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    Mice that make VL binding proteins
    1.
    发明授权
    Mice that make VL binding proteins 有权
    产生VL结合蛋白的小鼠

    公开(公告)号：US09516868B2

    公开(公告)日：2016-12-13

    申请号：US13195951

    申请日：2011-08-02

    申请人： Lynn Macdonald ,  Sean Stevens ,  Cagan Gurer ,  Karolina A. Hosiawa ,  Andrew J. Murphy

    发明人： Lynn Macdonald ,  Sean Stevens ,  Cagan Gurer ,  Karolina A. Hosiawa ,  Andrew J. Murphy

    IPC分类号： A01K67/027 ,  A01K67/033 ,  C12P21/00 ,  C07K16/00 ,  C12N15/85 ,  C07K16/46 ,  C07K16/08

    CPC分类号： A01K67/0278 ,  A01K67/0275 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/01 ,  C07K16/00 ,  C07K16/082 ,  C07K16/461 ,  C07K2317/21 ,  C12N15/8509

    摘要： Genetically modified mice and methods for making an using them are provided, wherein the mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene segments, D gene segments, and J gene segments with at least one light chain V gene segment and at least one light chain J gene segment. Mice that make binding proteins that comprise a light chain variable domain operably linked to a heavy chain constant region are provided. Binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Modified cells, embryos, and mice that encode sequences for making the binding proteins are provided.

    摘要翻译： 提供遗传修饰的小鼠和使用它们的方法，其中小鼠包含用至少一个轻链V基因区段替换全部或基本上所有的免疫球蛋白重链V基因区段，D基因区段和J基因区段， 至少一条轻链J基因片段。 提供了产生结合蛋白质的小鼠，其包含可操作地连接到重链恒定区的轻链可变结构域。 提供了与重链恒定区融合的含有免疫球蛋白轻链可变结构域的结合蛋白，包括体细胞超突变的轻链可变结构域。 提供编码用于制备结合蛋白的序列的修饰的细胞，胚胎和小鼠。

    Mice That Make VL Binding Proteins
    3.
    发明申请
    Mice That Make VL Binding Proteins 有权
    使VL结合蛋白的小鼠

    公开(公告)号：US20120096572A1

    公开(公告)日：2012-04-19

    申请号：US13195951

    申请日：2011-08-02

    申请人： Lynn Macdonald ,  Sean Stevens ,  Cagan Gurer ,  Karolina A. Hosiawa ,  Andrew J. Murphy

    发明人： Lynn Macdonald ,  Sean Stevens ,  Cagan Gurer ,  Karolina A. Hosiawa ,  Andrew J. Murphy

    IPC分类号： A01K67/027

    CPC分类号： A01K67/0278 ,  A01K67/0275 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/01 ,  C07K16/00 ,  C07K16/082 ,  C07K16/461 ,  C07K2317/21 ,  C12N15/8509

    摘要： Genetically modified mice and methods for making an using them are provided, wherein the mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene segments, D gene segments, and J gene segments with at least one light chain V gene segment and at least one light chain J gene segment. Mice that make binding proteins that comprise a light chain variable domain operably linked to a heavy chain constant region are provided. Binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Modified cells, embryos, and mice that encode sequences for making the binding proteins are provided.

    摘要翻译： 提供遗传修饰的小鼠和使用它们的方法，其中小鼠包含用至少一个轻链V基因区段替换全部或基本上所有的免疫球蛋白重链V基因区段，D基因区段和J基因区段， 至少一条轻链J基因片段。 提供了产生结合蛋白质的小鼠，其包含可操作地连接到重链恒定区的轻链可变结构域。 提供了与重链恒定区融合的含有免疫球蛋白轻链可变结构域的结合蛋白，包括体细胞超突变的轻链可变结构域。 提供编码用于制备结合蛋白的序列的修饰的细胞，胚胎和小鼠。

    Common light chain mouse
    9.
    发明授权
    Common light chain mouse 有权

    公开(公告)号：US10143186B2

    公开(公告)日：2018-12-04

    申请号：US13022759

    申请日：2011-02-08

    申请人： John McWhirter ,  Lynn Macdonald ,  Sean Stevens ,  David R. Buckler ,  Andrew J. Murphy

    发明人： John McWhirter ,  Lynn Macdonald ,  Sean Stevens ,  David R. Buckler ,  Andrew J. Murphy

    IPC分类号： A01K67/027 ,  C07K16/46 ,  C07K16/00 ,  C07K16/28 ,  C12N15/85 ,  C12N15/90 ,  C07K16/22

    摘要： A genetically modified mouse is provided, wherein the mouse is incapable of rearranging and expressing an endogenous mouse immunoglobulin light chain variable sequence, wherein the mouse expresses only one or two human light chain variable domains encoded by human immunoglobulin sequences operably linked to the mouse kappa (κ) constant gene at the endogenous mouse κ locus, wherein the mouse expresses a reverse chimeric antibody having a light chain variable domain derived from one of only two human light chain variable region gene segments and a mouse κ constant domain, and a human heavy chain variable domain and a mouse heavy chain constant domain, from an endogenous mouse heavy chain locus. Bispecific epitope-binding proteins that are fully human are provided, comprising two different heavy chains that associate with an identical light chain that comprises a variable domain derived from one of two different human light chain variable region gene segments.