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公开(公告)号：US20110135691A1
公开(公告)日：2011-06-09
申请号：US12992631
申请日：2009-05-14
IPC分类号： A61K39/00 , C07D471/04 , C07D417/04 , C07D401/04 , C07D413/04 , C07D417/14 , C07D401/14 , C07D403/04 , C12N5/078 , A61K31/437 , A61K31/427 , A61K31/4439 , A61K31/422 , A61K31/444 , A61K31/506 , C12N5/0781 , C12N5/0783 , C12N5/0784 , C12N5/0786 , A61P35/00 , A61P37/04 , A61P37/06 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/02 , A61P31/10 , A61P33/00
CPC分类号： A61K31/4439 , A61K31/421 , A61K31/427 , A61K31/506 , A61K39/0011 , A61K39/39 , A61K2039/55511 , A61K31/437 , A61K2300/00
摘要： The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.
摘要翻译： 本发明涉及含有IAP抑制剂（包括Smac模拟物）的免疫佐剂。 本发明还提供了含有IAP抑制剂和抗原的药物组合物和疫苗。 还提供了通过施用IAP抑制剂来增强免疫应答的方法，治疗或预防癌症的方法，治疗或预防感染的方法，治疗自身免疫疾病的方法，以及增强细胞因子或抗体产生的方法。
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公开(公告)号：US09750729B2
公开(公告)日：2017-09-05
申请号：US12992631
申请日：2009-05-14
IPC分类号： A01N43/00 , A61K31/33 , A61K31/4439 , A61K31/421 , A61K31/427 , A61K31/506 , A61K39/00 , A61K39/39
CPC分类号： A61K31/4439 , A61K31/421 , A61K31/427 , A61K31/506 , A61K39/0011 , A61K39/39 , A61K2039/55511 , A61K31/437 , A61K2300/00
摘要： The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.
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公开(公告)号：US20100189711A1
公开(公告)日：2010-07-29
申请号：US12444047
申请日：2007-10-04
申请人： Glenn Dranoff , Masahisa Jinushi
发明人： Glenn Dranoff , Masahisa Jinushi
IPC分类号： A61K39/395 , A61K39/00 , A61P35/00
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61K2039/55516 , A61K2039/55522
摘要： Disclosed herein are materials and methods for treating cancer. In particular, compositions for stimulating tumor immunity through modulation of MFG-E8 are provided.
摘要翻译： 本文公开了用于治疗癌症的材料和方法。 特别地，提供了通过调节MFG-E8刺激肿瘤免疫的组合物。
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公开(公告)号：US20080260680A1
公开(公告)日：2008-10-23
申请号：US12146386
申请日：2008-06-25
申请人： S. Brian Wilson , Glenn Dranoff , Silke Gillessen
发明人： S. Brian Wilson , Glenn Dranoff , Silke Gillessen
IPC分类号： A61K31/661 , A61K31/70 , A61K39/395 , A61P37/08 , A61P17/00
CPC分类号： A61K31/685 , A61K8/553 , A61K8/68 , A61K9/0014 , A61K9/0019 , A61K31/00 , A61K31/133 , A61K31/164 , A61K31/66 , A61K31/661 , A61K31/7028 , A61K31/7032 , A61K31/739 , A61K31/765 , A61K47/60 , A61Q7/00 , A61Q17/00 , A61Q19/00 , C07K16/2803 , C07K16/2896 , C07K2317/76
摘要： The present invention is directed to a method of inhibiting CDld activation by administering a composition containing a moiety that blocks CDld activation. Compositions of the invention are useful for the attenuation of CDld-restricted immune responses, including treatment of skin disorders due to hyperactive immune responses (e.g., contact hypersensitivity), for systemic administration to attenuate ongoing immune responses, and to provide hypoallergenic cosmetic products including pharmaceutical, cosmetic, and skin care compositions. Preferably, these compositions are in a form intended for topical administration.
摘要翻译： 本发明涉及通过施用含有阻断CDld活化的部分的组合物来抑制CDld活化的方法。 本发明的组合物可用于减弱CDld限制性免疫应答，包括治疗由于过度活动的免疫应答（例如接触超敏反应）引起的皮肤病症，用于全身给药以减轻持续的免疫应答，以及提供包含药物的低变应原性化妆品 ，化妆品和护肤组合物。 优选地，这些组合物是用于局部给药的形式。
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公开(公告)号：US09492518B2
公开(公告)日：2016-11-15
申请号：US12444047
申请日：2007-10-04
申请人： Glenn Dranoff , Masahisa Jinushi
发明人： Glenn Dranoff , Masahisa Jinushi
IPC分类号： A61K39/395 , A61K38/17 , A61K39/00 , C07K16/28
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61K2039/55516 , A61K2039/55522
摘要： Disclosed herein are materials and methods for treating cancer. In particular, compositions for stimulating tumor immunity through modulation of MFG-E8 are provided.
摘要翻译： 本文公开了用于治疗癌症的材料和方法。 特别地，提供了通过调节MFG-E8刺激肿瘤免疫的组合物。
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6.发明授权
公开(公告)号：US5904920A
公开(公告)日：1999-05-18
申请号：US486854
申请日：1995-06-07
申请人： Glenn Dranoff , Richard C. Mulligan , Drew Pardoll
发明人： Glenn Dranoff , Richard C. Mulligan , Drew Pardoll
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/21 , A61K39/39 , A61K48/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K14/52 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/545 , C07K14/55 , C07K14/57 , C07K14/705 , C12N5/10 , C12N15/85
CPC分类号： A61K39/21 , A61K39/0011 , A61K39/12 , A61K39/39 , C07K14/52 , C07K14/525 , C07K14/535 , C07K14/5406 , C07K14/5409 , C07K14/5412 , C07K14/545 , C07K14/55 , C07K14/57 , C07K14/705 , C07K14/70507 , C07K14/70525 , C12N15/85 , A61K2039/5152 , A61K2039/5156 , A61K2039/54 , A61K2039/545 , A61K2039/55522 , A61K2039/57 , A61K38/00 , A61K48/00 , C12N2740/13034 , C12N2799/027 , C12N2840/44
摘要： A method of altering the specific, systemic immune response of an individual to a target antigen by the co-administration of a cytokine an adhesion or accessory molecule and the target antigen. The target antigen may be a tumor cell, a tumor cell antigen, an infectious agent or other foreign antigen, or other antigens to which an enhanced systemic immune response is desirable. Alternatively, the antigen may be a non-foreign antigen when a suppression of a systemic immune response is desired. The resulting systemic immune response is specific for the target antigen.
摘要翻译： 通过共同施用细胞因子粘附或辅助分子和靶抗原来改变个体对靶抗原的特异性全身免疫应答的方法。 靶抗原可以是肿瘤细胞，肿瘤细胞抗原，感染因子或其它外来抗原，或其它需要增强的全身免疫应答的抗原。 或者，当需要抑制全身免疫应答时，抗原可以是非外源抗原。 所产生的全身免疫应答对靶抗原是特异性的。
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公开(公告)号：US10328133B2
公开(公告)日：2019-06-25
申请号：US12867426
申请日：2009-02-13
申请人： David J. Mooney , Omar Ali , Glenn Dranoff
发明人： David J. Mooney , Omar Ali , Glenn Dranoff
IPC分类号： A61K45/06 , A61K38/19 , A61K39/39 , A61K39/00 , A61K31/7088 , A61K39/385 , A61K31/4745 , A61K31/708
摘要： The present invention comprises compositions, methods and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer.
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公开(公告)号：US20180222982A1
公开(公告)日：2018-08-09
申请号：US15747873
申请日：2016-07-28
申请人： Glenn Dranoff , Gordon James Freeman , Arlene Helen Sharpe , Walter A. Blattler , Jennifer Marie Mataraza , Catherine Anne Sabatos-Peyton , Hwai Wen Chang , Gerhard Johann Frey , Novartis AG , DANA-FARBER CANCER INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： Glenn Dranoff , Gordon James Freeman , Arlene Helen Sharpe , Walter A. Blattler , Jennifer Marie Mataraza , Catherine Anne Sabatos-Peyton , Hwai Wen Chang , Gerhard Johann Frey
IPC分类号： C07K16/28 , A61P35/00 , A61K39/395
CPC分类号： C07K16/2818 , A61K39/00 , A61K39/39541 , A61K2039/505 , A61P35/00 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Combination therapies comprising antibody molecules that specifically bind to PD-1 disclosed. The combination therapies can be used to treat or prevent cancerous or infectious conditions and disorders.
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公开(公告)号：US20120100182A1
公开(公告)日：2012-04-26
申请号：US12867426
申请日：2009-02-13
申请人： David J. Mooney , Omar Ali , Glenn Dranoff
发明人： David J. Mooney , Omar Ali , Glenn Dranoff
IPC分类号： A61K45/06 , A61K38/19 , A61K9/00 , B05D5/00 , A61P35/00 , A61P37/02 , A61K39/00 , A61K31/7088 , A61P37/04
CPC分类号： A61K39/0011 , A61K31/4745 , A61K31/708 , A61K31/7088 , A61K38/193 , A61K39/39 , A61K45/06 , A61K2039/54 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/6093
摘要： The present invention comprises compositions, methods and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer.
摘要翻译： 本发明包括用于在聚合物支架内产生感染模拟环境以刺激抗原特异性树突状细胞活化的组合物，方法和装置。 本发明的装置用于为受试者提供针对感染和癌症的保护性免疫。
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公开(公告)号：US5637483A
公开(公告)日：1997-06-10
申请号：US265554
申请日：1994-06-23
申请人： Glenn Dranoff , Richard C. Mulligan , Drew Pardoll
发明人： Glenn Dranoff , Richard C. Mulligan , Drew Pardoll
CPC分类号： A61K39/21 , A61K39/0011 , A61K39/12 , A61K2039/5152 , A61K2039/5156 , A61K2039/55522 , A61K48/00 , C12N2740/13043
摘要： A method of altering the specific, systemic immune response of an individual to a target antigen by the co-administration of a cytokine an adhesion or accessory molecule and the target antigen. The target antigen may be a tumor cell, a tumor cell antigen, an infectious agent or other foreign antigen, or other antigens to which an enhanced systemic immune response is desirable. Alternatively, the antigen may be a non-foreign antigen when a suppression of a systemic immune response is desired. The resulting systemic immune response is specific for the target antigen.
摘要翻译： 通过共同施用细胞因子粘附或辅助分子和靶抗原来改变个体对靶抗原的特异性全身免疫应答的方法。 靶抗原可以是肿瘤细胞，肿瘤细胞抗原，感染因子或其它外来抗原，或其它需要增强的全身免疫应答的抗原。 或者，当需要抑制全身免疫应答时，抗原可以是非外源抗原。 所产生的全身免疫应答对靶抗原是特异性的。
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