公开(公告)号：US20060134608A1

公开(公告)日：2006-06-22

申请号：US10537378

申请日：2003-05-06

申请人： Lianghong Guo ,  Yuanguang Li ,  Na Wang ,  Fuquan Wang ,  Xiqiang Yang ,  Jing Cheng

发明人： Lianghong Guo ,  Yuanguang Li ,  Na Wang ,  Fuquan Wang ,  Xiqiang Yang ,  Jing Cheng

IPC分类号： C12Q1/70 ,  C12Q1/68 ,  G01N33/567

CPC分类号： G01N33/5438 ,  C12Q1/6825 ,  G01N27/3277 ,  G01N33/58 ,  G01N2458/30

摘要： This invention relates generally to the field of electrochemistry. In particular, the invention provides a method for assaying an analyte, using, inter alia, a reactant capable of binding and/or reacting with an analyte to be analyzed on an oxide electrode and a reducing agent not capable of being oxidized directly by said electrode to generate reduced electrochemically active molecule that participates in oxidation-reduction reactions repeatedly to generate an amplified electrochemical signal to determine presence and/or amount of said analyte in said sample.

摘要翻译： 本发明一般涉及电化学领域。 特别地，本发明提供了一种用于测定分析物的方法，特别是使用能够在不能被所述电极直接氧化的氧化物电极和还原剂上结合和/或与待分析的分析物反应的反应物 以产生重复参与氧化还原反应的还原电化学活性分子以产生放大的电化学信号以确定所述样品中所述分析物的存在和/或量。

公开(公告)号：US20060148102A1

公开(公告)日：2006-07-06

申请号：US10535905

申请日：2003-05-06

申请人： Lianghong Guo ,  Dong Dong ,  Dong Zheng ,  Fuquan Wang ,  Xiqiang Yang ,  Jing Cheng

发明人： Lianghong Guo ,  Dong Dong ,  Dong Zheng ,  Fuquan Wang ,  Xiqiang Yang ,  Jing Cheng

IPC分类号： G01N33/551

CPC分类号： G01N33/582 ,  C12Q1/6816 ,  G01N2458/30 ,  C12Q2563/113 ,  C12Q2523/313

摘要： The present invention provides apparatus, kits and methods for assaying analytes using photoelectrochemical molecules as labels. Specifically, the present invention provides a method for assaying an analyte, comprising: a) contacting a sample suspected of containing an analyte with a reactant capable of binding and/or reacting with the analyte under suitable conditions to allow binding of analyte, if present in the sample, to the reactant; and b) assessing binding and/or reacting between the analyte and the reactant to determine presence and/or amount of analyte in the sample, wherein the reactant, analyte, or additional reactant or additional analyte or analyte analog is labeled with a photoelectrochemically active molecule. The assessing step also comprises converting the photoelectrochemically active molecule with light to an excited state in the presence of an electrode, and assessing an electric current generated by an electron transfer between the excited photoelectrochemically active molecule and the electrode.

摘要翻译： 本发明提供了使用光电化学分子作为标记来测定分析物的装置，试剂盒和方法。 具体地，本发明提供了一种用于分析分析物的方法，其包括：a）在合适的条件下将疑似含有分析物的样品与能够与分析物结合和/或反应的反应物接触，以使分析物（如果存在于 样品，反应物; 和b）评估分析物和反应物之间的结合和/或反应以确定样品中分析物的存在和/或量，其中反应物，分析物或附加反应物或其他分析物或分析物类似物用光电化学活性分子标记 。 评估步骤还包括在电极存在下将光电化学活性分子与光转化为激发态，并评估由激发的光电化学活性分子和电极之间的电子转移产生的电流。

公开(公告)号：US08603750B2

公开(公告)日：2013-12-10

申请号：US10535905

申请日：2003-05-06

申请人： Lianghong Guo ,  Dong Dong ,  Dong Zheng ,  Fuquan Wang ,  Xiqiang Yang ,  Jing Cheng

发明人： Lianghong Guo ,  Dong Dong ,  Dong Zheng ,  Fuquan Wang ,  Xiqiang Yang ,  Jing Cheng

IPC分类号： G01N33/53 ,  G01N21/76

CPC分类号： G01N33/582 ,  C12Q1/6816 ,  G01N2458/30 ,  C12Q2563/113 ,  C12Q2523/313

摘要： The present invention provides apparatus, kits and methods for assaying analytes using photoelectrochemical molecules as labels. Specifically, the present invention provides a method for assaying an analyte, comprising: a) contacting a sample suspected of containing an analyte with a reactant capable of binding and/or reacting with the analyte under suitable conditions to allow binding of analyte, if present in the sample, to the reactant; and b) assessing binding and/or reacting between the analyte and the reactant to determine presence and/or amount of analyte in the sample, wherein the reactant, analyte, or additional reactant or additional analyte or analyte analog is labeled with a photoelectrochemically active molecule. The assessing step also comprises converting the photoelectrochemically active molecule with light to an excited state in the presence of an electrode, and assessing an electric current generated by an electron transfer between the excited photoelectrochemically active molecule and the electrode.

摘要翻译： 本发明提供了使用光电化学分子作为标记来测定分析物的装置，试剂盒和方法。 具体地，本发明提供了一种用于分析分析物的方法，其包括：a）在合适的条件下将疑似含有分析物的样品与能够与分析物结合和/或反应的反应物接触，以使分析物（如果存在于 样品，反应物; 和b）评估分析物和反应物之间的结合和/或反应以确定样品中分析物的存在和/或量，其中反应物，分析物或附加反应物或其他分析物或分析物类似物用光电化学活性分子标记 。 评估步骤还包括在电极存在下将光电化学活性分子与光转化为激发态，并评估由激发的光电化学活性分子和电极之间的电子转移产生的电流。

公开(公告)号：US20130165541A1

公开(公告)日：2013-06-27

申请号：US13334199

申请日：2011-12-22

申请人： Xiqiang Yang ,  James R. Bennett

发明人： Xiqiang Yang ,  James R. Bennett

IPC分类号： C08J9/00 ,  C08L67/00 ,  C08L25/08

CPC分类号： C08J9/0066 ,  C08J9/28 ,  C08J2201/0482 ,  C08J2325/14 ,  C08J2367/00

摘要： A process for forming polymer particles with aligned pores and controlled narrow particle size distribution, including: a) forming an oil phase by dissolving a polymeric binder in a solvent; b) dispersing the oil phase into a water phase containing a controlled amount of particulate stabilizer and forming an oil-in-water emulsion of controlled narrow dispersed oil phase droplet size distribution; c) freezing the emulsion to freeze solvent in the oil droplets to form frozen solvent domains within the polymeric binder, and also the water in the continuous water phase; and d) removing the frozen solvent from the polymeric binder and the frozen water in the continuous water phase, thereby forming porous polymer particles of controlled narrow particle size distribution and containing directional aligned non-spherical pore structures. Optionally, the porous particles may contain encapsulated functional ingredients.

摘要翻译： 一种用于形成具有排列孔和受控的窄粒度分布的聚合物颗粒的方法，包括：a）通过将聚合物粘合剂溶解在溶剂中形成油相; b）将油相分散到含有受控量的颗粒稳定剂的水相中并形成受控窄分散油相液滴尺寸分布的水包油乳液; c）冷冻乳液以在油滴中冷冻溶剂，以在聚合物粘合剂内形成冷冻溶剂结构域，以及连续水相中的水; 以及d）从连续水相中的聚合物粘合剂和冷冻水中除去冷冻的溶剂，从而形成受控窄粒度分布的多孔聚合物颗粒并且包含定向排列的非球形孔结构。 任选地，多孔颗粒可以含有包封的功能性成分。

公开(公告)号：US20120136080A1

公开(公告)日：2012-05-31

申请号：US12956022

申请日：2010-11-30

申请人： Xiqiang Yang ,  James R. Bennett

发明人： Xiqiang Yang ,  James R. Bennett

IPC分类号： C08J9/28 ,  C08B15/00 ,  C08B37/02 ,  C08B3/00

CPC分类号： C08J9/28 ,  C08B11/12 ,  C08J2201/05 ,  C08L1/284 ,  C08L1/286 ,  C08L5/02 ,  C08L33/26

摘要： A method of manufacturing porous polymer particles with improved filterability is described. One or more first water phases are formed comprising an anionic hydrocolloid with a mass-per-charge value of less than 600 and a relatively minor amount, compared to the anionic hydrocolloid, of at least one of a nonionic, cationic, zwitterionic, or weakly anionic water soluble or dispersible polymer, where the weakly anionic water soluble or dispersible polymer has a mass-per-charge value of larger than 600. A water-in-oil emulsion is formed by dispersing the one or more first water phases into an organic phase comprising at least one of either (i) preformed polymer dissolved in an organic solvent or (ii) polymerizable monomers, and homogenizing. A water-in-oil-in-water multiple emulsion is formed by dispersing the water-in-oil emulsion into a second water phase containing a stabilizing agent and homogenizing. The organic solvent is removed to precipitate the preformed polymer, or the polymerizable monomers are polymerized, to obtain a dispersion of porous polymer particles in an external aqueous phase, wherein individual porous particles each comprise a continuous polymer phase and internal pores containing an internal aqueous phase. The dispersion of porous polymer particles is filtered to remove the external aqueous phase. The method enables increased filtration rates of porous polymer particle dispersions containing water in the pores.

摘要翻译： 描述了制造具有改进的过滤性的多孔聚合物颗粒的方法。 形成一个或多个第一水相，其包含阴离子水胶体，每批电荷值小于600，并且与阴离子水胶体相比，非离子，阳离子，两性离子或弱的至少一种 阴离子水溶性或可分散的聚合物，其中弱阴离子水溶性或可分散聚合物的每次电荷值大于600.通过将一个或多个第一水相分散到有机物中形成油包水乳液 包含（i）预先形成的聚合物溶解在有机溶剂中的至少一种或（ii）可聚合单体，并均化。 通过将油包水乳液分散到含有稳定剂的第二水相中并均化来形成水包油包水多重乳液。 去除有机溶剂以沉淀预制的聚合物，或聚合单体，得到多孔聚合物颗粒在外部水相中的分散体，其中各个多孔颗粒各自包含连续聚合物相和含有内部水相的内孔 。 过滤多孔聚合物颗粒的分散体以除去外部水相。 该方法能够增加在孔中含有水的多孔聚合物颗粒分散体的过滤速率。

公开(公告)号：US20120003581A1

公开(公告)日：2012-01-05

申请号：US12826832

申请日：2010-06-30

申请人： Xiqiang Yang ,  James R. Bennett

发明人： Xiqiang Yang ,  James R. Bennett

IPC分类号： G03G9/087

CPC分类号： G03G9/08755 ,  G03G9/0804 ,  G03G9/08782 ,  G03G9/08795 ,  G03G9/08797

摘要： The present invention is directed towards methods of manufacturing wax-containing polymer particles by limited coalescence processes employing aqueous wax dispersions. In one embodiment, an aqueous wax dispersion or emulsion is dispersed in an oil phase comprising a water-immiscible solvent and a polymer to form a transient water-in-oil (W/O) emulsion, and a further aqueous phase containing a particulate stabilizer is then added to the W/O emulsion to induce phase inversion, and the mixture homogenized to form an oil-in-water (O/W) emulsion. The solvent is then removed from the emulsion to form particles containing wax domains inside. In another embodiment, the aqueous wax dispersion is first mixed with the aqueous phase containing the particulate stabilizer, and homogenization is made with the oil phase to form an O/W emulsion, from which wax-containing particles are obtained after solvent removal. In still further embodiments, the aqueous wax dispersion is used in the second water phase of a double emulsion (W1/O/W2) process to form porous polymer particles containing the wax.

摘要翻译： 本发明涉及通过使用含水蜡分散体的有限聚结方法制造含蜡聚合物颗粒的方法。 在一个实施方案中，水性蜡分散体或乳液分散在包含水不混溶溶剂和聚合物的油相中以形成瞬时油包水（W / O）乳液，以及含有颗粒稳定剂 然后加入到W / O乳液中以诱导相转化，并将混合物均质化以形成水包油（O / W）乳液。 然后将溶剂从乳液中除去以形成含有内部蜡区域的颗粒。 在另一个实施方案中，首先将含水蜡分散体与含有颗粒稳定剂的水相混合，并用油相进行均化以形成O / W乳液，在除去溶剂后从其中获得含蜡颗粒。 在另外的实施方案中，水性蜡分散体用于双乳液（W1 / O / W2）方法的第二水相中以形成含有蜡的多孔聚合物颗粒。

公开(公告)号：US20080268367A1

公开(公告)日：2008-10-30

申请号：US11739121

申请日：2007-04-24

申请人： Mridula Nair ,  Xiqiang Yang ,  Tamara K. Jones ,  James G. Popowych

发明人： Mridula Nair ,  Xiqiang Yang ,  Tamara K. Jones ,  James G. Popowych

IPC分类号： G03G5/00

CPC分类号： C08J3/14 ,  C08J9/28 ,  C08J2201/05 ,  G03G9/0806 ,  G03G9/0827

摘要： The present invention is a method for the preparation of porous particles that includes dissolving a polymer material in a first organic solvent and adding a second organic solvent and nonionic organic polymer particles to form an organic phase. The organic phase is dispersed in an aqueous phase that includes a particulate stabilizer to form a dispersion and the dispersion is homogenized. The first and second organic solvents are evaporated and the product is recovered.

摘要翻译： 本发明是一种制备多孔颗粒的方法，其包括将聚合物材料溶解在第一有机溶剂中并加入第二有机溶剂和非离子有机聚合物颗粒以形成有机相。 将有机相分散在包含微粒稳定剂的水相中以形成分散体，并将分散体均化。 将第一和第二有机溶剂蒸发并回收产物。

公开(公告)号：US07414146B2

公开(公告)日：2008-08-19

申请号：US09904616

申请日：2001-07-13

申请人： Wojciech K. Slusarek ,  Xiqiang Yang ,  David H. Levy

发明人： Wojciech K. Slusarek ,  Xiqiang Yang ,  David H. Levy

IPC分类号： C07C261/00

CPC分类号： G03C7/30511 ,  G03C1/42 ,  G03C7/305 ,  G03C7/30541 ,  G03C2200/21 ,  Y10S430/156 ,  Y10S430/158 ,  Y10S430/159 ,  Y10S430/16 ,  Y10S430/165

摘要： This invention relates to an imaging element comprising an imaging layer having associated therewith a compound of Structure I: In the above Structure I, the substituents are as defined in the application. Such compounds have good reactivity and can by used to block photographically useful compounds such as developing agents until thermally activated under preselected conditions. Compounds according to the present invention are especially useful in color photothermographic imaging elements.

摘要翻译： 本发明涉及一种成像元件，其包括具有结构I的化合物的成像层：在上述结构I中，取代基如本申请中所定义。 这些化合物具有良好的反应性，并且可以通过用于阻挡照相用的化合物如显影剂，直到在预选条件下热活化。 根据本发明的化合物在彩色光热敏成像元件中特别有用。

公开(公告)号：US06759187B1

公开(公告)日：2004-07-06

申请号：US09614035

申请日：2000-07-11

申请人： Wojciech K. Slusarek ,  Xiqiang Yang ,  Mark E. Irving ,  David H. Levy ,  Jared B. Mooberry ,  James J. Seifert ,  James H. Reynolds ,  Lyn M. Irving

发明人： Wojciech K. Slusarek ,  Xiqiang Yang ,  Mark E. Irving ,  David H. Levy ,  Jared B. Mooberry ,  James J. Seifert ,  James H. Reynolds ,  Lyn M. Irving

IPC分类号： G03C134

CPC分类号： G03C1/49809 ,  G03C1/42 ,  G03C1/43 ,  G03C1/49827 ,  G03C1/49845 ,  G03C7/30511 ,  G03C7/30541 ,  G03C7/39236 ,  G03C7/4136 ,  Y10S430/156 ,  Y10S430/158 ,  Y10S430/159

摘要： This invention relates to an imaging element comprising an imaging layer having associated therewith a compound of Structure I: wherein: the substituents are as defined in the application.

公开(公告)号：US06649332B2

公开(公告)日：2003-11-18

申请号：US10135752

申请日：2002-04-30

申请人： David T. Southby ,  Xiqiang Yang ,  Benjamin P. Hoag

发明人： David T. Southby ,  Xiqiang Yang ,  Benjamin P. Hoag

IPC分类号： G03C730

CPC分类号： G03C7/30511 ,  G03C7/30558 ,  G03C7/39256 ,  G03C7/407 ,  G03C8/4013

摘要： A method of processing an imagewise exposed color photographic film, said film having at least three light-sensitive units which have their individual sensitivities in different wavelength regions, each of the units comprising at least one light sensitive silver halide emulsion and image dye coupler, which method comprises contacting the imagewise exposed color photographic film with an aqueous solution containing a non-blocked developing agent, at a temperature of between 30 to 60° C.; and wherein said film further comprises an incorporated reducing agent, at least one organic silver salt and an amido compound wherein the reducing agent is substantially unreactive in the aqueous color development step described above, but wherein color development of the same imagewise exposed film is capable of being alternatively obtained, without any externally applied developing agent, by heating said film to a temperature above about 80° C. essentially in the absence of aqueous solutions, such that the incorporated reducing agent reacts to form dye by reacting with the image dye couplers; with the proviso that the amido compound effectively reduces contrast when the film is heated above 80° C. but does not substantially reduce contrast when the film is processed by contacting the imagewise exposed color photographic film with a non-blocked developing agent under aqueous conditions, at a temperature of between 30 to 60° C.