Irradiated tumor cell vaccine engineered to express GM-CSF
    1.
    发明授权
    Irradiated tumor cell vaccine engineered to express GM-CSF 失效
    辐射肿瘤细胞疫苗工程化以表达GM-CSF

    公开(公告)号:US5637483A

    公开(公告)日:1997-06-10

    申请号:US265554

    申请日:1994-06-23

    摘要: A method of altering the specific, systemic immune response of an individual to a target antigen by the co-administration of a cytokine an adhesion or accessory molecule and the target antigen. The target antigen may be a tumor cell, a tumor cell antigen, an infectious agent or other foreign antigen, or other antigens to which an enhanced systemic immune response is desirable. Alternatively, the antigen may be a non-foreign antigen when a suppression of a systemic immune response is desired. The resulting systemic immune response is specific for the target antigen.

    摘要翻译: 通过共同施用细胞因子粘附或辅助分子和靶抗原来改变个体对靶抗原的特异性全身免疫应答的方法。 靶抗原可以是肿瘤细胞,肿瘤细胞抗原,感染因子或其它外来抗原,或其它需要增强的全身免疫应答的抗原。 或者,当需要抑制全身免疫应答时,抗原可以是非外源抗原。 所产生的全身免疫应答对靶抗原是特异性的。