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    Optical tomography for microscopy, cell cytometry, microplate array instrumentation, crystallography, and other applications
    1.
    发明授权
    Optical tomography for microscopy, cell cytometry, microplate array instrumentation, crystallography, and other applications 有权
    光学断层扫描显微镜，细胞计数仪，微孔板阵列仪，晶体学等应用

    公开(公告)号：US09594239B1

    公开(公告)日：2017-03-14

    申请号：US13963917

    申请日：2013-08-09

    Applicant: Lester F. Ludwig

    Inventor： Lester F. Ludwig ,  Karen Hao ,  Frank Hu ,  Alice Huang ,  Pooncharas Tipgunlakant

    IPC: H04N7/18 ,  G02B21/06

    CPC classification number: G01N21/05 ,  G01N15/1475 ,  G01N2021/058 ,  G02B21/06 ,  G02B21/367

    Abstract: An electronic imaging flow-microscope for remote environmental sensing, bioreactor process monitoring, and optical microscopic tomography applications is described. A fluid conduit has a port on each end of a thin flat transparent fluid transport region. A planar illumination surface contacts one flat side of the transparent fluid transport region and a planar image sensing surface contacts the other flat side. Light from the illumination surface travels through the transparent fluid transport region to the planar image sensing surface, producing a light field affected by the fluid and objects present. The planar image sensing surface creates electrical image signals responsive to the light field. The planar illumination surface can be light emitting elements such as LEDs, OLEDs, or OLET. whose illumination can be sequenced in an image formation process. The flow microscope can further comprise flow-restricting valves, pumps, energy harvesting arrangements, and power management.

    Abstract translation: 描述了用于远程环境感测，生物反应器过程监测和光学显微镜层析成像应用的电子成像流动显微镜。 流体导管在薄平坦的透明流体输送区域的每一端具有一个端口。 平面照明面接触透明流体输送区域的一个平坦侧面，平面摄像面与另一平坦面接触。 来自照明表面的光穿过透明流体输送区域到达平面图像感测表面，产生受流体和存在的物体影响的光场。 平面图像感测表面产生响应于光场的电图像信号。 平面照明表面可以是诸如LED，OLED或OLET的发光元件。 其照明可以在图像形成过程中被排序。 流动显微镜还可以包括流量限制阀，泵，能量收集装置和电力管理。

    Optical tomography optoelectronic arrangements for microplate wells
    2.
    发明授权
    Optical tomography optoelectronic arrangements for microplate wells 有权

    公开(公告)号：US10816467B2

    公开(公告)日：2020-10-27

    申请号：US16036646

    申请日：2018-07-16

    Applicant: Lester F. Ludwig

    Inventor： Lester F. Ludwig ,  Karen Hao ,  Frank Hu ,  Alice Huang ,  Pooncharas Tipgunlakant

    IPC: G01N21/59 ,  G01N15/14 ,  G01N21/25 ,  G01N21/51 ,  G01N21/53 ,  G01N21/64 ,  G01N15/02 ,  G01N15/10 ,  G01N21/17

    Abstract: Optical tomography arrangements are disclosed for performing optical tomography on the transparent or translucent contents of individual microplate wells comprising a light emitting array having a plurality of light emitting elements, a sample module, and a light sensing array including a plurality of light sensing elements, wherein the light sensing array is configured to sense light emitted from the light emitting array which has passed through the sample module. The light emitting elements can comprise light emitting diodes (LEDs), organic light emitting diodes (OLEDs), organic light emitting transistors (OLETs), and/or other optoelectronic devices. The light sensing array can comprise organic light sensing devices, photodiodes, phototransistors, CMOS photodetectors, or charge-coupled devices (CCDs). The light emitting array can be flat or curved, and the light sensing array can be flat or curved. The collection of measurement values can be overspecified, and a generalized inverse operation can provide solutions rendering computational tomography data.

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