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公开(公告)号：US06380181B1
公开(公告)日：2002-04-30
申请号：US09202955
申请日：1999-09-10
IPC分类号： A61K3143
CPC分类号： C07D501/00 , A61K47/54 , A61K47/547 , C07C235/60 , C07C235/64 , C07C237/22 , C07C245/08 , C07C251/24 , C07C251/80 , C07C251/86 , C07D263/06 , C07D499/00
摘要： Catechol derivatives of general formula (I) in which R1 denotes O-acyl and R2 represents amino acid residues in the 3- and/or 4-position function as siderophores and/or as biological chelating agents for iron in gram-negative bacteria. Conjugates with antibiotics improve penetration into bacterial cells, thereby increasing antibacterial efficacy of the cells.
摘要翻译： 通式（I）的儿茶酚衍生物，其中R1表示O-酰基，R2表示作为铁载体的3-和/或4-位官能团中的氨基酸残基和/或作为革兰氏阴性细菌中铁的生物螯合剂。 与抗生素结合可改善细菌的渗透，从而提高细胞的抗菌功效。
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公开(公告)号：US08940320B2
公开(公告)日：2015-01-27
申请号：US12091925
申请日：2006-10-17
CPC分类号： A61C8/0013 , A61C8/0016
摘要： The invention relates to a dental implant, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterized in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component. The invention also relates to a method for producing a dental implant of this type and to a specific composition, which can be used to produce a coating of this type.
摘要翻译： 本发明涉及一种牙科植入物，其包括至少在植入时与硬组织和/或软组织接触的表面区域中的涂层。 为了确保涂层（二膦酸盐）中包含的活性成分被释放到周围组织中，或者以适当的速度以可控的方式在后者中起作用，其特征在于其包含双膦酸盐，各自的药学上相容的盐或 除了至少一种选自含有支链或直链，取代或未取代的饱和或部分不饱和或不饱和的C 10 -C 30烷基 - ，烯基，烷基芳基 - ，芳基 - ，环烷基 - ，烷基环烷基 - 烷基环芳基羧酸盐，磷酸盐或硫酸盐或其混合物和/或水溶性离子聚合物组分。 本发明还涉及这种类型的牙科植入物的制造方法以及可用于制造这种类型的涂层的特定组合物。
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公开(公告)号：US08642064B2
公开(公告)日：2014-02-04
申请号：US10580549
申请日：2004-11-25
CPC分类号： A61L24/0084 , A61L24/0036 , A61L24/0042 , A61L27/46 , A61L27/56 , A61L27/58 , A61L2430/02
摘要： A method of producing a self-hardening, bioabsorbable composite material, the material produced and its areas of application are described. The method is based on the principal method steps (I) immobilisation of a polymerisation initiator in a microporous pore system of a first partial amount of a bioabsorbable calcium phosphate used in producing the self-hardening, bioabsorbable composite material, (II) immobilisation of a polymerisation activator in the microporous pore system of a second partial amount of the bioabsorbable calcium phosphate used in producing the self-hardening, bioabsorbable composite material and (III) homogeneous mixing of the components according to (I) and (II) with a liquid or paste-form, multi-functional monomer capable of forming a biocompatible, bioabsorbable polymer network or a corresponding monomer mixture and, optionally, with further constituents which modify the properties of the monomer or monomer mixture. The described self-hardening, bioabsorbable composite materials can be used as bone adhesives for the fixing of bone fractures, as shaped pieces of standardised dimensions and as implants that are individual to a patient in the context of regenerative bone healing in humans and animals.
摘要翻译： 描述了生产自硬化生物可吸收复合材料的方法，所生产的材料及其应用领域。 该方法基于主要方法步骤（I）将聚合引发剂固定在用于生产自硬化生物可吸收复合材料的第一部分量的生物可吸收磷酸钙的微孔孔系统中，（II）固定化 用于生产自硬化生物可吸收复合材料的第二部分量的生物可吸收磷酸钙的微孔孔体系中的聚合活化剂和（III）根据（I）和（II）的组分与液体或 糊状的多功能单体，其能够形成生物相容的生物可吸收的聚合物网络或相应的单体混合物，并且任选地具有改变单体或单体混合物的性质的其它组分。 所描述的自硬化生物可吸收复合材料可用作固定骨折的骨粘合剂，作为标准尺寸的成形件，以及在人和动物的再生骨愈合背景下对患者个体的植入物。
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公开(公告)号：US20110053113A1
公开(公告)日：2011-03-03
申请号：US12919678
申请日：2009-02-23
IPC分类号： A61C13/00 , B05D1/02 , B05D1/18 , A61K31/366
CPC分类号： A61L27/34 , A61K31/366 , A61K47/61
摘要： What is described is an implant that comprises a coating, at least in areas, in the implanted state in the surface areas that are at least directly in contact with skin and/or soft tissue. The implant is preferably characterized in that the coating comprises both a statin, such as simvastatin, in the hydrolyzed or unhydrolyzed form, or pharmaceutically compatible salts thereof, as well as at least one other component selected from the group consisting of branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl, alkenyl, alkylaryl, aryl, cycloalkyl, alkylcycloalkyl, alkylcycloaryl amines or mixtures thereof and/or at least one water-soluble ionic polymer component. A method for production such an implant is also described as well as a composition that can be used in such a method.
摘要翻译： 描述的是植入物，其至少在表面区域中至少在植入状态的区域中至少直接与皮肤和/或软组织接触的涂层。 优选的植入物的特征在于，所述涂层包含水解或未水解形式的他汀类药物，例如辛伐他汀，或其药学上相容的盐，以及至少一种选自支链或直链，取代的其它组分 或未取代的饱和或部分不饱和的C 10 -C 30烷基，烯基，烷基芳基，芳基，环烷基，烷基环烷基，烷基环芳基胺或其混合物和/或至少一种水溶性离子聚合物组分。 还描述了用于生产这种植入物的方法以及可以在这种方法中使用的组合物。
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公开(公告)号：US07345024B2
公开(公告)日：2008-03-18
申请号：US10600556
申请日：2003-06-20
CPC分类号： A61K9/0024 , A61K31/192 , A61K31/405 , A61K31/573 , A61K31/65 , A61K31/655 , A61K31/7036 , A61K45/06 , A61K2300/00
摘要： The invention relates to hardly soluble antiphlogistic salts and antiphlogistic-antibiotic pharmaceutical preparations and their use. The hardly water soluble antiphlogistic antibiotics salts have as their cationic component one of the antibiotics gentamicin, clindamycin, neomycin, streptomycin, tetracycline, doxicyline, oxytetracycline and rolitetracycline and as their anionic component one of the antiphlogistics ibuprofen, naproxen, indomethacin, dexamethasone-21-phosphate, dexamethasone-21-sulfate, triamcinolone-21-phosphate and triamcinolone-21-sulfate. The antiphlogistic antibiotics salts are used in pharmaceutical preparations as controlled-release antibiotic/antibiotics drugs. The invention describes antiphlogistic-antibiotic pharmaceutical preparations for which mixtures in the solid state of aggregation are used, which are composed of an easily water soluble salt of gentamicin, clindamycin, neomycin, streptomycin, tetracycline, doxicycline, oxytetracycline and/or rolitetracycline and at least one easily water soluble salt of ibuprofen, naproxen, indomethacin, dexamethasone-21-phosphate, dexamethasone-21-sulfate, triamcinolone-21-phosphate and/or triamcinolone-21-sulfate and at least one inorganic and/or organic pharmaceutical adjuvant and which are used as permanent or temporary implants in the form of tablets and/or molded bodies.
摘要翻译： 本发明涉及难溶性消炎盐和消炎抗生素药物制剂及其应用。 难溶水性消炎抗生素盐作为其阳离子成分，其中一种抗生素是庆大霉素，克林霉素，新霉素，链霉素，四环素，多西环素，土霉素和四环素，作为其阴离子组分之一布洛芬，萘普生，吲哚美辛，地塞米松21- 磷酸盐，地塞米松21-硫酸盐，曲安西龙21-磷酸盐和曲安奈德21-硫酸盐。 消炎抗生素盐用作药物制剂作为控释抗生素/抗生素药物。 本发明描述了使用固体状态的混合物的消炎抗生素药物制剂，其由庆大霉素，克林霉素，新霉素，链霉素，四环素，多西环素，土霉素和/或四环素的易水溶性盐组成，至少 布洛芬，萘普生，吲哚美辛，地塞米松21-磷酸盐，地塞米松21-硫酸盐，曲安西龙21-磷酸盐和/或曲安奈德21-硫酸盐和至少一种无机和/或有机药物佐剂的一种易溶于水的盐， 用作片剂和/或成型体形式的永久或临时植入物。
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公开(公告)号：US20080058733A1
公开(公告)日：2008-03-06
申请号：US11931895
申请日：2007-10-31
CPC分类号： A61L31/16 , A61K9/0019 , A61K9/0024 , A61K31/00 , A61K31/7036 , A61K47/10 , A61K47/32 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/406 , A61L2300/45 , A61L2300/602 , A61L2300/606 , C08L33/04
摘要： The present invention relates to an antibiotic(s)-polymer combination, which under physiological conditions guarantees the continuous release of antibiotics over a period of several days and can be used in human and veterinary medicine. The invented antibiotic(s)-polymer combination is wherein in a homogeneous polymer mixture, consisting of one or more hydrophobic polymers from the groups of poly(methacrylic acid esters), the poly(acrylic acid esters) and the poly(methacrylic acid ester-co-acrylic acid esters) and one or more hydrophilic polymers from the group of polyethers, one or more slightly water-soluble antibiotics from the groups of aminoglycoside antibiotics, the lincosamide antibiotics, the tetracycline antibiotics and quinolone antibiotics, possibly an easily water-soluble antibiotic from the groups of aminoglycoside antibiotics, the lincosamide antibiotics and the tetracycline antibiotics, and possibly one or more organic adjuvants are suspended, and that this suspension forms a composite.
摘要翻译： 本发明涉及抗生素 - 聚合物组合，其在生理条件下保证抗生素在数天内持续释放并可用于人和兽医学。 本发明的抗生素聚合物组合是在由聚（甲基丙烯酸酯），聚（丙烯酸酯）和聚（甲基丙烯酸酯 - 酯）组成的一组或多种疏水聚合物组成的均匀聚合物混合物中， 共聚丙烯酸酯）和一种或多种来自聚醚组的亲水性聚合物，一种或多种来自氨基糖苷类抗生素的轻微水溶性抗生素，氯胺素抗生素，四环素抗生素和喹诺酮类抗生素，可能是易溶于水的 来自氨基糖苷类抗生素组的抗生素，林可素类抗生素和四环素抗生素，以及可能的一种或多种有机助剂悬浮，并且该悬浮液形成复合物。
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7.发明授权Magnetic nanoparticles having biochemical activity, method for the production thereof and their use 失效具有生化活性的磁性纳米颗粒，其生产方法及其用途公开(公告)号：US06767635B1
公开(公告)日：2004-07-27
申请号：US10088437
申请日：2002-05-24
申请人： Michael Bahr , Dimitri Berkov , Norbert Buske , Joachim Clement , Peter Görnert , Klaus Höffken , Kay-Oliver Kliche , Thomas Kober , Matthias Schnabelrauch , Sebastian Vogt , Kerstin Wagner , Christian Gansau
发明人： Michael Bahr , Dimitri Berkov , Norbert Buske , Joachim Clement , Peter Görnert , Klaus Höffken , Kay-Oliver Kliche , Thomas Kober , Matthias Schnabelrauch , Sebastian Vogt , Kerstin Wagner , Christian Gansau
IPC分类号： B32B516
CPC分类号： B82Y5/00 , A61K47/6923 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2998
摘要： The invention relates to magnetic nanoparticles, their production, and their use. The object of the invention is to provide nanoparticles capable of specifically forming bonds to intracellular biomacromolecules even in the intracellular region of cells, so that separation is possible by exposure to an exterior magnetic field. This is accomplished by means of magnetic nanoparticles having biochemical activity, consisting of a magnetic core particle and an envelope layer fixed to the core particle, and including a compound of general formula M-S-L-Z (I), the linkage sites between S and L and L and Z having covalently bound functional groups, wherein M represents said magnetic core particle; S represents a biocompatible substrate fixed to M; L represents a linker group; and Z represents a group comprised of nucleic acids, peptides or proteins or derivatives thereof, which group has at least one structure capable of specifically binding to a binding domain of an intracellular biomacromolecule.
摘要翻译： 本发明涉及磁性纳米颗粒及其制备及其用途。本发明的目的是提供即使在细胞的细胞内区域也能特异性地形成与细胞内生物大分子的结合的纳米粒子，从而可以通过暴露于外部磁性 这是通过具有生物化学活性的磁性纳米颗粒来实现的，该磁性纳米颗粒由固定在核心颗粒上的磁芯颗粒和包膜层组成，并且包括通式MSLZ（I）的化合物，S和L之间的连接位点和 L和Z具有共价结合的官能团，其中M表示所述磁芯颗粒; S表示固定于M的生物相容性底物; L表示连接基团; Z表示由核酸，肽或蛋白质或其衍生物组成的组，该基团具有至少一种能够特异性结合细胞内生物大分子的结合结构域的结构。
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公开(公告)号：US09050391B2
公开(公告)日：2015-06-09
申请号：US12091902
申请日：2006-10-17
CPC分类号： A61L27/32 , A61L27/54 , A61L2300/112 , A61L2300/606
摘要： The invention relates to an implant, e.g. a stent, bone replacement material, a prosthesis, a scaffold or similar, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterized in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component. The invention also relates to a method for producing an implant of this type and to a specific composition, which can be used to produce a coating of this type.
摘要翻译： 本发明涉及植入物，例如 支架，骨置换材料，假体，支架或类似物，其包括至少在植入时与硬组织和/或软组织接触的那些表面区域中的涂层。 为了确保涂层（二膦酸盐）中包含的活性成分被释放到周围组织中，或者以适当的速度以可控的方式在后者中起作用，其特征在于其包含双膦酸盐，各自的药学上相容的盐或 除了至少一种选自含有支链或直链，取代或未取代的饱和或部分不饱和或不饱和的C 10 -C 30烷基 - ，烯基，烷基芳基 - ，芳基 - ，环烷基 - ，烷基环烷基 - 烷基环芳基羧酸盐，磷酸盐或硫酸盐或其混合物和/或水溶性离子聚合物组分。 本发明还涉及一种用于生产这种类型的植入物和特定组合物的方法，其可用于制备这种类型的涂层。
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公开(公告)号：US08414958B2
公开(公告)日：2013-04-09
申请号：US12919678
申请日：2009-02-23
IPC分类号： A61L33/00
CPC分类号： A61L27/34 , A61K31/366 , A61K47/61
摘要： What is described is an implant that comprises a coating, at least in areas, in the implanted state in the surface areas that are at least directly in contact with skin and/or soft tissue. The implant is preferably characterized in that the coating comprises both a statin, such as simvastatin, in the hydrolyzed or unhydrolyzed form, or pharmaceutically compatible salts thereof, as well as at least one other component selected from the group consisting of branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl, alkenyl, alkylaryl, aryl, cycloalkyl, alkylcycloalkyl, alkylcycloaryl amines or mixtures thereof and/or at least one water-soluble ionic polymer component. A method for production such an implant is also described as well as a composition that can be used in such a method.
摘要翻译： 描述的是植入物，其至少在表面区域中至少在植入状态的区域中至少直接与皮肤和/或软组织接触的涂层。 优选的植入物的特征在于，所述涂层包含水解或未水解形式的他汀类药物，例如辛伐他汀，或其药学上相容的盐，以及至少一种选自支链或直链，取代的其它组分 或未取代的饱和或部分不饱和的C 10 -C 30烷基，烯基，烷基芳基，芳基，环烷基，烷基环烷基，烷基环芳基胺或其混合物和/或至少一种水溶性离子聚合物组分。 还描述了用于生产这种植入物的方法以及可以在这种方法中使用的组合物。
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公开(公告)号：US20070254011A1
公开(公告)日：2007-11-01
申请号：US10580549
申请日：2004-11-25
CPC分类号： A61L24/0084 , A61L24/0036 , A61L24/0042 , A61L27/46 , A61L27/56 , A61L27/58 , A61L2430/02
摘要： A method of producing a self-hardening, bioabsorbable composite material, the material produced and its areas of application are described. The method is based on the principal method steps (I) immobilisation of a polymerisation initiator in a microporous pore system of a first partial amount of a bioabsorbable calcium phosphate used in producing the self-hardening, bioabsorbable composite material, (II) immobilisation of a polymerisation activator in the microporous pore system of a second partial amount of the bioabsorbable calcium phosphate used in producing the self-hardening, bioabsorbable composite material and (III) homogeneous mixing of the components according to (I) and (II) with a liquid or paste-form, multi-functional monomer capable of forming a biocompatible, bioabsorbable polymer network or a corresponding monomer mixture and, optionally, with further constituents which modify the properties of the monomer or monomer mixture. The described self-hardening, bioabsorbable composite materials can be used as bone adhesives for the fixing of bone fractures, as shaped pieces of standardised dimensions and as implants that are individual to a patient in the context of regenerative bone healing in humans and animals.
摘要翻译： 描述了生产自硬化生物可吸收复合材料的方法，所生产的材料及其应用领域。 该方法基于主要方法步骤（I）将聚合引发剂固定在用于生产自硬化生物可吸收复合材料的第一部分量的生物可吸收磷酸钙的微孔孔系统中，（II）固定化 用于生产自硬化生物可吸收复合材料的第二部分量的生物可吸收磷酸钙的微孔孔体系中的聚合活化剂和（III）根据（I）和（II）的组分与液体或 糊状的多功能单体，其能够形成生物相容的生物可吸收的聚合物网络或相应的单体混合物，并且任选地具有改变单体或单体混合物的性质的其它组分。 所描述的自硬化生物可吸收复合材料可用作固定骨折的骨粘合剂，作为标准尺寸的成形件，以及在人和动物的再生骨愈合背景下对患者个体的植入物。
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