-
1.发明申请公开(公告)号：US20200277252A1
公开(公告)日：2020-09-03
申请号：US16753035
申请日：2018-10-04
申请人： Meredeth Ann McGowan , Abdelghani Achab , Xavier Fradera , Yongxin Han , Derun Li , Jongwon Lim , Kun Liu , Nunzio Sciammetta , Catherine M. White , Wensheng Yu , Hongjun Zhang , Hua Zhou , MERCK SHARP & DOHME CORP.
发明人： Meredeth Ann McGowan , Abdelghani Achab , Xavier Fradera , Yongxin Han , Derun Li , Jongwon Lim , Kun Liu , Nunzio Sciammetta , Catherine M. White , Wensheng Yu , Hongjun Zhang , Hua Zhou
IPC分类号： C07C237/42 , C07D241/24 , C07D213/82 , C07D233/90 , C07D263/34 , C07D231/14 , C07D277/56 , C07D239/28 , C07D213/75 , C07D309/14 , C07D237/20 , C07D307/14 , C07D205/04 , C07D285/06 , C07D487/04
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (Formula (I)). Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.
-
公开(公告)号：US11319283B2
公开(公告)日：2022-05-03
申请号：US16753035
申请日：2018-10-04
申请人： MERCK SHARP & DOHME CORP. , Meredeth Ann McGowan , Abdelghani Achab , Xavier Fradera , Yongxin Han , Derun Li , Jongwon Lim , Kun Liu , Nunzio Sciammetta , Catherine M. White , Wensheng Yu , Hongjun Zhang , Hua Zhou
发明人： Meredeth Ann McGowan , Abdelghani Achab , Xavier Fradera , Yongxin Han , Derun Li , Jongwon Lim , Kun Liu , Nunzio Sciammetta , Catherine M. White , Wensheng Yu , Hongjun Zhang , Hua Zhou
IPC分类号： C07D205/04 , C07C237/42 , C07D213/75 , C07D213/82 , C07D231/14 , C07D233/90 , C07D237/20 , C07D239/28 , C07D241/24 , C07D263/34 , C07D277/56 , C07D285/06 , C07D307/14 , C07D309/14 , C07D487/04
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (Formula (I)). Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.
-
公开(公告)号：US11319295B2
公开(公告)日：2022-05-03
申请号：US16753043
申请日：2018-10-04
申请人： MERCK SHARP & DOHME CORP. , Catherine M. White , Meredeth Ann McGowan , Yongxin Han , Nunzio Sciammetta
IPC分类号： C07D305/08 , A61P37/00 , A61P25/28 , A61P31/12 , A61P25/24 , A61P27/12 , A61P35/00 , C07D307/22 , C07D307/24 , C07D405/04 , A61K45/06
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (Formula (I)). Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.
-
4.发明申请公开(公告)号：US20200239423A1
公开(公告)日：2020-07-30
申请号：US16753043
申请日：2018-10-04
申请人： Catherine M. WHITE , Meredeth Ann MCGOWAN , Yongxin HAN , Nunzio SCIAMMETTA , MERCK SHARP & DOHME CORP.
IPC分类号： C07D305/08 , C07D307/24 , C07D307/22 , C07D405/04 , A61P35/00 , A61P31/12 , A61P25/24 , A61P25/28 , A61P27/12 , A61P37/00
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (Formula (I)). Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.
-
5.发明申请公开(公告)号：US20220235028A1
公开(公告)日：2022-07-28
申请号：US17615718
申请日：2020-06-08
申请人： Yongxin HAN , Yongqi DENG , Hua ZHOU , Meredeth A. MCGOWAN , Hongjun ZHANG , Wensheng YU , Brett A. HOPKINS , Xavier FRADERA , Nunzio SCIAMMETTA , Merck Sharp & Dohme Corp.
发明人： Yongxin Han , Yongqi Deng , Hua Zhou , Meredeth A. McGowan , Hongjun Zhang , Wensheng Yu , Brett A. Hopkins , Xavier Fradera , Nunzio Sciammetta
IPC分类号： C07D401/06 , C07D401/08 , C07D471/04 , C07D519/00
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
-
公开(公告)号：US20220259188A1
公开(公告)日：2022-08-18
申请号：US17614732
申请日：2020-06-01
申请人： Hua ZHOU , John J. ACTON, III , Michael J. ARDOLINO , Yi-Heng CHEN , Peter H. FULLER , Anmol GULATI , Rebecca Elizabeth JOHNSON , William P. KAPLAN , Solomon D. KATTAR , Mitchell H. KEYLOR , Derun LI , Kaitlyn Marie LOGAN , Min LU , Gregori J. MORRIELLO , Santhosh F. NEELAMKAVIL , Barbara PIO , Nunzio SCIAMMETTA , Vladimir SIMOV , Jing SU , Luis TORRES , Xin YAN , Merck Sharp & Dohme Corp.
发明人： Hua Zhou , John J. Acton, III , Michael J. Ardolino , Yi-Heng Chen , Peter H. Fuller , Anmol Gulati , Rebecca Elizabeth Johnson , William P. Kaplan , Solomon D. Kattar , Mitchell H. Keylor , Derun Li , Kaitlyn Marie Logan , Min Lu , Gregori J. Morriello , Santhosh F. Neelamkavil , Barbara Pio , Nunzio Sciammetta , Vladimir Simov , Jing Su , Luis Torres , Xin Yan
IPC分类号： C07D405/14 , C07D487/08 , C07D409/14 , C07D403/04 , C07D403/14 , C07D498/04 , C07D498/08 , C07D487/10 , C07D401/14 , C07D471/10 , C07D491/107 , C07D471/04 , C07D487/04 , A61P25/16
摘要： The present invention is directed to substituted certain 1-pyrazolyl, 5-, 6-disubstituted indazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and ring A are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.
-
公开(公告)号：US10538497B2
公开(公告)日：2020-01-21
申请号：US16061597
申请日：2016-12-12
发明人： Yongxin Han , Abdelghani Achab , Purakkattle Biju , Yongqi Deng , Xavier Fradera , Liangqin Guo , Shuwen He , Joseph Kozlowski , Ravi Kurukulasuriya , Kun Liu , Meredeth Ann McGowan , Qinglin Pu , Nunzio Sciammetta , Hongjun Zhang , Hua Zhou
IPC分类号： A61K31/4245 , A61K31/433 , C07D271/08 , C07D285/10 , C07D413/12 , C07D417/12 , A61P35/00 , A61P31/12 , A61P25/24 , A61P25/28 , A61P37/06 , A61P27/12 , A61P31/14 , A61P35/02
摘要： Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
-
公开(公告)号：US10221142B2
公开(公告)日：2019-03-05
申请号：US15549465
申请日：2016-02-11
发明人： Blair T. Lapointe , Peter H. Fuller , Hakan Gunaydin , Kun Liu , Nunzio Sciammetta , Benjamin Wesley Trotter , Hongjun Zhang , Kenneth J. Barr , John K. F. Maclean , Danielle F. Molinari , Vladimir Simov
IPC分类号： C07D231/56 , C07D487/04 , A61K45/06 , A61K31/416 , C07D471/04 , C07D491/052 , C07D491/107 , C07D495/04 , C07D403/12 , C07D487/14 , C07D405/12 , C07D413/06 , C07D487/06 , C07D513/04
摘要： The present invention relates to compounds according to Formula (I-1) and pharmaceutically acceptable salts thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.
-
9.发明授权3-cyclohexenyl and cyclohexyl substituted indole and indazole compounds as RORgammaT inhibitors and uses thereof 有权3-环己烯基和环己基取代的吲哚和吲唑化合物作为RORGAMAMT抑制剂及其用途公开(公告)号：US09487490B2
公开(公告)日：2016-11-08
申请号：US14421057
申请日：2013-08-14
发明人： Kenneth J. Barr , John K. Maclean , Hongjun Zhang , Richard T. Beresis , Dongshan Zhang , Brian M. Andresen , Neville J. Anthony , Blair T. Lapointe , Nunzio Sciammetta
IPC分类号： C07D471/04 , A61K31/4745 , C07D231/56 , A61K31/404 , A61K31/416 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D209/26 , C07D401/06 , C07D403/06 , C07D405/12 , C07D413/06
CPC分类号： C07D231/56 , A61K31/404 , A61K31/416 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D209/26 , C07D401/06 , C07D403/06 , C07D405/12 , C07D413/06 , C07D471/04 , Y02A50/409
摘要： The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.
-
公开(公告)号：US20210330676A1
公开(公告)日：2021-10-28
申请号：US17268995
申请日：2019-08-16
发明人： Dane Clausen , Xavier Fradera , Liangqin Guo , Yongxin Han , Shuwen He , Xianhai Huang , Joseph Kozlowski , Guoqing Li , Jongwon Lim , Theodore A. Martinot , Alexander Pasternak , Nunzio Sciammetta , Andreas Verras , Li Xiao , Wensheng Yu , Rui Zhang
IPC分类号： A61K31/5377 , A61K45/06 , C07D401/14 , C07D401/06 , C07D413/14 , C07D451/06 , A61K31/4545 , A61K31/496 , A61K31/454 , A61K31/46
摘要： Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
-
-
-
-
-
-
-
-
-
搜索结果
50 条记录 (耗时 0.041 秒)
