公开(公告)号：US08820357B2

公开(公告)日：2014-09-02

申请号：US13569155

申请日：2012-08-07

申请人： Manu Prakash ,  Neil Gershenfeld

发明人： Manu Prakash ,  Neil Gershenfeld

IPC分类号： F15B21/00

CPC分类号： F15C1/02 ,  B01L3/5027 ,  B01L3/502769 ,  F15C1/00 ,  Y10T137/0318 ,  Y10T137/0324 ,  Y10T137/2076 ,  Y10T137/9247

摘要： A method for implementing a logic operation employs an all fluid-based no-moving part micro-mechanical logic family of microfluidic bubble logic devices that are constructed from complex sequences of microfluidic channels, microfluidic bubble modulators for programming the devices, and microfluidic droplet/bubble memory elements for chemical storage and retrieval. The input is a sequence of bubbles/droplets encoding information, with the output being another sequence of bubbles/droplets. For performing a set of reactions/tasks, the modulators program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the microfluidic channel sequence, utilizing the generated bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, shift registers, multiplexers, and ring oscillators have been designed and fabricated.

摘要翻译： 用于实现逻辑操作的方法使用由微流体通道的复杂序列，用于编程器件的微流控气泡调制器和微流控液滴/气泡构成的所有基于流体的无动力部分微机械逻辑器件微流体逻辑器件 用于化学品储存和检索的记忆元素。 输入是编码信息的气泡/液滴序列，输出是气泡/液滴的另一个序列。 为了执行一组反应/任务，调制器通过产生精确定时的气泡/液滴序列对装置进行编程，从而在微流体通道序列内进行级联的逻辑运算，利用生成的气泡作为对照。 这些装置基于在精密通道几何形状内包围的两个流体相之间形成的最小能量界面的原理。 已经设计和制造了各种装置，包括逻辑门，非易失性双稳态存储器，移位寄存器，多路复用器和环形振荡器。

公开(公告)号：US08828335B2

公开(公告)日：2014-09-09

申请号：US13778103

申请日：2013-02-26

申请人： Manu Prakash ,  Neil Gershenfeld

发明人： Manu Prakash ,  Neil Gershenfeld

IPC分类号： G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N15/14

CPC分类号： G01N1/2035 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/02 ,  B01L2400/086 ,  F16K99/0001 ,  F16K99/0019 ,  F16K2099/0084 ,  F16K2099/0092 ,  F16L55/00 ,  G01N15/06 ,  G01N2001/002 ,  Y10T137/2076 ,  Y10T137/87153 ,  Y10T137/87249 ,  Y10T137/9247 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. For performing a set of reactions/tasks or process control, the modulators can be used to program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the micro- or nanofluidic channel sequence, utilizing the generated droplets/bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, ring oscillators, bubble synchronizers, analysis chips, and printers have been designed.

摘要翻译： 基于流体的无移动部件逻辑器件由微流体和纳流体通道的复杂序列构成，用于编程器件的按需气泡/液滴调制器和发生器，以及用于存储和检索的微流体和纳流体液滴/气泡存储元件 生物或化学元素。 气泡/液滴的输入序列编码信息，输出是气泡/液滴的另一个序列或片上化学合成。 为了执行一组反应/任务或过程控制，调制器可以用于通过产生精确定时的气泡/液滴序列对装置进行编程，从而在微流体或纳流体通道序列内进行级联的逻辑运算，利用 产生液滴/气泡作为对照。 这些装置基于在精密通道几何形状内包围的两个流体相之间形成的最小能量界面的原理。 已经设计了各种设备，包括逻辑门，非易失性双稳态存储器，环形振荡器，气泡同步器，分析芯片和打印机。

公开(公告)号：US20120291870A1

公开(公告)日：2012-11-22

申请号：US13569155

申请日：2012-08-07

申请人： Manu Prakash ,  Neil Gershenfeld

发明人： Manu Prakash ,  Neil Gershenfeld

IPC分类号： F17D1/00

CPC分类号： F15C1/02 ,  B01L3/5027 ,  B01L3/502769 ,  F15C1/00 ,  Y10T137/0318 ,  Y10T137/0324 ,  Y10T137/2076 ,  Y10T137/9247

摘要： A method for implementing a logic operation employs an all fluid-based no-moving part micro-mechanical logic family of microfluidic bubble logic devices that are constructed from complex sequences of microfluidic channels, microfluidic bubble modulators for programming the devices, and microfluidic droplet/bubble memory elements for chemical storage and retrieval. The input is a sequence of bubbles/droplets encoding information, with the output being another sequence of bubbles/droplets. For performing a set of reactions/tasks, the modulators program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the microfluidic channel sequence, utilizing the generated bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, shift registers, multiplexers, and ring oscillators have been designed and fabricated.

摘要翻译： 用于实现逻辑操作的方法使用由微流体通道的复杂序列，用于编程器件的微流控气泡调制器和微流控液滴/气泡构成的所有基于流体的无动力部分微机械逻辑器件微流体逻辑器件 用于化学品储存和检索的记忆元素。 输入是编码信息的气泡/液滴序列，输出是气泡/液滴的另一个序列。 为了执行一组反应/任务，调制器通过产生精确定时的气泡/液滴序列对装置进行编程，从而在微流体通道序列内进行级联的逻辑运算，利用生成的气泡作为对照。 这些装置基于在精密通道几何形状内包围的两个流体相之间形成的最小能量界面的原理。 已经设计和制造了各种装置，包括逻辑门，非易失性双稳态存储器，移位寄存器，多路复用器和环形振荡器。

公开(公告)号：US08235071B2

公开(公告)日：2012-08-07

申请号：US12871861

申请日：2010-08-30

申请人： Manu Prakash ,  Neil Gershenfeld

发明人： Manu Prakash ,  Neil Gershenfeld

IPC分类号： F15B21/00

CPC分类号： F15C1/02 ,  B01L3/5027 ,  B01L3/502769 ,  F15C1/00 ,  Y10T137/0318 ,  Y10T137/0324 ,  Y10T137/2076 ,  Y10T137/9247

摘要： A method for implementing a logic operation employs an all fluid-based no-moving part micro-mechanical logic family of microfluidic bubble logic devices that are constructed from complex sequences of microfluidic channels, microfluidic bubble modulators for programming the devices, and microfluidic droplet/bubble memory elements for chemical storage and retrieval. The input is a sequence of bubbles/droplets encoding information, with the output being another sequence of bubbles/droplets. For performing a set of reactions/tasks, the modulators program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the microfluidic channel sequence, utilizing the generated bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, shift registers, multiplexers, and ring oscillators have been designed and fabricated.

摘要翻译： 用于实现逻辑操作的方法使用由微流体通道的复杂序列，用于编程器件的微流控气泡调制器和微流控液滴/气泡构成的所有基于流体的无动力部分微机械逻辑器件微流体逻辑器件 用于化学品储存和检索的记忆元素。 输入是编码信息的气泡/液滴序列，输出是气泡/液滴的另一个序列。 为了执行一组反应/任务，调制器通过产生精确定时的气泡/液滴序列对装置进行编程，从而在微流体通道序列内进行级联的逻辑运算，利用生成的气泡作为对照。 这些装置基于在精密通道几何形状内包围的两个流体相之间形成的最小能量界面的原理。 已经设计和制造了各种装置，包括逻辑门，非易失性双稳态存储器，移位寄存器，多路复用器和环形振荡器。

公开(公告)号：US07784495B2

公开(公告)日：2010-08-31

申请号：US11416449

申请日：2006-05-02

申请人： Manu Prakash ,  Neil Gershenfeld

发明人： Manu Prakash ,  Neil Gershenfeld

IPC分类号： F15B21/00

CPC分类号： F15C1/02 ,  B01L3/5027 ,  B01L3/502769 ,  F15C1/00 ,  Y10T137/0318 ,  Y10T137/0324 ,  Y10T137/2076 ,  Y10T137/9247

摘要： An all fluid-based no-moving part micro-mechanical logic family of microfluidic bubble logic devices is constructed from complex sequences of microfluidic channels, microfluidic bubble modulators for programming the devices, and microfluidic droplet/bubble memory elements for chemical storage and retrieval. The input is a sequence of bubbles/droplets encoding information, with the output being another sequence of bubbles/droplets. For performing a set of reactions/tasks, the modulators program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the microfluidic channel sequence, utilizing the generated bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, shift registers, multiplexers, and ring oscillators have been designed and fabricated.

摘要翻译： 微流体气泡逻辑器件的所有基于流体的无动力部件微机械逻辑系列由微流体通道的复杂序列，用于编程器件的微流控气泡调制器和用于化学存储和检索的微流控液滴/气泡存储器元件构成。 输入是编码信息的气泡/液滴序列，输出是气泡/液滴的另一个序列。 为了执行一组反应/任务，调制器通过产生精确定时的气泡/液滴序列对装置进行编程，从而在微流体通道序列内进行级联的逻辑运算，利用生成的气泡作为对照。 这些装置基于在精密通道几何形状内包围的两个流体相之间形成的最小能量界面的原理。 已经设计和制造了各种装置，包括逻辑门，非易失性双稳态存储器，移位寄存器，多路复用器和环形振荡器。

公开(公告)号：US09404835B2

公开(公告)日：2016-08-02

申请号：US14481855

申请日：2014-09-09

申请人： Manu Prakash ,  Neil Gershenfeld

发明人： Manu Prakash ,  Neil Gershenfeld

IPC分类号： B01L3/00 ,  B01D21/00 ,  G01N1/20 ,  F16K99/00 ,  F16L55/00 ,  G01N15/06 ,  G01N1/00

CPC分类号： G01N1/2035 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/02 ,  B01L2400/086 ,  F16K99/0001 ,  F16K99/0019 ,  F16K2099/0084 ,  F16K2099/0092 ,  F16L55/00 ,  G01N15/06 ,  G01N2001/002 ,  Y10T137/2076 ,  Y10T137/87153 ,  Y10T137/87249 ,  Y10T137/9247 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. For performing a set of reactions/tasks or process control, the modulators can be used to program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the micro- or nanofluidic channel sequence, utilizing the generated droplets/bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, ring oscillators, bubble synchronizers, analysis chips, sample collectors, and printers have been designed.

摘要翻译： 基于流体的无移动部件逻辑器件由微流体和纳流体通道的复杂序列构成，用于编程器件的按需气泡/液滴调制器和发生器，以及用于存储和检索的微流体和纳流体液滴/气泡存储元件 生物或化学元素。 气泡/液滴的输入序列编码信息，输出是气泡/液滴的另一个序列或片上化学合成。 为了执行一组反应/任务或过程控制，调制器可用于通过产生精确定时的气泡/液滴序列对装置进行编程，导致在微流体或纳流体通道序列内的级联逻辑运算，利用 产生液滴/气泡作为对照。 这些装置基于在精密通道几何形状内包围的两个流体相之间形成的最小能量界面的原理。 已经设计了各种设备，包括逻辑门，非易失性双稳态存储器，环形振荡器，气泡同步器，分析芯片，样品收集器和打印机。

公开(公告)号：US20130167958A1

公开(公告)日：2013-07-04

申请号：US13778103

申请日：2013-02-26

申请人： Manu Prakash ,  Neil Gershenfeld

发明人： Manu Prakash ,  Neil Gershenfeld

IPC分类号： F16L55/00

CPC分类号： G01N1/2035 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/02 ,  B01L2400/086 ,  F16K99/0001 ,  F16K99/0019 ,  F16K2099/0084 ,  F16K2099/0092 ,  F16L55/00 ,  G01N15/06 ,  G01N2001/002 ,  Y10T137/2076 ,  Y10T137/87153 ,  Y10T137/87249 ,  Y10T137/9247 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. For performing a set of reactions/tasks or process control, the modulators can be used to program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the micro- or nanofluidic channel sequence, utilizing the generated droplets/bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, ring oscillators, bubble synchronizers, analysis chips, and printers have been designed.

摘要翻译： 基于流体的无移动部件逻辑器件由微流体和纳流体通道的复杂序列构成，用于编程器件的按需气泡/液滴调制器和发生器，以及用于存储和检索的微流体和纳流体液滴/气泡存储元件 生物或化学元素。 气泡/液滴的输入序列编码信息，输出是气泡/液滴的另一个序列或片上化学合成。 为了执行一组反应/任务或过程控制，调制器可以用于通过产生精确定时的气泡/液滴序列对装置进行编程，从而在微流体或纳流体通道序列内进行级联的逻辑运算，利用 产生液滴/气泡作为对照。 这些装置基于在精密通道几何形状内包围的两个流体相之间形成的最小能量界面的原理。 已经设计了各种设备，包括逻辑门，非易失性双稳态存储器，环形振荡器，气泡同步器，分析芯片和打印机。

公开(公告)号：US07918244B2

公开(公告)日：2011-04-05

申请号：US12028776

申请日：2008-02-08

申请人： Manu Prakash ,  Neil Gershenfeld

发明人： Manu Prakash ,  Neil Gershenfeld

IPC分类号： F15B21/00

CPC分类号： G01N1/2035 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/02 ,  B01L2400/086 ,  F16K99/0001 ,  F16K99/0019 ,  F16K2099/0084 ,  F16K2099/0092 ,  F16L55/00 ,  G01N15/06 ,  G01N2001/002 ,  Y10T137/2076 ,  Y10T137/87153 ,  Y10T137/87249 ,  Y10T137/9247 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. For performing a set of reactions/tasks or process control, the modulators can be used to program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the micro- or nanofluidic channel sequence, utilizing the generated droplets/bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, ring oscillators, bubble synchronizers, analysis chips, and printers have been designed.

摘要翻译： 基于流体的无移动部件逻辑器件由微流体和纳流体通道的复杂序列构成，用于编程器件的按需气泡/液滴调制器和发生器，以及用于存储和检索的微流体和纳流体液滴/气泡存储元件 生物或化学元素。 气泡/液滴的输入序列编码信息，输出是气泡/液滴的另一个序列或片上化学合成。 为了执行一组反应/任务或过程控制，调制器可用于通过产生精确定时的气泡/液滴序列对装置进行编程，导致在微流体或纳流体通道序列内的级联逻辑运算，利用 产生液滴/气泡作为对照。 这些装置基于在精密通道几何形状内包围的两个流体相之间形成的最小能量界面的原理。 已经设计了各种设备，包括逻辑门，非易失性双稳态存储器，环形振荡器，气泡同步器，分析芯片和打印机。

公开(公告)号：US20150011404A1

公开(公告)日：2015-01-08

申请号：US14481855

申请日：2014-09-09

申请人： Manu Prakash ,  Neil Gershenfeld

发明人： Manu Prakash ,  Neil Gershenfeld

IPC分类号： G01N1/20 ,  G01N15/06

CPC分类号： G01N1/2035 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/02 ,  B01L2400/086 ,  F16K99/0001 ,  F16K99/0019 ,  F16K2099/0084 ,  F16K2099/0092 ,  F16L55/00 ,  G01N15/06 ,  G01N2001/002 ,  Y10T137/2076 ,  Y10T137/87153 ,  Y10T137/87249 ,  Y10T137/9247 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. For performing a set of reactions/tasks or process control, the modulators can be used to program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the micro- or nanofluidic channel sequence, utilizing the generated droplets/bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, ring oscillators, bubble synchronizers, analysis chips, sample collectors, and printers have been designed.

摘要翻译： 基于流体的无移动部件逻辑器件由微流体和纳流体通道的复杂序列构成，用于编程器件的按需气泡/液滴调制器和发生器，以及用于存储和检索的微流体和纳流体液滴/气泡存储元件 生物或化学元素。 气泡/液滴的输入序列编码信息，输出是气泡/液滴的另一个序列或片上化学合成。 为了执行一组反应/任务或过程控制，调制器可以用于通过产生精确定时的气泡/液滴序列对装置进行编程，从而在微流体或纳流体通道序列内进行级联的逻辑运算，利用 产生液滴/气泡作为对照。 这些装置基于在精密通道几何形状内包围的两个流体相之间形成的最小能量界面的原理。 已经设计了各种设备，包括逻辑门，非易失性双稳态存储器，环形振荡器，气泡同步器，分析芯片，样品收集器和打印机。

公开(公告)号：US08383061B2

公开(公告)日：2013-02-26

申请号：US13079774

申请日：2011-04-04

申请人： Manu Prakash ,  Neil Gershenfeld

发明人： Manu Prakash ,  Neil Gershenfeld

IPC分类号： G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC分类号： G01N1/2035 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/02 ,  B01L2400/086 ,  F16K99/0001 ,  F16K99/0019 ,  F16K2099/0084 ,  F16K2099/0092 ,  F16L55/00 ,  G01N15/06 ,  G01N2001/002 ,  Y10T137/2076 ,  Y10T137/87153 ,  Y10T137/87249 ,  Y10T137/9247 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. For performing a set of reactions/tasks or process control, the modulators can be used to program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the micro- or nanofluidic channel sequence, utilizing the generated droplets/bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, ring oscillators, bubble synchronizers, analysis chips, and printers have been designed.

摘要翻译： 基于流体的无移动部件逻辑器件由微流体和纳流体通道的复杂序列构成，用于编程器件的按需气泡/液滴调制器和发生器，以及用于存储和检索的微流体和纳流体液滴/气泡存储元件 生物或化学元素。 气泡/液滴的输入序列编码信息，输出是气泡/液滴的另一个序列或片上化学合成。 为了执行一组反应/任务或过程控制，调制器可以用于通过产生精确定时的气泡/液滴序列对装置进行编程，从而在微流体或纳流体通道序列内进行级联的逻辑运算，利用 产生液滴/气泡作为对照。 这些装置基于在精密通道几何形状内包围的两个流体相之间形成的最小能量界面的原理。 已经设计了各种设备，包括逻辑门，非易失性双稳态存储器，环形振荡器，气泡同步器，分析芯片和打印机。