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公开(公告)号：US20050220996A1
公开(公告)日：2005-10-06
申请号：US10521369
申请日：2003-08-14
申请人： Larry Berger , Nutan Gangrade , Qian Zhao , Sean Dalziel , George Schurr , Thomas Friedmann , Torence Trout Jr.
发明人： Larry Berger , Nutan Gangrade , Qian Zhao , Sean Dalziel , George Schurr , Thomas Friedmann , Torence Trout Jr.
CPC分类号： A61K9/2081 , A61K9/4866 , A61K9/5026 , A61K9/5047 , B01J2/006 , B29B2009/163
摘要： A process of coating to create pharmaceutical particles is disclosed. The coating can enhance the pharmaceutical particle by providing a controlled release barrier, moisture barrier, surface modifying agent, wetting agent, flowability or fluidizing agent, hydrophobicity or hydrophilicity agent, flavor masking agent, odor masking agent, release control agent, or coloring agent; or an inert particle can be coated with a pharmaceutically active liquid. Also disclosed are coated pharmaceutical particles made by one of the processes of the invention.
摘要翻译： 公开了一种涂覆以产生药物颗粒的方法。 涂层可以通过提供控制释放屏障，防潮，表面改性剂，润湿剂，流动性或流化剂，疏水性或亲水性剂，风味掩蔽剂，气味掩蔽剂，释放控制剂或着色剂来增强药物颗粒。 或者可以用药物活性液体涂覆惰性颗粒。 还公开了通过本发明的方法之一制备的包衣药物颗粒。
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2.发明申请Bases and surfactants and their use in photoresist compositions for microlithography 审中-公开碱和表面活性剂及其在光刻胶组合物中用于微光刻的用途公开(公告)号：US20050100814A1
公开(公告)日：2005-05-12
申请号：US10399375
申请日：2001-11-26
CPC分类号： G03F7/0046 , G03F7/0382 , G03F7/0395
摘要： A photoresist composition having: (A) a polymer selected from the group consisting of: (a) a fluorine-containing copolymer having a repeat unit derived from at least one ethylenically unsaturated compound characterized in that at least one ethylenically unsaturated compound is polycyclic; (b) a branched polymer containing protected acid groups, said polymer comprising one or more branch segment(s) chemically linked along a linear backbone segment; (c) fluoropolymers having at least one fluoroalcohol group having the structure: —C(Rf)(Rf′)OH, wherein Rf and Rf′ are the same or different fluoroalkyl groups of from 1 to about 10 carbon atoms or taken together are (CF2)n wherein n is 2 to 10; (d) amorphous vinyl homopolymers of perfluoro(2,2-dimethyl-1,3-dioxole) or CX2═CY2 where X═F or CF3 and Y═—H or amorphous vinyl copolymers of perfluoro(2,2-dimethyl-1,3-dioxole) and CX2═CY2; and (e) nitrile/fluoroalcohol-containing polymers prepared from substituted or unsubstituted vinyl ethers; (B) at least one photoactive component; and (C) a functional compound selected from the group consisting of a base and a surfactant. The polymer may have an absorption coefficient of less than about 5.0m?−1 at a wavelength of about 157 nm. These photoresist compositions have improved imaging properties.
摘要翻译： 一种光致抗蚀剂组合物，其具有：（A）选自以下的聚合物：（a）具有衍生自至少一种烯键式不饱和化合物的重复单元的含氟共聚物，其特征在于至少一种烯属不饱和化合物是多环的; （b）含有保护的酸基团的支化聚合物，所述聚合物包含一个或多个沿着线性主链部分化学连接的支链段; （c）具有至少一个具有以下结构的氟代醇基的含氟聚合物：-C（R f）f（R f）f OH，其中R f 且R 1和R 2'是相同或不同的1至约10个碳原子的氟代烷基或一起为（CF 2 N 2）n - 其中n为2至10; （d）全氟（2,2-二甲基-1,3-间二氧杂环戊烯）或CX 2 -CY 2的无定形乙烯基均聚物，其中XF或CF 3， 和/或Y-H或全氟（2,2-二甲基-1,3-二氧杂环戊烯）和CX 2 -CY 2 N 2的无定形乙烯基共聚物。 和（e）由取代或未取代的乙烯基醚制备的含腈/氟代醇的聚合物; （B）至少一种光活性组分; 和（C）选自碱和表面活性剂的官能化合物。 在约157nm的波长下，该聚合物的吸收系数可以小于约5.0±0.1λ。 这些光刻胶组合物具有改善的成像性能
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3.发明申请Intimate coating of ibuprofen with poloxamers to enhance aqueous dissolution 审中-公开布洛芬与泊洛沙姆的亲和涂层以增强水溶解度公开(公告)号：US20060013871A1
公开(公告)日：2006-01-19
申请号：US11201890
申请日：2005-08-11
CPC分类号： A61K31/445 , A61K9/1635 , A61K9/2077 , A61K9/5026
摘要： This invention provides methods for enhancing the dissolution rate of Ibuprofen. More particularly, the invention provides a process for enhancing the solubility of Ibuprofen by intimately coating Ibuprofen particles with a Poloxamer. The invention also provides for a composition comprising a solid dosage form of Ibuprofen, wherein the surfaces of Ibuprofen particles have been intimately coated with a Poloxamer; a composition comprising a fast onset, solid dosage form of Ibuprofen; and a composition comprising Ibuprofen particles intimately coated with a Poloxamer.
摘要翻译： 本发明提供了提高布洛芬溶出速率的方法。 更具体地，本发明提供了通过用泊洛沙姆紧密涂布布洛芬颗粒来增强布洛芬的溶解度的方法。 本发明还提供包含布洛芬固体剂型的组合物，其中布洛芬颗粒的表面已用泊洛沙姆密封; 包含快速起效的布洛芬固体剂型的组合物; 以及包含用泊洛沙姆密封涂布的布洛芬颗粒的组合物。
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公开(公告)号：US20050040038A1
公开(公告)日：2005-02-24
申请号：US10815580
申请日：2004-03-31
IPC分类号： G01N27/26 , G01N27/403
CPC分类号： G01N27/4035
摘要： This invention improves the reliability of an Electro-chemical reference half-cell that contains 2 or more electrolyte chambers isolated with porous liquid junctions. The purpose of the reference half-cell is to provide a stable ionic contact to a solution, resulting in the output potential being a function only of the ion specific membrane. In this invention, the primary half-cell is isolated from the process by a second or third electrolyte chamber. In one of the secondary chambers an identical half-cell is inserted to monitor the difference between the primary junction and one of the secondary chambers that are being altered over time. The difference between these two halve cells are monitored and the user is alerted of the degradation of the exposed cell. This indication occurs in advance of significant attack of the primary reference half-cell.
摘要翻译： 本发明提高了包含用多孔液相分离的2个以上电解质室的电化学参考半电池的可靠性。 参考半电池的目的是提供与溶液的稳定离子接触，导致输出电势仅为离子特异性膜的功能。 在本发明中，初级半电池通过第二或第三电解质室与工艺隔离。 在一个次级室中，插入相同的半电池以监测正在随时间改变的主结与一个次室之间的差异。 监测这两个半个细胞之间的差异，并且向用户警告暴露的细胞的降解。 该指示在主要参考半细胞的显着攻击之前发生。
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5.发明申请公开(公告)号：US20050260519A1
公开(公告)日：2005-11-24
申请号：US10380990
申请日：2001-10-12
申请人： Larry Berger , Jerald Feldman , Viacheslav Petrov , Frank Schadt III , Andrew Feiring , Fredrick Zumsteg Jr.
发明人： Larry Berger , Jerald Feldman , Viacheslav Petrov , Frank Schadt III , Andrew Feiring , Fredrick Zumsteg Jr.
CPC分类号： G03F7/0392 , G03F7/0045 , G03F7/0046 , G03F7/0382 , G03F7/0395 , Y10S430/106 , Y10S430/108
摘要： The invention relates to a photoresist composition comprising a polymeric binder; a photoactive component; and at least one dissolution inhibitor comprising a paraffinic or cycloparaffinic compound containing at least one functional group having the structure —C(Rf)(Rf′)OR wherein Rf and Rf′ are the same or different fluoroalkyl groups of from one to about ten carbon atoms or taken together are (CF2)a wherein a is an integer ranging from 2 to about 10 and R is a hydrogen atom or an acid labile protecting group. Typically, the dissolution inhibitor has an absorption coefficient of less than about 4.0 μm at a wavelength of 157 nm.
摘要翻译： 本发明涉及包含聚合物粘合剂的光致抗蚀剂组合物; 光活性成分; 和至少一种溶解抑制剂，其包含链烷烃或环烷烃化合物，其含有至少一个具有结构-C（R f） 一个或多个碳原子的相同或不同的氟代烷基或一起为（CF 2 N 2）
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公开(公告)号：US20050042259A1
公开(公告)日：2005-02-24
申请号：US10862722
申请日：2004-06-07
申请人： Larry Berger
发明人： Larry Berger
摘要： The instant invention is directed to a protective covering for application on livestock feedstuffs to prevent spoilage of the feedstuffs that is also edible by livestock, and includes a nutritive starch source to provide a nutritive aggregate ingredient, a salt to promote stability in a protective solution, a non-protein nitrogen source to act as a surfactant, and cement to promote spraying application of the protective solution formed from the covering. The instant invention is directed to a protective covering that includes a dry mixture, to which a sufficient amount of water is added to form an aqueous solution. The dry mixture includes a nutritive starch source, a salt source, a non-protein nitrogen source such as urea, and a gelling agent. Water is added to the dry mixture, resulting in the instant protective solution. The protective solution is then applied to various target surfaces, which include typical livestock feedstuffs such as silage, hay and grain. After it has set-up, the protective solution forms a protective covering over the feedstuffs.
摘要翻译： 本发明涉及一种用于家畜饲料的保护性覆盖物，以防止也可由家畜食用的饲料的变质，并且包括营养淀粉源，以提供营养性骨料成分，以提高保护性溶液中的稳定性的盐， 用作表面活性剂的非蛋白氮源，以及水泥，以促进喷涂从覆盖物形成的保护溶液。 本发明涉及一种包括干燥混合物的保护性覆盖物，向其中加入足够量的水以形成水溶液。 干混合物包括营养淀粉源，盐源，非蛋白氮源如尿素和胶凝剂。 将水加入到干混合物中，得到即时保护溶液。 然后将保护溶液施加到各种目标表面，其包括典型的家畜饲料，例如青贮饲料，干草和谷物。 安装后，保护液在饲料上形成保护层。
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