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    Radiopaque amide polymers and medical devices formed thereof
    2.
    发明授权
    Radiopaque amide polymers and medical devices formed thereof 有权
    不透射线的酰胺聚合物及其形成的医疗器械

    公开(公告)号：US08507639B2

    公开(公告)日：2013-08-13

    申请号：US11519139

    申请日：2006-09-11

    申请人： Liliana Atanasoska ,  Scott Schewe ,  Robert Warner

    发明人： Liliana Atanasoska ,  Scott Schewe ,  Robert Warner

    IPC分类号： C08G69/08

    CPC分类号： A61L31/18 ,  A61L27/18 ,  A61L27/34 ,  A61L29/06 ,  A61L29/085 ,  A61L29/18 ,  A61L31/06 ,  A61L31/10 ,  C08F20/56 ,  C08G69/48 ,  C08L77/12

    摘要： Radiopaque polymers have a main chain and a plurality of amide groups which have bound to the amide nitrogen atom thereof an organohalide group that is pendant to the polymer main chain, the organo halide group including one or more iodine and/or bromine atoms thereon. The polymer may be a modified polyamide polymer, copolymer or block copolymer or a modified poly(meth)acrylamide or (meth)acrylamide copolymer or block copolymer. The polymers may be employed in medical devices and are useful for instance to track the movement of a catheter through the body or the inflation of a balloon at a site. The polymers may be made by coupling reactions performed on preexisting amide polymers.

    摘要翻译： 不透射线聚合物具有主链和多个与其酰胺氮原子结合的酰胺基，该有机卤化物基团垂直于聚合物主链，有机卤化物基团包括一个或多个碘和/或溴原子。 聚合物可以是改性聚酰胺聚合物，共聚物或嵌段共聚物或改性聚（甲基）丙烯酰胺或（甲基）丙烯酰胺共聚物或嵌段共聚物。 聚合物可以用于医疗装置中，并且可用于例如跟踪导管穿过身体的运动或在现场的气囊膨胀。 聚合物可以通过对预先存在的酰胺聚合物进行的偶联反应来制备。

    Organic-inorganic hybrid particle material and polymer compositions containing same
    4.
    发明授权
    Organic-inorganic hybrid particle material and polymer compositions containing same 有权
    有机 - 无机杂化颗粒材料和含有它们的聚合物组合物

    公开(公告)号：US08008395B2

    公开(公告)日：2011-08-30

    申请号：US11235743

    申请日：2005-09-27

    申请人： Michele Zoromski ,  Liliana Atanasoska ,  Scott Schewe ,  Mark Wolters ,  Robert Warner

    发明人： Michele Zoromski ,  Liliana Atanasoska ,  Scott Schewe ,  Mark Wolters ,  Robert Warner

    IPC分类号： C08K3/34 ,  C08L67/00 ,  C08G69/26

    CPC分类号： A61L27/427 ,  A61L31/124 ,  C08G77/458 ,  Y10T428/2982

    摘要： Particulate materials useful as fillers, reinforcing agents, radioopacifiers, or impact modifiers. The particulate material has an average particle size range of about 10,000 nm or less and comprises an organic-inorganic hybrid material that has a ceramic material network having organic polymer segments distributed throughout the ceramic network. The ceramic network may be prepared by a sol-gel technique. The particulate material may be compounded in thermoplastic polymer compositions useful in a variety of applications such as preparation of medical device components.

    摘要翻译： 可用作填料，增强剂，放射线光刻胶或抗冲改性剂的颗粒材料。 颗粒材料具有约10,000nm或更小的平均粒度范围，并且包含具有分布在整个陶瓷网络中的有机聚合物链段的陶瓷材料网络的有机 - 无机混合材料。 陶瓷网络可以通过溶胶 - 凝胶技术制备。 颗粒材料可以在可用于各种应用的热塑性聚合物组合物中复合，例如制备医疗装置组分。

    INTERNAL MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH A SOURCE OF ELECTRICAL POWER
    5.
    发明申请
    INTERNAL MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH A SOURCE OF ELECTRICAL POWER 有权
    用于与电力来源连接的治疗药物的内部医疗装置

    公开(公告)号：US20110046539A1

    公开(公告)日：2011-02-24

    申请号：US12939363

    申请日：2010-11-04

    申请人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    发明人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    IPC分类号： A61N1/30

    CPC分类号： A61N1/325 ,  A61N1/05 ,  A61N1/306 ,  A61N1/327

    摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

    摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

    Blood-contacting medical devices for the release of nitric oxide and anti-restenotic agents
    6.
    发明申请
    Blood-contacting medical devices for the release of nitric oxide and anti-restenotic agents 审中-公开
    用于释放一氧化氮和抗再狭窄剂的血液接触医疗装置

    公开(公告)号：US20080175881A1

    公开(公告)日：2008-07-24

    申请号：US11654884

    申请日：2007-01-18

    申请人： J. Thomas Ippoliti ,  Scott Schewe ,  Michele Zoromski ,  Robert W. Warner ,  Liliana Atanasoska ,  Jan Weber

    发明人： J. Thomas Ippoliti ,  Scott Schewe ,  Michele Zoromski ,  Robert W. Warner ,  Liliana Atanasoska ,  Jan Weber

    IPC分类号： A61L31/16 ,  A61L31/10 ,  A61F2/82

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/416 ,  A61L2300/45

    摘要： According to an aspect of the present invention, implantable or insertable blood-contacting devices are provided, which contain one or more release regions that release nitric oxide and one or more anti-restenotic agents. The release region contains one or more polymeric components. The release region also optionally contains one or more inorganic components. Nitric oxide producing groups may be attached to the polymeric component(s), to the optional inorganic component(s), or both. The one or more anti-restenotic agents may be admixed with the polymeric and optional inorganic components, attached to the polymeric component(s), attached to the optional inorganic component(s), or a combination thereof.

    摘要翻译： 根据本发明的一个方面，提供了可植入或可插入的血液接触装置，其包含一个或多个释放一氧化氮的释放区域和一种或多种抗再狭窄剂。 释放区域包含一种或多种聚合物组分。 释放区域还任选地含有一种或多种无机组分。 一氧化碳生成基团可以连接到聚合物组分，任选的无机组分或两者。 一种或多种抗再狭窄剂可以与附着于任选的无机组分的一种或多种聚合物组分的聚合物和任选的无机组分或其组合物混合。

    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
    9.
    发明申请
    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 失效

    公开(公告)号：US20060184092A1

    公开(公告)日：2006-08-17

    申请号：US11055930

    申请日：2005-02-11

    申请人： Liliana Atanasoska ,  Thomas Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    发明人： Liliana Atanasoska ,  Thomas Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    IPC分类号： A61N1/30

    CPC分类号： A61N1/325 ,  A61N1/05 ,  A61N1/306 ,  A61N1/327

    摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
    10.
    发明授权
    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 有权
    用于与电力源一起递送治疗剂的内部医疗装置

    公开(公告)号：US08152759B2

    公开(公告)日：2012-04-10

    申请号：US12077603

    申请日：2008-03-20

    申请人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    发明人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    IPC分类号： A61M29/00

    CPC分类号： A61N1/325 ,  A61N1/05 ,  A61N1/306 ,  A61N1/327

    摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

    摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。