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公开(公告)号：US20120190611A1
公开(公告)日：2012-07-26
申请号：US13181687
申请日：2011-07-13
申请人： Liora Braiman-Wiksman , Tamar Tennenbaum , Yuvai Sagiv , Marina Gartsbein , Ephraim Brener , Moshe Ben-Hamo , Liat Hammer
发明人： Liora Braiman-Wiksman , Tamar Tennenbaum , Yuvai Sagiv , Marina Gartsbein , Ephraim Brener , Moshe Ben-Hamo , Liat Hammer
IPC分类号： A61K38/08 , C07K7/06 , C07K7/08 , C07K14/00 , A61P1/00 , A61P17/04 , A61P17/06 , A61P17/08 , A61P11/06 , A61P1/04 , A61K38/10 , A61P17/00
CPC分类号： A61K38/10 , A61K38/08 , A61K38/4866 , C07K14/4703 , C12N9/12 , C12Y207/11013
摘要： The present disclosure provides a method, composition and kit for treatment of inflammatory disease and disorder using PKC isoform modulators. Exemplary modulators include inhibitors of PKC-alpha, PKC-epsilon and PKC-eta, as well as activators of PKC-delta.
摘要翻译： 本公开提供了使用PKC同种型调节剂治疗炎性疾病和病症的方法，组合物和试剂盒。 示例性调节剂包括PKC-α，PKC-ε和PKC-eta的抑制剂，以及PKC-δ的激活剂。
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公开(公告)号：US08349793B2
公开(公告)日：2013-01-08
申请号：US13181687
申请日：2011-07-13
申请人： Liora Braiman-Wiksman , Tamar Tennenbaum , Yuvai Sagiv , Marina Gartsbein , Ephraim Brener , Moshe Ben-Hamo , Liat Hammer
发明人： Liora Braiman-Wiksman , Tamar Tennenbaum , Yuvai Sagiv , Marina Gartsbein , Ephraim Brener , Moshe Ben-Hamo , Liat Hammer
IPC分类号： A61K38/08
CPC分类号： A61K38/10 , A61K38/08 , A61K38/4866 , C07K14/4703 , C12N9/12 , C12Y207/11013
摘要： The present disclosure provides a method, composition and kit for treatment of inflammatory disease and disorder using PKC isoform modulators. Exemplary modulators include inhibitors of PKC-alpha, PKC-epsilon and PKC-eta, as well as activators of PKC-delta.
摘要翻译： 本公开提供了使用PKC同种型调节剂治疗炎性疾病和病症的方法，组合物和试剂盒。 示例性调节剂包括PKC-α，PKC-ε和PKC-eta的抑制剂，以及PKC-δ的激活剂。
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公开(公告)号：US20100310542A1
公开(公告)日：2010-12-09
申请号：US12451625
申请日：2008-07-30
申请人： Tamar Tennenbaum , Liora Braiman-Wiksman , Inessa Solomonik , Ofra Levy-Hacham , Ephraim Brener
发明人： Tamar Tennenbaum , Liora Braiman-Wiksman , Inessa Solomonik , Ofra Levy-Hacham , Ephraim Brener
IPC分类号： A61K38/19 , A61K38/28 , A61P17/02 , A61P29/00 , A61K31/7028
CPC分类号： A61K38/45 , A61K31/7028 , A61K38/08 , A61K38/17 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to compositions and methods for accelerating the healing process of wounds, increasing the closure of skin wounds, and decreasing inflammation at the site of a skin wound. Specifically, the disclosure relates to compositions comprising a delta-PKC activator, an alpha-PKC inhibitor, and a pharmaceutically acceptable carrier that is free of Ca2+ and Mg2+ cations. The disclosure also relates to compositions comprising an insulin or insulin analog and a pharmaceutically acceptable carrier that is free of Ca2+ and Mg2+ cation
摘要翻译： 本公开涉及用于加速伤口愈合过程，增加皮肤伤口闭合以及减少皮肤伤口部位炎症的组合物和方法。 具体地，本公开涉及包含δ-PKC激活剂，α-PKC抑制剂和不含Ca 2+和Mg 2+阳离子的药学上可接受的载体的组合物。 本公开还涉及包含胰岛素或胰岛素类似物和不含Ca 2+和Mg 2+阳离子的药学上可接受的载体的组合物
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4.发明申请VISFATIN THERAPEUTIC AGENTS FOR THE TREATMENT OF ACNE AND OTHER CONDITIONS 审中-公开用于治疗ACNE和其他条件的VISFATIN治疗药物公开(公告)号：US20100215634A1
公开(公告)日：2010-08-26
申请号：US12652798
申请日：2010-01-06
IPC分类号： A61K38/45 , A61K38/16 , A61K31/7052 , A61P17/00
CPC分类号： A61K38/16 , A61K8/64 , A61K8/922 , A61K8/925 , A61K9/0014 , A61K9/06 , A61K31/18 , A61K31/4545 , A61K31/7052 , A61K38/45 , A61Q19/008 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12Y204/02012
摘要： The present disclosure relates to compositions and methods for treating acne and other conditions. In particular, the compositions and methods are useful for the treatment of sebum associated conditions.
摘要翻译： 本公开涉及用于治疗痤疮和其它病症的组合物和方法。 特别地，组合物和方法可用于治疗皮脂相关病症。
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5.发明申请METHOD AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF DIABETIC AND AGED SKIN 有权用于预防和治疗糖尿病和老化皮肤的方法和组合物公开(公告)号：US20110021422A1
公开(公告)日：2011-01-27
申请号：US11990583
申请日：2006-08-29
CPC分类号： A61K38/28 , A61K31/427 , A61K31/445 , A61K38/02 , A61K38/085 , A61K38/1709 , A61K38/191 , A61K38/2006 , A61K38/2026 , A61K38/204 , A61K38/2053 , A61K38/2264 , A61K38/2271 , A61K38/45 , A61K38/4886 , A61K38/57
摘要： Method and compositions are provided for treating or preventing a skin pathology or disorder associated with diabetes and/or aging, by topical administration of at least one agent capable of restoring an impaired physiological condition of the skin associated with said skin pathology or disorder. Examples of such agents include PKC modulating agents, various adipokines and insulin signaling related molecules. In particular, restoration of the subcutaneous adipose tissue can overcome many of the diabetic skin pathologies and aging skin disorders and conditions.
摘要翻译： 提供了通过局部施用至少一种能够恢复与所述皮肤病理学或病症相关的皮肤的生理条件受损的药剂来治疗或预防与糖尿病和/或衰老相关的皮肤病理学或病症的方法和组合物。 这些试剂的实例包括PKC调节剂，各种脂肪因子和胰岛素信号传导相关分子。 特别地，皮下脂肪组织的恢复可以克服许多糖尿病皮肤病理学和老化的皮肤病症和病症。
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6.发明授权Method and compositions for prevention and treatment of diabetic and aged skin 有权预防和治疗糖尿病和老年皮肤的方法和组合物公开(公告)号：US08367606B2
公开(公告)日：2013-02-05
申请号：US11990583
申请日：2006-08-29
IPC分类号： C07K14/00
CPC分类号： A61K38/28 , A61K31/427 , A61K31/445 , A61K38/02 , A61K38/085 , A61K38/1709 , A61K38/191 , A61K38/2006 , A61K38/2026 , A61K38/204 , A61K38/2053 , A61K38/2264 , A61K38/2271 , A61K38/45 , A61K38/4886 , A61K38/57
摘要： Method and compositions are provided for treating or preventing a skin pathology or disorder associated with diabetes and/or aging, by topical administration of at least one agent capable of restoring an impaired physiological condition of the skin associated with said skin pathology or disorder. Examples of such agents include PKC modulating agents, various adipokines and insulin signaling related molecules. In particular, restoration of the subcutaneous adipose tissue can overcome many of the diabetic skin pathologies and aging skin disorders and conditions.
摘要翻译： 提供了通过局部施用至少一种能够恢复与所述皮肤病理学或病症相关的皮肤的生理条件受损的药剂来治疗或预防与糖尿病和/或衰老相关的皮肤病理学或病症的方法和组合物。 这些试剂的实例包括PKC调节剂，各种脂肪因子和胰岛素信号传导相关分子。 特别地，皮下脂肪组织的恢复可以克服许多糖尿病皮肤病理学和老化的皮肤病症和病症。
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公开(公告)号：US07550282B2
公开(公告)日：2009-06-23
申请号：US10534469
申请日：2003-11-18
申请人： Shlomo Margel , Larisa Sheihet , Tamar Tennenbaum
发明人： Shlomo Margel , Larisa Sheihet , Tamar Tennenbaum
CPC分类号： A61L24/106 , A61K31/00 , A61K33/06 , A61K38/45 , A61K38/4833 , A61K45/06 , A61K47/643 , A61K47/6923 , A61K47/6929 , A61L2400/12 , B82Y5/00 , C07B2200/11 , C40B40/04 , A61K2300/00
摘要： Thrombin-conjugated nanoparticles, wherein said nanoparticles comprise one or more organic and/or inorganic compounds and process for preparing the same are provided. The thrombin-conjugated nanoparticles are suitable for use in the preparation of fibrin-based biological sealant.
摘要翻译： 凝血酶缀合的纳米颗粒，其中所述纳米颗粒包含一种或多种有机和/或无机化合物，并提供其制备方法。 凝血酶缀合的纳米颗粒适用于制备基于纤维蛋白的生物密封剂。
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公开(公告)号：US20100129332A1
公开(公告)日：2010-05-27
申请号：US12693968
申请日：2010-01-26
申请人： Tamar Tennenbaum , Sanford Sampson , Toshio Kuroki , Addy Alt , Shlomzion Shen
发明人： Tamar Tennenbaum , Sanford Sampson , Toshio Kuroki , Addy Alt , Shlomzion Shen
CPC分类号： A61K38/45 , A61K38/28 , C12N2799/022 , A61K2300/00
摘要： A pharmaceutical composition and method for inducing or accelerating a healing process of a skin wound are described. The pharmaceutical composition contains, as an active ingredient, a therapeutically effective amount of at least one agent for modulating PKC production and/or activation, and a pharmaceutically acceptable carrier. The method is effected by administering the composition to a wound.
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公开(公告)号：US07402571B2
公开(公告)日：2008-07-22
申请号：US10169801
申请日：2001-07-23
申请人： Tamar Tennenbaum , Sanford Sampson , Toshio Kuroki , Addy Alt , Shlomzlon Shen
发明人： Tamar Tennenbaum , Sanford Sampson , Toshio Kuroki , Addy Alt , Shlomzlon Shen
IPC分类号： A61K31/70
CPC分类号： C12N5/0629 , A61K35/12 , A61K38/28 , A61K38/45 , C12N9/1205 , C12N2501/33 , C12N2501/70 , C12N2510/00 , C12N2799/022
摘要： A pharmaceutical composition and method for inducing or accelerating a healing process of a skin wound are described. The pharmaceutical composition contains, as an active ingredient, a therapeutically effective amount of an agent for either enhancing PKC production and/or enhancing PKC activation; and a pharmaceutically acceptable carrier. The method is effected by administering the composition to a wound.
摘要翻译： 描述了用于诱导或加速皮肤伤口愈合过程的药物组合物和方法。 药物组合物含有治疗有效量的用于增强PKC产生和/或增强PKC活化的药剂作为活性成分; 和药学上可接受的载体。 该方法通过将组合物施用于伤口来实现。
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公开(公告)号：US08324447B2
公开(公告)日：2012-12-04
申请号：US11571343
申请日：2005-06-28
申请人： Ron Goldstein , Tamar Tennenbaum , Varda Deutsch
发明人： Ron Goldstein , Tamar Tennenbaum , Varda Deutsch
IPC分类号： A01K67/00 , A01K67/027 , G01N33/00 , C12N5/00
CPC分类号： C12Q1/025 , A01K67/0271 , A01K2227/105 , A01K2227/106 , A01K2227/30 , A01K2267/03 , C12N2799/022 , G01N33/5088 , G01N2500/00 , G01N2800/52
摘要： The present invention relates to animal model systems comprising a chimera between an avian embryo and a mammalian organism. Specifically, chimeric model systems comprising normal, diseased or genetically transformed mammalian cells and tissues transplanted into avian embryos, and uses thereof for in vivo testing of drugs and therapeutic modalities are disclosed.
摘要翻译： 本发明涉及包含禽类胚胎和哺乳动物生物之间的嵌合体的动物模型系统。 具体地，公开了包含正常，患病或遗传转化的哺乳动物细胞和移植到禽类胚胎中的组织的嵌合模型系统及其用于体内测试药物和治疗方式的用途。
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