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    Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same
    1.
    发明申请
    Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same 失效
    来自长链多不饱和脂肪酸的牛痘素及其制备和使用方法

    公开(公告)号：US20060241088A1

    公开(公告)日：2006-10-26

    申请号：US11284790

    申请日：2005-11-21

    申请人： Linda Arterburn ,  William Barclay ,  Bindi Dangi ,  James Flatt ,  Jung Lee ,  Mary Elswyk

    发明人： Linda Arterburn ,  William Barclay ,  Bindi Dangi ,  James Flatt ,  Jung Lee ,  Mary Elswyk

    IPC分类号： A61K31/60 ,  A61K31/22 ,  C07C69/02

    CPC分类号： C12P7/6472 ,  C07C59/42 ,  C07D303/38 ,  C12P7/6427

    摘要： Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.

    摘要翻译： 公开了衍生自C22多不饱和脂肪酸的新型oxylipin，本文称为多糖类，以及制备和使用这种oxylipin的方法。 还公开了二十二碳五烯酸（C22：5n-6）（DPAn-6），二十二碳五烯酸（C22：5n-3）（DPAn-3）和二十二碳四烯酸（DTAn-6：C22：4n-6） 作为生产新型oxylipins的底物，以及由此产生的oxylipin。 还公开了在治疗和营养或化妆品应用中使用DPAn-6，DPAn-3，DTAn-6和/或衍生自其的oxylipin，和/或衍生自C22脂肪酸结构的新型二十二烷酸，特别是 作为抗炎或抗神经变性化合物。 本发明还涉及生产长链多不饱和酸（LCPUFA）的油和组合物的新方法，其含有增强和有效量的LCPUFA衍生的草甘膦脂类，尤其是二十二烷酸。

    Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same
    2.
    发明授权
    Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same 失效
    来自长链多不饱和脂肪酸的牛痘素及其制备和使用方法

    公开(公告)号：US07884131B2

    公开(公告)日：2011-02-08

    申请号：US11284790

    申请日：2005-11-21

    申请人： Linda Arterburn ,  William Barclay ,  Bindi Dangi ,  James Flatt ,  Jung Lee ,  Mary Van Elswyk

    发明人： Linda Arterburn ,  William Barclay ,  Bindi Dangi ,  James Flatt ,  Jung Lee ,  Mary Van Elswyk

    IPC分类号： A61K31/22 ,  C07C59/00 ,  C07C57/00

    CPC分类号： C12P7/6472 ,  C07C59/42 ,  C07D303/38 ,  C12P7/6427

    摘要： Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.

    摘要翻译： 公开了衍生自C22多不饱和脂肪酸的新型oxylipin，本文称为多糖类，以及制备和使用这种oxylipin的方法。 还公开了二十二碳五烯酸（C22：5n-6）（DPAn-6），二十二碳五烯酸（C22：5n-3）（DPAn-3）和二十二碳四烯酸（DTAn-6：C22：4n-6） 作为生产新型oxylipins的底物，以及由此产生的oxylipin。 还公开了在治疗和营养或化妆品应用中使用DPAn-6，DPAn-3，DTAn-6和/或衍生自其的oxylipin，和/或衍生自C22脂肪酸结构的新型二十二烷酸，特别是 作为抗炎或抗神经变性化合物。 本发明还涉及生产长链多不饱和酸（LCPUFA）的油和组合物的新方法，其含有增强和有效量的LCPUFA衍生的草甘膦脂类，尤其是二十二烷酸。

    Oxylipins From Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same
    4.
    发明申请
    Oxylipins From Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same 审中-公开
    来自长链多不饱和脂肪酸的Oxylipins及其制备和使用方法

    公开(公告)号：US20110178047A1

    公开(公告)日：2011-07-21

    申请号：US12981261

    申请日：2010-12-29

    申请人： Linda Arterburn ,  William Barclay ,  Bindi Dangi ,  James Flatt ,  Jung Lee ,  Mary Van Elswyk

    发明人： Linda Arterburn ,  William Barclay ,  Bindi Dangi ,  James Flatt ,  Jung Lee ,  Mary Van Elswyk

    IPC分类号： A61K31/202 ,  C07C59/42 ,  A61K31/616 ,  A61P29/00 ,  A61P25/28

    CPC分类号： C12P7/6472 ,  C07C59/42 ,  C07D303/38 ,  C12P7/6427

    摘要： Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.

    摘要翻译： 公开了衍生自C22多不饱和脂肪酸的新型oxylipin，本文称为多糖类，以及制备和使用这种oxylipin的方法。 还公开了二十二碳五烯酸（C22：5n-6）（DPAn-6），二十二碳五烯酸（C22：5n-3）（DPAn-3）和二十二碳四烯酸（DTAn-6：C22：4n-6） 作为生产新型oxylipins的底物，以及由此产生的oxylipin。 还公开了在治疗和营养或化妆品应用中使用DPAn-6，DPAn-3，DTAn-6和/或衍生自其的oxylipin，和/或衍生自C22脂肪酸结构的新型二十二烷酸，特别是 作为抗炎或抗神经变性化合物。 本发明还涉及生产长链多不饱和酸（LCPUFA）的油和组合物的新方法，其含有增强和有效量的LCPUFA衍生的草甘膦脂类，尤其是二十二烷酸。

    OXYLIPINS FROM LONG CHAIN POLYUNSATURATED FATTY ACIDS AND METHODS OF MAKING AND USING THE SAME
    5.
    发明申请
    OXYLIPINS FROM LONG CHAIN POLYUNSATURATED FATTY ACIDS AND METHODS OF MAKING AND USING THE SAME 审中-公开
    来自长链多脂脂肪酸的氧化锌及其制备和使用方法

    公开(公告)号：US20110190389A1

    公开(公告)日：2011-08-04

    申请号：US12531344

    申请日：2008-02-20

    申请人： Linda Arterburn ,  William Barclay ,  Bindi Dangi ,  James Flatt ,  Jung Lee ,  Dutt Vinjamoori ,  Mary Van Elswyk

    发明人： Linda Arterburn ,  William Barclay ,  Bindi Dangi ,  James Flatt ,  Jung Lee ,  Dutt Vinjamoori ,  Mary Van Elswyk

    IPC分类号： A61K31/336 ,  A61K31/202 ,  C07C57/03 ,  A61P29/00 ,  C12P7/64 ,  C12P17/02 ,  C07D303/38 ,  A61P25/28

    CPC分类号： A61K31/202 ,  A23L33/12 ,  A61K8/361 ,  A61K31/60 ,  A61K45/06 ,  A61Q19/00 ,  C07C59/42 ,  C07D303/36 ,  C07D303/48 ,  A61K2300/00

    摘要： Disclosed are novel oxylipins, referred to herein as docosanoids and eicosanoids, that are derived from C22 polyunsaturated fatty acids and from C20 polyunsaturated fatty acids, respectively, and methods of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6), docosatrienoic acid (C22:3n-3) (DTrAn-3), docosadienoic acid (C22:2n-6) (DDAn-6), eicosatrienoic acid (C20:3n-3) (ETrAn-3) eicosapentaenoic acid and arachidonic acid as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUF A)-rich oils and compositions that contain enhanced and effective amounts of LCPUF A-derived oxylipins, and particularly, docosanoids.

    摘要翻译： 公开了分别衍生自C22多不饱和脂肪酸和C20多不饱和脂肪酸的新型牛脂素，本文称为二十二烷酸类和类二十烷酸，以及制备和使用这些牛脂素的方法。 还公开了二十二碳五烯酸（C22：5n-6）（DPAn-6），二十二碳五烯酸（C22：5n-3）（DPAn-3）和二十二碳四烯酸（DTAn-6：C22：4n-6） ，二十二碳三烯酸（C22：3n-3）（DTrAn-3），二十二碳烯酸（C22：2n-6）（DDAn-6），二十碳三烯酸（C20：3n-3）（ETrAn-3）二十碳五烯酸和花生四烯酸 作为生产新型oxylipins的底物，以及由此产生的oxylipin。 还公开了在治疗和营养或美容应用中使用DPAn-6，DPAn-3，DTAn-6和/或由其衍生的oxylipin，和/或衍生自C22脂肪酸结构的新型二醇类，特别是作为 抗炎或抗神经变性化合物。 本发明还涉及生产长链多不饱和酸（LCPUF A）的油和组合物的新方法，其含有增强和有效量的LCPUF A衍生的草甘膦脂类，特别是二十二烷酸。

    PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    10.
    发明申请
    PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 有权
    多不饱和脂多糖合成酶系统及其用途

    公开(公告)号：US20080044867A1

    公开(公告)日：2008-02-21

    申请号：US11777278

    申请日：2007-07-12

    申请人： James Metz ,  James Flatt ,  Jerry Kuner ,  William Barclay

    发明人： James Metz ,  James Flatt ,  Jerry Kuner ,  William Barclay

    IPC分类号： C12P7/64 ,  C12N1/20 ,  C12N15/00 ,  C12N15/11 ,  C12N5/04

    CPC分类号： C12N15/52 ,  C07K14/28 ,  C07K14/405 ,  C12N15/8247 ,  C12N15/8273 ,  C12P7/625 ,  C12P7/6427 ,  C12P7/6472

    摘要： The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.

    摘要翻译： 本发明通常涉及从分离自非细菌生物体或衍生自非细菌生物体的多不饱和脂肪酸（PUFA）聚酮化合物合酶（PKS）系统，其同源物，分离的核酸分子和编码这种PUFA PKS的生物活性结构域的重组核酸分子 系统，涉及包含PUFA PKS系统的转基因生物，制备和使用此类体系用于生产感兴趣的生物活性分子的方法，以及鉴定具有这种PUFA PKS系统的新细菌和非细菌微生物的新方法。