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公开(公告)号:US20050170344A1
公开(公告)日:2005-08-04
申请号:US10479874
申请日:2002-06-03
申请人: Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke , Mario Lioubin
发明人: Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke , Mario Lioubin
IPC分类号: A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/25 , C12Q1/42 , C12Q1/48 , C12Q1/527 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/567 , G01N33/573 , G01N33/574 , G01N33/68
CPC分类号: G01N33/68 , C12Q1/42 , C12Q1/485 , C12Q1/527 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/5308 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/4739 , G01N2333/705 , G01N2333/82 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要: Human CHD genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of CHD are provided.
摘要翻译: 人CHD基因被鉴定为p53途径的调节剂,因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法,包括筛选调节CHD活性的药剂。