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公开(公告)号：US20150119553A1
公开(公告)日：2015-04-30
申请号：US14552396
申请日：2014-11-24
Applicant: LI-COR, INC.
Inventor： Xinshe Xu , Daniel R. Draney , Lael Cheung
IPC: A61K49/00 , G01N33/58 , C08B37/08 , C07F9/6561 , C07D471/04 , C07K19/00
CPC classification number: A61K49/0058 , A61K49/0032 , A61K49/0052 , C07D471/04 , C07F9/6561 , C07K19/00 , C08B37/0072 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/574 , G01N33/58 , G01N33/582
Abstract: Compounds are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. Bioconjugate cyanine compounds of Formula II are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of:
Abstract translation: 公开了可用于近红外光谱范围内的无创成像的化合物。 提供了式II的生物共轭花青化合物：其中Q是选自以下的聚甲炔桥的一部分：
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Patent Agency Ranking
公开(公告)号：US09408924B2
公开(公告)日：2016-08-09
申请号：US14552396
申请日：2014-11-24
Applicant: LI-COR, INC.
Inventor： Xinshe Xu , Daniel R. Draney , Lael Cheung
IPC: C07D401/06 , C07D471/04 , A61K49/00 , C09B23/01 , C09B23/08 , C09B69/00 , G01N33/574 , G01N33/58 , C07F9/6561 , C07K19/00 , C08B37/08
CPC classification number: A61K49/0058 , A61K49/0032 , A61K49/0052 , C07D471/04 , C07F9/6561 , C07K19/00 , C08B37/0072 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/574 , G01N33/58 , G01N33/582
Abstract: Compounds are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. Bioconjugate cyanine compounds of Formula II are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of:
Abstract translation: 公开了可用于近红外光谱范围内的无创成像的化合物。 提供了式II的生物共轭花青化合物：其中Q是选自以下的聚甲炔桥的一部分：
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公开(公告)号：US09089603B2
公开(公告)日：2015-07-28
申请号：US13836202
申请日：2013-03-15
Applicant: LI-COR, INC.
Inventor： Xinshe Xu , Daniel R. Draney , Mark Cradduck , Lael Cheung , Kousik Kundu , William M. Volcheck
IPC: C07D471/04 , A61K49/00 , C09B23/01 , C09B23/08 , C09B69/00 , G01N33/574 , G01N33/58 , C07F9/6561 , C07K19/00 , C08B37/08
CPC classification number: A61K49/0058 , A61K49/0032 , A61K49/0052 , C07D471/04 , C07F9/6561 , C07K19/00 , C08B37/0072 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/574 , G01N33/58 , G01N33/582
Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
Abstract translation: 公开了可用于近红外光谱范围内的无创成像的化合物和方法。 呈现式I的花青化合物：其中Q是聚甲炔桥的一部分：还包括式I化合物的生物缀合物，用化合物标记生物分子的方法和成像方法。
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公开(公告)号：US08927719B2
公开(公告)日：2015-01-06
申请号：US13831345
申请日：2013-03-14
Applicant: Li-Cor, Inc.
Inventor： Xinshe Xu , Daniel R. Draney , Lael Cheung
IPC: C07D401/06 , A61K49/00 , C09B23/08 , G01N33/58 , C07D471/04 , G01N33/574 , C09B23/01 , C09B69/00
CPC classification number: A61K49/0058 , A61K49/0032 , A61K49/0052 , C07D471/04 , C07F9/6561 , C07K19/00 , C08B37/0072 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/574 , G01N33/58 , G01N33/582
Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
Abstract translation: 公开了可用于近红外光谱范围内的无创成像的化合物和方法。 呈现式I的花青化合物：其中Q是选自以下的聚甲炔桥的一部分：还包括式I化合物的生物缀合物，用化合物标记生物分子的方法和成像方法。
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公开(公告)号：US20130280172A1
公开(公告)日：2013-10-24
申请号：US13836202
申请日：2013-03-15
Applicant: LI-COR, INC.
Inventor： Xinshe Xu , Daniel R. Draney , Mark Cradduck , Lael Cheung , Kousik Kundu , William M. Volcheck
IPC: A61K49/00
CPC classification number: A61K49/0058 , A61K49/0032 , A61K49/0052 , C07D471/04 , C07F9/6561 , C07K19/00 , C08B37/0072 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/574 , G01N33/58 , G01N33/582
Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
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公开(公告)号：US20130274452A1
公开(公告)日：2013-10-17
申请号：US13831345
申请日：2013-03-14
Applicant: Li-Cor, Inc.
Inventor： Xinshe Xu , Daniel R. Draney , Lael Cheung
IPC: C07D471/04
CPC classification number: A61K49/0058 , A61K49/0032 , A61K49/0052 , C07D471/04 , C07F9/6561 , C07K19/00 , C08B37/0072 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/574 , G01N33/58 , G01N33/582
Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
Abstract translation: 公开了可用于近红外光谱范围内的无创成像的化合物和方法。 呈现式I的花青化合物：其中Q是选自以下的聚甲炔桥的一部分：还包括式I化合物的生物缀合物，用化合物标记生物分子的方法和成像方法。
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