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公开(公告)号：US20100210731A1
公开(公告)日：2010-08-19
申请号：US12708998
申请日：2010-02-19
IPC分类号： A61K31/165 , C07C233/11 , A61P25/00 , A61P25/16 , A61P25/28
CPC分类号： C07C317/50 , A61K31/165 , C07C317/44
摘要： Polymorphs and solvates of racemic, enantiomerically pure, and enantiomerically mixed modafinil are formed and discussed. In addition, said forms are described as useful for the treatment of many conditions including, but not limited to, narcolepsy.
摘要翻译： 形成和讨论了外消旋，对映异构体纯和对映体混合的莫达非尼的多晶型物和溶剂合物。 此外，所述形式被描述为可用于治疗许多病症，包括但不限于发作性睡病。
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公开(公告)号：US07566805B2
公开(公告)日：2009-07-28
申请号：US10570405
申请日：2004-09-04
IPC分类号： C07C323/22 , A61K31/165
CPC分类号： C07C317/38
摘要： Co-crystals and solvates of racemic, enantiomerically pure, and enantiomerically mixed modafinil are formed and several important physical properties are modulated. The solubility, dissolution, bioavailability, dose response, and stability of modafinil can be modulated to improve efficacy in pharmaceutical compositions.
摘要翻译： 形成外消旋，对映异构体纯和对映异构体混合的莫达非尼的共晶体和溶剂合物，并调制几种重要的物理性质。 可以调节莫达非尼的溶解度，溶解度，生物利用度，剂量反应和稳定性，以提高药物组合物的功效。
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公开(公告)号：US08338646B2
公开(公告)日：2012-12-25
申请号：US12708998
申请日：2010-02-19
IPC分类号： C07C233/65
CPC分类号： C07C317/50 , A61K31/165 , C07C317/44
摘要： Polymorphs and solvates of racemic, enantiomerically pure, and enantiomerically mixed modafinil are formed and discussed. In addition, said forms are described as useful for the treatment of many conditions including, but not limited to, narcolepsy.
摘要翻译： 形成和讨论了外消旋，对映异构体纯和对映体混合的莫达非尼的多晶型物和溶剂合物。 此外，所述形式被描述为可用于治疗许多病症，包括但不限于发作性睡病。
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公开(公告)号：US20090018202A1
公开(公告)日：2009-01-15
申请号：US10587086
申请日：2005-02-01
IPC分类号： A61K31/165 , C07C231/00 , A61P25/00
CPC分类号： C07C317/50 , A61K31/165 , C07C317/44
摘要： Polymorphs and solvates of racemic, enantiomerically pure, and enantiomerically mixed modafinil are formed and discussed. In addition, said forms are described as useful for the treatment of many conditions including, but not limited to, narcolepsy.
摘要翻译： 形成和讨论了外消旋，对映异构体纯和对映体混合的莫达非尼的多晶型物和溶剂合物。 此外，所述形式被描述为可用于治疗许多病症，包括但不限于发作性睡病。
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公开(公告)号：US20050267209A1
公开(公告)日：2005-12-01
申请号：US11139245
申请日：2005-05-27
IPC分类号： A01N37/18 , A61K9/00 , A61K9/20 , A61K9/26 , A61K31/165 , A61K31/191 , A61K31/205
CPC分类号： A61K31/165 , A61K9/145 , A61K31/191 , C07C55/10 , C07C57/15 , C07C317/44 , A61K2300/00
摘要： A mixed co-crystal comprising an API, a first co-crystal former, and a second co-crystal former which is isomorphically substitutable with said first co-crystal former is described. A pharmaceutical composition comprising a mixed co-crystal, methods of making mixed co-crystals, and methods of using mixed co-crystals are also described.
摘要翻译： 描述了包含API，第一共晶体形成器和与所述第一共晶体形成器同构取代的第二共晶体形成器的混合共晶体。 还描述了包含混合共晶的药物组合物，制备混合共晶体的方法和使用混合共晶体的方法。
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公开(公告)号：US07671093B2
公开(公告)日：2010-03-02
申请号：US11139245
申请日：2005-05-27
IPC分类号： A61K31/165
CPC分类号： A61K31/165 , A61K9/145 , A61K31/191 , C07C55/10 , C07C57/15 , C07C317/44 , A61K2300/00
摘要： A mixed co-crystal comprising an API, a first co-crystal former, and a second co-crystal former which is isomorphically substitutable with said first co-crystal former is described. A pharmaceutical composition comprising a mixed co-crystal, methods of making mixed co-crystals, and methods of using mixed co-crystals are also described.
摘要翻译： 描述了包含API，第一共晶体形成器和与所述第一共晶体形成体同构取代的第二共晶体形成器的混合共晶体。 还描述了包含混合共晶的药物组合物，制备混合共晶体的方法和使用混合共晶体的方法。
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公开(公告)号：US20050025791A1
公开(公告)日：2005-02-03
申请号：US10601092
申请日：2003-06-20
申请人： Julius Remenar , Matthew Peterson , Orn Almarsson , Hector Guzman , Hongming Chen , Mark Tawa , Mark Oliveira
发明人： Julius Remenar , Matthew Peterson , Orn Almarsson , Hector Guzman , Hongming Chen , Mark Tawa , Mark Oliveira
IPC分类号： A61K9/14 , A61K9/16 , A61K9/64 , A61K31/18 , A61K31/365 , A61K31/415 , A61K31/635 , A61K47/10 , A61K47/32 , C07B63/00 , G01N21/27 , G01N25/08 , G01N25/12 , G01N33/15 , A61K9/00
CPC分类号： A61K9/1652 , A61K9/145 , A61K9/146 , A61K31/18 , A61K31/365 , A61K31/415 , A61K31/635 , A61K47/10 , A61K47/32 , C07D231/12
摘要： The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a recrystallization/precipitation retardant and an optional enhancer.
摘要翻译： 本发明涉及筛选含有药物化合物和赋形剂的混合物的方法，以鉴定延缓固态成核的药物化合物/赋形剂组合的性质。 本发明还涉及通过将药物与重结晶/沉淀阻滞剂和任选的增强剂组合来增加在胃液条件下溶解度低的药物的溶解度，溶解度和生物利用度。
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公开(公告)号：US20070021510A1
公开(公告)日：2007-01-25
申请号：US10570405
申请日：2004-09-04
申请人： Magali Hickey , Matthew Peterson , Orn Almarsson , Mark Oliveira
发明人： Magali Hickey , Matthew Peterson , Orn Almarsson , Mark Oliveira
IPC分类号： A61K31/165
CPC分类号： C07C317/38
摘要： Co-crystals and solvates of racemic, enantiomerically pure, and enantiomerically mixed modafinil are formed and several important physical properties are modulated. The solubility, dissolution, bioavailability, dose response, and stability of modafinil can be modulated to improve efficacy in pharmaceutical compositions.
摘要翻译： 形成外消旋，对映异构体纯和对映异构体混合的莫达非尼的共晶体和溶剂合物，并调制几种重要的物理性质。 可以调节莫达非尼的溶解度，溶解度，生物利用度，剂量反应和稳定性，以提高药物组合物的功效。
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公开(公告)号：US20060134198A1
公开(公告)日：2006-06-22
申请号：US10541216
申请日：2003-12-24
申请人： Mark Tawa , Julius Remenar , Matthew Peterson , Orn Almarsson , Hector Guzman , Hongming Chen , Mark Oliveira
发明人： Mark Tawa , Julius Remenar , Matthew Peterson , Orn Almarsson , Hector Guzman , Hongming Chen , Mark Oliveira
IPC分类号： A61K9/20
CPC分类号： A61K9/1652 , A61K9/145 , A61K9/146 , A61K31/18 , A61K31/365 , A61K31/415 , A61K31/635 , A61K47/10 , A61K47/32 , C07D231/12
摘要： The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a precipitation retardant and an optional enhancer.
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公开(公告)号：US20060052432A1
公开(公告)日：2006-03-09
申请号：US10528244
申请日：2003-09-16
申请人： Julius Remenar , Matthew Peterson , Orn Almarsson , Hector Guzman , Hongming Chen , Mark Tawa , Mark Oliveira
发明人： Julius Remenar , Matthew Peterson , Orn Almarsson , Hector Guzman , Hongming Chen , Mark Tawa , Mark Oliveira
IPC分类号： A61K9/00 , A61K31/18 , A61K31/415 , A61K31/365
CPC分类号： A61K9/0019 , A61K9/145 , A61K9/146 , A61K31/18 , A61K31/365 , A61K31/415 , A61K31/635 , A61K47/10
摘要： The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a precipitation retardant and an optional enhancer.
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