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公开(公告)号：US11133163B2
公开(公告)日：2021-09-28
申请号：US16985076
申请日：2020-08-04
Applicant: Labcyte, Inc. , DH Technologies Development Pte. Ltd.
Inventor： Sammy Datwani , Don W. Arnold , Lucien P. Ghislain , Chang Liu , Thomas Covey
IPC: H01J49/04 , H01J49/16 , H01J49/00 , B01L3/02 , G01N29/28 , G01N29/24 , G01N24/00 , G01N1/38 , G01N29/22 , G01N29/02 , G01N35/10 , B05B17/06
Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.
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公开(公告)号：US20210090867A1
公开(公告)日：2021-03-25
申请号：US16985076
申请日：2020-08-04
Applicant: Labcyte, Inc. , DH Technologies Development Pte. Ltd.
Inventor： Sammy Datwani , Don W. Arnold , Lucien P. Ghislain , Chang Liu , Thomas Covey
Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.
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3.发明公开公开(公告)号：US20230290627A1
公开(公告)日：2023-09-14
申请号：US18121550
申请日：2023-03-14
Applicant: Labcyte, Inc. , DH Technologies Development Pte. Ltd.
Inventor： Sammy Datwani , Don W. Arnold , Lucien P. Ghislain , Chang Liu , Thomas Covey
CPC classification number: H01J49/0454 , H01J49/0404 , H01J49/165 , H01J49/0031 , B01L3/0268 , G01N29/222 , G01N29/02 , H01J49/045 , H01J49/0445 , B01L2400/0439 , B01L2400/0436
Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.
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公开(公告)号：US20210384023A1
公开(公告)日：2021-12-09
申请号：US17410758
申请日：2021-08-24
Applicant: Labcyte, Inc. , DH Technologies Development Pte. Ltd.
Inventor： Sammy Datwani , Don W. Arnold , Lucien P. Ghislain , Chang Liu , Thomas Covey
IPC: H01J49/04 , H01J49/16 , H01J49/00 , B01L3/02 , G01N29/28 , G01N29/24 , G01N24/00 , G01N1/38 , G01N29/22 , G01N29/02 , G01N35/10 , B05B17/06
Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.
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公开(公告)号：US12154776B2
公开(公告)日：2024-11-26
申请号：US18121550
申请日：2023-03-14
Applicant: LABCYTE INC. , DH Technologies Development Pte. Ltd.
Inventor： Sammy Datwani , Don W. Arnold , Lucien P. Ghislain , Chang Liu , Thomas Covey
Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.
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Patent Agency Ranking
公开(公告)号：US11637006B2
公开(公告)日：2023-04-25
申请号：US17410758
申请日：2021-08-24
Applicant: Labcyte, Inc. , DH Technologies Development Pte. Ltd.
Inventor： Sammy Datwani , Don W. Arnold , Lucien P. Ghislain , Chang Liu , Thomas Covey
Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.
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公开(公告)号：US10770277B2
公开(公告)日：2020-09-08
申请号：US16198667
申请日：2018-11-21
Applicant: Labcyte, Inc. , DH Technologies Development Pte. Ltd.
Inventor： Sammy Datwani , Don W. Arnold , Lucien P. Ghislain , Chang Liu , Thomas Covey
Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.
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8.发明申请公开(公告)号：US20190157060A1
公开(公告)日：2019-05-23
申请号：US16198667
申请日：2018-11-21
Applicant: Labcyte, Inc. , DH Technologies Development Pte. Ltd.
Inventor： Sammy Datwani , Donald W. Arnold , Lucien P. Ghislain , Chang Liu , Thomas Covey
CPC classification number: H01J49/0454 , B01L3/0268 , B01L2400/0439 , H01J49/0031 , H01J49/0404 , H01J49/165
Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.
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公开(公告)号：US20160181082A1
公开(公告)日：2016-06-23
申请号：US14910032
申请日：2014-08-05
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Thomas Covey , Peter Kovarik
CPC classification number: H01J49/165 , H01J49/045
Abstract: Methods and systems for generating ions from a liquid sample for mass spectrometry are provided herein. In various aspects, the methods and systems can enhance the break-up of a jet of the liquid sample upon injection into an ionization chamber. In some aspects, methods and systems perturb the liquid sample prior to discharge to increase the internal energy of the sample so as to enhance the formation of liquid droplets when the liquid sample is injected into the ionization chamber.
Abstract translation: 本文提供了用于从用于质谱的液体样品产生离子的方法和系统。 在各个方面，所述方法和系统可以在注入电离室时增强液体样品的射流的分解。 在一些方面，方法和系统在放电之前扰乱液体样品以增加样品的内部能量，以便当液体样品注入电离室时增强液滴的形成。
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10.发明授权Method and system for introducing make-up flow in an electrospray ion source system 有权在电喷雾离子源系统中引入补充流的方法和系统公开(公告)号：US09196468B2
公开(公告)日：2015-11-24
申请号：US14395705
申请日：2013-05-17
Applicant: DH Technologies Development Pte. Ltd.
Inventor： John L. Campbell , Thomas Covey , Yves LeBlanc , Bradley B. Schneider
CPC classification number: H01J49/165 , G01N27/622 , H01J49/0081 , H01J49/0431
Abstract: An electrospray ion source method and system is provided for detecting emitter failure comprising a liquid chromatography column suitable for chromatographic separation of a sample. The column can have an inlet for receiving the sample; and an outlet for ejecting the sample. A make-up flow channel is provided for introducing make-up flow of liquid to the sample post-column, wherein the make-up flow normalizes the spray current. An electrospray ionization source is provided having one or more electrospray ionization emitter nozzles for receiving the make-up flow containing sample. A power supply can provide a voltage to the one or more emitter nozzles, and a measurement device can measure and monitor the spray current.
Abstract translation: 提供了一种用于检测发射器故障的电喷雾离子源方法和系统，其包括适于样品色谱分离的液相色谱柱。 该柱可以具有用于接收样品的入口; 以及用于喷射样品的出口。 提供了补充流动通道，用于将液体的补充流引入样品后柱，其中补充流使归一化喷雾电流。 提供了具有一个或多个电喷雾电离发射器喷嘴的电喷雾离子源，用于接收含有补充流的样品。 电源可以向一个或多个发射器喷嘴提供电压，并且测量装置可以测量和监测喷射电流。
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