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公开(公告)号:US4189374A
公开(公告)日:1980-02-19
申请号:US969160
申请日:1978-12-13
CPC分类号: C10G1/065
摘要: A coal liquefaction process wherein a feed coal-solvent slurry is preheated in a thoroughly back-mixed preheater zone and then passed to a dissolver zone. Hot hydrogen is introduced to the process downstream from the preheater zone at or in advance of the dissolver zone and exothermic hydrocracking reactions occur in the dissolver zone. A dissolver zone effluent stream is passed through a vapor-liquid separator and separated hot dissolver vapor at process pressure is vented through the preheater zone wherein it is quenched to provide direct transfer to the preheater zone of the exothermic heat generated in the dissolver zone. The preheater zone is continuously vented to provide rapid removal of cooled vapor from the preheater zone and from the process, advantageously leaving an accumulation of liquid in the preheater zone boiling between the temperatures of the vapor-liquid separator and the preheater zone at process pressure. Venting of hot vapor generated in the exothermic dissolver zone through the preheater zone to accomplish direct internal heat exchange within the process requires continuous venting of cooled vapor from the preheater zone independently of removal of slurry from the preheater zone. Such independent venting of the preheating zone is feasible because of the introduction of hydrogen to the process downstream from the preheating zone.
摘要翻译: 一种煤液化方法,其中将进料煤溶剂浆料在完全回混的预热器区域中预热,然后通入溶解区。 在溶解区内或预先将热氢气引入到预热区下游的过程中,并且在溶解区中发生放热加氢裂化反应。 溶解区流出物流通过气 - 液分离器并且在处理压力下分离热溶解蒸汽通过预热器区域排出,其中它被骤冷以提供在预热器区域中在溶解区中产生的放热热的直接转移。 预热器区域被连续地排出以提供从预热器区域和从该方法快速去除冷却的蒸气,有利的是在处理压力下在蒸气 - 液体分离器和预热器区域的温度之间沸腾的预热器区域中的液体积聚。 通过预热器区域在放热溶解区中产生的热蒸气排出,以在该过程内实现直接的内部热交换,需要连续排出来自预热器区域的冷却蒸汽,而与预热器区域中的浆料的去除无关。 由于将氢引入到预热区下游的过程中,预热区的独立排气是可行的。
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公开(公告)号:US4189375A
公开(公告)日:1980-02-19
申请号:US969161
申请日:1978-12-13
CPC分类号: C10G1/065
摘要: A process for liquefying coal involving heating only a portion of a the total process hydrogen stream to increase its temperature to a relatively high level and admixing said heated hydrogen with only a portion of the total coal slurry in the upstream region of a dissolver zone. The hydrogen stream has a relatively low specific heat and the addition thereto of a relatively small amount of heat increases its temperature to a level which is sufficiently high to initiate hydrocracking reactions when the hot hydrogen stream is intermixed with only a portion of the dissolver feed slurry, provided that the dissolver feed slurry contains recycle mineral residue in an amount adequate to catalyze hydrocracking reactions. Because the recycle mineral residue catalyzes the exothermic hydrocracking reactions, sufficient process heat is generated to permit addition to the dissolver zone in a downstream region thereof the remainder of dissolver feed slurry and process hydrogen in a relatively cool condition.
摘要翻译: 一种用于液化煤的方法,包括仅加热一部分总工艺氢气流以将其温度升高至相对较高的水平,并将所述加热的氢气与溶解区域的上游区域中仅一部分总煤浆料混合。 氢气流具有相对低的比热,并且相对少量热量的添加将其温度升高到足够高的水平,以便当热氢流与仅一部分溶解器进料浆液混合时引发加氢裂化反应 ,条件是溶解剂进料浆料含有足以催化加氢裂化反应的再循环矿物残余物。 由于再循环矿物残留物催化放热加氢裂化反应,产生足够的加工热量以允许在其下游区域中的溶解区域中添加剩余的溶解剂进料浆料并在相对较冷的条件下处理氢气。
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公开(公告)号:US20160253690A1
公开(公告)日:2016-09-01
申请号:US15055056
申请日:2016-02-26
申请人: Thomas E. Richardson
发明人: Thomas E. Richardson
CPC分类号: G06Q30/0206 , G06Q20/201 , G06Q20/202 , G06Q20/203 , G06Q40/12
摘要: A system and method for providing insights into pricing strategy for a retail store, particularly for optimizing prices of fast moving, long life cycle items in the consumer package goods industries is disclosed. The system includes a computer having a display, a processor, and memory, an input device for allowing a user to interact with the computer processor and display to change one or more parameters of sales and gross margin percent (GM %) so as to determine a price for at least one item for sale and an output device for outputting new pricing information for the at least one item. The method includes steps of receiving sales and cost data for items, displaying one or more graphs of sales and GM % for a plurality of items, iteratively updating the graphs based on user selected optimization parameters and outputting new prices for the one or more items based on the optimization.
摘要翻译: 公开了一种用于提供对零售商店的定价策略的洞察的系统和方法,特别是用于优化消费品包装产业中快速移动,长寿命周期项目的价格。 该系统包括具有显示器,处理器和存储器的计算机,用于允许用户与计算机处理器交互并显示以改变销售额和毛利率百分比(GM%)的一个或多个参数的输入装置,以便确定 至少一个待售物品的价格和用于输出至少一个物品的新定价信息的输出装置。 该方法包括以下步骤:接收项目的销售和成本数据,显示多个项目的销售和GM%的一个或多个图表,并基于用户选择的优化参数迭代地更新图表,并输出用于一个或多个项目的新价格 对优化。
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公开(公告)号:US08710044B2
公开(公告)日:2014-04-29
申请号:US13703276
申请日:2011-07-01
申请人: Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
发明人: Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
IPC分类号: A61K31/00 , A61K31/519 , C07D239/72
CPC分类号: C07D239/94 , A61K31/517 , A61K45/06 , C07D239/74 , C07D403/12
摘要: The invention provides novel bicyclic azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了根据式(I)的新型双环氮杂杂环甲酰胺化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US08637532B2
公开(公告)日:2014-01-28
申请号:US13148903
申请日:2010-02-04
申请人: Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Stieber , Brian L. Hodous , Hui Qiu , Reinaldo Jones , Brian H. Heasley
发明人: Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Stieber , Brian L. Hodous , Hui Qiu , Reinaldo Jones , Brian H. Heasley
IPC分类号: A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号: C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氨基氮杂环甲酰胺化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US10138233B2
公开(公告)日:2018-11-27
申请号:US14900215
申请日:2014-06-24
申请人: Merck Patent GmbH , Henry Yu , Thomas E. Richardson , Marianne Donnelly , Ngan Nguyen , Xuliang Jiang
IPC分类号: C07D471/04 , C07D498/04 , C07D493/14 , C07D471/02 , C07D498/14
摘要: The present invention relates to imidazole compounds, and pharmaceutically acceptable compositions thereof, useful as positive allosteric modulators of follicle stimulating hormone receptor (FSHR).
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公开(公告)号:US09023847B2
公开(公告)日:2015-05-05
申请号:US13388690
申请日:2010-07-22
申请人: Amanda E. Sutton , Nadia Brugger , Thomas E. Richardson , Harold George Vandeveer , Bayard R. Huck , Ruoxi Lan , Justin Potnick
发明人: Amanda E. Sutton , Nadia Brugger , Thomas E. Richardson , Harold George Vandeveer , Bayard R. Huck , Ruoxi Lan , Justin Potnick
IPC分类号: C07D471/04 , C07D333/02 , C07D487/04
CPC分类号: C07D471/04 , C07D333/02 , C07D487/04
摘要: The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氮杂环化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US20120277228A1
公开(公告)日:2012-11-01
申请号:US13388690
申请日:2010-07-22
申请人: Amanda E. Sutton , Nadia Brugger , Thomas E. Richardson , Harold George Vandeveer , Bayard R. Huck , Ruoxi Lan , Justin Potnick
发明人: Amanda E. Sutton , Nadia Brugger , Thomas E. Richardson , Harold George Vandeveer , Bayard R. Huck , Ruoxi Lan , Justin Potnick
IPC分类号: C07D471/04 , A61K31/5377 , A61K31/496 , C07D487/04 , A61K31/519 , A61P35/00 , A61P29/00 , A61P1/18 , A61P13/12 , A61P25/00 , A61P17/00 , A61P13/08 , A61P17/06 , A61P3/10 , A61P27/02 , A61K31/437
CPC分类号: C07D471/04 , C07D333/02 , C07D487/04
摘要: The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氮杂环化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US20100093790A1
公开(公告)日:2010-04-15
申请号:US12639670
申请日:2009-12-16
申请人: Mitchell A. deLong , Marcos L. Sznaidman , Robert H. Oakley , Allen E. Eckhardt , Christine Hudson , Jeffrey D. Yingling , Michael Peel , Thomas E. Richardson , Clare Louise Murray , Byappanahally N. Narasinga Rao , Brian H. Heasley , Paresma R. Patel
发明人: Mitchell A. deLong , Marcos L. Sznaidman , Robert H. Oakley , Allen E. Eckhardt , Christine Hudson , Jeffrey D. Yingling , Michael Peel , Thomas E. Richardson , Clare Louise Murray , Byappanahally N. Narasinga Rao , Brian H. Heasley , Paresma R. Patel
IPC分类号: A61K31/472 , C07D217/02 , C07D401/12 , C12N5/00 , A61K31/4725 , A61P27/02 , A61P19/00 , A61P9/00 , A61P13/12
CPC分类号: C07D217/02
摘要: Isoquinoline compounds with G are provided that influence, inhibit or reduce the action of a G-protein receptor kinase. Pharmaceutical compositions including therapeutically effective amounts of the isoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, osteoporosis and glaucoma are also provided.
摘要翻译: 提供了具有G的异喹啉化合物,其影响,抑制或降低G蛋白受体激酶的作用。 还提供包含治疗有效量的异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响疾病状态或病症如癌症,骨质疏松症和青光眼的各种方法。
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公开(公告)号:US07470787B2
公开(公告)日:2008-12-30
申请号:US11485172
申请日:2006-07-11
申请人: Mitchell A. deLong , Marcos L. Sznaidman , Robert H. Oakley , Allen E. Eckhardt , Christine Hudson , Jeffrey D. Yingling , Michael Peel , Thomas E. Richardson , Claire Louise Murray , Byappanahally N. Narasinga Rao , Brian H. Heasley , Paresma R. Patel
发明人: Mitchell A. deLong , Marcos L. Sznaidman , Robert H. Oakley , Allen E. Eckhardt , Christine Hudson , Jeffrey D. Yingling , Michael Peel , Thomas E. Richardson , Claire Louise Murray , Byappanahally N. Narasinga Rao , Brian H. Heasley , Paresma R. Patel
IPC分类号: C07D217/00 , C07D401/00 , C07D215/00
CPC分类号: C07D217/02
摘要: Isoquinoline compounds with G are provided that influence, inhibit or reduce the action of a G-protein receptor kinase. Pharmaceutical compositions including therapeutically effective amounts of the isoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, osteoporosis and glaucoma are also provided.
摘要翻译: 提供了具有G的异喹啉化合物,其影响,抑制或降低G蛋白受体激酶的作用。 还提供包含治疗有效量的异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响疾病状态或病症如癌症,骨质疏松症和青光眼的各种方法。
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