公开(公告)号：US11719638B2

公开(公告)日：2023-08-08

申请号：US16625467

申请日：2018-06-27

Applicant: Life Technologies Holdings PTE LTD

Inventor： Katja Eklin ,  Adyary Fallarero ,  Tommi Suvanto ,  Marika J. Raitio

IPC: G01N21/25 ,  G01N21/64 ,  C12Q1/686

CPC classification number: G01N21/6452 ,  C12Q1/686 ,  G01N21/253 ,  G01N2201/04 ,  G01N2201/0461 ,  G01N2201/0469

Abstract: The method of analyzing one or more samples arranged in sample receptacles of a platform that is configured to receive a plurality of separate samples includes the steps of measuring electromagnetic radiation transmitted or emitted by each sample, repeating the measurement a plurality of times at predetermined intervals, on the basis of each measurement, forming a result matrix comprising a plurality of cells, each cell of the result matrix corresponding to a sample receptacle of the plat-form, wherein a measurement value of each sample is used as an input for determining the visual properties of the respective cell in the result matrix, and displaying the results as consecutive matrixes in respect of time.

公开(公告)号：US09382585B2

公开(公告)日：2016-07-05

申请号：US12261548

申请日：2008-10-30

Applicant: Arnold Oliphant

Inventor： Arnold Oliphant

IPC: C12Q1/68 ,  G01N35/00 ,  G01N21/64

CPC classification number: C12Q1/6874 ,  G01N21/6486 ,  G01N35/0099 ,  G01N2035/00158 ,  G01N2201/0461

Abstract: A scalable reaction and detection system for automated high throughput sequencing of nucleic acids involving a combination of chemical processes and observation processes independent of the chemistry processes. Discrete functional units may be configured in a manner that allows the system to interchangeably utilize different sequencing reaction components in conjunction with discrete apparatus components for optical image collection and/or analysis.

Abstract translation: 一种可扩展的反应和检测系统，用于核酸的自动化高通量测序，涉及独立于化学过程的化学过程和观察过程的组合。 离散功能单元可以以允许系统与用于光学图像收集和/或分析的分立装置组件可互换地利用不同排序反应组分的方式来配置。

公开(公告)号：US07283245B2

公开(公告)日：2007-10-16

申请号：US10760438

申请日：2004-01-20

Applicant: Caibin Xiao ,  Scott M. Boyette ,  Radislav A. Potyrailo

Inventor： Caibin Xiao ,  Scott M. Boyette ,  Radislav A. Potyrailo

IPC: G01N21/27 ,  G01N21/47 ,  G01N21/00 ,  G06F19/00

CPC classification number: G01N21/7703 ,  G01N21/253 ,  G01N21/272 ,  G01N21/274 ,  G01N21/314 ,  G01N21/552 ,  G01N21/8483 ,  G01N2021/7783 ,  G01N2021/8488 ,  G01N2201/0221 ,  G01N2201/0245 ,  G01N2201/0461 ,  G01N2201/122

Abstract: A portable system and method for measuring the concentration of multiple chemical or biological substances where an onsite analysis of such substances is needed. The new and original handheld sensor system uses a disposable optical test element and a spectroscopic detector that measures the test element response to specific analytes through a change in light absorbance, luminescence, and other forms of light-based response. In this way, reflection light intensities indicative of the test element response can be used to measure the concentration of the target analytes. The sensor system is also capable of being interfaced to an information processing unit or computer so that analytical data can be manipulated or stored electronically.

Abstract translation: 用于测量需要对这些物质进行现场分析的多种化学或生物物质的浓度的便携式系统和方法。 新的和原始的手持传感器系统使用一次性光学测试元件和光谱检测器，其通过光吸收，发光和其他形式的基于光的响应的变化来测量测试元件对特定分析物的响应。 以这种方式，可以使用指示测试元件响应的反射光强度来测量目标分析物的浓度。 传感器系统还能够连接到信息处理单元或计算机，从而可以电子地操纵或存储分析数据。

公开(公告)号：US20060202133A1

公开(公告)日：2006-09-14

申请号：US11345262

申请日：2006-02-01

Applicant: Gyeong-sik Ok ,  Su-hyeon Kim ,  Jin-tae Kim ,  Kwang-wook Oh

Inventor： Gyeong-sik Ok ,  Su-hyeon Kim ,  Jin-tae Kim ,  Kwang-wook Oh

IPC: G01J1/58 ,  F21V9/16

CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N21/05 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/0346 ,  G01N2021/3174 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0407 ,  G01N2201/0461 ,  G01N2201/0612 ,  G01N2201/0627 ,  G01N2201/0631 ,  G01N2201/0806 ,  G01N2201/0833

Abstract: A multi-channel fluorescence measuring optical system and a multi-channel fluorescence sample analyzer using the optical system are provided. The multi-channel fluorescence measuring optical system, which irradiates light onto a plurality of sample channels and detecting fluorescence radiated from samples, includes: a light source; an integrator for giving the light irradiated from the light source a uniform intensity distribution; a sample holder having a plurality of sample channels on which the samples are mounted, wherein the samples are exited by the light emitted from the integrator; and a beam splitter between the integrator and the sample holder for dividing the incident light in a predetermined ratio. Since the light intensities of fluorescence images are detected using optical fiber bundles and photodiodes, the manufacturing cost can be greatly reduced, and the optical system can be miniaturized.

Abstract translation: 提供多通道荧光测量光学系统和使用该光学系统的多通道荧光样品分析仪。 多通道荧光测量光学系统，其将光照射到多个样品通道上并检测从样品辐射的荧光，包括：光源; 用于给从光源照射的光均匀的强度分布的积分器; 具有多个样品通道的样品架，样品安装在样品通道上，其中采样由积分器发出的光退出; 以及在积分器和样品保持器之间的分束器，用于以预定比例分割入射光。 由于使用光纤束和光电二极管检测荧光图像的光强度，因此可以大大降低制造成本，并且可以使光学系统小型化。

公开(公告)号：US20160057413A1

公开(公告)日：2016-02-25

申请号：US14799969

申请日：2015-07-15

Applicant: Xerox Corporation

Inventor： Jing Zhou ,  Nancy Y. Jia ,  Wei Hong ,  Mandakini Kanungo ,  Xing Liu

IPC: H04N17/02 ,  G01N21/25 ,  G06K9/62 ,  G01N21/78 ,  G06T7/40 ,  G06K9/46

CPC classification number: H04N17/02 ,  G01N21/253 ,  G01N21/274 ,  G01N21/78 ,  G01N21/8483 ,  G01N2021/7759 ,  G01N2201/0461 ,  G06K9/4652 ,  G06K9/6201 ,  G06K2009/4666 ,  G06T7/90

Abstract: The present disclosure proposes a colorimetric method that couples sensor design with image processing to enable automated evaluation of test results obtained by paper-based sensors. The proposed method can match ink color and dye used in colorimetric reaction in terms of their absorption in spectral range (e.g., red, green, blue). A near-zero absorption channel can then be used to normalize absorption channels and construct a composite image.

Abstract translation: 本公开提出了一种比色方法，其将传感器设计与图像处理相结合，以便能够对由纸基传感器获得的测试结果进行自动评估。 所提出的方法可以根据其在光谱范围内的吸收（例如，红，绿，蓝）来匹配用于比色反应中的油墨颜色和染料。 然后可以使用近零吸收通道来归一化吸收通道并构建合成图像。

公开(公告)号：US20090218514A1

公开(公告)日：2009-09-03

申请号：US11720842

申请日：2005-12-07

Applicant: Derk Jan Wilfred Klunder ,  Maarten Van Herpen ,  Marcello Balistreri ,  Coen Liedenbaum ,  Menno Prins ,  Reinhold Wimberger-Friedl ,  Ralph Kurt

Inventor： Derk Jan Wilfred Klunder ,  Maarten Van Herpen ,  Marcello Balistreri ,  Coen Liedenbaum ,  Menno Prins ,  Reinhold Wimberger-Friedl ,  Ralph Kurt

IPC: G01J1/58

CPC classification number: G01N21/6456 ,  G01N21/6452 ,  G01N21/648 ,  G01N2021/1772 ,  G01N2021/6463 ,  G01N2021/6478 ,  G01N2201/0461

Abstract: The invention relates to a method and an apparatus for the investigation of a sample material by multiple sample light spots (501) generated by evanescent waves. An array of source light spots (510) is generated by a multi-spot generator, e.g. a multi-mode interferometer (106), and mapped onto sample light spots (501) in a sample layer (302) by (micro-)lenses (202, 203) or by the Talbot effect. The input light (504) of the source light spots (510) is shaped such that all of it is totally internally reflected at the interface between a transparent carrier plate (301) and the sample layer (302). Thus the sample light spots (501) consist of evanescent waves only and are restricted to a limited volume. In a preferred application, fluorescence stimulated in the sample light spots (501) is detected with spatial resolution by a CCD array (401).

Abstract translation: 本发明涉及一种通过由ev逝波产生的多个样本光点（501）来研究样品材料的方法和装置。 源光点阵列（510）由多点发生器产生，例如， 多模干涉仪（106），并且通过（微）透镜（202,203）或通过Talbot效应将样品层（302）中的样品光点（501）映射。 源光点（510）的输入光（504）被成形为使得它们全部在内部被透明载体板（301）和样品层（302）之间的界面反射。 因此，样本光点（501）仅由ev逝波组成，并被限制在有限的体积。 在优选的应用中，通过CCD阵列（401）以空间分辨率检测样品光点（501）中刺激的荧光。

公开(公告)号：US5337139A

公开(公告)日：1994-08-09

申请号：US866751

申请日：1992-04-10

Applicant: Yoshiaki Shirasawa

Inventor： Yoshiaki Shirasawa

IPC: G01N21/01 ,  G01N21/25 ,  G01N21/64 ,  G01N21/78 ,  G01N21/82 ,  G01N21/59

CPC classification number: G01N21/253 ,  G01N2021/6421 ,  G01N21/64 ,  G01N2201/0461 ,  G01N2201/0826

Abstract: A multichannel optical measuring system for measuring optical responses of samples illuminated by light of differing wavelengths has a plurality of measurement sample cuvettes each contain a sample to be measured. A first single light source provides a first illumination light. A plurality of sets of optical fibers direct the first illumination light from the first single light source to illuminate, along an optical axis, the samples contained in respective sample cuvettes. A second light source is provided for illuminating each respective sample cuvette with a second illumination light for measuring an intensity of transmitted light through the sample. The optical axis of the second illumination light is perpendicular to the optical axis of the first illumination light. A common photosensor disposed on the optical axis of the second light source measures the intensity of the first illumination light and the intensity of the transmitted light from each sample. Thus, the multichannel optical measuring system can simultaneously measure both the intensity of a first illumination light from a single light source, and the intensity of light transmitted through each sample, for a plurality of samples.

Abstract translation: 用于测量由不同波长的光照射的样品的光学响应的​​多通道光学测量系统具有多个测量样品比色皿，每个测量样本比色皿包含待测量的样品。 第一单个光源提供第一照明光。 多组光纤引导来自第一单个光源的第一照明光沿着光轴照射包含在各个样品比色皿中的样品。 提供第二光源，用于用用于测量通过样品的透射光的强度的第二照明光照射每个相应的样本比色皿。 第二照明光的光轴垂直于第一照明光的光轴。 设置在第二光源的光轴上的公共光传感器测量第一照明光的强度和来自每个样品的透射光的强度。 因此，多通道光学测量系统可以同时测量来自单个光源的第一照明光的强度和透过每个样品的光的强度，用于多个样品。

公开(公告)号：US5275951A

公开(公告)日：1994-01-04

申请号：US939570

申请日：1992-09-03

Applicant: Herbert S. Chow ,  John J. Kotlarik ,  Mieczyslaw Wroblewski ,  Thomas J. Wilson ,  Jimmy D. McCoy

Inventor： Herbert S. Chow ,  John J. Kotlarik ,  Mieczyslaw Wroblewski ,  Thomas J. Wilson ,  Jimmy D. McCoy

IPC: G01N21/17 ,  B01L3/00 ,  B01L3/02 ,  G01N15/14 ,  G01N21/82 ,  G01N33/48 ,  G01N33/483 ,  G01N33/543 ,  G01N33/80 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G02B7/28 ,  G06T1/00 ,  G01F23/00 ,  G01F23/28

CPC classification number: G01N35/109 ,  B01L3/0262 ,  B01L3/5085 ,  G01N15/1468 ,  G01N21/82 ,  G01N35/0095 ,  G01N35/0098 ,  G01N35/028 ,  G02B7/28 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/0491 ,  G01N2035/1018 ,  G01N2035/1025 ,  G01N2035/1034 ,  G01N2201/0446 ,  G01N2201/0461 ,  G01N2201/0492 ,  G01N35/1004 ,  Y10T137/7306 ,  Y10T436/115831

Abstract: An apparatus is provided which includes a reaction cartridge having a plurality of reaction wells having different reagents disposed thereon, at least one well adapted to receive a sample, a well containing particles adapted to bind to the sample and which have the capability of being separated from cells which are not bound to the separation particles and at least one fluorophore adapted to bind to a specific type of cell in the sample, and a wash area adapted for washing a probe. An image forming device is provided to detect images which indicate whether specific reactions have occurred in each of the reaction wells. The apparatus also includes a mechanism for dispensing and aspirating liquids including a mechanism for detecting liquid levels. The device further includes logic for analyzing the information received from the image detection apparatus and processing the information to generate a visual indication of the results of the assays being performed. A microprocessor is provided to assist in the operation of the device as well as in the image processing.

Abstract translation: 提供了一种装置，其包括具有多个反应孔的反应筒，反应孔具有设置在其上的不同试剂，至少一个适于接收样品的孔，含有适于结合样品的颗粒的孔，并具有与样品分离的能力 不结合分离颗粒的细胞和至少一种适于结合样品中特定类型的细胞的荧光团和适于洗涤探针的洗涤区域。 提供图像形成装置以检测指示每个反应孔中是否发生特定反应的图像。 该装置还包括用于分配和抽吸液体的机构，包括用于检测液位的机构。 该装置还包括用于分析从图像检测装置接收的信息并处理信息以生成正在执行的测定结果的视觉指示的逻辑。 提供微处理器以帮助设备的操作以及图像处理。

公开(公告)号：US4892409A

公开(公告)日：1990-01-09

申请号：US218874

申请日：1988-07-14

Applicant: Harry F. Smith

Inventor： Harry F. Smith

IPC: G01N21/25

CPC classification number: G01N21/253 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/0461 ,  G01N2201/065

Abstract: The invention relates to photometric apparatus and method for determining a characteristic of individual ones of a plurality of samples contained within a plurality of sample chambers. The photometric apparatus includes an enclosure; a substantially uniform source of radiation coupled to the enclosure such that a plurality of sample chambers, disposed within the enclosure, are simultaneously illuminated by the uniform source; and apparatus for detecting an amount of radiation which is transmitted through individual ones of the sample chambers, the detecting apparatus having an output signal having a magnitude which is a function of the amount of radiation which is transmitted through an individual one of the sample chambers. The substantially uniform source of radiation may include at least one source of radiation having an output comprising wavelengths within a first range of wavelengths and an optically integrating sphere having a radiation input port coupled to the output of the source of radiation and a radiation output port coupled to the enclosure. The photometric apparatus may further include radiation directing devices interposed between the radiation output port and the plurality of sample chambers for simultaneously directing radiation emanating from the output port into each of the sample chambers. The directed radiation may be either focussed or collimated.

Abstract translation: 本发明涉及用于确定包含在多个样品室内的多个样品中的各个样品的特性的光度测定装置和方法。 测光装置包括外壳; 耦合到外壳的基本上均匀的辐射源，使得设置在外壳内的多个样品室同时被均匀光源照射; 以及用于检测通过单个样本室传输的辐射量的装置，该检测装置具有输出信号，该输出信号的幅度是通过单独一个样本室传输的辐射量的函数。 基本上均匀的辐射源可以包括至少一个辐射源，其具有包括在第一波长范围内的波长的输出和具有耦合到辐射源的输出的辐射输入端口的光学积分球，以及辐射输出端口 到外壳。 测光装置还可以包括插入在辐射输出端口和多个样品室之间的辐射导向装置，用于同时将从输出端口发出的辐射引导到每个样品室中。 定向辐射可以是聚焦的或准直的。

公开(公告)号：US4566792A

公开(公告)日：1986-01-28

申请号：US463961

申请日：1983-02-04

Applicant: Jugoro Suzuki

Inventor： Jugoro Suzuki

IPC: G01J3/36 ,  G01N21/25 ,  G02B6/34 ,  G01J3/18 ,  G01J3/42

CPC classification number: G01J3/36 ,  G01N21/253 ,  G01N2201/0461 ,  G01N2201/08

Abstract: The disclosure is directed to a spectrophotometric measuring device equipped with a plurality of channels which automatically analyze many specimens with different testing items in a short period of time for application in biochemical automatic analysis or the like. The device of the invention is characterized in that white light from one light source is subjected to spectral diffraction through a long slit in X direction and wavelength dispersion irradiation light of an optical system including a spectroscope for dispersing spectrum of monochromatic light in Y direction intersecting at right angles with the slit, is projected onto one plate surface so as to select positions of the plate surface in the Y direction and X direction, and by providing the incident end faces of the optical fibers on the selected positions for free change-over, monochromatic lights of arbitrary wavelengths determined by the respective testing items are taken out, while the sample cell and detector are disposed to confront the optical fiber incident end faces for detection of intensity of light transmitting through the sample cell.

Abstract translation: 本发明涉及配备有多个通道的分光光度测量装置，其在短时间内自动分析具有不同测试项目的许多样品以用于生化自动分析等。 本发明的装置的特征在于，来自一个光源的白光通过X方向的长狭缝和包括用于分散Y光谱的Y光方向的光学系统的波长分散照射光进行光谱衍射 与狭缝成直角地投影到一个板表面上，以便选择板表面在Y方向和X方向上的位置，并且通过将光纤的入射端面设置在所选择的位置上进行自由转换， 取出由相应测试项目确定的任意波长的单色光，同时将样品池和检测器设置为面对光纤入射端面，以检测通过样品池传输的光的强度。