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    Cooling Compounds
    5.
    发明申请
    Cooling Compounds 审中-公开
    冷却化合物

    公开(公告)号：US20080319055A1

    公开(公告)日：2008-12-25

    申请号：US11884980

    申请日：2006-03-15

    申请人： Lucienne Cole ,  Stefan Michael Furrer ,  Christophe C. Galopin ,  Pablo Victor Krawec ,  Jay Patrick Slack

    发明人： Lucienne Cole ,  Stefan Michael Furrer ,  Christophe C. Galopin ,  Pablo Victor Krawec ,  Jay Patrick Slack

    IPC分类号： A61K31/166 ,  A61K31/277 ,  A61K31/235 ,  A61K31/357 ,  C07C229/54 ,  C07C255/58 ,  C07C233/67 ,  C07D317/68

    CPC分类号： C07C233/65 ,  A23L27/204 ,  A23L27/205 ,  A24B15/301 ,  A24B15/36 ,  A24B15/385 ,  A61K8/42 ,  A61K8/4973 ,  A61K2800/244 ,  A61Q11/00 ,  C07C255/57 ,  C07C2601/14 ,  C07C2602/42 ,  C07D317/48

    摘要： A method of providing a cooling sensation to the skin or the mucous membranes of the body by applying thereto a compound of Formula I in which X is H or (CH2)n—R, n is 0 or 1, Y and Z are selected independently from the group consisting of H, OH, phenyl, C1-C4 straight or branched alkyl, or, a C1-C4 straight or branched alkoxy, or X and Y form together a bivalent radical selected from the group consisting of —O—CH2—O—, —N═CH—O— and —N═CH—S— which forms together with the carbon atoms to which they are attached a 5-membered ring; and R is a group with non-bonding electrons, R1 is H or C1-C5 branched alkyl, R2 and R3 are C1-C4 branched alkyls, or R2 and R3 taken together form a monocyclic, bicyclic or tricyclic radical of up to 10 carbons provided that R1, R2 and R3 together comprise at least 6 carbons. The compounds may be incorporated into products such as dentifrices, foodstuffs, confectionery, beverages, and cosmetic and medicinal preparations.

    摘要翻译： 通过向其中施加X为H或（CH 2）n R，n为0或1的式I化合物，其中Y和Z独立地选自其中的任意一种，可以向身体的皮肤或粘膜提供冷却感觉的方法， 由H，OH，苯基，C 1 -C 4直链或支链烷基或C 1 -C 4直链或支链烷氧基组成的基团，或X和Y一起形成选自-O-CH 2 -O- ，-N-CH-O-和-N-CH-S-与它们所连接的碳原子一起形成5元环; 并且R是具有非键合电子的基团，R 1是H或C 1 -C 5支链烷基，R 2和R 3是C 1 -C 4支链烷基，或者R 2和R 3一起形成多至10个碳的单环，双环或三环基团 条件是R1，R2和R3一起包含至少6个碳。 这些化合物可以掺入诸如洁牙剂，食品，糖果，饮料，化妆品和药物制剂的产品中。