公开(公告)号：US20210269767A1

公开(公告)日：2021-09-02

申请号：US17307234

申请日：2021-05-04

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Richard FIKE ,  Bruce BRANCHAUD ,  Shawn BARRETT

IPC: C12N5/00

Abstract: Methods for increasing the stability of, or protecting, labile components, such as ethanolamine, growth factors, vitamins, etc., in compositions such as a cell culture medium, are described. Stability of the labile compound is increased either, by derivatization or by sequestering the labile compound. Sequestering can be done either by encapsulation within a microcapsule or by the use of sequestering agents. Encapsulation can provide controlled release of the susceptible compound being protected. These methods may improve or extend the storage conditions, the shipping and handling of media compositions comprising the labile compounds at room temperature rather than at lower temperatures, thereby decreasing shipping costs.

公开(公告)号：US20190322681A1

公开(公告)日：2019-10-24

申请号：US16366908

申请日：2019-03-27

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Lai-Qiang YING ,  Bruce BRANCHAUD ,  Yu-Zhong ZHANG ,  Stephen YUE

IPC: C07D495/04 ,  C12N5/0783 ,  C08B37/00 ,  G01N33/533 ,  G01N33/532 ,  G01N33/543 ,  G01N33/58 ,  C07D403/12 ,  C07K1/13 ,  C07K1/22 ,  C07K16/42 ,  C09B11/24 ,  C09K11/06 ,  G01N33/68

Abstract: Biotin derivatives, methods of using the biotin derivatives and kits comprising the biotin derivatives.

公开(公告)号：US20150183754A1

公开(公告)日：2015-07-02

申请号：US14656315

申请日：2015-03-12

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Bruce BRANCHAUD

IPC: C07D303/48 ,  C07C205/55

CPC classification number: C07D303/48 ,  C07C57/03 ,  C07C205/55 ,  C07C2601/02 ,  C07D203/08 ,  C07D205/04 ,  C07D303/38 ,  C07D305/04 ,  C07D305/06 ,  C07D305/08 ,  C07D331/02 ,  C07D331/04

Abstract: Fatty acid inhibitors, pharmaceutical compositions including fatty acid inhibitors, methods for using fatty acid inhibitors to treat a variety of diseases, and methods for preparing fatty acid inhibitors are provided herein.

Abstract translation: 本文提供了脂肪酸抑制剂，包括脂肪酸抑制剂的药物组合物，使用脂肪酸抑制剂治疗各种疾病的方法以及制备脂肪酸抑制剂的方法。

公开(公告)号：US20140080966A1

公开(公告)日：2014-03-20

申请号：US14081263

申请日：2013-11-15

Applicant: LIFE TECHNOLOGIES AS ,  LIFE TECHNOLOGIES CORPORATION

Inventor： Nini H. KJUS ,  Geir FONNUM ,  Bruce BRANCHAUD ,  Lai-Qiang Ying ,  Steven M. MENCHEN ,  Dmitriy GREMYACHINSKIY ,  Hee Chol KANG

IPC: C07F7/10 ,  C08K3/20 ,  C08F236/20

CPC classification number: C08F230/08 ,  C07F7/10 ,  C07F7/1804 ,  C08F220/58 ,  C08F222/385 ,  C08F236/20 ,  C08K3/20

Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.

公开(公告)号：US20240010657A1

公开(公告)日：2024-01-11

申请号：US18349609

申请日：2023-07-10

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Lai-Qiang YING ,  Stephen YUE ,  Bruce BRANCHAUD ,  Yu-Zhong ZHANG

IPC: C07D495/04 ,  C08B37/00 ,  G01N33/532 ,  G01N33/543 ,  B01D15/38 ,  G01N33/53 ,  G01N33/554 ,  G01N33/569 ,  C07K16/00 ,  G01N33/58 ,  C07D403/12 ,  C07K1/13 ,  C07K1/22 ,  C07K16/42 ,  C09B11/24 ,  C09K11/06 ,  C12N5/0783 ,  G01N33/533 ,  G01N33/68

CPC classification number: C07D495/04 ,  A61K2039/625 ,  G01N33/532 ,  G01N33/54353 ,  B01D15/3823 ,  G01N33/53 ,  G01N33/554 ,  G01N33/569 ,  C07K16/00 ,  G01N33/58 ,  G01N33/582 ,  C07D403/12 ,  C07K1/13 ,  C07K1/22 ,  C07K16/42 ,  C09B11/24 ,  C09K11/06 ,  C12N5/0636 ,  C12N5/0637 ,  C12N5/0638 ,  G01N33/533 ,  G01N33/6803 ,  C08B37/00

Abstract: Biotin derivatives, methods of using the biotin derivatives and kits comprising the biotin derivatives.

公开(公告)号：US20170174700A1

公开(公告)日：2017-06-22

申请号：US15390820

申请日：2016-12-27

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Lai-Qiang YING ,  Bruce BRANCHAUD ,  Yu-Zhong ZHANG ,  Stephen YUE

IPC: C07D495/04 ,  C07K1/13 ,  C07D403/12 ,  C09B11/24 ,  G01N33/58 ,  C07K16/42 ,  G01N33/68 ,  G01N33/543 ,  G01N33/533 ,  C12N5/0783 ,  C07K1/22 ,  C09K11/06

CPC classification number: C07D495/04 ,  C07B2200/11 ,  C07D403/12 ,  C07K1/13 ,  C07K1/22 ,  C07K16/42 ,  C07K2317/20 ,  C07K2317/92 ,  C08B37/00 ,  C09B11/24 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1088 ,  C12N5/0636 ,  C12N5/0637 ,  C12N5/0638 ,  G01N33/532 ,  G01N33/533 ,  G01N33/54353 ,  G01N33/58 ,  G01N33/582 ,  G01N33/6803

Abstract: Biotin derivatives, methods of using the biotin derivatives and kits comprising the biotin derivatives.

公开(公告)号：US20150284496A1

公开(公告)日：2015-10-08

申请号：US14745815

申请日：2015-06-22

Applicant: LIFE TECHNOLOGIES CORPORATION ,  LIFE TECHNOLOGIES AS

Inventor： Nini Hofslokken KJUS ,  Geir FONNUM ,  Bruce BRANCHAUD ,  Lai-Qiang YING ,  Steven M. MENCHEN ,  Dmitriy GREMYACHINSKIY ,  Hee Chol KANG

IPC: C08F230/08

CPC classification number: C08F230/08 ,  C07F7/10 ,  C07F7/1804 ,  C08F220/58 ,  C08F222/385 ,  C08F236/20 ,  C08K3/20

Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.

Abstract translation: 描述了甲硅烷基保护的二丙烯酰胺化合物。 形成这种化合物的方法包括在第一反应条件下将甲硅烷基化试剂与羟基化二胺化合物混合以在第一溶液中形成产物，将产物与第一溶液分离，并在第二反应条件下将产物与丙烯酰氯混合 形成甲硅烷基保护的二丙烯酰胺化合物的第二溶液。

公开(公告)号：US20200308096A1

公开(公告)日：2020-10-01

申请号：US16670141

申请日：2019-10-31

Applicant: COMPLEXA, INC. ,  UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  LIFE TECHNOLOGIES CORPORATION

Inventor： Bruce A. FREEMAN ,  Bruce BRANCHAUD

IPC: C07C205/50

Abstract: Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.

公开(公告)号：US20160326291A1

公开(公告)日：2016-11-10

申请号：US15212532

申请日：2016-07-18

Applicant: LIFE TECHNOLOGIES CORPORATION ,  LIFE TECHNOLOGIES AS

Inventor： Nini Hofslokken KJUS ,  Geir FONNUM ,  Bruce BRANCHAUD ,  Lai-Qiang YING ,  Steven M. MENCHEN ,  Dmitriy GREMYACHINSKIY ,  Hee Chol KANG

IPC: C08F230/08

CPC classification number: C08F230/08 ,  C07F7/10 ,  C07F7/1804 ,  C08F220/58 ,  C08F222/385 ,  C08F236/20 ,  C08K3/20

Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.

公开(公告)号：US20140073756A1

公开(公告)日：2014-03-13

申请号：US14081224

申请日：2013-11-15

Applicant: LIFE TECHNOLOGIES AS ,  LIFE TECHNOLOGIES CORPORATION

Inventor： Nini H. KJUS ,  Geir FONNUM ,  Bruce BRANCHAUD ,  Lai-Qiang Ying ,  Steven M. MENCHEN ,  Dmitriy GREMYACHINSKIY ,  Hee Chol KANG

IPC: C07F7/18 ,  C08F236/20

CPC classification number: C08F230/08 ,  C07F7/10 ,  C07F7/1804 ,  C08F220/58 ,  C08F222/385 ,  C08F236/20 ,  C08K3/20

Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.

Abstract translation: 描述了甲硅烷基保护的二丙烯酰胺化合物。 形成这种化合物的方法包括在第一反应条件下将甲硅烷基化试剂与羟基化二胺化合物混合以在第一溶液中形成产物，将产物与第一溶液分离，并在第二反应条件下将产物与丙烯酰氯混合 形成甲硅烷基保护的二丙烯酰胺化合物的第二溶液。