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13 条记录 (耗时 0.035 秒)

    Peptidically buffered formulations for electrotransport applications and methods of making
    5.
    发明申请
    Peptidically buffered formulations for electrotransport applications and methods of making 审中-公开
    用于电转运应用的肽缓冲制剂和制备方法

    公开(公告)号：US20050142531A1

    公开(公告)日：2005-06-30

    申请号：US10993649

    申请日：2004-11-19

    申请人： David Rauser ,  Rama Padmanabhan ,  Joseph Phipps ,  Michel Cormier

    发明人： David Rauser ,  Rama Padmanabhan ,  Joseph Phipps ,  Michel Cormier

    IPC分类号： A01N1/00 ,  A61K9/00 ,  A61K31/74 ,  A61N1/30

    CPC分类号： A61N1/0448 ,  A61K9/0095 ,  A61N1/0412

    摘要： Methods for preparing compositions for use in electrotransport delivery systems. The method includes providing a drug solution comprising drug ions and associated counterions; adjusting the pH of the drug solution by contacting the drug solution with a ion exchange material first; separating the ion exchange material from the pH-adjusted drug solution; and buffering the pH-adjusted drug solution with a buffer. A peptidic buffer is preferably used. The methods result in compositions suitable for use in electrotransport delivery systems.

    摘要翻译： 制备用于电转运系统的组合物的方法。 该方法包括提供包含药物离子和相关联的抗衡离子的药物溶液; 首先通过使药液与离子交换材料接触来调节药液的pH值; 将离子交换材料与pH调节药液分离; 并用缓冲液缓冲pH调节的药物溶液。 优选使用肽缓冲剂。 该方法导致组合物适用于电转运递送系统。

    Methods for preparing polymeric buffer formulations for electrotransport applications
    7.
    发明申请
    Methods for preparing polymeric buffer formulations for electrotransport applications 审中-公开
    制备用于电转运应用的聚合物缓冲剂配方的方法

    公开(公告)号：US20050129655A1

    公开(公告)日：2005-06-16

    申请号：US10994004

    申请日：2004-11-19

    申请人： David Rauser ,  Rama Padmanabhan ,  Joseph Phipps ,  Janardhanan Subramony

    发明人： David Rauser ,  Rama Padmanabhan ,  Joseph Phipps ,  Janardhanan Subramony

    IPC分类号： A01N1/00 ,  A61K9/00 ,  A61K31/74 ,  A61N1/30

    CPC分类号： A61N1/0448 ,  A61K9/0095 ,  A61N1/0412

    摘要： The present invention provides methods for preparing compositions for use in electrotransport delivery systems that comprise providing a drug solution comprising drug ions and associated counterions; adjusting the pH of the drug solution by contacting the drug solution with a first ion exchange material; separating the first ion exchange material from the pH-adjusted drug solution; adding the pH-adjusted drug solution to a reservoir of an electrotransport delivery system; and contacting the pH-adjusted drug solution with a second ion exchange material.

    摘要翻译： 本发明提供了用于制备用于电转运递送系统的组合物的方法，其包括提供包含药物离子和相关抗衡离子的药物溶液; 通过使药液与第一离子交换材料接触来调节药液的pH; 将第一离子交换材料与pH调节药液分离; 将pH调节的药物溶液加入到电转运递送系统的储存器中; 并将pH调节的药物溶液与第二离子交换材料接触。

    Stereospecific delivery of a drug using electrotransport
    8.
    发明授权
    Stereospecific delivery of a drug using electrotransport 失效
    使用电转运的药物的立体特异性递送

    公开(公告)号：US6136327A

    公开(公告)日：2000-10-24

    申请号：US982245

    申请日：1997-12-01

    申请人： Suneel K. Gupta ,  Gayatri Sathyan ,  Rama Padmanabhan

    发明人： Suneel K. Gupta ,  Gayatri Sathyan ,  Rama Padmanabhan

    IPC分类号： A61K9/00 ,  A61N1/30 ,  A61K9/70

    CPC分类号： A61N1/30

    摘要： Preferential delivery via electrotransport of a preferred isomeric form of a pharmaceutically active chiral compound from a mixture of the isomeric forms of said compound is provided. A method of decreasing the delivery via electrotransport of a less preferred isomer of a drug is also provided. Drug delivery devices suitable for such preferential delivery and methods of making the same are also provided.

    摘要翻译： 提供了从所述化合物的异构体形式的混合物通过优选异构体形式的药学活性手性化合物的电转运优先递送。 还提供了通过药物较不优选异构体的电转运减少递送的方法。 还提供了适合于这种优先递送的药物输送装置及其制备方法。

    Methods and Devices for Transdermal Electrotransport Delivery of Lofentanil and Carfentanil
    9.
    发明申请
    Methods and Devices for Transdermal Electrotransport Delivery of Lofentanil and Carfentanil 审中-公开
    Lofentanil和Carfentanil的透皮电传递方法和装置

    公开(公告)号：US20080009782A1

    公开(公告)日：2008-01-10

    申请号：US11768569

    申请日：2007-06-26

    申请人： Robert Gale ,  Rama Padmanabhan ,  Joseph Phipps

    发明人： Robert Gale ,  Rama Padmanabhan ,  Joseph Phipps

    IPC分类号： A61N1/30

    CPC分类号： A61N1/30 ,  A61N1/0424 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/327

    摘要： Electrotransport drug delivery devices, systems and methods for delivery of lofentanil or carfentanil are disclosed. The lofentanil or carfentanil may be provided as a water soluble salt (e.g., lofentanil or carfentanil hydrochloride), such as in a hydrogel formulation. A transdermal, electrotransport delivered dose of lofentanil or carfentanil is provided which is sufficient to induce analgesia in (e.g., adult) human patients suffering from chronic, acute and/or breakthrough pain.

    摘要翻译： 公开了递送药物递送装置，递送洛芬太尼或卡芬太尼的系统和方法。 洛芬太尼或卡芬太尼可以作为水溶性盐（例如，洛芬太尼或盐酸卡芬太尼）提供，例如在水凝胶制剂中。 提供透皮，电转运量的洛芬太尼或卡芬太尼，其足以在患有慢性，急性和/或突破性疼痛的（例如成人）人类患者中诱发镇痛。

    Dry matrices as drug reservoirs in electrotransport applications
    10.
    发明申请
    Dry matrices as drug reservoirs in electrotransport applications 审中-公开
    干基质作为电转运应用中的药物储库

    公开(公告)号：US20070149916A1

    公开(公告)日：2007-06-28

    申请号：US11613327

    申请日：2006-12-20

    申请人： Janardhanan Subramony ,  Rama Padmanabhan ,  Joseph Phipps

    发明人： Janardhanan Subramony ,  Rama Padmanabhan ,  Joseph Phipps

    IPC分类号： A61N1/30 ,  A61K38/16 ,  A61K31/573 ,  A61K31/473 ,  A61K31/445 ,  A61K31/24

    CPC分类号： A61N1/30 ,  A61N1/0448

    摘要： The present invention provides methods and devices for the electrotransport delivery of beneficial agents that utilize polymer electrolyte matrices as drug reservoirs. In certain aspects of the invention, the beneficial agents are hydrolytically unstable, and methods are provided for enhancing the stability of the hydrolytically unstable beneficial agents during long-term storage of devices for the electrotransport delivery of the hydrolytically unstable beneficial agents and during electrotransport delivery of the hydrolytically unstable beneficial agents.

    摘要翻译： 本发明提供了利用聚合物电解质基质作为药物储库的有益药物的电转运递送方法和装置。 在本发明的某些方面，有益试剂是水解不稳定的，并且提供了用于增强水解不稳定有益试剂在长期储存用于电转移递送水解不稳定有益剂的装置和在电输送期间的稳定性的方法 水解不稳定的有益剂。