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公开(公告)号：US20050170344A1
公开(公告)日：2005-08-04
申请号：US10479874
申请日：2002-06-03
申请人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke , Mario Lioubin
发明人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke , Mario Lioubin
IPC分类号： A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/25 , C12Q1/42 , C12Q1/48 , C12Q1/527 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/567 , G01N33/573 , G01N33/574 , G01N33/68
CPC分类号： G01N33/68 , C12Q1/42 , C12Q1/485 , C12Q1/527 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/5308 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/4739 , G01N2333/705 , G01N2333/82 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human CHD genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of CHD are provided.
摘要翻译： 人CHD基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节CHD活性的药剂。
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公开(公告)号：US20050227228A1
公开(公告)日：2005-10-13
申请号：US10479871
申请日：2002-06-03
申请人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke
发明人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke
IPC分类号： C12Q1/48 , C12Q1/68 , G01N33/574
CPC分类号： C12Q1/485 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57407 , G01N2333/91215 , G01N2500/02
摘要： Human MAP3K genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MAP3K are provided.
摘要翻译： 人MAP3K基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节MAP3K活性的试剂。
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公开(公告)号：US20060121457A1
公开(公告)日：2006-06-08
申请号：US10480021
申请日：2002-06-02
申请人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke
发明人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57484 , G01N33/5011 , G01N2510/00
摘要： Human GFAT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of GFAT are provided.
摘要翻译： 人GFAT基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节GFAT活性的试剂。
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公开(公告)号：US20060024665A1
公开(公告)日：2006-02-02
申请号：US11241347
申请日：2005-09-30
申请人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke , Rolf Ryseck , Lata Jayaraman , David Bol , Matthew Lorenzi
发明人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke , Rolf Ryseck , Lata Jayaraman , David Bol , Matthew Lorenzi
CPC分类号： G01N33/6872 , C12Q1/42 , G01N33/57496 , G01N2500/00
摘要： Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.
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公开(公告)号：US20060160764A1
公开(公告)日：2006-07-20
申请号：US11378923
申请日：2006-03-17
申请人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke
发明人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke
IPC分类号： A61K48/00 , C12Q1/68 , G01N33/574 , C12Q1/48 , A61K39/395
CPC分类号： G01N33/57423 , C12Q1/42 , C12Q1/485 , C12Q1/527 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/5308 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/4739 , G01N2333/62 , G01N2333/705 , G01N2333/82 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human LIMK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of LIMK are provided.
摘要翻译： 人LIMK基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节LIMK活性的试剂。
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公开(公告)号：US20060024673A1
公开(公告)日：2006-02-02
申请号：US10479873
申请日：2002-06-03
申请人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke
发明人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke
CPC分类号： C07K14/4746 , G01N33/6872 , G01N33/6893 , G01N2500/00 , G01N2510/00
摘要： Human SLC2A genes are identified as modulators of the p53 pathway, and thus as therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SLC2A are provided.
摘要翻译： 人类SLC2A基因被鉴定为p53途径的调节剂，因此被认为是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节SLC2A活性的试剂。
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公开(公告)号：US20050186566A9
公开(公告)日：2005-08-25
申请号：US10164278
申请日：2002-06-05
申请人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke , Rolf Ryseck , Lata Jayaraman , David Bol , Matthew Lorenzi
发明人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke , Rolf Ryseck , Lata Jayaraman , David Bol , Matthew Lorenzi
IPC分类号： C12Q1/68 , G01N33/574 , C12Q1/48
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2333/4739 , G01N2500/10
摘要： Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.
摘要翻译： 人PRMT基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节PRMT活性的试剂。
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公开(公告)号：US20050181481A1
公开(公告)日：2005-08-18
申请号：US11103035
申请日：2005-04-11
申请人： Lori Friedman , Gregory Plowman , Roel Funke , Marcia Belvin , Danxi Li , Stephanie Robertson
发明人： Lori Friedman , Gregory Plowman , Roel Funke , Marcia Belvin , Danxi Li , Stephanie Robertson
IPC分类号： G01N33/50 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/574 , G01N33/68 , C12P21/02 , C07H21/04 , C07K14/705
CPC分类号： G01N33/5008 , A01K2227/706 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/502 , G01N33/5091 , G01N33/574 , G01N33/57419 , G01N33/57449 , G01N33/5748 , G01N33/57496 , G01N33/6872 , G01N2333/82 , G01N2333/914 , G01N2500/10
摘要： Human HADH genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of HADH are provided.
摘要翻译： 人HADH基因被鉴定为p21途径的调节剂，因此是与缺陷型p21功能相关的病症的治疗靶点。 提供了鉴定p21调节剂的方法，包括筛选调节HADH活性的药剂。
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公开(公告)号：US20050186200A1
公开(公告)日：2005-08-25
申请号：US11103068
申请日：2005-04-11
申请人： Lori Friedman , Gregory Plowman , Roel Funke , Marcia Belvin , Danxi Li , Stephanie Robertson
发明人： Lori Friedman , Gregory Plowman , Roel Funke , Marcia Belvin , Danxi Li , Stephanie Robertson
IPC分类号： G01N33/50 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/574 , G01N33/68 , A61K39/395 , A61K38/22
CPC分类号： G01N33/5008 , A01K2227/706 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/502 , G01N33/5091 , G01N33/574 , G01N33/57419 , G01N33/57449 , G01N33/5748 , G01N33/57496 , G01N33/6872 , G01N2333/82 , G01N2333/914 , G01N2500/10
摘要： Human HADH genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of HADH are provided.
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公开(公告)号：US20050112568A1
公开(公告)日：2005-05-26
申请号：US10480068
申请日：2002-06-03
申请人： Lori Friedman , Gregory Plowman , Mercia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke
发明人： Lori Friedman , Gregory Plowman , Mercia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke
IPC分类号： A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/25 , C12Q1/42 , C12Q1/48 , C12Q1/527 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/567 , G01N33/573 , G01N33/574 , G01N33/68
CPC分类号： G01N33/68 , C12Q1/42 , C12Q1/485 , C12Q1/527 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/5308 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/4739 , G01N2333/705 , G01N2333/82 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human DGK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53,comprising screening for agents that modulate the activity of DKG are provided.
摘要翻译： 人DGK基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节DKG活性的试剂。
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