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    Cooling compounds
    1.
    发明授权
    Cooling compounds 有权
    冷却化合物

    公开(公告)号：US07959958B2

    公开(公告)日：2011-06-14

    申请号：US12137928

    申请日：2008-06-12

    申请人： Stefan Michael Furrer ,  Gregory Lee Yep ,  Eric Flamme

    发明人： Stefan Michael Furrer ,  Gregory Lee Yep ,  Eric Flamme

    IPC分类号： A61K36/534 ,  A61K31/195 ,  A61K31/19

    CPC分类号： A61Q11/00 ,  A61K8/37 ,  A61K8/41 ,  A61K8/42 ,  A61K8/44 ,  A61K2800/244 ,  C07C69/38 ,  C07C69/40 ,  C07C229/12 ,  C07C2602/42

    摘要： A cooling composition comprising at least one compound of the Formula I in which R is selected from the group of moieties consisting of (CH2)nCOOR″; (CH2)nCONMe2; (CH2)nOR″; and CHNH2CH3; where n is 1-3 and R″ is independently selected from hydrogen, methyl and ethyl; and R′ is selected from the group consisting of the moieties fenchyl, D-bornyl, L-bornyl, exo-norbornyl, 2-methylisobornyl, 2-ethylfenchyl, 2-methylbornyl, cis-pinan-2-yl, verbanyl and isobornyl. The compositions are useful in providing cooling sensations to the skin or mucous membranes of the body.

    摘要翻译： 一种冷却组合物，其包含至少一种式I化合物，其中R选自由（CH 2）n COOR“组成的部分; （CH2）nCONMe2; （CH2）nOR“; 和CHNH 2 CH 3; 其中n为1-3，R“独立地选自氢，甲基和乙基; 并且R'选自萜烯基，D-冰片基，L-冰片基，外降冰片基，2-甲基异山梨醇基，2-乙基枞基，2-甲基戊酰基，顺式 - 蒎烷-2-基，缬氨酰基和异冰片基。 该组合物可用于向身体的皮肤或粘膜提供冷却感。

    Benzimidazole As Cooling Compounds
    3.
    发明申请
    Benzimidazole As Cooling Compounds 审中-公开
    苯并咪唑作为冷却剂

    公开(公告)号：US20090312384A1

    公开(公告)日：2009-12-17

    申请号：US12307835

    申请日：2007-07-16

    申请人： Stefan Michael Furrer ,  Karen Ann Bell ,  Christophe C. Galopin ,  Thomas Scott McCluskey ,  Jay Patrick Slack

    发明人： Stefan Michael Furrer ,  Karen Ann Bell ,  Christophe C. Galopin ,  Thomas Scott McCluskey ,  Jay Patrick Slack

    IPC分类号： A61K31/4184 ,  C07D235/12

    CPC分类号： A61K8/4946 ,  A61K8/69 ,  A61K2800/244 ,  A61Q11/00 ,  A61Q19/00

    摘要： A method of providing a cooling sensation to the skin or mucous membranes of the mouth by applying thereto a quantity of at least one chemical compound sufficient to cause a desirable degree of cooling sensation, the chemical compound comprising a compound of formula I: in which R1, R2 are independently in either the meta- or para-position and independently comprise at least one of hydrogen, halide, C1-C3 alkyl (linear or branched), halide, C1-C3 alkoxy, nitro, nitrile, amide or ester; R3 comprises at least one of C1-C5 alkyl or C1-C5 alkenyl groups (linear or branched), R4 comprises at least one of hydrogen, C1-C3 alkyl (linear or branched), or a halide. The cooling effect provided is in some instances superior to that achievable by any of the known commercial cooling agents.

    摘要翻译： 通过向其施加一定量的至少一种足以引起所需程度的冷却感觉的化合物，向口腔的皮肤或粘膜提供冷却感觉的方法，所述化合物包含式I化合物：其中R1 卤素，C 1 -C 3烷基（直链或支链），卤素，C 1 -C 3烷氧基，硝基，腈，酰胺或酯中的至少一种; R 3独立地为间位或对位， R 3包括C 1 -C 5烷基或C 1 -C 5烯基（直链或支链）中的至少一个，R 4包括氢，C 1 -C 3烷基（直链或支链）或卤化物中的至少一种。 在某些情况下，提供的冷却效果优于任何已知的商业冷却剂可实现的。

    Cooling compounds
    4.
    发明申请
    Cooling compounds 审中-公开
    冷却化合物

    公开(公告)号：US20090105237A1

    公开(公告)日：2009-04-23

    申请号：US11920813

    申请日：2006-05-24

    申请人： Karen Ann Bell ,  Stefan Michael Furrer ,  Christophe C. Galopin ,  Pablo Victor Krawec ,  Jay Patrick Slack

    发明人： Karen Ann Bell ,  Stefan Michael Furrer ,  Christophe C. Galopin ,  Pablo Victor Krawec ,  Jay Patrick Slack

    IPC分类号： A61K31/167 ,  A61K31/4965 ,  A61K31/357 ,  C07D295/14 ,  C07C229/40 ,  C07C237/24 ,  A61P17/00 ,  C07C229/36 ,  C07D317/30 ,  A61K31/216 ,  A61K31/5375

    CPC分类号： C07C237/42 ,  A23G3/34 ,  A23G4/06 ,  A23L27/204 ,  A61K8/42 ,  A61K8/494 ,  A61K2800/244 ,  A61Q11/00 ,  A61Q19/00 ,  C07C2601/14 ,  C07D295/192

    摘要： A method of conferring a cooling effect on the skin or mucous membranes by applying thereto at least one compound of the Formula I: (a) wherein B is selected from H, CH3, C2H5, OCH3, OC2H5; and OH; and (b) wherein A is a moiety of the formula —CO-D, wherein D is selected from the following moieties: (i) —NR1R2, wherein R1 and R2 are independently selected from H and C1-C8 straight or branched-chain aliphatic, alkoxyalkyl, hydroxyalkyl, araliphatic and cycloalkyl groups, or R1 and R2 together with the nitrogen atom to which they are attached form part of an optionally-substituted, five- or six-membered heterocyclic ring; (ii) —NHCH2COOCH2CH3, —NHCH2CONH2, —NHCH2CH2OCH3, —NHCH2CH2OH, —NHCH2CH(OH)CH2OH and (iii) a moiety selected from the group consisting of: The compounds are useful for providing cooling effects in a variety of products, such as foodstuffs, confectionery, tobacco products, beverages, cosmetics, dentifrices, medicinal preparations, mouthwashes and toiletries.

    摘要翻译： 通过施用至少一种式I的化合物，赋予皮肤或粘膜冷却效果的方法：（a）其中B选自H，CH 3，C 2 H 5，OCH 3，OC 2 H 5; 和OH; 和（b）其中A是式-CO-D的部分，其中D选自以下部分：（i）-NR 1 R 2，其中R 1和R 2独立地选自H和C 1 -C 8直链或支链 脂族，烷氧基烷基，羟基烷基，芳脂族和环烷基，或者R1和R2与它们所连接的氮原子一起形成任选取代的五元或六元杂环的一部分; （ii）-NHCH 2 COOCH 2 CH 3，-NHCH 2 CONH 2，-NHCH 2 CH 2 OCH 3，-NHCH 2 CH 2 OH，-NHCH 2 CH（OH）CH 2 OH和（iii）选自以下的部分：该化合物可用于在各种产品中提供冷却效果， 食品，糖果，烟草制品，饮料，化妆品，洁牙剂，药用制剂，漱口剂和洗浴用品。

    Amide addition reaction
    10.
    发明授权
    Amide addition reaction 有权
    酰胺加成反应

    公开(公告)号：US07880011B2

    公开(公告)日：2011-02-01

    申请号：US12173447

    申请日：2008-07-15

    申请人： Stefan Michael Furrer ,  David C. Bom ,  David Max Dastrup ,  Ioana Maria Ungureanu

    发明人： Stefan Michael Furrer ,  David C. Bom ,  David Max Dastrup ,  Ioana Maria Ungureanu

    IPC分类号： C07D213/40

    CPC分类号： C07D213/127

    摘要： A method of making a compound of formula II comprising the reaction of a compound of formula RCONH2 with a compound of formula III R being a moiety having between 1 and 15 carbon atoms and optionally from 1 to 5 heteroatoms independently selected from oxygen, nitrogen and sulfur, and X and Y being independently selected front the group consisting of H, methyl, ethyl, OMe, OEt, and mixtures thereof; the reaction being performed in a solvent in the presence of a base. The method is useful for the inexpensive manufacture of certain commercially-valuable compounds, including some that have desirable cooling properties.

    摘要翻译： 制备式II化合物的方法，其包括式RCONH 2化合物与式III化合物的反应，R是具有1至15个碳原子和任选地1至5个独立地选自氧，氮和硫的杂原子的部分 X和Y独立地选自H，甲基，乙基，OMe，OEt及其混合物组成的组; 反应在溶剂中在碱的存在下进行。 该方法对于廉价制造某些商业上有价值的化合物是有用的，包括一些具有期望的冷却性质的化合物。