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    Drug eluting medical devices having porous layers
    3.
    发明授权
    Drug eluting medical devices having porous layers 有权
    具有多孔层的药物洗脱医学装置

    公开(公告)号：US08815273B2

    公开(公告)日：2014-08-26

    申请号：US11881749

    申请日：2007-07-27

    申请人： Liliana Atanasoska ,  Robert W. Warner ,  Michael S. Arney ,  Jan Weber

    发明人： Liliana Atanasoska ,  Robert W. Warner ,  Michael S. Arney ,  Jan Weber

    IPC分类号： A61F13/00 ,  A61F2/06

    CPC分类号： A61L31/16 ,  A61L31/022 ,  A61L31/082 ,  A61L31/10 ,  A61L31/146 ,  A61L31/148 ,  A61L2300/608 ,  Y10T428/13 ,  Y10T428/249994

    摘要： In accordance with an aspect of the invention, implantable or insertable medical devices are provided that comprise (a) a substrate and (b) a porous layer comprising close packed spherical pores disposed over the substrate. The porous layer may also comprise a therapeutic agent. In another aspect, the present invention provides methods of forming implantable or insertable medical devices. These methods comprise forming a predecessor structure that comprises (i) a substrate over which is disposed (ii) an assembly of microspheres. This assembly of microspheres is then used as a template for the formation of a porous layer, which may be subsequently loaded with a therapeutic agent.

    摘要翻译： 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包括（a）基底和（b）包含设置在基底上的紧密堆积的球形孔的多孔层。 多孔层还可以包含治疗剂。 在另一方面，本发明提供了形成可植入或可插入的医疗装置的方法。 这些方法包括形成前身结构，其包括（i）在其上设置（ii）微球组件的基底。 然后将该微球体组合物用作形成多孔层的模板，随后可以加入治疗剂。

    MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH GALVANIC CORROSION
    8.
    发明申请
    MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH GALVANIC CORROSION 失效
    用于与治疗性腐蚀相关的用于输送治疗药物的医疗装置

    公开(公告)号：US20090326638A1

    公开(公告)日：2009-12-31

    申请号：US12489948

    申请日：2009-06-23

    申请人： Liliana Atanasoska ,  Jan Weber ,  Paul Grosso ,  Robert W. Warner ,  Kasyap V. Seethamraju

    发明人： Liliana Atanasoska ,  Jan Weber ,  Paul Grosso ,  Robert W. Warner ,  Kasyap V. Seethamraju

    IPC分类号： A61F2/06

    CPC分类号： A61L31/022 ,  A61L31/10 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00

    摘要： According to an aspect of the present invention, at least one ionic therapeutic agent is delivered from an implantable or insertable medical device that comprises an ion-conductive polymeric region that is disposed on a metallic region. The metallic region is in electrical contact with a dissimilar metallic region, such that a galvanic current is generated by the dissimilar metals when the device is implanted or inserted into a patient. Delivery of the ionic therapeutic agent from the ion-conductive polymeric region may be, for example, either accelerated or retarded by the galvanic current. According to another aspect of the present invention, implantable or insertable medical devices are provided which comprise: (a) a first metallic region having a first corrosion potential, (b) a second metallic region in electrical contact with the first metallic region and having a second corrosion potential that is greater than the first corrosion potential, and (c) a solid ion-conductive polymeric region, comprising an ion conducting polymer and an ionic therapeutic agent, disposed on the first metallic region, the second metallic region, or both.

    摘要翻译： 根据本发明的一个方面，至少一种离子治疗剂从可植入或可插入的医疗装置输送，其包括设置在金属区域上的离子导电聚合物区域。 金属区域与异种金属区域电接触，使得当器件植入或插入患者体内时，异种金属产生电流。 离子导电聚合物区域的离子治疗剂的递送可以例如由电流加速或延迟。 根据本发明的另一方面，提供了可植入或可插入的医疗装置，其包括：（a）具有第一腐蚀电位的第一金属区域，（b）与第一金属区域电接触的第二金属区域， 第二腐蚀电位大于第一腐蚀电位，和（c）固体离子传导聚合物区域，其包含离子导电聚合物和离子治疗剂，设置在第一金属区域，第二金属区域或两者上。

    Blood-contacting medical devices for the release of nitric oxide and anti-restenotic agents
    10.
    发明申请
    Blood-contacting medical devices for the release of nitric oxide and anti-restenotic agents 审中-公开
    用于释放一氧化氮和抗再狭窄剂的血液接触医疗装置

    公开(公告)号：US20080175881A1

    公开(公告)日：2008-07-24

    申请号：US11654884

    申请日：2007-01-18

    申请人： J. Thomas Ippoliti ,  Scott Schewe ,  Michele Zoromski ,  Robert W. Warner ,  Liliana Atanasoska ,  Jan Weber

    发明人： J. Thomas Ippoliti ,  Scott Schewe ,  Michele Zoromski ,  Robert W. Warner ,  Liliana Atanasoska ,  Jan Weber

    IPC分类号： A61L31/16 ,  A61L31/10 ,  A61F2/82

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/416 ,  A61L2300/45

    摘要： According to an aspect of the present invention, implantable or insertable blood-contacting devices are provided, which contain one or more release regions that release nitric oxide and one or more anti-restenotic agents. The release region contains one or more polymeric components. The release region also optionally contains one or more inorganic components. Nitric oxide producing groups may be attached to the polymeric component(s), to the optional inorganic component(s), or both. The one or more anti-restenotic agents may be admixed with the polymeric and optional inorganic components, attached to the polymeric component(s), attached to the optional inorganic component(s), or a combination thereof.

    摘要翻译： 根据本发明的一个方面，提供了可植入或可插入的血液接触装置，其包含一个或多个释放一氧化氮的释放区域和一种或多种抗再狭窄剂。 释放区域包含一种或多种聚合物组分。 释放区域还任选地含有一种或多种无机组分。 一氧化碳生成基团可以连接到聚合物组分，任选的无机组分或两者。 一种或多种抗再狭窄剂可以与附着于任选的无机组分的一种或多种聚合物组分的聚合物和任选的无机组分或其组合物混合。