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公开(公告)号：US08820357B2
公开(公告)日：2014-09-02
申请号：US13569155
申请日：2012-08-07
申请人： Manu Prakash , Neil Gershenfeld
发明人： Manu Prakash , Neil Gershenfeld
IPC分类号： F15B21/00
CPC分类号： F15C1/02 , B01L3/5027 , B01L3/502769 , F15C1/00 , Y10T137/0318 , Y10T137/0324 , Y10T137/2076 , Y10T137/9247
摘要： A method for implementing a logic operation employs an all fluid-based no-moving part micro-mechanical logic family of microfluidic bubble logic devices that are constructed from complex sequences of microfluidic channels, microfluidic bubble modulators for programming the devices, and microfluidic droplet/bubble memory elements for chemical storage and retrieval. The input is a sequence of bubbles/droplets encoding information, with the output being another sequence of bubbles/droplets. For performing a set of reactions/tasks, the modulators program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the microfluidic channel sequence, utilizing the generated bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, shift registers, multiplexers, and ring oscillators have been designed and fabricated.
摘要翻译： 用于实现逻辑操作的方法使用由微流体通道的复杂序列，用于编程器件的微流控气泡调制器和微流控液滴/气泡构成的所有基于流体的无动力部分微机械逻辑器件微流体逻辑器件 用于化学品储存和检索的记忆元素。 输入是编码信息的气泡/液滴序列，输出是气泡/液滴的另一个序列。 为了执行一组反应/任务，调制器通过产生精确定时的气泡/液滴序列对装置进行编程，从而在微流体通道序列内进行级联的逻辑运算，利用生成的气泡作为对照。 这些装置基于在精密通道几何形状内包围的两个流体相之间形成的最小能量界面的原理。 已经设计和制造了各种装置，包括逻辑门，非易失性双稳态存储器，移位寄存器，多路复用器和环形振荡器。
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公开(公告)号：US08828335B2
公开(公告)日：2014-09-09
申请号：US13778103
申请日：2013-02-26
申请人： Manu Prakash , Neil Gershenfeld
发明人： Manu Prakash , Neil Gershenfeld
CPC分类号： G01N1/2035 , B01L3/502746 , B01L3/502784 , B01L2200/0673 , B01L2300/02 , B01L2400/086 , F16K99/0001 , F16K99/0019 , F16K2099/0084 , F16K2099/0092 , F16L55/00 , G01N15/06 , G01N2001/002 , Y10T137/2076 , Y10T137/87153 , Y10T137/87249 , Y10T137/9247 , Y10T436/11 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. For performing a set of reactions/tasks or process control, the modulators can be used to program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the micro- or nanofluidic channel sequence, utilizing the generated droplets/bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, ring oscillators, bubble synchronizers, analysis chips, and printers have been designed.
摘要翻译： 基于流体的无移动部件逻辑器件由微流体和纳流体通道的复杂序列构成，用于编程器件的按需气泡/液滴调制器和发生器，以及用于存储和检索的微流体和纳流体液滴/气泡存储元件 生物或化学元素。 气泡/液滴的输入序列编码信息，输出是气泡/液滴的另一个序列或片上化学合成。 为了执行一组反应/任务或过程控制，调制器可以用于通过产生精确定时的气泡/液滴序列对装置进行编程，从而在微流体或纳流体通道序列内进行级联的逻辑运算，利用 产生液滴/气泡作为对照。 这些装置基于在精密通道几何形状内包围的两个流体相之间形成的最小能量界面的原理。 已经设计了各种设备，包括逻辑门，非易失性双稳态存储器，环形振荡器，气泡同步器，分析芯片和打印机。
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公开(公告)号：US20130146459A1
公开(公告)日：2013-06-13
申请号：US13120744
申请日：2010-06-15
申请人： Martin Bazant , Manu Prakash
发明人： Martin Bazant , Manu Prakash
IPC分类号： G01N27/447
CPC分类号： G01N27/447 , B01F13/0071 , B01F13/0076 , B01L3/50273 , B01L3/502738 , B01L3/502784 , B01L2200/0647 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/088 , B01L2300/0883 , B01L2400/0415 , B01L2400/0418 , B01L2400/0424 , B03C5/005 , B03C5/026
摘要： This invention provides devices and apparatuses comprising the same and methods of use thereof for efficient pumping and/or mixing of relatively small volumes of fluid, wherein the fluid contains a sample within an inner fluid phase dispersed in an outer phase. Such devices utilize nonlinear electrokinetics as a primary mechanism for driving fluid flow and/or mixing the fluid. Methods of cellular analysis, drug delivery and others, utilizing the devices are described.
摘要翻译： 本发明提供了包括其的装置和装置及其使用方法，用于有效泵送和/或混合相对较小体积的流体，其中流体包含分散在外相中的内部流体相内的样品。 这种装置利用非线性电动机作为驱动流体流动和/或混合流体的主要机构。 描述了利用这些装置的细胞分析，药物递送等方法。
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公开(公告)号：US20120291870A1
公开(公告)日：2012-11-22
申请号：US13569155
申请日：2012-08-07
申请人： Manu Prakash , Neil Gershenfeld
发明人： Manu Prakash , Neil Gershenfeld
IPC分类号： F17D1/00
CPC分类号： F15C1/02 , B01L3/5027 , B01L3/502769 , F15C1/00 , Y10T137/0318 , Y10T137/0324 , Y10T137/2076 , Y10T137/9247
摘要： A method for implementing a logic operation employs an all fluid-based no-moving part micro-mechanical logic family of microfluidic bubble logic devices that are constructed from complex sequences of microfluidic channels, microfluidic bubble modulators for programming the devices, and microfluidic droplet/bubble memory elements for chemical storage and retrieval. The input is a sequence of bubbles/droplets encoding information, with the output being another sequence of bubbles/droplets. For performing a set of reactions/tasks, the modulators program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the microfluidic channel sequence, utilizing the generated bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, shift registers, multiplexers, and ring oscillators have been designed and fabricated.
摘要翻译： 用于实现逻辑操作的方法使用由微流体通道的复杂序列，用于编程器件的微流控气泡调制器和微流控液滴/气泡构成的所有基于流体的无动力部分微机械逻辑器件微流体逻辑器件 用于化学品储存和检索的记忆元素。 输入是编码信息的气泡/液滴序列，输出是气泡/液滴的另一个序列。 为了执行一组反应/任务，调制器通过产生精确定时的气泡/液滴序列对装置进行编程，从而在微流体通道序列内进行级联的逻辑运算，利用生成的气泡作为对照。 这些装置基于在精密通道几何形状内包围的两个流体相之间形成的最小能量界面的原理。 已经设计和制造了各种装置，包括逻辑门，非易失性双稳态存储器，移位寄存器，多路复用器和环形振荡器。
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公开(公告)号：US08235071B2
公开(公告)日：2012-08-07
申请号：US12871861
申请日：2010-08-30
申请人： Manu Prakash , Neil Gershenfeld
发明人： Manu Prakash , Neil Gershenfeld
IPC分类号： F15B21/00
CPC分类号： F15C1/02 , B01L3/5027 , B01L3/502769 , F15C1/00 , Y10T137/0318 , Y10T137/0324 , Y10T137/2076 , Y10T137/9247
摘要： A method for implementing a logic operation employs an all fluid-based no-moving part micro-mechanical logic family of microfluidic bubble logic devices that are constructed from complex sequences of microfluidic channels, microfluidic bubble modulators for programming the devices, and microfluidic droplet/bubble memory elements for chemical storage and retrieval. The input is a sequence of bubbles/droplets encoding information, with the output being another sequence of bubbles/droplets. For performing a set of reactions/tasks, the modulators program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the microfluidic channel sequence, utilizing the generated bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, shift registers, multiplexers, and ring oscillators have been designed and fabricated.
摘要翻译： 用于实现逻辑操作的方法使用由微流体通道的复杂序列，用于编程器件的微流控气泡调制器和微流控液滴/气泡构成的所有基于流体的无动力部分微机械逻辑器件微流体逻辑器件 用于化学品储存和检索的记忆元素。 输入是编码信息的气泡/液滴序列，输出是气泡/液滴的另一个序列。 为了执行一组反应/任务，调制器通过产生精确定时的气泡/液滴序列对装置进行编程，从而在微流体通道序列内进行级联的逻辑运算，利用生成的气泡作为对照。 这些装置基于在精密通道几何形状内包围的两个流体相之间形成的最小能量界面的原理。 已经设计和制造了各种装置，包括逻辑门，非易失性双稳态存储器，移位寄存器，多路复用器和环形振荡器。
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公开(公告)号：US07784495B2
公开(公告)日：2010-08-31
申请号：US11416449
申请日：2006-05-02
申请人： Manu Prakash , Neil Gershenfeld
发明人： Manu Prakash , Neil Gershenfeld
IPC分类号： F15B21/00
CPC分类号： F15C1/02 , B01L3/5027 , B01L3/502769 , F15C1/00 , Y10T137/0318 , Y10T137/0324 , Y10T137/2076 , Y10T137/9247
摘要： An all fluid-based no-moving part micro-mechanical logic family of microfluidic bubble logic devices is constructed from complex sequences of microfluidic channels, microfluidic bubble modulators for programming the devices, and microfluidic droplet/bubble memory elements for chemical storage and retrieval. The input is a sequence of bubbles/droplets encoding information, with the output being another sequence of bubbles/droplets. For performing a set of reactions/tasks, the modulators program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the microfluidic channel sequence, utilizing the generated bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, shift registers, multiplexers, and ring oscillators have been designed and fabricated.
摘要翻译： 微流体气泡逻辑器件的所有基于流体的无动力部件微机械逻辑系列由微流体通道的复杂序列，用于编程器件的微流控气泡调制器和用于化学存储和检索的微流控液滴/气泡存储器元件构成。 输入是编码信息的气泡/液滴序列，输出是气泡/液滴的另一个序列。 为了执行一组反应/任务，调制器通过产生精确定时的气泡/液滴序列对装置进行编程，从而在微流体通道序列内进行级联的逻辑运算，利用生成的气泡作为对照。 这些装置基于在精密通道几何形状内包围的两个流体相之间形成的最小能量界面的原理。 已经设计和制造了各种装置，包括逻辑门，非易失性双稳态存储器，移位寄存器，多路复用器和环形振荡器。
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公开(公告)号：US09714941B2
公开(公告)日：2017-07-25
申请号：US12183916
申请日：2008-07-31
申请人： Shuguang Zhang , Andreas Mershin , Liselotte Kaiser , Brian Cook , Johanna F. Graveland-Bikker , Manu Prakash , David Kong , Yael Maguire
发明人： Shuguang Zhang , Andreas Mershin , Liselotte Kaiser , Brian Cook , Johanna F. Graveland-Bikker , Manu Prakash , David Kong , Yael Maguire
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , G01N2333/726
摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.
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公开(公告)号：US09404835B2
公开(公告)日：2016-08-02
申请号：US14481855
申请日：2014-09-09
申请人： Manu Prakash , Neil Gershenfeld
发明人： Manu Prakash , Neil Gershenfeld
CPC分类号： G01N1/2035 , B01L3/502746 , B01L3/502784 , B01L2200/0673 , B01L2300/02 , B01L2400/086 , F16K99/0001 , F16K99/0019 , F16K2099/0084 , F16K2099/0092 , F16L55/00 , G01N15/06 , G01N2001/002 , Y10T137/2076 , Y10T137/87153 , Y10T137/87249 , Y10T137/9247 , Y10T436/11 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. For performing a set of reactions/tasks or process control, the modulators can be used to program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the micro- or nanofluidic channel sequence, utilizing the generated droplets/bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, ring oscillators, bubble synchronizers, analysis chips, sample collectors, and printers have been designed.
摘要翻译： 基于流体的无移动部件逻辑器件由微流体和纳流体通道的复杂序列构成，用于编程器件的按需气泡/液滴调制器和发生器，以及用于存储和检索的微流体和纳流体液滴/气泡存储元件 生物或化学元素。 气泡/液滴的输入序列编码信息，输出是气泡/液滴的另一个序列或片上化学合成。 为了执行一组反应/任务或过程控制，调制器可用于通过产生精确定时的气泡/液滴序列对装置进行编程，导致在微流体或纳流体通道序列内的级联逻辑运算，利用 产生液滴/气泡作为对照。 这些装置基于在精密通道几何形状内包围的两个流体相之间形成的最小能量界面的原理。 已经设计了各种设备，包括逻辑门，非易失性双稳态存储器，环形振荡器，气泡同步器，分析芯片，样品收集器和打印机。
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公开(公告)号：US08998609B2
公开(公告)日：2015-04-07
申请号：US13764764
申请日：2013-02-11
申请人： Manu Prakash , Dhruv Boddupalli , James Clements , Aditya Gande
发明人： Manu Prakash , Dhruv Boddupalli , James Clements , Aditya Gande
CPC分类号： A61B1/24 , A61B1/00009 , A61B1/00032 , A61B1/0005 , A61B1/00052 , A61B1/00108 , A61B1/00147 , A61B1/00172 , A61B1/042 , A61B1/043 , A61B1/0684 , A61C5/90
摘要： A method, system and apparatus for imaging an oral cavity of a subject include a bracket comprising a mouthpiece and a camera mount. The mouthpiece has upper and lower bite guides disposed on a posterior side and separated by an opening through the mouthpiece. The bite guides are spaced apart so a subject biting on the guides opens the oral cavity to inspection through the opening. The mount is disposed on an anterior side of the mouthpiece; and has a flange to engage and slide along the opening and an optical path for light to pass through the mount and mouthpiece. A clip on an anterior side of the mount is configured to removeably hold a camera to record light passing through the optical path from the posterior side of the mount. In one embodiment, the camera is a programmable cell phone with digital camera.
摘要翻译： 用于成像对象的口腔的方法，系统和装置包括包括接口管和相机安装座的支架。 接口具有设置在后侧并具有通过接口管的开口隔开的上咬合引导引导件。 咬合引导件间隔开，使得咬合在引导件上的受试者打开口腔以通过开口检查。 安装件设置在接口管的前侧; 并且具有沿着开口接合和滑动的凸缘和用于光通过安装件和接口管的光路。 安装件的前侧上的夹子被配置为可移除地保持相机以记录从安装座的后侧穿过光路的光。 在一个实施例中，相机是具有数码相机的可编程手机。
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公开(公告)号：US20130209954A1
公开(公告)日：2013-08-15
申请号：US13764764
申请日：2013-02-11
申请人： Manu Prakash , Dhruv Boddupalli , James Clements , Aditya Gande
发明人： Manu Prakash , Dhruv Boddupalli , James Clements , Aditya Gande
CPC分类号： A61B1/24 , A61B1/00009 , A61B1/00032 , A61B1/0005 , A61B1/00052 , A61B1/00108 , A61B1/00147 , A61B1/00172 , A61B1/042 , A61B1/043 , A61B1/0684 , A61C5/90
摘要： A method, system and apparatus for imaging an oral cavity of a subject include a bracket comprising a mouthpiece and a camera mount. The mouthpiece has upper and lower bite guides disposed on a posterior side and separated by an opening through the mouthpiece. The bite guides are spaced apart so a subject biting on the guides opens the oral cavity to inspection through the opening. The mount is disposed on an anterior side of the mouthpiece; and has a flange to engage and slide along the opening and an optical path for light to pass through the mount and mouthpiece. A clip on an anterior side of the mount is configured to removeably hold a camera to record light passing through the optical path from the posterior side of the mount. In one embodiment, the camera is a programmable cell phone with digital camera.
摘要翻译： 用于成像对象的口腔的方法，系统和装置包括包括接口管和相机安装座的支架。 接口具有设置在后侧并具有通过接口管的开口隔开的上咬合引导引导件。 咬合引导件间隔开，使得咬合在引导件上的受试者打开口腔以通过开口检查。 安装件设置在接口管的前侧; 并且具有沿着开口接合和滑动的凸缘和用于光通过安装件和接口管的光路。 安装件的前侧上的夹子被配置为可移除地保持相机以记录从安装座的后侧穿过光路的光。 在一个实施例中，相机是具有数码相机的可编程手机。
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