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公开(公告)号：US20070208053A1
公开(公告)日：2007-09-06
申请号：US11654814
申请日：2007-01-18
申请人： Lee Arnold , Xin Chen , Hanqing Dong , Andrew Garton , Mark Mulvihill , Colin Sambrook Smith , Gerard Thomas , Thomas Krulle , Jing Wang
发明人： Lee Arnold , Xin Chen , Hanqing Dong , Andrew Garton , Mark Mulvihill , Colin Sambrook Smith , Gerard Thomas , Thomas Krulle , Jing Wang
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X5, X7, R1, and Q1 are defined herein, inhibit kinase enzymes and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer. The compounds are also useful in the treatment of inflammation, allergy, asthma, disease and conditions of the immune system, disease and conditions of the nervous system, cardiovascular diseases, disease and conditions of the eye, dermatological diseases, osteoporosis, diabetes, multiple sclerosis, and infections.
摘要翻译： 下式的化合物及其药学上可接受的盐，其中X 1，X 2，X 3，X 4， X 5，X 5，X 7，R 1和Q 1 在本文中定义，抑制激酶，并且可用于治疗和/或预防过度增殖性疾病如癌症。 该化合物还可用于治疗炎症，过敏，哮喘，免疫系统的疾病和状况，神经系统的疾病和状况，心血管疾病，眼睛疾病和病症，皮肤病，骨质疏松症，糖尿病，多发性硬化 和感染。
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公开(公告)号：US4739028A
公开(公告)日：1988-04-19
申请号：US20948
申请日：1987-03-02
申请人： Paul D. McLean , Andrew Garton , Robert F. Scott
发明人： Paul D. McLean , Andrew Garton , Robert F. Scott
CPC分类号： C08G59/066 , C08G59/226 , C08G59/38 , C08G59/50
摘要： Epoxy resins have been found to be fortified (increased in strength and modulus yet not made brittle) by compounding:(a) a resin-forming polyepoxide(b) an amine curing agent for (a) and(c) a fortifier for (a)+(b) comprising the reaction product of(i) an aromatic polyhydroxy compound and(ii) a diepoxide with one epoxy group less reactive than the other:and heat curing the mixture. Strengths as high as 140 MPa and moduli as high as 4500 MPa have been attained with a ductile mode of failure.
摘要翻译： 已经发现环氧树脂通过混合而被强化（强度和模量增加但不变脆）：（a）树脂形成聚环氧化物（b）用于（a）和（c）的胺固化剂，（c） ）+（b）包括（i）芳族多羟基化合物和（ii）一种环氧基的反应产物的反应产物比另一种反应性低的反应产物：加热固化该混合物。 具有高达140MPa的强度和高达4500MPa的模量已经通过延性失效模式获得。
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公开(公告)号：US4480082A
公开(公告)日：1984-10-30
申请号：US516575
申请日：1983-07-25
CPC分类号： C08G59/182 , C08G59/44
摘要： The reaction product of (i) an aromatic amide having the amine group of the amide attached to an aromatic ring, and (ii) a mono- or di-epoxide, has been found to be a good fortifier of epoxy resins. Epoxy resins have been found to attain increased strength and modulus (yet not brittle) by compounding:(a) a resin-forming polyepoxide,(b) an amine curing agent for (a), and(c) the above fortifier; and heat curing the mixture. Strengths as high as 130-150 MPa and modulus values to as high as 5000 MPa have been achieved yet with a ductile mode of fracture.
摘要翻译： 已经发现，（i）具有与芳环连接的酰胺的胺基的芳族酰胺和（ii）单 - 或二 - 环氧化物的反应产物是环氧树脂的良好增强剂。 已经发现环氧树脂通过配混来获得增加的强度和模量（但不脆性）：（a）形成树脂的聚环氧化物，（b）（a）的胺固化剂和（c）上述增强剂; 并加热固化混合物。 已经实现高达130-150MPa的强度和高达5000MPa的模量值，并且具有延性破坏模式。
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公开(公告)号：US4851484A
公开(公告)日：1989-07-25
申请号：US163807
申请日：1988-03-03
申请人： Andrew Garton , Paul D. McLean
发明人： Andrew Garton , Paul D. McLean
摘要： An anhydride-cured epoxy resin (epoxy resin+anhydride curing agent+catalyst) may be fortified (i.e. increased in strength and modulus without being made brittle) by the addition of a carboxylic acid and the reaction product of a carboxylic acid anhydride and a substituted aromatic amine. Strengths as high as 125 MPa and moduli as high as 3500 MPa have been attained, as well as elongations up to 6% and an increase in the ability of the plastic to yield before fracture (ductility), compared to 80 MPa strength, 3000 MPa modulus and 2.4% elongation for the unfortified system (strengths and moduli are tensile).
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公开(公告)号：US4816533A
公开(公告)日：1989-03-28
申请号：US83949
申请日：1987-08-07
申请人： Paul D. McLean , Andrew Garton , Robert F. Scott
发明人： Paul D. McLean , Andrew Garton , Robert F. Scott
IPC分类号： C08G59/00 , C08G59/10 , C08G59/18 , C08G59/22 , C08G59/38 , C08G59/44 , C08G59/64 , C08L63/02
CPC分类号： C08G59/64 , C08G59/10 , C08G59/184 , C08G59/226 , C08G59/38
摘要： Epoxy resins have been found to be fortified (increased strength and modulus yet not brittle) by compounding(a) a resin-forming polyepoxide,(b) an amine curing agent for (a),(c) a fortifier for (a)+(b) comprising the reaction product of(i) an aromatic amine having an amine group attached to an aromatic ring; and(ii) non-symmetrical diepoxide; the reaction product optionally being further reacted with isocyanates or nitriles, in which case (ii) may be at least partly, a monoepoxide;and heat curing the mixture. Strengths as high as 130-150 MPa and modulus increases to as high as 5000 MPa have been attained along with a ductile mode of fracture.
摘要翻译： 已经发现环氧树脂通过（a）形成树脂的聚环氧化物，（b）胺固化剂（a），（c）（a）+ （b）包含（i）具有连接到芳香环上的胺基的芳族胺的反应产物; 和（ii）不对称的二环氧化物; 反应产物任选进一步与异氰酸酯或腈反应，在这种情况下（ii）可以至少部分为单环氧化物; 并加热固化混合物。 已经获得高达130-150MPa的强度和模量增加到高达5000MPa的断裂模式。
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