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24 条记录 (耗时 0.028 秒)

    Chemical process
    6.
    发明授权
    Chemical process 失效
    化学工艺

    公开(公告)号：US07405332B2

    公开(公告)日：2008-07-29

    申请号：US10528645

    申请日：2003-09-18

    申请人： Frank Brady ,  Sajinder Luthra ,  Yongjun Zhao

    发明人： Frank Brady ,  Sajinder Luthra ,  Yongjun Zhao

    IPC分类号： C07C17/00 ,  C07C19/08 ,  C07C213/00 ,  C07F7/08 ,  C07D257/00

    CPC分类号： C07B59/001 ,  C07C17/093 ,  C07C303/26

    摘要： The invention provides a process for preparation of a fluorohaloalkane, preferably an [18F]fluorohaloalkane of formula (I) wherein X is halo and n is an integer of from 1 to 6; which comprises: reaction of the corresponding organosilicon compound of formula (II): wherein n is as defined for the compound of formula (I); and R′, R″, and R′″ are independently selected from C1-6 alkyl and C1-6 haloalkyl; and R″ may alternatively be the group: with a compound of formula (III): wherein X is as defined for the compound of formula (I) and Y is halo. Intermediates having use in such processes are also claimed.

    摘要翻译： 本发明提供了制备式（I）的氟代卤代烷烃，优选其中X为卤素且n为1至6的整数的式（I）的[F 18 F]氟卤代烷烃的方法; 其包括：相应的式（II）的有机硅化合物的反应：其中n如对于式（I）的化合物所定义; 和R'，R“和R”'独立地选自C 1-6烷基和C 1-6卤代烷基; 和R“可以另选地为：与式（III）化合物：其中X如式（I）化合物所定义，Y是卤素。 也要求使用在这些方法中的中间体。

    Solid-Phase Preparation of [18F]Fluorohaloalkanes
    8.
    发明申请
    Solid-Phase Preparation of [18F]Fluorohaloalkanes 失效
    固相制备[18 F]氟卤代烷烃

    公开(公告)号：US20070202039A1

    公开(公告)日：2007-08-30

    申请号：US11742687

    申请日：2007-05-01

    申请人： Frank Brady ,  Sajinder Luthra ,  Yongjun Zhao

    发明人： Frank Brady ,  Sajinder Luthra ,  Yongjun Zhao

    IPC分类号： A61K51/00 ,  C07C19/08

    CPC分类号： C07C17/204 ,  C07B2200/05 ,  C07C17/093

    摘要： The invention relates to a process for the production of an [18F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2—O—(CH2)nX  (I) wherein n is an integer of from 1 to 7 and X is chloro, bromo or iodo; with 18F− to produce the [18F]fluorohaloalkane of formula (II) 18F—(CH2)n—X  (II) wherein n and X are as defined for the compound of formula (I), optionally followed by (i) removal of excess 18F−, for example by ion-exchange chromatography; and/or (ii) removal of organic solvent.

    摘要翻译： 本发明涉及一种制备[ - 18 F]氟卤代烷烃的方法，该方法包括处理式（I）的固体载体结合的前体：<β在线式描述=“In “公式”end =“lead”？>固体支持物 - SO 2 -O - （CH 2）n X（I ）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中n为1至7的整数，X为氯，溴或碘; 与
    以产生式（II）的 18 F氟卤代烷烃<？in-line-formula description =“In- 线公式“end =”lead“？> （CH 2）n -X（II）<？in-line- 其中n和X如对于式（I）化合物所定义，任选地之后是（i）除去过量的18 F 例如通过离子交换色谱法; 和/或（ii）除去有机溶剂。

    Solid-phase preparation of [18f] fluorohaloalkanes
    9.
    发明申请
    Solid-phase preparation of [18f] fluorohaloalkanes 失效
    [18f]氟卤代烷烃的固相制备

    公开(公告)号：US20060069294A1

    公开(公告)日：2006-03-30

    申请号：US10539163

    申请日：2003-12-19

    申请人： Frank Brady ,  Sajinder Luthra ,  Yongjun Zhao

    发明人： Frank Brady ,  Sajinder Luthra ,  Yongjun Zhao

    IPC分类号： C07C17/093

    CPC分类号： C07C17/204 ,  C07B2200/05 ,  C07C17/093

    摘要： The invention relates to a process for the production of an [18F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2—O—(CH2)nX (I) wherein n is an integer of from (1) to (7) and X is chloro, bromo or iodo; with 18F− to produce the [18F]fluorohaloalkane of formula (II) 18F—(CH2)nX (II) wherein n and X are as defined for the compound of formula (I), optionally followed by (i) removal of excess 18F−, for example by ion-exchange chromatography; and/or (ii) removal of organic solvent.

    摘要翻译： 本发明涉及一种制备[ - 18 F]氟卤代烷烃的方法，该方法包括处理式（I）的固体载体结合的前体：固体支持物 - 其中n为（1）至（7）的整数，X为氯，溴或氯，或（C 1 -C 4） 碘 以产生式（II）的[ - 18 F]氟代卤代烷基（F）（CH 3） 其中n和X如对于式（I）化合物所定义，其中任选地随后是（i）除去过量的18 例如通过离子交换色谱法; 和/或（ii）除去有机溶剂。

    Chemical process
    10.
    发明申请
    Chemical process 失效
    化学工艺

    公开(公告)号：US20060106219A1

    公开(公告)日：2006-05-18

    申请号：US10528645

    申请日：2003-09-18

    申请人： Frank Brady ,  Sajinder Luthra ,  Yongjun Zhao

    发明人： Frank Brady ,  Sajinder Luthra ,  Yongjun Zhao

    IPC分类号： A61K51/00 ,  C07D451/02 ,  C07F7/08

    CPC分类号： C07B59/001 ,  C07C17/093 ,  C07C303/26

    摘要： The invention provides a process for preparation of a fluorohaloalkane, preferably an [18F]fluorohaloalkane of formula (I) wherein X is halo and n is an integer of from 1 to 6; which comprises: reaction of the corresponding organosilicon compound of formula (II): wherein n is as defined for the compound of formula (I); and R′, R″, and R′″ are independently selected from C1-6 alkyl and C1-6 haloalkyl; and R″ may alternatively be the group: with a compound of formula (III): wherein X is as defined for the compound of formula (I) and Y is halo. Intermediates having use in such processes are also claimed.

    摘要翻译： 本发明提供了制备式（I）的氟代卤代烷烃，优选其中X为卤素且n为1至6的整数的式（I）的[F 18 F]氟卤代烷烃的方法; 其包括：相应的式（II）的有机硅化合物的反应：其中n如对于式（I）的化合物所定义; 和R'，R“和R”'独立地选自C 1-6烷基和C 1-6卤代烷基; 和R“可以另选地为：与式（III）化合物：其中X如式（I）化合物所定义，Y是卤素。 也要求使用在这些方法中的中间体。