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    Modified variant bowman birk protease inhibitors
    1.
    发明授权
    Modified variant bowman birk protease inhibitors 有权
    改良型bowman birk蛋白酶抑制剂

    公开(公告)号：US07803902B2

    公开(公告)日：2010-09-28

    申请号：US12252062

    申请日：2008-10-15

    申请人： Neelam S. Amin ,  Katherine D. Collier ,  Melodie Estabrook ,  David A. Estell ,  Bryan P. Fox ,  Scott D. Power ,  Brian F. Schmidt ,  Gudrun Vogtentanz

    发明人： Neelam S. Amin ,  Katherine D. Collier ,  Melodie Estabrook ,  David A. Estell ,  Bryan P. Fox ,  Scott D. Power ,  Brian F. Schmidt ,  Gudrun Vogtentanz

    IPC分类号： C07K14/00

    CPC分类号： C07K14/811 ,  A61K8/64 ,  A61Q7/02

    摘要： The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.

    摘要翻译： 本发明涉及包含结合靶蛋白的肽的修饰变体Bowman Birk蛋白酶抑制剂蛋白（BBPI），并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。 本发明包括多核苷酸构建体和含有编码修饰变体BBPI的多核苷酸序列的表达载体，表达和产生修饰变体BBPI的转化宿主细胞，修饰变体BBPI蛋白，包含修饰变体BBPI的组合物和制备方法 并在个人护理中使用修改后的变体BBPI。

    Production of fermented food
    5.
    发明授权
    Production of fermented food 失效
    生产发酵食品

    公开(公告)号：US5639648A

    公开(公告)日：1997-06-17

    申请号：US458316

    申请日：1995-06-02

    申请人： Stanley E. Mainzer ,  Sienna Yoast ,  Robin M. Adams ,  Tony V. Palombella ,  Brian F. Schmidt

    发明人： Stanley E. Mainzer ,  Sienna Yoast ,  Robin M. Adams ,  Tony V. Palombella ,  Brian F. Schmidt

    IPC分类号： A23C9/123 ,  C12N9/38 ,  C07H21/04 ,  C12N1/20 ,  C12N15/00

    CPC分类号： A23C9/1238 ,  C12N9/2471 ,  C12Y302/01023

    摘要： This invention discloses novel methods of making fermented food products such as yogurt. It also discloses novel Lactobacillus bulgaricus organisms for making fermented food products which are conditionally sensitive, that is, operate to metabolize a desired compound normally under the processing conditions for fermented food products but slow or decrease in activity beyond what is normal under the routine storage temperatures for the fermented food products. Such fermented food products exhibits improved shelf life and long-term taste.

    摘要翻译： 本发明公开了制造发酵食品如酸奶的新方法。 它还公开了用于制备有条件敏感的发酵食品的新型保加利亚乳杆菌生物，即通常在发酵食品的加工条件下代谢期望的化合物，但在常规储存温度下超出正常范围的活性减慢或降低 用于发酵食品。 这种发酵食品具有改善的保质期和长期的味道。

    Modified variant Bowman Birk Protease Inhibitors
    6.
    发明授权
    Modified variant Bowman Birk Protease Inhibitors 有权
    改良型Bowman Birk蛋白酶抑制剂

    公开(公告)号：US08394941B2

    公开(公告)日：2013-03-12

    申请号：US13082979

    申请日：2011-04-08

    申请人： Neelam S. Amin ,  Katherine D. Collier ,  Melodie Estabrook ,  David A. Estell ,  Bryan P. Fox ,  Scott D. Power ,  Brian F. Schmidt ,  Gudrun Vogtentanz

    发明人： Neelam S. Amin ,  Katherine D. Collier ,  Melodie Estabrook ,  David A. Estell ,  Bryan P. Fox ,  Scott D. Power ,  Brian F. Schmidt ,  Gudrun Vogtentanz

    IPC分类号： C12N15/00

    CPC分类号： C07K14/811 ,  A61K8/64 ,  A61Q7/02

    摘要： The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.

    摘要翻译： 本发明涉及包含结合靶蛋白的肽的修饰变体Bowman Birk蛋白酶抑制剂蛋白（BBPI），并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。 本发明包括多核苷酸构建体和含有编码修饰变体BBPI的多核苷酸序列的表达载体，表达和产生修饰变体BBPI的转化宿主细胞，修饰变体BBPI蛋白，包含修饰变体BBPI的组合物和制备方法 并在个人护理中使用修改后的变体BBPI。

    Proteases With Modified Pre-Pro Regions
    8.
    发明申请
    Proteases With Modified Pre-Pro Regions 审中-公开
    具有改良Pre-Pro区域的蛋白酶

    公开(公告)号：US20110171718A1

    公开(公告)日：2011-07-14

    申请号：US12761253

    申请日：2010-04-15

    申请人： Alexander Pisarchik ,  Brian F. Schmidt

    发明人： Alexander Pisarchik ,  Brian F. Schmidt

    IPC分类号： C12N9/54 ,  C07H21/00 ,  C12N9/48 ,  C12N15/63 ,  C12N1/21

    CPC分类号： C12N9/54

    摘要： The invention relates to modified polynucleotides encoding modified proteases, and methods for altering the production of proteases in microorganisms. In particular, the modified polynucleotides comprise one or more mutations that encode modified proteases having modifications of the pre-pro region that enhance the production of the active enzyme. The present invention further relates to methods for altering the production of proteases in microorganisms, such as Bacillus species.

    摘要翻译： 本发明涉及编码修饰的蛋白酶的修饰多核苷酸，以及改变微生物中蛋白酶生成的方法。 特别地，修饰的多核苷酸包含一个或多个编码经修饰的蛋白酶的突变，所述修饰的蛋白酶具有增强活性酶生产的pre-pro区的修饰。 本发明还涉及用于改变微生物如芽孢杆菌属物种中蛋白酶的产生的方法。

    Modified Variant Bowman Birk Protease Inhibitors
    9.
    发明申请
    Modified Variant Bowman Birk Protease Inhibitors 有权
    改良变体Bowman Birk蛋白酶抑制剂

    公开(公告)号：US20100221780A1

    公开(公告)日：2010-09-02

    申请号：US12779793

    申请日：2010-05-13

    申请人： Neelam S. Amin ,  Katherine D. Collier ,  Melodie Estabrook ,  David A. Estell ,  Bryan P. Fox ,  Scott D. Power ,  Brian F. Schmidt ,  Gudrun Vogtentanz

    发明人： Neelam S. Amin ,  Katherine D. Collier ,  Melodie Estabrook ,  David A. Estell ,  Bryan P. Fox ,  Scott D. Power ,  Brian F. Schmidt ,  Gudrun Vogtentanz

    IPC分类号： C12P21/00

    CPC分类号： C07K14/811 ,  A61K8/64 ,  A61Q7/02

    摘要： The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.

    摘要翻译： 本发明涉及包含结合靶蛋白的肽的修饰变体Bowman Birk蛋白酶抑制剂蛋白（BBPI），并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。 本发明包括多核苷酸构建体和含有编码修饰变体BBPI的多核苷酸序列的表达载体，表达和产生修饰变体BBPI的转化宿主细胞，修饰变体BBPI蛋白，包含修饰变体BBPI的组合物和制备方法 并在个人护理中使用修改后的变体BBPI。