公开(公告)号：US5118609A

公开(公告)日：1992-06-02

申请号：US648685

申请日：1991-01-31

申请人： Manfred Baier ,  Helmut Jering ,  Rolf Lerch ,  Dieter Mangold ,  Ellen Mossner ,  Gunter Pappert ,  Siegfried Notzel

发明人： Manfred Baier ,  Helmut Jering ,  Rolf Lerch ,  Dieter Mangold ,  Ellen Mossner ,  Gunter Pappert ,  Siegfried Notzel

IPC分类号： C07K1/16 ,  C07K16/00 ,  C07K17/10 ,  C12Q1/00 ,  C12Q1/34 ,  D04H1/54 ,  D04H1/58 ,  D21H11/12 ,  D21H13/08 ,  D21H13/16 ,  D21H13/24 ,  D21H13/26 ,  D21H17/34 ,  D21H17/36 ,  D21H17/37 ,  D21H17/39 ,  G01N33/545 ,  G01N33/548

CPC分类号： D21H17/34 ,  G01N33/545 ,  D21H11/12 ,  D21H13/08 ,  D21H13/16 ,  D21H13/24 ,  D21H13/26 ,  D21H17/36 ,  D21H17/37 ,  D21H17/39 ,  Y10S435/805 ,  Y10S435/97 ,  Y10S530/814 ,  Y10S530/815

摘要： A carrier fleece is prepared for use as reagent carrier from which reagents can be dissolved in as assay such as immunological analysis. The carrier fleece contains from 5 to 60% by weight of cellulose-containing fibers, from 40 to 95% by weight of polyester or polyamide polymer fibers or a combination thereof and from 5 to 30% by weight of the fibers of an organic binding agent which has a hydroxyl or an ester group or a combination thereof. In an immunological analysis, the carrier fleece is impregnated with an immunologically active agent such as a beta-galactosidase conjugate and then introduced into a solution of a sample containing an immunologically active substance to be analyzed. The immunologically active agent is eluted into the sample solution and the presence of the immunologically active substance in the sample is determined.

摘要翻译： 制备载体羊毛作为试剂载体，试剂可以作为试剂溶解，如免疫分析。 载体绒毛含有5至60重量％的含纤维素的纤维，40至95重量％的聚酯或聚酰胺聚合物纤维或其组合，和5至30重量％的有机粘合剂的纤维 其具有羟基或酯基或其组合。 在免疫学分析中，载体羊毛用免疫活性剂例如β-半乳糖苷酶缀合物浸渍，然后引入含有待分析的免疫活性物质的样品的溶液中。 将免疫活性剂洗脱到样品溶液中，并测定样品中免疫活性物质的存在。

公开(公告)号：US4803171A

公开(公告)日：1989-02-07

申请号：US940500

申请日：1986-12-11

申请人： Manfred Baier ,  Klaus P. Kaspar ,  Rainer Schafer ,  Ulrich Trager ,  Siegfried Notzel

发明人： Manfred Baier ,  Klaus P. Kaspar ,  Rainer Schafer ,  Ulrich Trager ,  Siegfried Notzel

IPC分类号： G01N33/548 ,  G01N33/52 ,  G01N33/543 ,  G01N33/544 ,  G01N33/545 ,  G01N33/53

CPC分类号： G01N33/545 ,  G01N33/544 ,  Y10S435/805 ,  Y10S436/81

摘要： The present invention provides a process for the preparation of a reagent paper for immunological analysis, wherein a fiber fleece of a cellulose/synthetic fiber mixture, in which the weight ratio of cellulose/synthetic fiber is 1 to 90/99 to 10, is activated by treatment with periodate, the so activated fiber fleece is loaded with an acid-treated protein and non-bound protein is removed.The present invention also provides a reagent paper for immunological analysis, wherein it comprises a fiber fleece of a cellulose/synthetic fiber mixture, in which the weight ratio of cellulose/synthetic fiber is from 1 to 90/99 to 10.Furthermore, the present invention is concerned with the use of a fiber fleece of a cellulose/synthetic fiber mixture, wherein the weight ratio of cellulose/synthetic fiber is 90 to 1/10 to 99, as reagent carrier for heterogeneous immunological analysis.

摘要翻译： 本发明提供一种制备用于免疫学分析的试剂纸的方法，其中纤维素/合成纤维混合物的纤维绒毛纤维素/合成纤维的重量比为1至90/99至10，被激活 通过用高碘酸盐处理，如此活化的纤维羊毛装载有酸处理的蛋白质，并且去除非结合蛋白质。 本发明还提供了一种用于免疫学分析的试剂纸，其中纤维素/合成纤维混合物的纤维绒毛的纤维素/合成纤维的重量比为1〜90/99〜10。此外，本发明 本发明涉及使用纤维素/合成纤维混合物的纤维绒，其中纤维素/合成纤维的重量比为90至1/10至99作为用于异质免疫分析的试剂载体。

公开(公告)号：US4670383A

公开(公告)日：1987-06-02

申请号：US775596

申请日：1985-09-13

申请人： Manfred Baier ,  Helmut Jering ,  Sigmar Klose

发明人： Manfred Baier ,  Helmut Jering ,  Sigmar Klose

IPC分类号： G01N33/541 ,  G01N33/543 ,  G01N33/563 ,  G01N33/564 ,  G01N33/94 ,  G01N33/53 ,  G01N33/537

CPC分类号： G01N33/564 ,  G01N33/541 ,  G01N33/54306 ,  G01N33/563 ,  G01N33/9453 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/971 ,  Y10S435/975 ,  Y10S436/808 ,  Y10S436/824

摘要： This invention describes a process for immuno-chemical quantitative determination of immunologically active substances. The method involves a first incubation of a sample containing the active substance with a labelled binder, which contains an antibody or antibody fragment. After complexing has taken place, solid phase bound active substance identical to the substance being quantitatively determined is added. The solid phase bound substance binds with free binder, and the solid and liquid phases are separated. A second antibody which is specific either to antibody or the solid phase antibody-substance complex is then added to the liquid phase. This second antibody is non cross-reactive with individual complex components. The amount of labelled first antibody bound to second antibody is then determined.

摘要翻译： 本发明描述了免疫学定量测定免疫活性物质的方法。 该方法包括将含有活性物质的样品与含有抗体或抗体片段的标记的粘合剂进行第一次孵育。 发生络合后，加入与待定量物质相同的固相结合活性物质。 固相结合的物质与游离的粘合剂结合，并分离固相和液相。 然后将与抗体或固相抗体 - 物质复合物特异性的第二抗体加入到液相中。 该第二抗体与单个复合组分是非交叉反应的。 然后测定与第二抗体结合的标记的第一抗体的量。

公开(公告)号：US5013294A

公开(公告)日：1991-05-07

申请号：US272315

申请日：1988-11-17

申请人： Manfred Baier

发明人： Manfred Baier

IPC分类号： A61B1/12 ,  A61M13/00

CPC分类号： A61B1/015 ,  A61M13/003

摘要： An insufflation device for filling a body cavity, such as an abdominal cavity, with a gas from a gas bottle via an expansion valve and a feed pipe leading to the body cavity characterized by the feed pipe being formed along in length by two channels with the first of the two channels having an expansion valve for setting an overpressure for rapid filling of the body cavity during an initial period and the second channel having an expansion valve to adjust the pressure to the pressure desired in the body cavity. The pressure of the second flow is monitored and compared by an electronic evaluator system, which will interrupt the flow and sound alarms if the pressure exceeds a predetermined amount over the desired value and also if the pressure exceeds a predetermined maximum amount.

摘要翻译： 一种用于通过膨胀阀和通向所述体腔的进料管将来自气瓶的气体填充到诸如腹腔的体腔的吹入装置，其特征在于，所述进料管沿着两个通道长度形成， 两个通道中的第一个具有膨胀阀，用于在初始阶段期间设定用于快速填充体腔的超压，并且第二通道具有膨胀阀，以将压力调节到体腔所需的压力。 通过电子评估器系统来监测和比较第二流量的压力，如果压力超过期望值上的预定量以及压力超过预定最大量时将会中断流量和声音报警。

公开(公告)号：US4995877A

公开(公告)日：1991-02-26

申请号：US311758

申请日：1989-02-17

申请人： Felix Ams ,  Manfred Baier ,  Roland Schafer

发明人： Felix Ams ,  Manfred Baier ,  Roland Schafer

IPC分类号： A61B17/00 ,  A61B17/16 ,  B23Q5/00 ,  G05B19/10

CPC分类号： B23Q5/00 ,  A61B17/1626 ,  G05B19/106 ,  A61B2017/00973

摘要： The device comprises a rotationally driven surgical instrument incorporating a hand-held element having a mount rotatably installed therein for reception of interchangeable cutting and milling inserts, a driving motor for driving the mount receiving the tool inserts, a control unit for controlling the driving motor with means of setting the rotational speed and of preselecting the rotational speed range and direction of rotation as well as a digital indicator for displaying the rotational speed set up in each case. For the purpose of accessible storage of setting data, the control unit incorporates a non-volatile read-write memory for digital storage of rotational speeds, a code carrier as well as a coding/decoding arrangement.

摘要翻译： 该装置包括旋转驱动的手术器械，其包括手持元件，该手持元件具有可旋转地安装在其中的托架，用于接收可互换的切割和铣削插入件，用于驱动接收工具插入件的安装件的驱动马达，用于控制驱动马达的控制单元 设定旋转速度和预选旋转速度范围和旋转方向的装置以及用于显示在每种情况下设定的转速的数字指示器。 为了存储设置数据的可访问性，控制单元包括用于旋转速度的数字存储的非易失性读写存储器，代码载体以及编码/解码装置。

公开(公告)号：US4885255A

公开(公告)日：1989-12-05

申请号：US173779

申请日：1988-03-28

申请人： Werner Stock ,  Manfred Baier ,  Klaus P. Kaspar ,  Peter Kirch

发明人： Werner Stock ,  Manfred Baier ,  Klaus P. Kaspar ,  Peter Kirch

IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/563 ,  G01N33/74

CPC分类号： G01N33/54366 ,  G01N33/53 ,  G01N33/74 ,  Y10S436/824

摘要： The present invention provides a process for the quantitative determination of a polyvalent antigen by incubation with three different receptors of which the first (R1) and the third (R3) are present in liquid phase and are bindable with the antigen, the second receptor (R2) is present in solid phase and is bindable with receptor (R1), and receptor (R3) carries a label and does not cross-react with (R1) and (R2), separation of the solid phase from the liquid phase and measurement of the label in one of the phases, wherein a first receptor (R1) is used which consists of at least two antibody molecules or antibody molecule fragments bound with one another, at least one of which binds specifically with the antigen to be determined.The present invention also provides a reagent for the quantitative determination of a polyvalent antigen containing three receptors (R1, R2 and R3) of which (R1) and (R3) are soluble and bindable with the antigen, (R3) is labelled and does not cross-react with (R1) and (R2), wherein (R1) consists of at least two antibody molecules or antibody molecule fragments bound with one another, at least one of which binds specifically with the antigen to be determined.

摘要翻译： 本发明提供了一种通过与三种不同的受体（其中第一（R1）和第三（R3））以液相存在并且可与抗原，第二受体（R2 ）存在于固相中并且与受体（R1）结合，并且受体（R3）携带标记并且不与（R1）和（R2）交叉反应，固相与液相的分离和测量 其中一个相中的标记，其中使用由至少两个彼此结合的抗体分子或抗体分子片段组成的第一受体（R1），其中至少一个与要测定的抗原特异性结合。 本发明还提供了用于定量测定含有三种受体（R1，R2和R3）的多价抗原的试剂，其中（R1）和（R3）可溶解并与抗原结合，（R3）被标记，并且不 与（R1）和（R2）交叉反应，其中（R1）由至少两个彼此结合的抗体分子或抗体分子片段组成，其中至少一个与要测定的抗原特异性结合。

公开(公告)号：US4585399A

公开(公告)日：1986-04-29

申请号：US743828

申请日：1985-06-12

申请人： Manfred Baier

发明人： Manfred Baier

IPC分类号： F04B43/12

CPC分类号： F04B43/1253

摘要： The hose pump in particular for drawing flushing liquids out of bodily cavities, is so constructed that the extremities of the hose which is to be inserted into the pump housing have different coupling or plug elements for suction and pressure hoses which are to be connected, and different fitting elements for complementary fitting elements of the pump housing or of the coupling element, whereby the positions of the two extremities in the housing cannot be transposed and accidental reversal of the suction and pressure hoses is prevented.

摘要翻译： 特别是用于将冲洗液体从身体腔抽出的软管泵被构造成使得待插入泵壳体中的软管的末端具有用于要连接的吸入和压力软管的不同联接或插塞元件，以及 用于泵壳体或耦合元件的互补装配元件的不同的装配元件，由此壳体中的两个末端的位置不能被转置，并且防止了吸入和压力软管的意外反转。

公开(公告)号：US5098375A

公开(公告)日：1992-03-24

申请号：US529976

申请日：1990-05-29

申请人： Manfred Baier

发明人： Manfred Baier

IPC分类号： A61B18/00 ,  A61M13/00

CPC分类号： A61M13/003 ,  A61M13/006 ,  A61B2218/006

摘要： A insufflation unit for distending a body cavity such as a uterus which is to be examined or treated endoscopically has a gas control circuit which connects a gas supply unit to the endoscope via a flowmeter, a shut-off valve and a filter. Associated with this gas control circuit is an extractor circuit which comprises a pump whose suction end is coupled up to the output of the flowmeter. A pressure-measuring transducer logs the pressure at the suction end of the pump and its measurements, together with those from the flowmeter, are made use of in analyzer electronics by switching off the pump before a pressure likely to put the patient at risk occurs should there be a fault in the extractor circuit.

摘要翻译： 用于使内窥镜等体腔膨胀的内窥镜的检查或处理的吹入单元具有通过流量计，截止阀和过滤器将气体供给单元与内窥镜连接的气体控制回路。 与该气体控制回路相关联的是抽吸回路，其包括泵，其吸入端连接到流量计的输出端。 一个压力测量传感器记录泵的吸力端的压力，其测量结果与流量计的测量值一起在分析仪电子设备中通过在可能导致患者发生危险的压力之前关闭泵来使用。 提取器电路有故障。

公开(公告)号：US4415700A

公开(公告)日：1983-11-15

申请号：US331114

申请日：1981-12-16

申请人： Hans-Georg Batz ,  Paul Tanswell ,  Manfred Baier ,  Karel Bouchal ,  Jaroslav Kalal ,  Frantisek Svec ,  Eva Zurkova

发明人： Hans-Georg Batz ,  Paul Tanswell ,  Manfred Baier ,  Karel Bouchal ,  Jaroslav Kalal ,  Frantisek Svec ,  Eva Zurkova

IPC分类号： A61K39/44 ,  C08F2/22 ,  C12N11/08 ,  G01N33/543 ,  G01N33/74 ,  C08L33/00 ,  C08F20/32 ,  C08L37/00 ,  G01N33/54

CPC分类号： A61K39/44 ,  C08F2/22 ,  C12N11/08 ,  G01N33/54313 ,  G01N33/74

摘要： Hydrophilic latex particles consisting of a homo- or co-polymer of monomers which are sparingly soluble in water, which hydrophilic latex particles can be prepared by emulsion polymerization in the presence of a water-soluble, radical-forming initiator but without an addition of an emulsifier, stabilizer or wetting agent. A process for the preparation of these hydrophilic latex particles, wherein a monomer which is sparingly soluble in water or several monomers which are sparingly soluble in water are dispersed in water and, with the exclusion of oxygen, for example in an inert atmosphere, are homo- or co-polymerized by emulsion polymerization in the presence of a water-soluble, radical-forming initiator but without any addition of an emulsifier, stabilizer or wetting agent.A diagnostic agent containing these hydrophilic latex particles as carrier and biologically and/or immunologically active substances covalently bound to this carrier either directly or via a coupling agent as a bridge.

摘要翻译： 亲水胶乳颗粒由单体的均聚物或共聚物组成，其单独溶于水，该亲水胶乳颗粒可以通过在水溶性自由基形成引发剂存在下的乳液聚合制备，但不加入 乳化剂，稳定剂或润湿剂。 制备这些亲水胶乳颗粒的方法，其中微溶于水的单体或少量微溶于水的单体分散在水中，并且除了氧以外，例如在惰性气氛中是均一的 - 或者在水溶性自由基形成引发剂的存在下通过乳液聚合共聚，但不加入乳化剂，稳定剂或润湿剂。 包含这些亲水性胶乳颗粒作为载体的诊断剂，以及直接或通过偶联剂作为桥接共价结合到该载体的生物和/或免疫活性物质。

公开(公告)号：US5150373A

公开(公告)日：1992-09-22

申请号：US668026

申请日：1991-03-12

申请人： Achim Kolb ,  Manfred Baier ,  Klaus Muller

发明人： Achim Kolb ,  Manfred Baier ,  Klaus Muller

IPC分类号： A61B1/12 ,  A61B18/00 ,  A61B18/20

CPC分类号： A61B1/12 ,  A61B18/201 ,  A61B2018/00017

摘要： The hollow guide is designed as a thin ceramic hollow tube which is guided in an outer tube while leaving a hollow space between the outer tube and the ceramic hollow tube, the outer tube being provided at its proximal end with a connecting part having a gas connection and receiving a focusing optical system. The ceramic hollow tube is guided in the outer tube through at least one mounting part arranged at the proximal end and at least one mounting part at the distal end, which in each case is supported locally with respect to the inner wall of the outer tube. The mounting parts are thus arranged so that free flow cross-sections to conduct the rinsing gas remain in the region of support, these being matched with the internal inner cross-section of the ceramic hollow tube, so that gas flow flowing past the ceramic hollow tube is produced both on the outside and on the inside. The gas flow effects cooling of the ceramic hollow tube on the one hand and prevents impurities penetrating the distal end of the ceramic hollow tube on the other hand.

摘要翻译： 空心导轨设计为薄陶瓷中空管，其在外管中被引导，同时在外管和陶瓷中空管之间留下中空空间，外管在其近端处设置有具有气体连接的连接部 并接收聚焦光学系统。 陶瓷中空管通过布置在近端的至少一个安装部分和在远端的至少一个安装部分在外管中被引导，每个安装部分在每个壳体中相对于外管的内壁局部地被支撑。 因此，安装部件被布置成使得漂洗气体的自由流动截面保持在支撑区域中，这些与陶瓷中空管的内部内部横截面相匹配，使得流过陶瓷中空部的气流 管是在外部和内部产生的。 气体流动一方面影响陶瓷中空管的冷却，另一方面防止杂质渗透到陶瓷中空管的远端。