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公开(公告)号：US20110251073A1
公开(公告)日：2011-10-13
申请号：US12996538
申请日：2009-06-03
CPC分类号： C12N9/54 , A23K20/189 , C11D3/386 , C11D3/38681 , C11D11/0017 , C12N9/52 , C12Y304/21062
摘要： The present invention provides methods for protein engineering. Specifically, the invention provides methods utilizing site evaluation libraries to design libraries that optimize two or more properties of a protein. The present invention also provides variant subtilisins suitable for various uses.
摘要翻译： 本发明提供蛋白质工程方法。 具体地说，本发明提供了使用位点评估库来设计优化蛋白质的两个或多个性质的文库的方法。 本发明还提供适用于各种用途的变体枯草杆菌蛋白酶。
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公开(公告)号：US20120003718A1
公开(公告)日：2012-01-05
申请号：US13128854
申请日：2009-11-10
IPC分类号： C12N9/54 , C12N15/75 , C12S11/00 , B08B3/00 , C11D3/60 , C12N1/21 , D06L1/16 , C12N15/57 , C12S9/00
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38663 , C11D3/38681 , C12N15/52 , C12Y304/21062
摘要： The present invention provides engineered protease variants. In particular, the protease variants comprise combinable mutations at selected surface positions that affect the charge and/or hydrophobicity of the enzyme to enhance at least one desired property of the resulting variant enzyme in a chosen application. Compositions comprising the protease variants, and methods for using the same are also provided.
摘要翻译： 本发明提供工程蛋白酶变体。 特别地，蛋白酶变体在选定的表面位置包含影响酶的电荷和/或疏水性的可组合突变，以在所选择的应用中增强所得变体酶的至少一种所需性质。 还提供了包含蛋白酶变体的组合物及其使用方法。
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公开(公告)号：US20100192985A1
公开(公告)日：2010-08-05
申请号：US12616097
申请日：2009-11-10
申请人： Wolfgang Aehle , Luis G. Cascao-Pereira , David A. Estell , Frits Goedegebuur , James T. Kellis, JR. , Ayrookaran J. Poulose , Brian F. Schmidt
发明人： Wolfgang Aehle , Luis G. Cascao-Pereira , David A. Estell , Frits Goedegebuur , James T. Kellis, JR. , Ayrookaran J. Poulose , Brian F. Schmidt
CPC分类号： C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38636 , C11D3/38645 , C11D3/38654 , C12N9/50 , C12N9/54 , C12Y304/21062
摘要： The present invention provides methods for protein engineering and serine protease variants produced there from. Specifically, the present invention provides serine protease variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants.
摘要翻译： 本发明提供蛋白质工程方法和丝氨酸蛋白酶变体。 具体地，本发明提供了与参考丝氨酸蛋白酶相比具有一个或多个取代的丝氨酸蛋白酶变体。 此外，本发明提供包含这些丝氨酸蛋白酶变体的组合物。 在一些实施方案中，本发明提供了包含这些丝氨酸蛋白酶变体中的至少一种的清洁组合物。
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公开(公告)号：US20140154782A1
公开(公告)日：2014-06-05
申请号：US14115801
申请日：2012-05-04
申请人： Neelam S. Amin , Katherine Augustyn , Joshua R. Basler , Luis G. Cascao-Pereira , Katherine D. Collier , Edward M. Concar , David A. Estell , James T. Kellis, JR. , Euan John Magennis , Alexander Pisarchik , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
发明人： Neelam S. Amin , Katherine Augustyn , Joshua R. Basler , Luis G. Cascao-Pereira , Katherine D. Collier , Edward M. Concar , David A. Estell , James T. Kellis, JR. , Euan John Magennis , Alexander Pisarchik , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
摘要： The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides serine protease variants, more specifically subtilisin variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants, more specifically subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants, more specifically subtilisin variants.
摘要翻译： 本发明提供丝氨酸蛋白酶变体，更具体地是从其产生的枯草杆菌蛋白酶变体。 具体而言，与参考丝氨酸蛋白酶相比，本发明提供丝氨酸蛋白酶变体，更具体地具有一个或多个取代的枯草杆菌蛋白酶变体。 此外，本发明提供包含这些丝氨酸蛋白酶变体，更具体地枯草杆菌蛋白酶变体的组合物。 在一些实施方案中，本发明提供了包含这些丝氨酸蛋白酶变体，更具体地枯草杆菌蛋白酶变体中的至少一种的清洁组合物。
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公开(公告)号：US20110256609A1
公开(公告)日：2011-10-20
申请号：US12996564
申请日：2009-06-03
IPC分类号： C12N9/54 , C11D3/60 , C12N15/63 , B08B1/00 , C12S11/00 , C12S9/00 , D06L1/00 , C07H21/04 , C12N1/00
CPC分类号： C12N9/54 , A23K20/189 , C11D3/386 , C11D3/38681 , C11D11/0017 , C12N9/52 , C12Y304/21062
摘要： The present invention provides variant subtilisins and compositions comprising at least one variant subtilisin set forth herein, as well as methods for using these variants and compositions. In some embodiments, the present invention provides variant subtilisins suitable for laundry cleaning applications.
摘要翻译： 本发明提供了变体枯草杆菌蛋白酶和包含本文所述的至少一种变体枯草杆菌蛋白酶的组合物，以及使用这些变体和组合物的方法。 在一些实施方案中，本发明提供适用于洗衣清洁应用的变体枯草杆菌蛋白酶。
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公开(公告)号：US20100152087A1
公开(公告)日：2010-06-17
申请号：US12616106
申请日：2009-11-10
申请人： Luis G. Cascao-Pereira , David A. Estell , Frits Goedegebuur , James T. Kellis, JR. , Ayrookaran J. Poulise
发明人： Luis G. Cascao-Pereira , David A. Estell , Frits Goedegebuur , James T. Kellis, JR. , Ayrookaran J. Poulise
CPC分类号： C11D3/386 , C11D3/38681 , C11D17/0086
摘要： The present invention provides a subtilisin variant that is particularly well suited to cleaning applications. In particular, the present invention provides a Bacillus sp. subtilisin variant and cleaning compositions comprising this variant.
摘要翻译： 本发明提供了特别适合于清洁应用的枯草杆菌蛋白酶变体。 特别地，本发明提供芽孢杆菌属 枯草溶菌素变体和包含该变体的清洁组合物。
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公开(公告)号：US20090252828A1
公开(公告)日：2009-10-08
申请号：US12263886
申请日：2008-11-03
申请人： Luis G. Cascao-Pereira , James T. Kellis, JR. , Bradley A. Paulson , Scott D. Power , Sandra W. Ramer , Vivek Sharma , Andrew Shaw , Jayarama K. Shetty , Donald E. Ward
发明人： Luis G. Cascao-Pereira , James T. Kellis, JR. , Bradley A. Paulson , Scott D. Power , Sandra W. Ramer , Vivek Sharma , Andrew Shaw , Jayarama K. Shetty , Donald E. Ward
CPC分类号： C11D3/38681 , C11D3/386 , C12N9/2417 , D06M16/003
摘要： Disclosed are compositions comprising variants of alpha-amylase that have alpha-amylase activity and which exhibit altered properties relative to a parent AmyS-like alpha-amylase from which they are derived. The compositions comprise an additional enzyme such as a phytase. Also disclosed are methods of using the compositions, and kits related thereto.
摘要翻译： 公开了包含α-淀粉酶变体的组合物，其具有α-淀粉酶活性，并且相对于其来源的亲本AmyS样α-淀粉酶表现出改变的性质。 组合物包含另外的酶如植酸酶。 还公开了使用组合物的方法和与其相关的试剂盒。
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公开(公告)号：US20130005029A1
公开(公告)日：2013-01-03
申请号：US13540064
申请日：2012-07-02
申请人： Luis G. CASCAO-PEREIRA , Claudine Chang , Clement Choy , James T. Kellis, JR. , Brain E. Jones , Melodie Estabrook , Marc Kolkman , Chris Leeflang , Casper Vroemen , Walter Weyler
发明人： Luis G. CASCAO-PEREIRA , Claudine Chang , Clement Choy , James T. Kellis, JR. , Brain E. Jones , Melodie Estabrook , Marc Kolkman , Chris Leeflang , Casper Vroemen , Walter Weyler
CPC分类号： C12N9/2417 , A21D8/042 , A23K20/189 , A23K50/75 , A23L29/06
摘要： Described are variants (mutants) of a parent alpha-amylase having alpha-amylase activity and exhibiting altered properties relative to the parent alpha-amylase, and methods of use, thereof.
摘要翻译： 描述了具有α-淀粉酶活性并且相对于母体α-淀粉酶具有改变的性质的亲本α-淀粉酶的变体（突变体）及其使用方法。
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公开(公告)号：US20110256610A1
公开(公告)日：2011-10-20
申请号：US12996576
申请日：2009-06-03
申请人： Viktor Yuryevich Alekseyev , Luis G. Cascao-Pereira , James T. Kellis, JR. , Alexander Pisarchik
发明人： Viktor Yuryevich Alekseyev , Luis G. Cascao-Pereira , James T. Kellis, JR. , Alexander Pisarchik
CPC分类号： C12N9/54 , A23K20/189 , C11D3/386 , C11D3/38681 , C11D11/0017 , C12N9/52 , C12Y304/21062
摘要： The present invention provides variant subtilisins and compositions comprising at least one variant subtilisin set forth herein, as well as methods for using these variants and compositions. In some embodiments, the present invention provides variant proteases suitable for laundry cleaning applications.
摘要翻译： 本发明提供了变体枯草杆菌蛋白酶和包含本文所述的至少一种变体枯草杆菌蛋白酶的组合物，以及使用这些变体和组合物的方法。 在一些实施方案中，本发明提供适用于衣物洗涤应用的变体蛋白酶。
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公开(公告)号：US20100048446A1
公开(公告)日：2010-02-25
申请号：US12365646
申请日：2009-02-04
申请人： Luis G. Cascao-Pereira , Claudine Chang , Clement Choy , James T. Kellis, JR. , Brian E. Jones , Melodie Estabrook , Marc Kolkman , Chris Leeflang , Casper Vroemen , Walter Weyler
发明人： Luis G. Cascao-Pereira , Claudine Chang , Clement Choy , James T. Kellis, JR. , Brian E. Jones , Melodie Estabrook , Marc Kolkman , Chris Leeflang , Casper Vroemen , Walter Weyler
CPC分类号： C12N9/2417 , A21D8/042 , A23K20/189 , A23K50/75 , A23L29/06
摘要： Described are variants (mutants) of a parent alpha-amylase having alpha-amylase activity and exhibiting altered properties relative to the parent alpha-amylase, and methods of use, thereof.
摘要翻译： 描述了具有α-淀粉酶活性并且相对于母体α-淀粉酶具有改变的性质的亲本α-淀粉酶的变体（突变体）及其使用方法。
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