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公开(公告)号：US6070583A
公开(公告)日：2000-06-06
申请号：US391209
申请日：1995-02-21
申请人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Roa Dasari , Irving Itzkan , Michael S. Feld
发明人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Roa Dasari , Irving Itzkan , Michael S. Feld
CPC分类号： A61B5/0073 , G01N21/4795
摘要： The present invention relates to the use of inelastically scattered light, particularly fluorescent and Raman scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions as well as histological information that can be used for diagnosing disease and various medical conditions.
摘要翻译： 本发明涉及非弹性散射光，特别是荧光和拉曼散射光的用途，用于确定人体各种器官内材料的位置和组成。 本发明的系统和方法提供三维医学成像以及可用于诊断疾病和各种医疗状况的组织学信息。
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公开(公告)号：US06321111B1
公开(公告)日：2001-11-20
申请号：US09347050
申请日：1999-07-02
申请人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Rac Dasari , Irving Itzkan , Michael S. Feld
发明人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Rac Dasari , Irving Itzkan , Michael S. Feld
IPC分类号： A61B600
CPC分类号： G01N21/4795 , A61B5/0073
摘要： The present invention relates to the use of time gated scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions of internal body structures for diagnostic purposes.
摘要翻译： 本发明涉及时间门控散射光的使用，用于确定人体各种器官内材料的位置和组成。 本发明的系统和方法提供用于诊断目的的内部身体结构的三维的医学成像。
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公开(公告)号：US5919140A
公开(公告)日：1999-07-06
申请号：US549623
申请日：1995-10-27
申请人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Rao Dasari , Irving Itzkan , Michael S. Feld
发明人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Rao Dasari , Irving Itzkan , Michael S. Feld
CPC分类号： G01N21/4795 , A61B5/0073
摘要： The present invention relates to the use of time gated scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions of internal body structures for diagnostic purposes.
摘要翻译： 本发明涉及时间门控散射光的使用，用于确定人体各种器官内材料的位置和组成。 本发明的系统和方法提供用于诊断目的的内部身体结构的三维的医学成像。
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公开(公告)号：US06922583B1
公开(公告)日：2005-07-26
申请号：US09545992
申请日：2000-04-10
申请人： Lev T. Perelman , Vadim Backman , Michael S. Feld , George Zonios , Irving Itzkan , Ramasamy Manoharan
发明人： Lev T. Perelman , Vadim Backman , Michael S. Feld , George Zonios , Irving Itzkan , Ramasamy Manoharan
CPC分类号： A61B5/0084 , A61B5/0075 , A61B5/0086
摘要： The present invention relates to systems and methods for measuring one or more physical characteristics of material such as tissue using optical radiation. The system can use light that is scattered by a tissue layer to determine, for example, the size of nuclei in the tissue layer to aid in the characterization of the tissue. These methods can include the use of fiber optic devices to deliver and collect light from a tissue region of interest to diagnose, for example, whether the tissue is normal or precancerous.
摘要翻译： 本发明涉及用于使用光学辐射测量诸如组织的材料的一种或多种物理特性的系统和方法。 该系统可以使用由组织层散射的光来确定例如组织层中的核的大小以帮助表征组织。 这些方法可以包括使用光纤装置来递送和收集来自感兴趣的组织区域的光，以诊断例如组织是正常还是癌前。
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公开(公告)号：US6091984A
公开(公告)日：2000-07-18
申请号：US948734
申请日：1997-10-10
申请人： Lev T. Perelman , Vadim Backman , Michael S. Feld , George Zonios , Irving Itzkan , Ramasamy Manoharan
发明人： Lev T. Perelman , Vadim Backman , Michael S. Feld , George Zonios , Irving Itzkan , Ramasamy Manoharan
CPC分类号： A61B5/0084 , A61B5/0075 , A61B5/0086
摘要： The present invention relates to systems and methods for measuring one or more physical characteristics of material such as tissue using optical radiation. The system can use light that is scattered by a tissue layer to determine, for example, the size of nuclei in the tissue layer to aid in the characterization of the tissue. These methods can include the use of fiber optic devices to deliver and collect light from a tissue region of interest to diagnose, for example, whether the tissue is normal or precancerous.
摘要翻译： 本发明涉及用于使用光学辐射测量诸如组织的材料的一种或多种物理特性的系统和方法。 该系统可以使用由组织层散射的光来确定例如组织层中的核的大小以帮助表征组织。 这些方法可以包括使用光纤装置来递送和收集来自感兴趣的组织区域的光，以诊断例如组织是正常还是癌前。
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6.发明授权Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes 失效用于分析血气和分析物的拉曼光谱仪的装置和方法
公开(公告)号：US5615673A
公开(公告)日：1997-04-01
申请号：US410927
申请日：1995-03-27
申请人： Andrew J. Berger , James F. Brennan, III , Ramanchandra R. Dasari , Michael S. Feld , Irving Itzkan , Kaz Tanaka , Yang Wang
发明人： Andrew J. Berger , James F. Brennan, III , Ramanchandra R. Dasari , Michael S. Feld , Irving Itzkan , Kaz Tanaka , Yang Wang
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1459 , G01N21/65
CPC分类号： G01J3/02 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14551 , G01J3/021 , G01J3/0221 , G01N21/65 , A61B2562/12 , G01N2021/656
摘要： The present invention relates to systems of methods of measuring selected analytes in blood and tissue using Raman spectroscopy to aid in diagnosis. More particularly, Raman spectra are collected and analyzed to measure the concentration of dissolved gases and other analytes of interest in blood. Methods include in vivo transdermal and continuous monitoring as well as in vitro blood analysis.
摘要翻译： 本发明涉及使用拉曼光谱法测量血液和组织中选定分析物以辅助诊断的方法的系统。 更具体地，收集和分析拉曼光谱，以测量溶解气体和其他有关血液中分析物的浓度。 方法包括体内透皮和连续监测以及体外血液分析。
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公开(公告)号：US06847456B2
公开(公告)日：2005-01-25
申请号：US09844286
申请日：2001-04-27
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , G01N21/45
摘要： The present invention relates to systems and methods of field-based light scattering spectroscopy. These systems and methods provide for the diagnosis of tissue by measuring the size and distribution of cellular characteristics. Field based measurements provide phase information resulting from the interaction of scatterers within the material and the incident wavefront. These measurements can be used to provide three dimensional images of tissue.
摘要翻译： 本发明涉及基于场的光散射光谱的系统和方法。 这些系统和方法通过测量细胞特征的大小和分布来提供对组织的诊断。 基于场的测量提供由材料内的散射体与入射波前的相互作用产生的相位信息。 这些测量可用于提供组织的三维图像。
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公开(公告)号：US06624890B2
公开(公告)日：2003-09-23
申请号：US10155194
申请日：2002-05-24
申请人： Vadim Backman , Ramachandra R. Dasari , Rajan Gurjar , Irving Itzkan , Lev Perelman , Michael S. Feld
发明人： Vadim Backman , Ramachandra R. Dasari , Rajan Gurjar , Irving Itzkan , Lev Perelman , Michael S. Feld
IPC分类号： G01J400
CPC分类号： A61B5/0084 , A61B5/0075
摘要： The present invention relates to the use of polarized light to measure properties of tissue. More particularly, polarized light can be used to detect dysplasia in tissue as the polarization of back-scattered light from such tissues is preserved while the contribution of diffusely scattered light from underlying tissues can be removed. A fiber optic system for delivery and collection of light can be used to measure tissues within the human body.
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公开(公告)号：US06404497B1
公开(公告)日：2002-06-11
申请号：US09237153
申请日：1999-01-25
申请人： Vadim Backman , Ramanchandra R. Dasari , Rajan Gurjar , Irving Itzkan , Lev Perelman , Michael S. Feld
发明人： Vadim Backman , Ramanchandra R. Dasari , Rajan Gurjar , Irving Itzkan , Lev Perelman , Michael S. Feld
IPC分类号： G01J400
CPC分类号： A61B5/0084 , A61B5/0075
摘要： The present invention relates to the use of polarized light to measure properties of tissue. More particularly, polarized light can be used to detect dysplasia in tissue as the polarization of backscattered light from such tissues is preserved while the contribution of diffusely scattered light from underlying tissues can be removed. A fiber optic system for delivery and collection of light can be used to measure tissues within the human body.
摘要翻译： 本发明涉及使用偏振光来测量组织的性质。 更具体地，偏振光可用于检测组织中的发育不良，因为来自这些组织的反向散射光的偏振被保留，同时可以去除来自下层组织的漫散射光的贡献。 用于光的传送和收集的光纤系统可用于测量人体内的组织。
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公开(公告)号：US5312396A
公开(公告)日：1994-05-17
申请号：US644202
申请日：1991-01-22
申请人： Michael S. Feld , Irving Itzkan , Douglas Albagli , Joseph A. Izatt , Gary B. Hayes , Richard Rava
发明人： Michael S. Feld , Irving Itzkan , Douglas Albagli , Joseph A. Izatt , Gary B. Hayes , Richard Rava
CPC分类号： B23K26/0665 , A61B18/245 , B23K26/06 , B23K26/064 , A61B2017/00154 , A61B2018/207
摘要： Removal of body tissue with a long pulsed lasers is achieved such that sufficient energy to remove tissue is transmitted to the desired body without damaging an optical fiber transmitting the laser radiation. Pairs of pulses having the same or different wavelengths are coupled to more effectively remove tissue from the surgical site.
摘要翻译： 实现用长脉冲激光去除身体组织，使得足够的能量去除组织被传递到所需的身体，而不损害透射激光辐射的光纤。 具有相同或不同波长的脉冲对被耦合以更有效地从手术部位去除组织。
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