专利检索 ap:("Glay Chinea Santiago" OR "Vivian Huerta Galindo" OR "Alejandro Miguel Martin Dunn" OR "Jorge Victor Gavilondo Cowley" OR "Noralvis Fleitas Salazar" OR "Osmany Guirola Cruz" OR "Jeovanis Gil Valdés" OR "Aída Zulueta Morales" OR "Lisset Hermida Cruz" OR "Marta Ayala Avila" OR "Diamilé Gonzáles Roche" OR "Rolando Paez Meireles" OR "Patricia Gabriela Toledo Mayora" OR "Mónica Sarria Núnez" OR "Alexis Musacchio Lasa" OR "Yuliet Mazola Reyes") AND inv:"Yuliet Mazola Reyes" 第 1 页

1.

发明申请
Methods and Proteins for the Prophylactic and/or Therapeutic Treatment of Four Serotypes of Dengue Virus and Other Flaviviruses 审中-公开
标题翻译：用于预防和/或治疗四种登革热病毒和其他黄病毒血清型的方法和蛋白质

公开(公告)号：US20090312190A1

公开(公告)日：2009-12-17

申请号：US12094503

申请日：2006-11-21

申请人： Glay Chinea Santiago , Vivian Huerta Galindo , Alejandro Miguel Martin Dunn , Jorge Victor Gavilondo Cowley , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Jeovanis Gil Valdés , Aída Zulueta Morales , Lisset Hermida Cruz , Marta Ayala Avila , Diamilé Gonzáles Roche , Rolando Paez Meireles , Patricia Gabriela Toledo Mayora , Mónica Sarria Núnez , Alexis Musacchio Lasa , Yuliet Mazola Reyes

发明人： Glay Chinea Santiago , Vivian Huerta Galindo , Alejandro Miguel Martin Dunn , Jorge Victor Gavilondo Cowley , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Jeovanis Gil Valdés , Aída Zulueta Morales , Lisset Hermida Cruz , Marta Ayala Avila , Diamilé Gonzáles Roche , Rolando Paez Meireles , Patricia Gabriela Toledo Mayora , Mónica Sarria Núnez , Alexis Musacchio Lasa , Yuliet Mazola Reyes

IPC分类号： C40B30/02 , A61K39/00 , A61K39/12 , C12N7/00 , C12N5/00 , C40B30/04 , C40B40/10 , C07K16/00 , C07H21/04 , A61K39/02

CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/55566 , C07K2319/02 , C07K2319/21 , C12N2770/24022 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396

摘要： The present invention is related to the field of the pharmaceutical industry, and describes a conserved area on the surface of the E protein that can be used for the development of wide-spectrum antiviral molecules to be employed in the prophylaxis and/or treatment of infections due to Dengue Virus serotypes 1-4 and other flaviviruses. The invention also covers chimeric proteins to be used as vaccines or as a prophylactic or therapeutic treatment against the four serotypes of Dengue Virus and other flaviviruses.

摘要翻译： 本发明涉及制药工业的领域，并且描述了可用于开发用于预防和/或治疗感染的广谱抗病毒分子的E蛋白表面上的保守区域由于登革热病毒血清型1-4和其他黄病毒。本发明还涵盖用作疫苗的嵌合蛋白或针对登革热病毒和其他黄病毒的四种血清型的预防或治疗性治疗。

2.

发明授权
Chemical compounds having antiviral activity against Dengue virus and other Flaviviruses 有权
标题翻译：对登革热病毒和其他黄病毒具有抗病毒活性的化合物

公开(公告)号：US08722742B2

公开(公告)日：2014-05-13

申请号：US12919416

申请日：2009-02-27

申请人： Yuliet Mazola Reyes , Glay Chinea Santiago , Osmany Guirola Cruz , Roberto Vera Alvarez , Vivian Huerta Galindo , Noralvis Fleitas Salazar , Alexis Musacchio Lasa

发明人： Yuliet Mazola Reyes , Glay Chinea Santiago , Osmany Guirola Cruz , Roberto Vera Alvarez , Vivian Huerta Galindo , Noralvis Fleitas Salazar , Alexis Musacchio Lasa

IPC分类号： A01N41/06 , A61K31/18 , A61K31/535 , A61K31/497 , A61K31/4965 , A01N43/40 , A61K31/445

CPC分类号： A61K31/16 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/495 , A61K31/4965 , A61K31/50 , A61K31/506 , A61K31/535 , A61K31/55 , A61K47/54 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395

摘要： Use of chemical compounds obtained in silico for the preparation of pharmaceutical compositions to attenuate or inhibit Dengue virus infection. Particularly, through the interference or the modulation of several stages of viral replication cycle related with the entry of virus into host cells and the assembly of mature progeny virions. The invention also comprises the use of such pharmaceutical compositions for prophylactic and/or therapeutic treatment of infection caused by all four serotypes of Dengue virus and other flaviviruses.

摘要翻译： 使用在硅胶中获得的化学化合物用于制备药物组合物以减轻或抑制登革热病毒感染。特别是通过与病毒进入宿主细胞相关的几个阶段的病毒复制循环的干扰或调节以及成熟后代病毒粒子的组装。本发明还包括使用这种药物组合物预防和/或治疗由登革热病毒和其他黄病毒的四种血清型引起的感染。

3.

发明申请
CHEMICAL COMPOUNDS HAVING ANTIVIRAL ACTIVITY AGAINST DENGUE VIRUS AND OTHER FLAVIVIRUSES 有权
标题翻译：具有针对登革病毒和其他感染病毒的抗病毒活性的化学化合物

公开(公告)号：US20110065686A1

公开(公告)日：2011-03-17

申请号：US12919416

申请日：2009-02-27

申请人： Yuliet Mazola Reyes , Glay Chinea Santiago , Osmany Guirola Cruz , Roberto Vera Alvarez , Vivian Huerta Galindo , Noralvis Fleitas Salazar , Alexis Musacchio Lasa

发明人： Yuliet Mazola Reyes , Glay Chinea Santiago , Osmany Guirola Cruz , Roberto Vera Alvarez , Vivian Huerta Galindo , Noralvis Fleitas Salazar , Alexis Musacchio Lasa

IPC分类号： A61K31/55 , C12Q1/70 , A61K31/18 , A61K31/36 , A61K31/4965 , A61K31/34 , A61K31/38 , A61K31/445 , A61K31/5375 , A61K31/50 , A61K31/505 , A61K31/428 , A61K31/5377 , A61P31/12

CPC分类号： A61K31/16 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/495 , A61K31/4965 , A61K31/50 , A61K31/506 , A61K31/535 , A61K31/55 , A61K47/54 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395

摘要： Use of chemical compounds obtained in silico for the preparation of pharmaceutical compositions to attenuate or inhibit Dengue virus infection. Particularly, through the interference or the modulation of several stages of viral replication cycle related with the entry of virus into host cells and the assembly of mature progeny virions. The invention also comprises the use of such pharmaceutical compositions for prophylactic and/or therapeutic treatment of infection caused by all four serotypes of Dengue virus and other flaviviruses.

摘要翻译： 使用在硅胶中获得的化学化合物用于制备药物组合物以减轻或抑制登革热病毒感染。特别是通过与病毒进入宿主细胞相关的几个阶段的病毒复制循环的干扰或调节以及成熟后代病毒粒子的组装。本发明还包括使用这种药物组合物预防和/或治疗由登革热病毒和其他黄病毒的四种血清型引起的感染。