁屏蔽室的频率特性引起的检测到的生物磁信号波形中消除噪声。
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公开(公告)号：US06665552B2
公开(公告)日：2003-12-16
申请号：US09940507
申请日：2001-08-29
IPC分类号： A61B505
CPC分类号： G01R33/022 , G01R33/0358
摘要： A gradiometer integrating pickup coils comprises pickup coils 11Xp, 11Xn magnetically connected to a SQUID through associated input coils 2, and pickup coils 11Yp, 11Yn magnetically connected to a SQUID through associated input coils 2, respectively. Two superconducting loops are connected in series to each of the SQUIDs, when viewed from Josephson junctions 5. The input coils 2 form superconducting closed loops together with the pickup coils 11Xp, 11Xn, 11Yp, 11Yn associated therewith. The SQUIDs are respectively connected to form an 8-figured shape as a whole such that currents flow in two superconducting loops of each SQUID in opposite directions to each other, with respect to the application of a uniform field, in order to reduce environmental magnetic field noise.
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公开(公告)号：US07455648B2
公开(公告)日：2008-11-25
申请号：US10788377
申请日：2004-03-01
申请人： Akihiko Kandori , Tsuyoshi Miyashita , Keiji Tsukada , Kenko Uchida , Hideo Kawaguchi , Minoru Sakairi
发明人： Akihiko Kandori , Tsuyoshi Miyashita , Keiji Tsukada , Kenko Uchida , Hideo Kawaguchi , Minoru Sakairi
CPC分类号： A61B5/1101 , A61B5/4082 , A61B5/6824 , A61B5/6826 , A61B5/6828 , A61B5/6838 , A61B5/7239
摘要： A living body inspection apparatus including an oscillation coil which passes an AC current, a detection coil which detects an AC magnetic field generated from the detection coil, an amplification circuit which amplifies a voltage generated by the magnetic field induced by the detection coil, a detecting unit for detecting the output signal of the amplification circuit, a low pass filter to which the output signal of the detecting unit is input, a unit for setting the oscillation coil and detection coil in first and second regions of the living body, a recording unit for recording the output of the low pass filter while the first region and the second region of the living body are moving and a displaying unit for displaying the data recorded in the recording unit or results of analysis of the recorded data.
摘要翻译： 一种生物体检查装置，包括通过交流电流的振荡线圈，检测由检测线圈产生的交流磁场的检测线圈，放大电路，放大电路，放大由检测线圈感应出的磁场产生的电压， 用于检测放大电路的输出信号的单元，输入检测单元的输出信号的低通滤波器，用于在生物体的第一和第二区域设置振荡线圈和检测线圈的单元，记录单元 用于在活体的第一区域和第二区域移动时记录低通滤波器的输出，以及用于显示记录在记录单元中的数据的显示单元或记录数据的分析结果。
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