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公开(公告)号：US4505921A
公开(公告)日：1985-03-19
申请号：US529735
申请日：1983-09-06
IPC分类号： A61K31/64 , A61P3/08 , A61P3/10 , C07D209/46 , C07D209/48 , C07D401/04 , C07D405/04 , C07D409/04 , C07D491/048 , A61K31/395 , C07D519/00
CPC分类号： C07D209/48 , C07D209/46 , C07D401/04 , C07D405/04 , C07D409/04 , Y10S514/866
摘要： New sulfonylurea compounds of the formula: ##STR1## in which n is 1 or 2,R is thienyl, furyl, pyridyl or phenyl optionally mono or disubstituted,R.sub.1 and R.sub.2, the same or different, each are hydrogen, halogen, (C.sub.1 to C.sub.5)-alkyl, (C.sub.1 to C.sub.5)-alkoxy, or trifluoromethyl, or together represent --CH.sub.2 --O--CH.sub.2 --,R.sub.3 is hydrogen, or hydroxy, andR.sub.4 is (C.sub.1 to C.sub.5)-alkyl, (C.sub.3 to C.sub.8)-cycloalkyl or azacycloalkyl of the formula: ##STR2## in which p is zero or an integer from 1 to 5, or azabicycloalkyl of the formula: ##STR3## in which m is 1, 2, or 3. These new compounds and physiologically tolerable salts thereof may be used as medicines especially in the treatment of diabetes.
摘要翻译： 新的具有下式的磺酰脲化合物：其中n为1或2，R为噻吩基，呋喃基，吡啶基或苯基，任选单取代或二取代，R 1和R 2相同或不同，各自为氢，卤素，（C 1至 C 1 -C 5） - 烷基，（C 1 -C 5） - 烷氧基或三氟甲基，或一起表示-CH 2 -O-CH 2 - ，R 3为氢或羟基，且R 4为（C 1至C 5） - 烷基，（C 3至C 8） 环烷基或氮杂环烷基，其中p为0或1至5的整数，或下式的氮杂双环烷基：其中m为1,2或3.这些新化合物和生理上可耐受的 其盐可以用作药物，特别是用于治疗糖尿病。
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公开(公告)号：US4064245A
公开(公告)日：1977-12-20
申请号：US705330
申请日：1976-07-14
IPC分类号： C07D295/08 , A61K31/495 , A61P3/04 , A61P3/06 , A61P3/08 , A61P9/10 , C07D295/096 , C07D295/14 , C07D295/155
CPC分类号： C07D295/096 , C07D295/155
摘要： Phenoxy compounds of the formula: ##STR1## wherein R and R', which are the same or different, are hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, lower alkoxy-carbonyl or dimethylsulfamoyl.These compounds are used as medicines especially in the treatment of glucid -- and lipid -- metabolism disorders.
摘要翻译： 下式的苯氧基化合物：其中R和R'相同或不同，为氢，卤素，低级烷基，低级烷氧基，低级烷硫基，硝基，三氟甲基，三氟甲硫基，三氟甲氧基，低级烷氧羰基或二甲基氨磺酰 。
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3.发明授权
公开(公告)号：US4161529A
公开(公告)日：1979-07-17
申请号：US877601
申请日：1978-02-14
IPC分类号： C07D207/08 , A61K31/40 , A61P3/06 , A61P3/08 , C07D207/09 , C07D207/06
CPC分类号： C07D207/09
摘要： Pyrrolidone derivatives of the formula: ##STR1## wherein R is hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl,AndY is hydrogen, saturated or unsaturated hydrocarbon radical up to C.sub.4, hydroxyethyl, hydroxypropyl or carboxymethyl.These compounds are used as medicines especially in the treatment of lipid-metabolism disorders.
摘要翻译： 吡咯烷酮衍生物，其结构式如下：其中R为氢，卤素，低级烷基，低级烷氧基或三氟甲基，Y为氢，饱和或不饱和烃基直至C 4，羟乙基，羟丙基或羧甲基。
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公开(公告)号：US4032658A
公开(公告)日：1977-06-28
申请号：US570876
申请日：1975-04-23
IPC分类号： C07D295/08 , A61K31/215 , A61K31/22 , A61P1/00 , C07C67/00 , C07C227/00 , C07C227/14 , C07C227/16 , C07C227/18 , C07C229/14 , C07C229/36 , C07D209/52 , C07D295/088 , C07C101/04
CPC分类号： C07D295/088 , C07D209/52
摘要： Alkanolamine derivatives and their optical isomers of the formula: ##STR1## wherein: N IS 2 OR 3, ANDR.sub.1 and R.sub.2 are lower alkyl or taken together with the nitrogen to which they are bonded, they form pyrrolidinyl, piperidino, dimethyl piperidino, morpholino, 1-thiomorpholino, azabicyclo [3, 3, 0] octyl or azabicyclo [3, 2, 2] nonyl.These compounds are used as medicines especially in the treatment of obesity, atheroma or metabolic diseases requiring weight reduction and regulation.
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公开(公告)号：US3956501A
公开(公告)日：1976-05-11
申请号：US494748
申请日：1974-08-05
申请人： Laszlo Beregi , Charles Malen , Pierre Hugon , Jacques Duhault
发明人： Laszlo Beregi , Charles Malen , Pierre Hugon , Jacques Duhault
IPC分类号： A61K31/24 , A61K31/335 , A61K31/357 , A61P3/04 , A61P3/06 , A61P3/08 , C07C67/00 , C07C227/00 , C07C227/08 , C07C227/10 , C07C229/14 , C07C229/36 , C07D317/54 , C07D317/58 , C07C101/16 , C07D317/64
CPC分类号： C07D317/54
摘要： N-substituted glycinates of the formula: ##EQU1## optical isomers and acid addition salts thereof, wherein R is cyclopentyl, cyclohexyl, benzyl, halobenzyl, lower alkylbenzyl, lower alkoxybenzyl, methylenedioxybenzyl or trifluoromethylbenzyl.These compounds are used as medicines especially in the treatment of obesity or other metabolic diseases needing weight reduction and regulation.
摘要翻译： 其中R为环戊基，环己基，苄基，卤代苄基，低级烷基苄基，低级烷氧基苄基，亚甲二氧基苄基或三氟甲基苄基的N-取代甘氨酸盐，其分子式如下：CH2-CH-NH-CH2-COOR | CH3光学异构体及其酸加成盐。
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公开(公告)号：US5266718A
公开(公告)日：1993-11-30
申请号：US898916
申请日：1992-06-12
IPC分类号： C07C219/14 , C07C233/51 , C07C235/34 , C07C101/34
CPC分类号： C07C219/14 , C07C233/51 , C07C235/34 , C07C2103/18
摘要： New ethanolamine benzoate compounds which can be used as medicaments and correspond to the formula: ##STR1## wherein R is as defined in the description, in the form of racemic compounds and enantiomers. These new compounds and their physiologically tolerable salts can be used therapeutically for treatment of insulin-resistance states.
摘要翻译： 新的可用作药物的乙醇胺苯甲酸酯化合物，其对应于下式：其中R如说明书中所定义，以外消旋化合物和对映体的形式。 这些新化合物及其生理上可耐受的盐可用于治疗胰岛素抵抗状态。
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公开(公告)号：US5266591A
公开(公告)日：1993-11-30
申请号：US979202
申请日：1992-11-20
IPC分类号： A61K31/24 , A61P3/06 , A61P3/08 , A61P7/00 , A61P9/12 , C07C233/51 , C07C235/34
CPC分类号： C07C233/51 , C07C2103/18
摘要： The compounds are ethanolamine benzoate compounds useful for the treatment of syndrome X, and of hypertension in patients who are insulin resistant or have one or more metabolic anomalies.A compound disclosed is S-1-(m-trifluoromethylphenyl)-2-{.beta.-{4-[2-(N-(3,3-diphenylpropionyl)amino)ethyl] benzoyloxy}ethylamino} propane.
摘要翻译： 这些化合物是可用于治疗综合征X的乙醇胺苯甲酸酯化合物，以及患有胰岛素抵抗或具有一种或多种代谢异常的患者的高血压。 所公开的化合物是S-1-（间三氟甲基苯基）-2- {β-（4- [2-（N-（3,3-二苯基丙酰基）氨基）乙基]苯甲酰氧基}乙基氨基}丙烷。
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8.发明授权
公开(公告)号：US4066662A
公开(公告)日：1978-01-03
申请号：US755476
申请日：1976-12-30
IPC分类号： C07D209/44 , C07D209/52 , A61K31/40
CPC分类号： C07D209/52 , C07D209/44 , Y10S514/926
摘要： Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.
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公开(公告)号：US4042598A
公开(公告)日：1977-08-16
申请号：US685757
申请日：1976-05-13
IPC分类号： C07D209/44 , C07D209/52
CPC分类号： C07D209/44 , C07D209/52
摘要： Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.
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公开(公告)号：US3972994A
公开(公告)日：1976-08-03
申请号：US525623
申请日：1974-11-20
IPC分类号： A61K31/40 , A61K31/403 , A61K31/4035 , A61P1/08 , A61P9/12 , B01J21/00 , B01J25/00 , C07B61/00 , C07D209/44 , C07D209/52
CPC分类号： C07D209/44 , C07D209/52
摘要： Disubstituted azabicycloalkanes of the formula ##SPC1##Wherein:n is 0, 1 or 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.
摘要翻译： 下式的二取代的氮杂双环烷烃：
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