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    POLYPEPTIDE LIBRARIES WITH A PREDETERMINED SCAFFOLD
    4.
    发明申请
    POLYPEPTIDE LIBRARIES WITH A PREDETERMINED SCAFFOLD 有权
    具有预测SCAFFOLD的多肽图书馆

    公开(公告)号：US20100286366A1

    公开(公告)日：2010-11-11

    申请号：US12735069

    申请日：2008-12-22

    申请人： Lars Abrahmsén ,  Nina Herne ,  Christofer Lendel ,  Joachim Feldwisch

    发明人： Lars Abrahmsén ,  Nina Herne ,  Christofer Lendel ,  Joachim Feldwisch

    IPC分类号： C07K14/00 ,  C40B40/10 ,  C40B30/04 ,  C07H21/00 ,  C12Q1/68 ,  C07K7/00 ,  C12P21/06

    CPC分类号： C07K14/31 ,  C07K1/047 ,  C12N15/1037 ,  C12N15/1041 ,  C12N15/1044 ,  C12N15/1075 ,  C40B40/10 ,  G01N33/6845 ,  G01N2333/31

    摘要： Populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the scaffold amino acid sequence EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ or AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q, wherein each X individually corresponds to an amino acid residue which is varied in the population are disclosed. Also populations of polynucleotides, wherein each member encodes a member of a polypeptide population are disclosed. Furthermore, combinations of such polypeptide populations and such polynucleotide populations are disclosed, wherein each member of polypeptide population is physically or spatially associated with the polynucleotide encoding that member via means for genotype-phenotype coupling. Furthermore, methods for selecting a desired polypeptide having an affinity for a predetermined target from a population of polypeptides, isolation of a polynucleotide encoding a desired polypeptide having an affinity for a predetermined target, identifying a desired polypeptide having an affinity for a predetermined target, selecting and identifying a desired polypeptide having affinity for a predetermined target, and production of a desired polypeptide having an affinity for a predetermined target are disclosed.

    摘要翻译： 基于常见支架的多肽变体群体，群体中的每个多肽包含支架氨基酸序列EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ或AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q，其中每个X分别对应于在群体中变化的氨基酸残基 被披露。 还公开了多核苷酸的种群，其中每个成员编码多肽群体的成员。 此外，公开了这种多肽群体和这种多核苷酸群体的组合，其中多肽群体的每个成员通过用于基因型 - 表型偶联的方式与编码该成员的多核苷酸物理或空间相关联。 此外，从多肽群体中选择对预定靶标具有亲和性的期望多肽的方法，分离编码对预定靶标具有亲和性的期望多肽的多核苷酸，鉴定对预定靶标具有亲和性的期望多肽，选择 并鉴定对预定靶标具有亲和力的所需多肽，以及对预定靶标具有亲和性的所需多肽的制备。

    POLYPEPTIDES HAVING AFFINITY FOR HER2
    5.
    发明申请
    POLYPEPTIDES HAVING AFFINITY FOR HER2 有权
    具有HER2的亲和力的多肽

    公开(公告)号：US20110020223A1

    公开(公告)日：2011-01-27

    申请号：US12735068

    申请日：2008-12-22

    申请人： Lars Abrahmsén ,  Nina Herne ,  Joachim Feldwisch ,  Christofer Lendel ,  Vladimir Tolmachew

    发明人： Lars Abrahmsén ,  Nina Herne ,  Joachim Feldwisch ,  Christofer Lendel ,  Vladimir Tolmachew

    IPC分类号： A61K51/08 ,  C07K14/00 ,  A61P35/00 ,  C12N15/12 ,  C12N15/63 ,  C12N5/00

    CPC分类号： A61K51/08 ,  A61K38/00 ,  A61K51/088 ,  C07K16/32

    摘要： HER2 binding polypeptides comprising the amino acid sequence EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ wherein X1 in position 2 is M, I or L, and X2 in position 39 is S or C (SEQ ID NO:1) are disclosed. Moreover, such peptides comprising a chelating environment are disclosed. Also radiolabeled polypeptides formed by the peptides comprising a chelating environment and radionuclides are disclosed. Furthermore, methods of in vivo imaging of the body of a mammalian subject having or suspected of having a cancer characterized by overexpression of HER2 comprising administration of such a radiolabeled polypeptide followed by obtainment of an image of the body using a medical imaging instrument and also methods of treating such cancer are disclosed. Furthermore, the use of such a radiolabeled polypeptide in diagnosis and treatment of cancer characterized by overexpression of HER2. Nucleic acids encoding the polypeptides, expression vectors comprising the nucleic acids and host cells comprising the expression vectors are also disclosed.

    摘要翻译： HER2结合多肽包含氨基酸序列EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ，其中位置2中的X1是M，I或L，而位置39的X2是S或C（SEQ ID NO：1）。 此外，公开了包含螯合环境的这些肽。 还公开了由包含螯合环境和放射性核素的肽形成的放射性标记的多肽。 此外，具有或怀疑具有HER2过表达的哺乳动物受试者的身体的体内成像方法包括施用这种放射性标记的多肽，然后使用医学成像仪获得身体的图像，以及方法 公开了治疗这种癌症的方法。 此外，这种放射性标记的多肽在诊断和治疗HER2过表达的癌症中的应用。 还公开了编码多肽的核酸，包含核酸的表达载体和包含表达载体的宿主细胞。

    Polypeptides having affinity for HER2
    6.
    发明授权
    Polypeptides having affinity for HER2 有权
    对HER2具有亲和力的多肽

    公开(公告)号：US08501909B2

    公开(公告)日：2013-08-06

    申请号：US12735068

    申请日：2008-12-22

    申请人： Lars Abrahmsén ,  Nina Herne ,  Joachim Feldwisch ,  Christofer Lendel ,  Vladimir Tolmachev

    发明人： Lars Abrahmsén ,  Nina Herne ,  Joachim Feldwisch ,  Christofer Lendel ,  Vladimir Tolmachev

    IPC分类号： A61K38/00 ,  A61K51/08 ,  A61K49/00

    CPC分类号： A61K51/08 ,  A61K38/00 ,  A61K51/088 ,  C07K16/32

    摘要： HER2 binding polypeptides comprising the amino acid sequence EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ wherein X1 in position 2 is M, I or L, and X2 in position 39 is S or C (SEQ ID NO: 1) are disclosed. Moreover, such peptides comprising a chelating environment are disclosed. Also radiolabeled polypeptides formed by the peptides comprising a chelating environment and radionuclides are disclosed. Furthermore, methods of in vivo imaging of the body of a mammalian subject having or suspected of having a cancer characterized by overexpression of HER2 comprising administration of such a radiolabeled polypeptide followed by obtainment of an image of the body using a medical imaging instrument and also methods of treating such cancer are disclosed. Furthermore, the use of such a radiolabeled polypeptide in diagnosis and treatment of cancer characterized by overexpression of HER2. Nucleic acids encoding the polypeptides, expression vectors comprising the nucleic acids and host cells comprising the expression vectors are also disclosed.

    摘要翻译： HER2结合多肽包含氨基酸序列EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ，其中位置2中的X1是M，I或L，而位置39的X2是S或C（SEQ ID NO：1）。 此外，公开了包含螯合环境的这些肽。 还公开了由包含螯合环境和放射性核素的肽形成的放射性标记的多肽。 此外，具有或怀疑具有HER2过表达的哺乳动物受试者的身体的体内成像方法包括施用这种放射性标记的多肽，然后使用医学成像仪获得身体的图像，以及方法 公开了治疗这种癌症的方法。 此外，这种放射性标记的多肽在诊断和治疗HER2过表达的癌症中的应用。 还公开了编码多肽的核酸，包含核酸的表达载体和包含表达载体的宿主细胞。

    Polypeptide libraries with a predetermined scaffold
    7.
    发明授权
    Polypeptide libraries with a predetermined scaffold 有权
    具有预定支架的多肽文库

    公开(公告)号：US09469670B2

    公开(公告)日：2016-10-18

    申请号：US12735069

    申请日：2008-12-22

    申请人： Lars Abrahmsén ,  Nina Herne ,  Christofer Lendel ,  Joachim Feldwisch

    发明人： Lars Abrahmsén ,  Nina Herne ,  Christofer Lendel ,  Joachim Feldwisch

    IPC分类号： C40B40/10 ,  C07K1/04 ,  C12N15/10 ,  C07K14/31

    CPC分类号： C07K14/31 ,  C07K1/047 ,  C12N15/1037 ,  C12N15/1041 ,  C12N15/1044 ,  C12N15/1075 ,  C40B40/10 ,  G01N33/6845 ,  G01N2333/31

    摘要： Populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the scaffold amino acid sequence EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ (SEQ ID NO: 1) or AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q (SEQ ID NO:2), wherein each X individually corresponds to an amino acid residue which is varied in the population are disclosed. Also populations of polynucleotides, wherein each member encodes a member of a polypeptide population are disclosed. Furthermore, combinations of such polypeptide populations and such polynucleotide populations are disclosed, wherein each member of polypeptide population is physically or spatially associated with the polynucleotide encoding that member via means for genotype-phenotype coupling.

    摘要翻译： 基于共同支架的多肽变体群体，群体中的每个多肽包含支架氨基酸序列EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ（SEQ ID NO：1）或AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q（SEQ ID NO：2），其中每个 X分别对应于在群体中变化的氨基酸残基。 还公开了多核苷酸的种群，其中每个成员编码多肽群体的成员。 此外，公开了这种多肽群体和这种多核苷酸群体的组合，其中多肽群体的每个成员通过用于基因型 - 表型偶联的方式与编码该成员的多核苷酸物理或空间相关联。

    Modified/chimeric superantigens and their use
    9.
    发明授权
    Modified/chimeric superantigens and their use 失效
    改良/嵌合型超抗原及其用途

    公开(公告)号：US06514498B1

    公开(公告)日：2003-02-04

    申请号：US08695692

    申请日：1996-08-12

    申请人： Per Antonsson ,  Per Björk ,  Mikael Dohlsten ,  Johan Hansson ,  Göran Forsberg ,  Lars Abrahmsén ,  Terje Kalland

    发明人： Per Antonsson ,  Per Björk ,  Mikael Dohlsten ,  Johan Hansson ,  Göran Forsberg ,  Lars Abrahmsén ,  Terje Kalland

    IPC分类号： A61K3944

    CPC分类号： C07K14/31 ,  A61K38/00 ,  A61K47/6817 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/3023 ,  C07K16/3046 ,  C07K19/00 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2319/00

    摘要： A conjugate between a target-seeking moiety and a modified superantigen, characterized in that the superantigen is a wild-type superantigen (SA I) in which an amino acid residue in a superantigen region (region I) determining binding to TCR, referably TCRV&bgr;, and T cell activation has been replaced by another amino acid residue while retaining the ability to activate a subset of T cells. In a preferred embodiment the modified superantigen is a chimer between at least two wild-type superantigens (SA I, SA II etc) characterized in that one or more amino acid residues in a region determining binding to TCR and T cell activation have been interchanged between various wild-type superantigens. A therapeutic method making use of modified/chimeric superantigens as defined in the preceding paragraphs. An antibody preparation in which the cysteine residues that provide for interchain disulfide bonds have been mutated so as to forbid interchain disulfide bridges, preferably to serine residues, for use as a pharmaceutical.

    摘要翻译： 靶寻求部分和修饰的超抗原之间的缀合物，其特征在于超抗原是野生型超抗原（SAI），其中确定结合TCR的超抗原区（区域I）中的氨基酸残基，可以指TCRVβ， 并且T细胞激活已被另一个氨基酸残基取代，同时保留激活T细胞亚群的能力。在优选实施方案中，修饰的超抗原是至少两种野生型超级抗原（SAI，SA II等）之间的嵌合体， 其特征在于确定结合TCR和T细胞活化的区域中的一个或多个氨基酸残基已经在各种野生型超级抗原之间互换.1。一种使用前述段落中定义的修饰/嵌合超级抗原的治疗方法。抗体制备 其中提供链间二硫键的半胱氨酸残基已被突变，以便禁止链间二硫键，优选为丝氨酸残基，用于 用作药物。