公开(公告)号：US5693387A

公开(公告)日：1997-12-02

申请号：US484767

申请日：1995-06-07

申请人： Larry Rosenbaum ,  Steven Giovanetto ,  Sidney T. Smith ,  David V. Bacehowski ,  Gregg Nebgen ,  Varsha Kalyankar

发明人： Larry Rosenbaum ,  Steven Giovanetto ,  Sidney T. Smith ,  David V. Bacehowski ,  Gregg Nebgen ,  Varsha Kalyankar

IPC分类号： B32B27/28 ,  B32B27/08 ,  B32B27/30 ,  B32B27/32 ,  C08L23/08 ,  C08L23/10 ,  C08L25/04 ,  C08L53/00 ,  C08L53/02 ,  C08L77/00 ,  B29D22/00

CPC分类号： B32B27/08 ,  B29C47/0021 ,  B29C47/061 ,  B32B7/12 ,  B32B27/302 ,  B32B27/32 ,  B32B27/34 ,  B32B2323/04 ,  B32B2325/00 ,  B32B2377/00 ,  B32B2439/80 ,  B32B2597/00 ,  C08L23/08 ,  C08L23/0815 ,  C08L23/0846 ,  C08L23/0853 ,  C08L23/0869 ,  C08L23/10 ,  C08L25/04 ,  C08L53/00 ,  C08L53/02 ,  C08L77/00 ,  C08L2203/02 ,  Y10T428/1341 ,  Y10T428/2495 ,  Y10T428/2878 ,  Y10T428/2883 ,  Y10T428/31743 ,  Y10T428/31746 ,  Y10T428/31909 ,  Y10T428/31913 ,  Y10T428/31917 ,  Y10T428/31928 ,  Y10T428/31931 ,  Y10T428/31935 ,  C08L2666/04 ,  C08L2666/20

摘要： A multiple layer structure comprising a skin layer, a barrier layer, a radio frequency susceptible layer having a first polyolefin in an amount within a range of 30-60% by weight, a second polyolefin in an amount within the range of 25-50% by weight, a radio frequency susceptible polymer in an amount within the range of 3-40% by weight, a styrene and hydrocarbon block copolymer in an amount within the range of 5-40% by weight of the sealant layer.

摘要翻译： 一种多层结构，包括表皮层，阻挡层，具有30-60重量％范围内的第一聚烯烃的射频敏感层，第二聚烯烃的量为25-50重量％ ，3-70重量％范围内的无线电频率敏感聚合物，密封剂层重量5-40重量％范围内的苯乙烯和烃嵌段共聚物。

公开(公告)号：US5993949A

公开(公告)日：1999-11-30

申请号：US975602

申请日：1997-11-21

申请人： Larry Rosenbaum ,  Steven Giovanetto ,  Sidney T. Smith ,  David V. Bacehowski ,  Gregg Nebgen ,  Varsha Kalyankar

发明人： Larry Rosenbaum ,  Steven Giovanetto ,  Sidney T. Smith ,  David V. Bacehowski ,  Gregg Nebgen ,  Varsha Kalyankar

IPC分类号： B32B27/28 ,  B32B27/08 ,  B32B27/30 ,  B32B27/32 ,  C08L23/08 ,  C08L23/10 ,  C08L25/04 ,  C08L53/00 ,  C08L53/02 ,  C08L77/00

CPC分类号： B32B27/08 ,  B29C47/0021 ,  B29C47/061 ,  C08L23/08 ,  C08L23/10 ,  C08L2203/02 ,  C08L23/0815 ,  C08L23/0846 ,  C08L23/0853 ,  C08L23/0869 ,  C08L25/04 ,  C08L53/00 ,  C08L53/02 ,  C08L77/00 ,  Y10T428/1341 ,  Y10T428/2495 ,  Y10T428/2878 ,  Y10T428/2883 ,  Y10T428/31743 ,  Y10T428/31746 ,  Y10T428/31909 ,  Y10T428/31913 ,  Y10T428/31917 ,  Y10T428/31928 ,  Y10T428/31931 ,  Y10T428/31935

摘要： A multiple layer structure comprising a skin layer, a barrier layer, a radio frequency susceptible layer having a first polyolefin in an amount within a range of 30-60% by weight, a second polyolefin in an amount within the range of 25-50% by weight, a radio frequency susceptible polymer in an amount within the range of 3-40% by weight, a styrene and hydrocarbon block copolymer in an amount within the range of 5-40% by weight of the sealant layer.

摘要翻译： 一种多层结构，包括表皮层，阻挡层，具有30-60重量％范围内的第一聚烯烃的射频敏感层，第二聚烯烃的量为25-50重量％ ，3-70重量％范围内的无线电频率敏感聚合物，密封剂层重量5-40重量％范围内的苯乙烯和烃嵌段共聚物。

公开(公告)号：US6083587A

公开(公告)日：2000-07-04

申请号：US934924

申请日：1997-09-22

申请人： Sidney T. Smith ,  Larry Rosenbaum ,  Steven Giovanetto ,  Bradley Buchanan ,  Y. Samuel Ding ,  Suchuan C. Fan ,  Gregg Nebgen

发明人： Sidney T. Smith ,  Larry Rosenbaum ,  Steven Giovanetto ,  Bradley Buchanan ,  Y. Samuel Ding ,  Suchuan C. Fan ,  Gregg Nebgen

IPC分类号： A61J1/10 ,  B32B27/08 ,  B32B27/28 ,  B32B1/08

CPC分类号： B29C47/061 ,  B32B27/08 ,  B29C47/0021 ,  B29C47/0023 ,  Y10T428/1379 ,  Y10T428/1383 ,  Y10T428/26 ,  Y10T428/28

摘要： The present invention provides a multiple layer structure for fabricating medical products. The layer structure has a core layer of an ethylene vinyl alcohol copolymer having an ethylene content of about 25-45 mole percent, a solution contact layer of a polyolefin positioned on a first side of the core layer, an outer layer positioned on a second side of the core layer opposite the solution contact layer, the outer layer being selected from the group consisting of polyamides, polyesters and polyolefins; two tie layers--one of each adhered to the first and second sides of the core layer and positioned between the solution contact layer and the core layer and between the outer layer and the core layer, and wherein the structure is produced in a cast coextrusion process.

摘要翻译： 本发明提供用于制造医疗产品的多层结构。 层结构具有乙烯含量约25-45摩尔％的乙烯 - 乙烯醇共聚物的芯层，位于芯层第一侧上的聚烯烃的溶液接触层，位于第二侧的外层 所述芯层与所述溶液接触层相对，所述外层选自聚酰胺，聚酯和聚烯烃; 两个粘结层 - 其中一个粘附到芯层的第一和第二侧并且定位在溶液接触层和芯层之间以及外层和芯层之间，并且其中该结构以铸造共挤出工艺 。

公开(公告)号：US06361843B1

公开(公告)日：2002-03-26

申请号：US09607058

申请日：2000-06-29

申请人： Sidney T. Smith ,  Larry A. Rosenbaum ,  Steven Giovanetto ,  Bradley Buchanan ,  Y. Samuel Ding ,  Suchuan C. Fan ,  Gregg Nebgen

发明人： Sidney T. Smith ,  Larry A. Rosenbaum ,  Steven Giovanetto ,  Bradley Buchanan ,  Y. Samuel Ding ,  Suchuan C. Fan ,  Gregg Nebgen

IPC分类号： B32B108

CPC分类号： B32B27/08 ,  B29C47/0021 ,  B29C47/0023 ,  B29C47/061 ,  B32B27/32 ,  B32B27/34 ,  B32B37/153 ,  B32B2323/046 ,  B32B2377/00 ,  B32B2535/00 ,  Y10T428/1379 ,  Y10T428/1383 ,  Y10T428/26 ,  Y10T428/28 ,  Y10T428/31725 ,  Y10T428/3175 ,  Y10T428/31855 ,  Y10T428/31909 ,  Y10T428/3192

摘要： The present invention provides a multiple layer structure (10) for fabricating medical products. The layer structure (10) has a core layer (14) of an ethylene vinyl alcohol copolymer having an ethylene content of about 25-45 mole percent, a solution contact layer of a polyolefin positioned on a first side of the core layer, an outer layer (12) positioned on a second side of the core layer opposite the solution contact layer (16), the outer layer (12) being selected from the group consisting of polyamides, polyesters and polyolefins; two tie layers (18)—one of each adhered to the first and second sides of the core layer (14) and positioned between the solution contact layer (16) and the core layer (14) and between the outer layer (12) and the core layer (14), and wherein the structure (10) is produced in a cast coextrusion process.

摘要翻译： 本发明提供一种用于制造医疗产品的多层结构（10）。 层结构（10）具有乙烯含量约25-45摩尔％的乙烯乙烯醇共聚物的芯层（14），位于芯层第一侧的聚烯烃的溶液接触层，外层 层（12）位于与溶液接触层（16）相对的芯层的第二侧上，外层（12）选自聚酰胺，聚酯和聚烯烃; 两个粘结层（18） - 一个粘合到芯层（14）的第一和第二侧并且位于溶液接触层（16）和芯层（14）之间以及外层（12）和 所述芯层（14），并且其中所述结构（10）以铸造共挤出工艺制造。

公开(公告)号：US20060074393A1

公开(公告)日：2006-04-06

申请号：US11282121

申请日：2005-11-18

申请人： Sidney Smith ,  Larry Rosenbaum ,  Gregg Nebgen ,  Steven Giovanetto ,  Sue Rosenbaum

发明人： Sidney Smith ,  Larry Rosenbaum ,  Gregg Nebgen ,  Steven Giovanetto ,  Sue Rosenbaum

IPC分类号： A61B19/00

CPC分类号： B32B27/30 ,  A61J1/10 ,  A61M2207/00 ,  B32B1/08 ,  Y10S128/24 ,  Y10S128/912 ,  Y10S206/828 ,  Y10S604/905 ,  Y10T428/1334 ,  Y10T428/1341 ,  Y10T428/2495 ,  Y10T428/269 ,  Y10T428/31757 ,  Y10T428/31909 ,  Y10T428/31913 ,  Y10T428/31935

摘要： The present invention provides a receptacle (30) for a therapeutic fluid susceptible to deterioration on exposure to a gas such as oxygen or carbon dioxide. The receptacle (30) has walls of sheet material each including at least one layer forming a barrier essentially impermeable to such gas, and a seal sealing the walls together in a region thereof. A transfer tube (40) is sealed in the seal having a proximal end in the receptacle (30), a distal end accessible from outside the receptacle (30), a flow passage (56) extending between said proximal and distal ends, and a closure (54) blocking flow through the flow passage (56) adapted to be pierced by a tubular needle for transfer of therapeutic through the needle. The transfer tube (40) and closure (54) are essentially impermeable to said gas.

摘要翻译： 本发明提供了一种用于治疗性液体的容器（30），其易于暴露于诸如氧气或二氧化碳的气体中的劣化。 容器（30）具有片状材料壁，每个层包括至少一层形成对这种气体基本上不可渗透的阻挡层，以及在其区域中将壁密封在一起的密封件。 传送管（40）被密封在密封件中，该密封件具有在容器（30）中的近端，可从容器（30）的外部接近的远端，在所述近端和远端之间延伸的流动通道（56） 封闭件（54）阻止流过通道（56）的流动，该流动通道（56）适于被管状针刺穿，用于通过针转运治疗剂。 输送管（40）和封闭件（54）对所述气体基本上是不可渗透的。

公开(公告)号：US07914900B2

公开(公告)日：2011-03-29

申请号：US12196061

申请日：2008-08-21

申请人： Sidney T. Smith ,  Larry Rosenbaum ,  Sue Rosenbaum, legal representative ,  Gregg Nebgen ,  Steven H. Giovanetto

发明人： Sidney T. Smith ,  Larry Rosenbaum ,  Gregg Nebgen ,  Steven H. Giovanetto

IPC分类号： B32B27/30 ,  B32B7/02

CPC分类号： B32B27/30 ,  A61J1/10 ,  A61M2207/00 ,  B32B1/08 ,  Y10S128/24 ,  Y10S128/912 ,  Y10S206/828 ,  Y10S604/905 ,  Y10T428/1334 ,  Y10T428/1341 ,  Y10T428/2495 ,  Y10T428/269 ,  Y10T428/31757 ,  Y10T428/31909 ,  Y10T428/31913 ,  Y10T428/31935

摘要： The present invention provides a receptacle (30) for a therapeutic fluid susceptible to deterioration on exposure to a gas such as oxygen or carbon dioxide. The receptacle (30) has walls of sheet material each including at least one layer forming a barrier essentially impermeable to such gas, and a seal sealing the walls together in a region thereof. A transfer tube (40) is sealed in the seal having a proximal end in the receptacle (30), a distal end accessible from outside the receptacle (30), a flow passage (56) extending between said proximal and distal ends, and a closure (54) blocking flow through the flow passage (56) adapted to be pierced by a tubular needle for transfer of therapeutic through the needle. The transfer tube (40) and closure (54) are essentially impermeable to said gas.

摘要翻译： 本发明提供了一种用于治疗性液体的容器（30），其易于暴露于诸如氧气或二氧化碳的气体中的劣化。 容器（30）具有片状材料壁，每个层包括至少一层形成对这种气体基本上不可渗透的阻挡层，以及在其区域中将壁密封在一起的密封件。 传送管（40）被密封在密封件中，该密封件具有在容器（30）中的近端，可从容器（30）的外部接近的远端，在所述近端和远端之间延伸的流动通道（56） 封闭件（54）阻止流过通道（56）的流动，该流动通道（56）适于被管状针刺穿，用于通过针转运治疗剂。 输送管（40）和封闭件（54）对所述气体基本上是不可渗透的。

公开(公告)号：US20090022985A1

公开(公告)日：2009-01-22

申请号：US12196061

申请日：2008-08-21

申请人： Sidney T. Smith ,  Larry Rosenbaum ,  Gregg Nebgen ,  Steven H. Giovanetto ,  Sue Rosenbaum

发明人： Sidney T. Smith ,  Larry Rosenbaum ,  Gregg Nebgen ,  Steven H. Giovanetto ,  Sue Rosenbaum

IPC分类号： B32B27/08 ,  B32B27/34 ,  B32B27/32 ,  B32B27/30

CPC分类号： B32B27/30 ,  A61J1/10 ,  A61M2207/00 ,  B32B1/08 ,  Y10S128/24 ,  Y10S128/912 ,  Y10S206/828 ,  Y10S604/905 ,  Y10T428/1334 ,  Y10T428/1341 ,  Y10T428/2495 ,  Y10T428/269 ,  Y10T428/31757 ,  Y10T428/31909 ,  Y10T428/31913 ,  Y10T428/31935

摘要： The present invention provides a receptacle (30) for a therapeutic fluid susceptible to deterioration on exposure to a gas such as oxygen or carbon dioxide. The receptacle (30) has walls of sheet material each including at least one layer forming a barrier essentially impermeable to such gas, and a seal sealing the walls together in a region thereof. A transfer tube (40) is sealed in the seal having a proximal end in the receptacle (30), a distal end accessible from outside the receptacle (30), a flow passage (56) extending between said proximal and distal ends, and a closure (54) blocking flow through the flow passage (56) adapted to be pierced by a tubular needle for transfer of therapeutic through the needle. The transfer tube (40) and closure (54) are essentially impermeable to said gas.

摘要翻译： 本发明提供了一种用于治疗性液体的容器（30），其易于暴露于诸如氧气或二氧化碳的气体中的劣化。 容器（30）具有片状材料壁，每个层包括至少一层形成对这种气体基本上不可渗透的阻挡层，以及在其区域中将壁密封在一起的密封件。 传送管（40）被密封在密封件中，该密封件具有在容器（30）中的近端，可从容器（30）的外部接近的远端，在所述近端和远端之间延伸的流动通道（56） 封闭件（54）阻止流过通道（56）的流动，该流动通道（56）适于被管状针刺穿，用于通过针转运治疗剂。 输送管（40）和封闭件（54）对所述气体基本上是不可渗透的。

公开(公告)号：US06974447B2

公开(公告)日：2005-12-13

申请号：US10124599

申请日：2002-04-16

申请人： Sidney T. Smith ,  Larry Rosenbaum ,  Gregg Nebgen ,  William S. Hurst ,  William S. Hoerle ,  Adel M. Sadik ,  Melissa J. Skelnik ,  Steven H. Giovanetto ,  Bradley Buchanan

发明人： Sidney T. Smith ,  Larry Rosenbaum ,  Gregg Nebgen ,  William S. Hurst ,  William S. Hoerle ,  Adel M. Sadik ,  Melissa J. Skelnik ,  Steven H. Giovanetto ,  Bradley Buchanan

IPC分类号： B65D30/02 ,  A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  B32B1/08 ,  B32B27/08 ,  B32B27/30 ,  B65D65/40 ,  A61B19/00 ,  A61M37/00 ,  B29D22/00 ,  B65D30/08 ,  B65D37/00

CPC分类号： B32B27/30 ,  A61J1/10 ,  A61M2207/00 ,  B32B1/08 ,  Y10S128/24 ,  Y10S128/912 ,  Y10S206/828 ,  Y10S604/905 ,  Y10T428/1334 ,  Y10T428/1341 ,  Y10T428/2495 ,  Y10T428/269 ,  Y10T428/31757 ,  Y10T428/31909 ,  Y10T428/31913 ,  Y10T428/31935

摘要： The present invention provides a receptacle for a therapeutic fluid susceptible to deterioration on exposure to a gas such as oxygen or carbon dioxide. The receptacle has walls of sheet material each including at least one layer forming a barrier essentially impermeable to such gas, and a seal sealing the walls together in a region thereof. A transfer tube is sealed in the seal having a proximal end in the receptacle, a distal end accessible from outside the receptacle, a flow passage extending between said proximal and distal ends, and a closure blocking flow through the flow passage adapted to be pierced by a tubular needle for transfer of therapeutic through the needle. The transfer tube and closure are essentially impermeable to said gas.

摘要翻译： 本发明提供了一种用于暴露于诸如氧气或二氧化碳等气体的劣化的治疗性流体的容器。 容器具有片状材料壁，每个层包括至少一层形成对这种气体基本上不可渗透的阻挡层，以及将壁密封在一起的区域中。 输送管被密封在密封件中，该密封件具有在容器中的近端，可从容器外部接近的远端，在所述近端和远端之间延伸的流动通道，以及封闭流经所述流动通道的流体，其适于被 用于通过针转运治疗的管状针。 转移管和封闭物基本上不透气于所述气体。

公开(公告)号：US06461696B1

公开(公告)日：2002-10-08

申请号：US09498674

申请日：2000-02-07

申请人： Michael T. K. Ling ,  Lecon Woo ,  Robert Wojnarowski ,  Ketan Shah ,  Gregg Nebgen ,  Yuan-pang Samuel Ding ,  Varsha Kalyankar ,  Keith M. K. Anderson ,  Lillian G. Zakarija ,  Colleen S. Cramer ,  Michael Scharf ,  Larry A. Rosenbaum

发明人： Michael T. K. Ling ,  Lecon Woo ,  Robert Wojnarowski ,  Ketan Shah ,  Gregg Nebgen ,  Yuan-pang Samuel Ding ,  Varsha Kalyankar ,  Keith M. K. Anderson ,  Lillian G. Zakarija ,  Colleen S. Cramer ,  Michael Scharf ,  Larry A. Rosenbaum

IPC分类号： B32B2708

CPC分类号： B32B27/08 ,  B29C47/0023 ,  B29C47/0026 ,  B29C47/061 ,  B32B7/02 ,  B32B27/306 ,  B32B27/32 ,  B32B27/34 ,  B32B2250/24 ,  B32B2307/7242 ,  B32B2323/043 ,  B32B2323/046 ,  B32B2329/04 ,  B32B2377/00 ,  B32B2535/00 ,  C08L23/08 ,  C08L23/0853 ,  C08L23/0869 ,  C08L23/10 ,  C08L25/04 ,  C08L53/00 ,  C08L53/02 ,  Y10T428/1314 ,  Y10T428/1379 ,  Y10T428/1383 ,  Y10T428/2874 ,  Y10T428/2878 ,  Y10T428/2883 ,  Y10T428/2887 ,  Y10T428/2891 ,  Y10T428/2896 ,  Y10T428/31573 ,  Y10T428/31587 ,  Y10T428/3175 ,  Y10T428/31757 ,  Y10T428/31909 ,  Y10T428/31913 ,  Y10T428/31917 ,  Y10T428/31924 ,  Y10T428/31928 ,  Y10T428/31931 ,  Y10T428/31935 ,  Y10T428/31938 ,  C08L2666/04

摘要： The present invention provides a multiple layer thermoplastic structure of a (1) skin layer selected from the group consisting of polypropylene, ethylene homopolymers having a density of from about 0.930 g/cc to about 0.960 g/cc, and ethylene homopolymers having a density of from about 0.930 g/cc to about 0.960 g/cc blended with an ethylene and a-olefin copolymers having a density less than about 0.930 g/cc, the skin layer having a thickness of greater than about 3.0 mils; (2) a radio frequency susceptible layer adhered to the skin layer, the radio frequency susceptible layer having a dielectric loss greater than 0.05 at 1-60 MHz and at temperatures of ambient to 250° C., the radio frequency susceptible layer having: (a) a first polyolefin selected from the group consisting of polypropylene and polypropylene copolymers, (b) a second polyolefin selected from the group consisting of ethylene copolymers, ultra-low density polyethylene, polybutene, and butene ethylene copolymers; (c) a radio frequency susceptible polymer selected from the group consisting of (i) ethylene copolymers having 50-85% ethylene content with comonomers selected from a first group consisting of acrylic acid, methacrylic acid, ester derivatives of acrylic acid with alcohols having 1-10 carbons, ester derivatives of methacrylic acid with alcohols having 1-10 carbons, vinyl acetate, and vinyl alcohol (ii) homopolymers and copolymers containing at least one segment of urethanes, esters, ureas, imides, sulfones, and amides, and (d) a compatibilizing agent of a styrene and hydrocarbon copolymer; wherein the structure when fabricated into a 50 ml container has a water vapor transmission rate of less than 8% by weight after the container has been autoclaved at 121° C. for 20 minutes and stored for 90 days in an environmentally regulated compartment having 15% relative humidity at 40° C.

公开(公告)号：US08053048B2

公开(公告)日：2011-11-08

申请号：US11114517

申请日：2005-04-25

申请人： Michael T. K. Lang ,  Angeles Lillian Buan ,  Teresa L. White ,  Varsha Kalyankar ,  Gregg Nebgen ,  Scott Edwards ,  Kuo Zong Hong

发明人： Michael T. K. Lang ,  Angeles Lillian Buan ,  Teresa L. White ,  Varsha Kalyankar ,  Gregg Nebgen ,  Scott Edwards ,  Kuo Zong Hong

IPC分类号： B32B1/08 ,  B32B1/02

CPC分类号： C08L23/16 ,  C08L23/10 ,  Y10T428/13 ,  Y10T428/1303 ,  Y10T428/1334 ,  Y10T428/1352 ,  Y10T428/1359 ,  Y10T428/139 ,  C08L23/00

摘要： A polymer blend comprising a high density polyethylene and a surface enhancing polymer is provided. The surface enhancing polymer may be an elastomer such as an ethylene propylene diene monomer terpolymer. The polymer blend may be fabricated into articles such as a film or a flexible overpouch for storing, and transporting medical components. Overpouch films made from the blend advantageously do not wrinkle or deform medical components contained therein when the overpouch—medical component combination is autoclaved.

摘要翻译： 提供了包含高密度聚乙烯和表面增强聚合物的聚合物共混物。 表面增强聚合物可以是弹性体，例如乙烯丙烯二烯单体三元共聚物。 聚合物共混物可以制造成诸如膜或柔性外袋的制品，用于储存和运输医疗部件。 当外敷袋医疗部件组合被高压灭菌时，由共混物制成的过度包装膜有利地不会使包含在其中的医疗部件发生皱纹或变形。