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1.发明授权Biosensor with one-dimensional sub-diffraction-limited apertures composed of a grid and a polarizer 有权具有由栅格和偏振器组成的一维亚衍射限制孔的生物传感器公开(公告)号：US08075841B2
公开(公告)日：2011-12-13
申请号：US12158347
申请日：2006-12-11
CPC分类号： G01N21/648 , Y10T436/11
摘要： A method and sensor for the detection of luminescence radiation generated by at least one luminophore is disclosed. In the context of the present invention the biosensor comprises a grid (120) defined as arrays of apertures with the apertures having a first dimension below and a second dimension above the diffraction limit of the excitation light (102) in a medium, a polarizer (115), and luminophores (117) positioned in a volume selected from the group consisting of: the volume inside the apertures of the grid (120), the volume in between the array of slits (120) and the polarizer (115) and a volume that extends into the polarizer (115), wherein the grid (120) providing a transmission axis extending in a first direction and the polarizer (115) providing a transmission axis extending in a second direction, the first direction and the second direction being substantially perpendicular with respect to each other, wherein the excitation radiation (102) is polarized such that it is substantially suppressed by one of the at least one grid (120) and polarizer (115) and substantially not suppressed by the other of the at least one grid (120) and polarizer (115).
摘要翻译： 公开了一种用于检测由至少一个发光体产生的发光辐射的方法和传感器。 在本发明的上下文中，生物传感器包括定义为孔阵列的格栅（120），孔格具有第一尺寸，第二维度高于介质中的激发光（102）的衍射极限，偏振器（ 115）和位于选自以下的体积中的发光体（117）：栅格（120）的孔内的体积，狭缝阵列（120）和偏振器（115）之间的体积和 延伸到偏振器（115）的体积，其中提供沿第一方向延伸的透射轴的格栅（120）和提供沿第二方向延伸的透射轴的偏振器（115），第一方向和第二方向基本上 垂直于彼此垂直，其中所述激发辐射（102）被极化，使得其基本上被所述至少一个格栅（120）和偏振器（115）中的一个所抑制，并且基本上不被所述o 该至少一个格栅（120）和偏振器（115）。
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公开(公告)号：US07947946B2
公开(公告)日：2011-05-24
申请号：US11909638
申请日：2006-03-27
IPC分类号： G01D5/36
CPC分类号： G01N21/645 , G02B27/0037 , G02B27/4205 , G02B27/4277
摘要： The invention relates to an optical system that particularly allows an improved detection of signal light propagating from a light source (1) through a flat glass substrate (11). SC-modes of this signal light that would normally be totally internally reflected at the backside (10) of the substrate (11) are coupled out by a first diffractive optical element DOE (21). To map all signal light leaving the substrate (11) onto a single target location (51), a focusing lens (31) and a second DOE (41) are disposed in the optical path behind the substrate (11). The DOEs (21, 41) may for example be a ID sinusoidal grating or a 2D blaze grating. The optical system may particularly be applied in an investigation apparatus for detecting multiple spots of a fluorescent sample material.
摘要翻译： 本发明涉及一种特别允许改进从光源（1）通过平板玻璃基板（11）传播的信号光的检测的光学系统。 通常在基板（11）的背面（10）处内部反射的该信号光的SC模式由第一衍射光学元件DOE（21）耦合出来。 为了将离开基板（11）的所有信号光映射到单个目标位置（51）上，在基板（11）后面的光路中设置聚焦透镜（31）和第二DOE（41）。 DOE（21,41）可以例如是ID正弦光栅或2D火焰光栅。 光学系统可以特别应用于用于检测荧光样品材料的多个点的检查装置中。
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公开(公告)号：US20110047747A1
公开(公告)日：2011-03-03
申请号：US12865470
申请日：2009-01-28
IPC分类号： A47L9/24
CPC分类号： A47L9/248 , A47L9/0027 , A47L9/2842 , A47L9/2857 , A47L9/327
摘要： The invention relates to a suction attachment, a handgrip assembly (16) and a vacuum cleaner. The suction attachment comprises a tube assembly (2), a first handgrip (18), and a second handgrip (20), respectively, both of which extend from the tube assembly (2). This provides two handgrip portions separate from the tube assembly (2), which improves its ergonomic handling.
摘要翻译： 本发明涉及吸附装置，手柄组件（16）和真空吸尘器。 抽吸附件包括分别从管组件（2）延伸的管组件（2），第一手柄（18）和第二手柄（20）。 这提供了与管组件（2）分开的两个手柄部分，这改善了其人体工程学处理。
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公开(公告)号：US20100140464A1
公开(公告)日：2010-06-10
申请号：US11909638
申请日：2006-03-27
IPC分类号： H01L31/0232 , G02B27/42 , G02B5/18 , G02B27/44
CPC分类号： G01N21/645 , G02B27/0037 , G02B27/4205 , G02B27/4277
摘要： The invention relates to an optical system that particularly allows an improved detection of signal light propagating from a light source (1) through a flat glass substrate (11). SC-modes of this signal light that would normally be totally internally reflected at the backside (10) of the substrate (11) are coupled out by a first diffractive optical element DOE (21). To map all signal light leaving the substrate (11) onto a single target location (51), a focusing lens (31) and a second DOE (41) are disposed in the optical path behind the substrate (11). The DOEs (21, 41) may for example be a ID sinusoidal grating or a 2D blaze grating. The optical system may particularly be applied in an investigation apparatus for detecting multiple spots of a fluorescent sample material.
摘要翻译： 本发明涉及一种特别允许改进从光源（1）通过平板玻璃基板（11）传播的信号光的检测的光学系统。 通常在基板（11）的背面（10）处内部反射的该信号光的SC模式由第一衍射光学元件DOE（21）耦合出来。 为了将离开基板（11）的所有信号光映射到单个目标位置（51）上，在基板（11）后面的光路中设置聚焦透镜（31）和第二DOE（41）。 DOE（21,41）可以例如是ID正弦光栅或2D火焰光栅。 光学系统可以特别应用于用于检测荧光样品材料的多个点的检查装置中。
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公开(公告)号：US20100051788A1
公开(公告)日：2010-03-04
申请号：US11721392
申请日：2005-12-13
CPC分类号： G01N21/645 , B01L3/5085 , G01N21/6452 , G01N2201/0635
摘要： The invention relates to a method and an apparatus for the investigation of a sample material that is stored in the sample chamber (303) of a storage unit (300). A multi-spot generator MSG (100) and a transmission section (200) generate an array of sample light spots (501) within the sample chamber. Input light (504) that leaves the storage unit (300) in forward direction is mapped onto a CCD array (401) and measured as reference. Moreover, fluorescence light (500) that is stimulated in the sample chamber (303) is measured by a second CCD array which is disposed perpendicular to the optical path of the input light (504).
摘要翻译： 本发明涉及一种用于研究存储在存储单元（300）的样品室（303）中的样品材料的方法和装置。 多点发生器MSG（100）和透射部分（200）在样品室内产生样品光点阵列（501）。 将存储单元（300）向前移动的输入光（504）映射到CCD阵列（401）上并作为参考进行测量。 此外，通过垂直于输入光（504）的光路设置的第二CCD阵列来测量在样品室（303）中被刺激的荧光（500）。
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公开(公告)号：US20090292202A1
公开(公告)日：2009-11-26
申请号：US11721468
申请日：2005-12-15
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/0095 , A61B5/02007 , A61B5/489
摘要： A pulsed radiation beam is directed toward a body structure having a configuration or physical characteristic that changes over time, the radiation being pulsed at a pulse modulation frequency. A detector detects acoustic oscillations set up in the body resultant from the incident pulsed radiation and produces an output signal representative of one or more parameters of the acoustic oscillations. A control system controls operation of the radiation delivery and a processor to process the detector output signal. The pulse modulation frequency of the pulsed radiation is changed over a predetermined range of modulation frequencies and the processor determines the structure resonant frequency from the detector output.
摘要翻译： 脉冲辐射束指向具有随时间变化的配置或物理特性的体结构，辐射以脉冲调制频率脉冲。 检测器检测由入射脉冲辐射产生的身体中产生的声振荡并产生表示声振荡的一个或多个参数的输出信号。 控制系统控制辐射传送的操作和处理器来处理检测器输出信号。 脉冲辐射的脉冲调制频率在调制频率的预定范围内改变，并且处理器从检测器输出确定结构谐振频率。
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公开(公告)号：US08185189B2
公开(公告)日：2012-05-22
申请号：US11721468
申请日：2005-12-15
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/0095 , A61B5/02007 , A61B5/489
摘要： A pulsed radiation beam is directed toward a body structure having a configuration or physical characteristic that changes over time, the radiation being pulsed at a pulse modulation frequency. A detector detects acoustic oscillations set up in the body resultant from the incident pulsed radiation and produces an output signal representative of one or more parameters of the acoustic oscillations. A control system controls operation of the radiation delivery and a processor to process the detector output signal. The pulse modulation frequency of the pulsed radiation is changed over a predetermined range of modulation frequencies and the processor determines the structure resonant frequency from the detector output.
摘要翻译： 脉冲辐射束指向具有随时间变化的配置或物理特性的体结构，辐射以脉冲调制频率脉冲。 检测器检测由入射脉冲辐射产生的身体中产生的声振荡并产生表示声振荡的一个或多个参数的输出信号。 控制系统控制辐射传送的操作和处理器来处理检测器输出信号。 脉冲辐射的脉冲调制频率在调制频率的预定范围内改变，并且处理器从检测器输出确定结构谐振频率。
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公开(公告)号：US20090218514A1
公开(公告)日：2009-09-03
申请号：US11720842
申请日：2005-12-07
申请人： Derk Jan Wilfred Klunder , Maarten Van Herpen , Marcello Balistreri , Coen Liedenbaum , Menno Prins , Reinhold Wimberger-Friedl , Ralph Kurt
发明人： Derk Jan Wilfred Klunder , Maarten Van Herpen , Marcello Balistreri , Coen Liedenbaum , Menno Prins , Reinhold Wimberger-Friedl , Ralph Kurt
IPC分类号： G01J1/58
CPC分类号： G01N21/6456 , G01N21/6452 , G01N21/648 , G01N2021/1772 , G01N2021/6463 , G01N2021/6478 , G01N2201/0461
摘要： The invention relates to a method and an apparatus for the investigation of a sample material by multiple sample light spots (501) generated by evanescent waves. An array of source light spots (510) is generated by a multi-spot generator, e.g. a multi-mode interferometer (106), and mapped onto sample light spots (501) in a sample layer (302) by (micro-)lenses (202, 203) or by the Talbot effect. The input light (504) of the source light spots (510) is shaped such that all of it is totally internally reflected at the interface between a transparent carrier plate (301) and the sample layer (302). Thus the sample light spots (501) consist of evanescent waves only and are restricted to a limited volume. In a preferred application, fluorescence stimulated in the sample light spots (501) is detected with spatial resolution by a CCD array (401).
摘要翻译： 本发明涉及一种通过由ev逝波产生的多个样本光点（501）来研究样品材料的方法和装置。 源光点阵列（510）由多点发生器产生，例如， 多模干涉仪（106），并且通过（微）透镜（202,203）或通过Talbot效应将样品层（302）中的样品光点（501）映射。 源光点（510）的输入光（504）被成形为使得它们全部在内部被透明载体板（301）和样品层（302）之间的界面反射。 因此，样本光点（501）仅由ev逝波组成，并被限制在有限的体积。 在优选的应用中，通过CCD阵列（401）以空间分辨率检测样品光点（501）中刺激的荧光。
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